TY  - JOUR
AU  - Simonović, Mladen
AU  - Mix, Thorsten
AU  - Glumac, Miodrag
AU  - Pejin, Boris
PY  - 2022
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/1547
AB  - A new protein detector of 2,4,6-trinitrophenol (TNP, picric acid) is concisely reported herein for the first time. In brief, the gene of a specific scFv fragment, namely 3.5, was fused separately with the gene of beta-lactamase and, subsequently, expressed in the periplasmic space of Escherichia coli, affording in such a way the recombinant fusion protein 3.5-scFv-beta-lactamase. This bifunctional immunoreagent tool was further convincingly demonstrated for being capable to directly detect trinitrophenol-tris(hydroxymethyl)aminomethane (TNP-Tris), a less toxic TNP derivative of choice compared to TNP itself, with competitive sensitivity (50 +/- 2 fmol or 175 +/- 6 pg/mL).
PB  - Taylor & Francis Ltd, Abingdon
T2  - Natural Product Research
T1  - 3.5-scFv-beta-lactamase, a new protein detector of picric acid, the highly nitrated organic explosive
EP  - 1320
IS  - 5
SP  - 1317
VL  - 36
DO  - 10.1080/14786419.2020.1860977
ER  - 

@article{
author = "Simonović, Mladen and Mix, Thorsten and Glumac, Miodrag and Pejin, Boris",
year = "2022",
abstract = "A new protein detector of 2,4,6-trinitrophenol (TNP, picric acid) is concisely reported herein for the first time. In brief, the gene of a specific scFv fragment, namely 3.5, was fused separately with the gene of beta-lactamase and, subsequently, expressed in the periplasmic space of Escherichia coli, affording in such a way the recombinant fusion protein 3.5-scFv-beta-lactamase. This bifunctional immunoreagent tool was further convincingly demonstrated for being capable to directly detect trinitrophenol-tris(hydroxymethyl)aminomethane (TNP-Tris), a less toxic TNP derivative of choice compared to TNP itself, with competitive sensitivity (50 +/- 2 fmol or 175 +/- 6 pg/mL).",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Natural Product Research",
title = "3.5-scFv-beta-lactamase, a new protein detector of picric acid, the highly nitrated organic explosive",
pages = "1320-1317",
number = "5",
volume = "36",
doi = "10.1080/14786419.2020.1860977"
}

Simonović, M., Mix, T., Glumac, M.,& Pejin, B.. (2022). 3.5-scFv-beta-lactamase, a new protein detector of picric acid, the highly nitrated organic explosive. in Natural Product Research
Taylor & Francis Ltd, Abingdon., 36(5), 1317-1320.
https://doi.org/10.1080/14786419.2020.1860977

Simonović M, Mix T, Glumac M, Pejin B. 3.5-scFv-beta-lactamase, a new protein detector of picric acid, the highly nitrated organic explosive. in Natural Product Research. 2022;36(5):1317-1320.
doi:10.1080/14786419.2020.1860977 .

Simonović, Mladen, Mix, Thorsten, Glumac, Miodrag, Pejin, Boris, "3.5-scFv-beta-lactamase, a new protein detector of picric acid, the highly nitrated organic explosive" in Natural Product Research, 36, no. 5 (2022):1317-1320,
https://doi.org/10.1080/14786419.2020.1860977 . .

TY  - JOUR
AU  - Simonović, Mladen
AU  - Ostojic, Sanja
AU  - Micic, Darko
AU  - Bisercic-Savić, Marjetka
AU  - Mix, Thorsten
AU  - Glumac, Miodrag
AU  - Pejin, Boris
PY  - 2022
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/1537
AB  - This study aimed to develop a fast and reliable protocol for Trinitrophenol-Tris(hydroxymethyl)aminomethane (TNP-Tris) detection applying a beta-lactamase-fusion protein of choice, the natural product-based immunoreagent tool of competitive sensitivity developed herein for the first time. Since the fusion protein 11B3-scFv-beta-lactamase is constructed from a scFv-antibody (11B3) linked to an enzyme (beta-lactamase), the step related to the use of secondary antibody in the enzyme-linked immunosorbent assay (ELISA) is completely omitted. Indeed, this fusion protein itself serves both as binding mean of the antigen model and detecting agent, due to the presence of the naturally occurring enzyme. In such a way, it actually affords the one-step TNP-Tris detection reaching a promising LOD value of 45 +/- 2 fmol or 157 +/- 6 pg/mL. Taken all together, the current protocol does represent much cheaper and significantly less-time consuming alternative compared both to the recombinant antibodies and recombinant phages, previously designed means in our labs for the same purpose. [GRAPHICS] .
PB  - Taylor & Francis Ltd, Abingdon
T2  - Natural Product Research
T1  - A novel and effective natural product-based immunodetection tool for TNT-like compounds
EP  - 861
IS  - 3
SP  - 857
VL  - 36
DO  - 10.1080/14786419.2020.1806269
ER  - 

@article{
author = "Simonović, Mladen and Ostojic, Sanja and Micic, Darko and Bisercic-Savić, Marjetka and Mix, Thorsten and Glumac, Miodrag and Pejin, Boris",
year = "2022",
abstract = "This study aimed to develop a fast and reliable protocol for Trinitrophenol-Tris(hydroxymethyl)aminomethane (TNP-Tris) detection applying a beta-lactamase-fusion protein of choice, the natural product-based immunoreagent tool of competitive sensitivity developed herein for the first time. Since the fusion protein 11B3-scFv-beta-lactamase is constructed from a scFv-antibody (11B3) linked to an enzyme (beta-lactamase), the step related to the use of secondary antibody in the enzyme-linked immunosorbent assay (ELISA) is completely omitted. Indeed, this fusion protein itself serves both as binding mean of the antigen model and detecting agent, due to the presence of the naturally occurring enzyme. In such a way, it actually affords the one-step TNP-Tris detection reaching a promising LOD value of 45 +/- 2 fmol or 157 +/- 6 pg/mL. Taken all together, the current protocol does represent much cheaper and significantly less-time consuming alternative compared both to the recombinant antibodies and recombinant phages, previously designed means in our labs for the same purpose. [GRAPHICS] .",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Natural Product Research",
title = "A novel and effective natural product-based immunodetection tool for TNT-like compounds",
pages = "861-857",
number = "3",
volume = "36",
doi = "10.1080/14786419.2020.1806269"
}

Simonović, M., Ostojic, S., Micic, D., Bisercic-Savić, M., Mix, T., Glumac, M.,& Pejin, B.. (2022). A novel and effective natural product-based immunodetection tool for TNT-like compounds. in Natural Product Research
Taylor & Francis Ltd, Abingdon., 36(3), 857-861.
https://doi.org/10.1080/14786419.2020.1806269

Simonović M, Ostojic S, Micic D, Bisercic-Savić M, Mix T, Glumac M, Pejin B. A novel and effective natural product-based immunodetection tool for TNT-like compounds. in Natural Product Research. 2022;36(3):857-861.
doi:10.1080/14786419.2020.1806269 .

Simonović, Mladen, Ostojic, Sanja, Micic, Darko, Bisercic-Savić, Marjetka, Mix, Thorsten, Glumac, Miodrag, Pejin, Boris, "A novel and effective natural product-based immunodetection tool for TNT-like compounds" in Natural Product Research, 36, no. 3 (2022):857-861,
https://doi.org/10.1080/14786419.2020.1806269 . .

TY  - JOUR
AU  - Simonović, Mladen
AU  - Kojić, Vesna
AU  - Jakimov, Dimitar
AU  - Glumac, Miodrag
AU  - Pejin, Boris
PY  - 2021
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/1513
AB  - This study was focused on in vitro cytotoxicity screening of the raspberry seeds methanol extract towards a number of cancer cell lines of human origin. The tested extract at the preferred concentrations (IC50  lt 30 mu g/mL) inhibited only the growth of the lung cancer A-549 cells (IC50 = 14.07 +/- 0.96 mu g/mL). At the same time, it was practically inactive (IC50 >300 mu g/mL) and non-mutagenic towards normal MRC-5 lung cells. Finally, the extract potently scavenged both OH center dot (IC50 = 20.11 +/- 1.77 mu g/mL) and O2-center dot (IC50 = 47.23 +/- 3.82 mu g/mL), the free radicals of proved relevance for cancer pathophysiology. Though seeds were enriched with phenolic compounds (TPC = 5.21 +/- 0.07 mg GAE/g), anthocyanins were present in traces only (TAC = 0.07 +/- 0.003 mg cyn-3-glu/g), while flavonoids were not detected at all. This is the first report on anti-lung cancer potential of the seeds of any soft fruit.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Natural Product Research
T1  - Raspberry seeds extract selectively inhibits the growth of human lung cancer cells in vitro
EP  - 2256
IS  - 13
SP  - 2253
VL  - 35
DO  - 10.1080/14786419.2019.1666391
ER  - 

@article{
author = "Simonović, Mladen and Kojić, Vesna and Jakimov, Dimitar and Glumac, Miodrag and Pejin, Boris",
year = "2021",
abstract = "This study was focused on in vitro cytotoxicity screening of the raspberry seeds methanol extract towards a number of cancer cell lines of human origin. The tested extract at the preferred concentrations (IC50  lt 30 mu g/mL) inhibited only the growth of the lung cancer A-549 cells (IC50 = 14.07 +/- 0.96 mu g/mL). At the same time, it was practically inactive (IC50 >300 mu g/mL) and non-mutagenic towards normal MRC-5 lung cells. Finally, the extract potently scavenged both OH center dot (IC50 = 20.11 +/- 1.77 mu g/mL) and O2-center dot (IC50 = 47.23 +/- 3.82 mu g/mL), the free radicals of proved relevance for cancer pathophysiology. Though seeds were enriched with phenolic compounds (TPC = 5.21 +/- 0.07 mg GAE/g), anthocyanins were present in traces only (TAC = 0.07 +/- 0.003 mg cyn-3-glu/g), while flavonoids were not detected at all. This is the first report on anti-lung cancer potential of the seeds of any soft fruit.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Natural Product Research",
title = "Raspberry seeds extract selectively inhibits the growth of human lung cancer cells in vitro",
pages = "2256-2253",
number = "13",
volume = "35",
doi = "10.1080/14786419.2019.1666391"
}

Simonović, M., Kojić, V., Jakimov, D., Glumac, M.,& Pejin, B.. (2021). Raspberry seeds extract selectively inhibits the growth of human lung cancer cells in vitro. in Natural Product Research
Taylor & Francis Ltd, Abingdon., 35(13), 2253-2256.
https://doi.org/10.1080/14786419.2019.1666391

Simonović M, Kojić V, Jakimov D, Glumac M, Pejin B. Raspberry seeds extract selectively inhibits the growth of human lung cancer cells in vitro. in Natural Product Research. 2021;35(13):2253-2256.
doi:10.1080/14786419.2019.1666391 .

Simonović, Mladen, Kojić, Vesna, Jakimov, Dimitar, Glumac, Miodrag, Pejin, Boris, "Raspberry seeds extract selectively inhibits the growth of human lung cancer cells in vitro" in Natural Product Research, 35, no. 13 (2021):2253-2256,
https://doi.org/10.1080/14786419.2019.1666391 . .

TY  - JOUR
AU  - Pejin, Boris
AU  - Simonović, Mladen
AU  - Talevska, Aleksandra
AU  - Glumac, Miodrag
AU  - Jakimov, Dimitar
AU  - Kojić, Vesna
PY  - 2021
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/1511
AB  - The cytotoxicity of the methanol extract of the freshwater sponge Ochridaspongia rotunda (Arndt, 1937) (Malawispongiidae) was evaluated by MTT assay at in vitro conditions against three brain tumour cell lines (Neuro-2A, U-251 MG and U-87 MG). The extract was actually found to be most effective against the malignant glioma U-251 MG cells reaching a promising IC50 value of 1.87 +/- 0.09 mu g/mL at 96 h. However, it exhibited only a bit of cytotoxicity (IC50 321.14 +/- 11.29 mu g/mL, 96 h) towards the normal cells. Also, this sponge extract was 5-fold more selective for U-251 MG versus U-87 MG cells. Finally, monitoring genotoxicity at chromosomal level using the micronucleus test practically revealed lack of any significant toxicity of O. rotunda extract, compared to doxorubicin. [GRAPHICS] .
PB  - Taylor & Francis Ltd, Abingdon
T2  - Natural Product Research
T1  - A neglected natural source for targeting glioblastoma
EP  - 1860
IS  - 11
SP  - 1856
VL  - 35
DO  - 10.1080/14786419.2019.1638386
ER  - 

@article{
author = "Pejin, Boris and Simonović, Mladen and Talevska, Aleksandra and Glumac, Miodrag and Jakimov, Dimitar and Kojić, Vesna",
year = "2021",
abstract = "The cytotoxicity of the methanol extract of the freshwater sponge Ochridaspongia rotunda (Arndt, 1937) (Malawispongiidae) was evaluated by MTT assay at in vitro conditions against three brain tumour cell lines (Neuro-2A, U-251 MG and U-87 MG). The extract was actually found to be most effective against the malignant glioma U-251 MG cells reaching a promising IC50 value of 1.87 +/- 0.09 mu g/mL at 96 h. However, it exhibited only a bit of cytotoxicity (IC50 321.14 +/- 11.29 mu g/mL, 96 h) towards the normal cells. Also, this sponge extract was 5-fold more selective for U-251 MG versus U-87 MG cells. Finally, monitoring genotoxicity at chromosomal level using the micronucleus test practically revealed lack of any significant toxicity of O. rotunda extract, compared to doxorubicin. [GRAPHICS] .",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Natural Product Research",
title = "A neglected natural source for targeting glioblastoma",
pages = "1860-1856",
number = "11",
volume = "35",
doi = "10.1080/14786419.2019.1638386"
}

Pejin, B., Simonović, M., Talevska, A., Glumac, M., Jakimov, D.,& Kojić, V.. (2021). A neglected natural source for targeting glioblastoma. in Natural Product Research
Taylor & Francis Ltd, Abingdon., 35(11), 1856-1860.
https://doi.org/10.1080/14786419.2019.1638386

Pejin B, Simonović M, Talevska A, Glumac M, Jakimov D, Kojić V. A neglected natural source for targeting glioblastoma. in Natural Product Research. 2021;35(11):1856-1860.
doi:10.1080/14786419.2019.1638386 .

Pejin, Boris, Simonović, Mladen, Talevska, Aleksandra, Glumac, Miodrag, Jakimov, Dimitar, Kojić, Vesna, "A neglected natural source for targeting glioblastoma" in Natural Product Research, 35, no. 11 (2021):1856-1860,
https://doi.org/10.1080/14786419.2019.1638386 . .

TY  - JOUR
AU  - Karaman, Maja
AU  - Tesanović, Kristina
AU  - Gorjanović, Stanislava
AU  - Pastor, Ferenc
AU  - Simonović, Mladen
AU  - Glumac, Miodrag
AU  - Pejin, Boris
PY  - 2021
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/1510
AB  - This study was focused on in vitro screening of the total antioxidant activity of the selected extracts of the mushroom Coprinus comatus and quinic acid, one of their antidiabetic ingredients, by an uncommon electrochemical assay. Indeed, direct current (DC) polarographic HydroxoPerhydroxo Mercury(II) Complex (HPMC) assay based on decrease of anodic limiting current originating from HPMC formation in alkaline solutions of hydrogen peroxide at potential of mercury dissolution, observed upon gradual addition of antioxidants, was applied herein for the estimation of the natural products' antioxidativity. Quinic acid was found to exhibit most promising antioxidant potential (4.0 +/- 0.2%mu L-1) being approximate to 2-fold more active than the screened C. comatus extract samples. Actually, such a finding puts some light on the antioxidativity of cyclic polyols, well understimated class of organic compounds, compared to aromatic (poly)phenolics. As a low cost, easy-to handle and accurate this polarographic assay may be thoroughly recommended for much broader use.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Natural Product Research
T1  - Polarography as a technique of choice for the evaluation of total antioxidant activity: The case study of selected Coprinus Comatus extracts and quinic acid, their antidiabetic ingredient
EP  - 1716
IS  - 10
SP  - 1711
VL  - 35
DO  - 10.1080/14786419.2019.1628753
ER  - 

@article{
author = "Karaman, Maja and Tesanović, Kristina and Gorjanović, Stanislava and Pastor, Ferenc and Simonović, Mladen and Glumac, Miodrag and Pejin, Boris",
year = "2021",
abstract = "This study was focused on in vitro screening of the total antioxidant activity of the selected extracts of the mushroom Coprinus comatus and quinic acid, one of their antidiabetic ingredients, by an uncommon electrochemical assay. Indeed, direct current (DC) polarographic HydroxoPerhydroxo Mercury(II) Complex (HPMC) assay based on decrease of anodic limiting current originating from HPMC formation in alkaline solutions of hydrogen peroxide at potential of mercury dissolution, observed upon gradual addition of antioxidants, was applied herein for the estimation of the natural products' antioxidativity. Quinic acid was found to exhibit most promising antioxidant potential (4.0 +/- 0.2%mu L-1) being approximate to 2-fold more active than the screened C. comatus extract samples. Actually, such a finding puts some light on the antioxidativity of cyclic polyols, well understimated class of organic compounds, compared to aromatic (poly)phenolics. As a low cost, easy-to handle and accurate this polarographic assay may be thoroughly recommended for much broader use.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Natural Product Research",
title = "Polarography as a technique of choice for the evaluation of total antioxidant activity: The case study of selected Coprinus Comatus extracts and quinic acid, their antidiabetic ingredient",
pages = "1716-1711",
number = "10",
volume = "35",
doi = "10.1080/14786419.2019.1628753"
}

Karaman, M., Tesanović, K., Gorjanović, S., Pastor, F., Simonović, M., Glumac, M.,& Pejin, B.. (2021). Polarography as a technique of choice for the evaluation of total antioxidant activity: The case study of selected Coprinus Comatus extracts and quinic acid, their antidiabetic ingredient. in Natural Product Research
Taylor & Francis Ltd, Abingdon., 35(10), 1711-1716.
https://doi.org/10.1080/14786419.2019.1628753

Karaman M, Tesanović K, Gorjanović S, Pastor F, Simonović M, Glumac M, Pejin B. Polarography as a technique of choice for the evaluation of total antioxidant activity: The case study of selected Coprinus Comatus extracts and quinic acid, their antidiabetic ingredient. in Natural Product Research. 2021;35(10):1711-1716.
doi:10.1080/14786419.2019.1628753 .

Karaman, Maja, Tesanović, Kristina, Gorjanović, Stanislava, Pastor, Ferenc, Simonović, Mladen, Glumac, Miodrag, Pejin, Boris, "Polarography as a technique of choice for the evaluation of total antioxidant activity: The case study of selected Coprinus Comatus extracts and quinic acid, their antidiabetic ingredient" in Natural Product Research, 35, no. 10 (2021):1711-1716,
https://doi.org/10.1080/14786419.2019.1628753 . .

TY  - JOUR
AU  - Simonović, Mladen
AU  - Ostojic, Sanja
AU  - Micic, Darko
AU  - Pejin, Boris
PY  - 2021
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/1402
AB  - This study focuses on the impact of low and high temperature regimes on the chemical composition and antioxidativity of low sugar berry fruits jellies. High quality fruits (strawberry, raspberry and blackberry) were collected from Western Serbia region, quite well recognised both nationally and internationally due to an extremely well developed practice in growing berry fruits. The obtained results have clearly indicated the importance of low temperature regime for enriched contents of both total phenolics and anthocyanins followed by an enhanced antioxidativity. Rubus fruticosus L. Cacak Thornless cultivar, the only autochthonous berry fruit variety screened herein, may be firmly recommended as a raw material for industrial production of low sugar blackberry jellies with exceptional characteristics. This innovative procedure of preparing berry fruit jellies have encompassed the application of low temperature regime (55 degrees C), lower content of sugar (40%), seeds separation from jellies followed by no use of pectin throughout the whole process. [GRAPHICS] .
PB  - Taylor & Francis Ltd, Abingdon
T2  - Natural Product Research
T1  - Low sugar jellies of berry fruits: the impact of low vs. high temperature regime on their chemical composition and antioxidativity
EP  - 341
IS  - 2
SP  - 337
VL  - 35
DO  - 10.1080/14786419.2019.1622109
ER  - 

@article{
author = "Simonović, Mladen and Ostojic, Sanja and Micic, Darko and Pejin, Boris",
year = "2021",
abstract = "This study focuses on the impact of low and high temperature regimes on the chemical composition and antioxidativity of low sugar berry fruits jellies. High quality fruits (strawberry, raspberry and blackberry) were collected from Western Serbia region, quite well recognised both nationally and internationally due to an extremely well developed practice in growing berry fruits. The obtained results have clearly indicated the importance of low temperature regime for enriched contents of both total phenolics and anthocyanins followed by an enhanced antioxidativity. Rubus fruticosus L. Cacak Thornless cultivar, the only autochthonous berry fruit variety screened herein, may be firmly recommended as a raw material for industrial production of low sugar blackberry jellies with exceptional characteristics. This innovative procedure of preparing berry fruit jellies have encompassed the application of low temperature regime (55 degrees C), lower content of sugar (40%), seeds separation from jellies followed by no use of pectin throughout the whole process. [GRAPHICS] .",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Natural Product Research",
title = "Low sugar jellies of berry fruits: the impact of low vs. high temperature regime on their chemical composition and antioxidativity",
pages = "341-337",
number = "2",
volume = "35",
doi = "10.1080/14786419.2019.1622109"
}

Simonović, M., Ostojic, S., Micic, D.,& Pejin, B.. (2021). Low sugar jellies of berry fruits: the impact of low vs. high temperature regime on their chemical composition and antioxidativity. in Natural Product Research
Taylor & Francis Ltd, Abingdon., 35(2), 337-341.
https://doi.org/10.1080/14786419.2019.1622109

Simonović M, Ostojic S, Micic D, Pejin B. Low sugar jellies of berry fruits: the impact of low vs. high temperature regime on their chemical composition and antioxidativity. in Natural Product Research. 2021;35(2):337-341.
doi:10.1080/14786419.2019.1622109 .

Simonović, Mladen, Ostojic, Sanja, Micic, Darko, Pejin, Boris, "Low sugar jellies of berry fruits: the impact of low vs. high temperature regime on their chemical composition and antioxidativity" in Natural Product Research, 35, no. 2 (2021):337-341,
https://doi.org/10.1080/14786419.2019.1622109 . .

TY  - JOUR
AU  - Lakicević, Svetlana H.
AU  - Popovic-Đorđević, Jelena
AU  - Pejin, Boris
AU  - Đorđević, Aleksandra S.
AU  - Matijasević, Sasa M.
AU  - Lazic, Miodrag L.
PY  - 2020
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/1315
AB  - Autochthonous variety 'Prokupac' (Vitis vinifera L.) red wines with the addition of selected aromatic herbs (Artemisia absinthium, Cinnamomum zeylanicum, Glycyrrhiza glabra and Pimpinella anisum L.) were evaluated for chemical composition and biological activity. Furthermore, their polyphenolic profiles were determined by HPLC-DAD. While total phenolic (TPC) and flavonoid (TFC) contents, along with antioxidant activity, were significantly higher in all examined wine samples, the content of total anthocyanins was decreased, compared to a pure 'Prokupac' wine, used as the control one. On the other hand, 'Prokupac' wines with the addition of cinnamon (S. zeylanicum) and wormwood (A. absinthium) displayed highest antioxidant (EC50, 0.021 +/- 0.001 mg/mL) and antibacterial (Enterococcus faecalis, MIC/MBC 15.63/62.50 mu L/mL) activities, respectively. The study showed that 'Prokupac' wine with the addition of cinnamon was significantly enriched both with TPC and TFC, compared to control wine (p  lt  0.05), which may contribute to its market potential.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Natural Product Research
T1  - An insight into chemical composition and bioactivity of 'Prokupac' red wine
EP  - 1546
IS  - 11
SP  - 1542
VL  - 34
DO  - 10.1080/14786419.2018.1516219
ER  - 

@article{
author = "Lakicević, Svetlana H. and Popovic-Đorđević, Jelena and Pejin, Boris and Đorđević, Aleksandra S. and Matijasević, Sasa M. and Lazic, Miodrag L.",
year = "2020",
abstract = "Autochthonous variety 'Prokupac' (Vitis vinifera L.) red wines with the addition of selected aromatic herbs (Artemisia absinthium, Cinnamomum zeylanicum, Glycyrrhiza glabra and Pimpinella anisum L.) were evaluated for chemical composition and biological activity. Furthermore, their polyphenolic profiles were determined by HPLC-DAD. While total phenolic (TPC) and flavonoid (TFC) contents, along with antioxidant activity, were significantly higher in all examined wine samples, the content of total anthocyanins was decreased, compared to a pure 'Prokupac' wine, used as the control one. On the other hand, 'Prokupac' wines with the addition of cinnamon (S. zeylanicum) and wormwood (A. absinthium) displayed highest antioxidant (EC50, 0.021 +/- 0.001 mg/mL) and antibacterial (Enterococcus faecalis, MIC/MBC 15.63/62.50 mu L/mL) activities, respectively. The study showed that 'Prokupac' wine with the addition of cinnamon was significantly enriched both with TPC and TFC, compared to control wine (p  lt  0.05), which may contribute to its market potential.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Natural Product Research",
title = "An insight into chemical composition and bioactivity of 'Prokupac' red wine",
pages = "1546-1542",
number = "11",
volume = "34",
doi = "10.1080/14786419.2018.1516219"
}

Lakicević, S. H., Popovic-Đorđević, J., Pejin, B., Đorđević, A. S., Matijasević, S. M.,& Lazic, M. L.. (2020). An insight into chemical composition and bioactivity of 'Prokupac' red wine. in Natural Product Research
Taylor & Francis Ltd, Abingdon., 34(11), 1542-1546.
https://doi.org/10.1080/14786419.2018.1516219

Lakicević SH, Popovic-Đorđević J, Pejin B, Đorđević AS, Matijasević SM, Lazic ML. An insight into chemical composition and bioactivity of 'Prokupac' red wine. in Natural Product Research. 2020;34(11):1542-1546.
doi:10.1080/14786419.2018.1516219 .

Lakicević, Svetlana H., Popovic-Đorđević, Jelena, Pejin, Boris, Đorđević, Aleksandra S., Matijasević, Sasa M., Lazic, Miodrag L., "An insight into chemical composition and bioactivity of 'Prokupac' red wine" in Natural Product Research, 34, no. 11 (2020):1542-1546,
https://doi.org/10.1080/14786419.2018.1516219 . .

TY  - JOUR
AU  - Karaman, Maja
AU  - Tesanović, Kristina
AU  - Novaković, Aleksandra
AU  - Jakovljević, Dragica
AU  - Janjusević, Ljiljana
AU  - Sibul, Filip
AU  - Pejin, Boris
PY  - 2020
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/1318
AB  - In vitroacetylholinesterase (AChE) inhibitory activity of an autochthonous sample of the mushroomCoprinus comatus(encompassing fruiting body FB, mycelia M and filtrate F from the submerged cultivation) was the subject of this study.C. comatusF extract exhibited rather potent anti-AChE activity (73.0 +/- 1.5%) atin liquidconditions, comparable to those of the conventional drug donepezil (80.6 +/- 1.4%). Also, the same extract exhibited high anti-AChE activity (1 mu g)in solid. While its FTIR spectrum indicated the presence of phenolic compounds, quercetin (28.1 mu g g(-1)d.w.) was found to affect the observed bioactivity (59.8 +/- 0.9%). This is the first report of profound anti-AChE activity of anyC. comatusextract, a medicinal mushroom that has been successfully cultivated in P.R. China, due to the demanding needs of food industry.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Natural Product Research
T1  - Coprinus comatusfiltrate extract, a novel neuroprotective agent of natural origin
EP  - 2350
IS  - 16
SP  - 2346
VL  - 34
DO  - 10.1080/14786419.2018.1533831
ER  - 

@article{
author = "Karaman, Maja and Tesanović, Kristina and Novaković, Aleksandra and Jakovljević, Dragica and Janjusević, Ljiljana and Sibul, Filip and Pejin, Boris",
year = "2020",
abstract = "In vitroacetylholinesterase (AChE) inhibitory activity of an autochthonous sample of the mushroomCoprinus comatus(encompassing fruiting body FB, mycelia M and filtrate F from the submerged cultivation) was the subject of this study.C. comatusF extract exhibited rather potent anti-AChE activity (73.0 +/- 1.5%) atin liquidconditions, comparable to those of the conventional drug donepezil (80.6 +/- 1.4%). Also, the same extract exhibited high anti-AChE activity (1 mu g)in solid. While its FTIR spectrum indicated the presence of phenolic compounds, quercetin (28.1 mu g g(-1)d.w.) was found to affect the observed bioactivity (59.8 +/- 0.9%). This is the first report of profound anti-AChE activity of anyC. comatusextract, a medicinal mushroom that has been successfully cultivated in P.R. China, due to the demanding needs of food industry.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Natural Product Research",
title = "Coprinus comatusfiltrate extract, a novel neuroprotective agent of natural origin",
pages = "2350-2346",
number = "16",
volume = "34",
doi = "10.1080/14786419.2018.1533831"
}

Karaman, M., Tesanović, K., Novaković, A., Jakovljević, D., Janjusević, L., Sibul, F.,& Pejin, B.. (2020). Coprinus comatusfiltrate extract, a novel neuroprotective agent of natural origin. in Natural Product Research
Taylor & Francis Ltd, Abingdon., 34(16), 2346-2350.
https://doi.org/10.1080/14786419.2018.1533831

Karaman M, Tesanović K, Novaković A, Jakovljević D, Janjusević L, Sibul F, Pejin B. Coprinus comatusfiltrate extract, a novel neuroprotective agent of natural origin. in Natural Product Research. 2020;34(16):2346-2350.
doi:10.1080/14786419.2018.1533831 .

Karaman, Maja, Tesanović, Kristina, Novaković, Aleksandra, Jakovljević, Dragica, Janjusević, Ljiljana, Sibul, Filip, Pejin, Boris, "Coprinus comatusfiltrate extract, a novel neuroprotective agent of natural origin" in Natural Product Research, 34, no. 16 (2020):2346-2350,
https://doi.org/10.1080/14786419.2018.1533831 . .

TY  - JOUR
AU  - Talevski, Trajce
AU  - Talevska-Leshoska, Aleksandra
AU  - Pejoski, Elena
AU  - Pejin, Boris
AU  - Machalowski, Tomasz
AU  - Wysokowski, Marcin
AU  - Tsurkan, Mikhail, V
AU  - Petrova, Olga
AU  - Sivkov, Viktor
AU  - Martinović, Rajko
AU  - Pantović, Snežana
AU  - Khrunyk, Yuliya
AU  - Trylis, Volodymyr
AU  - Fursov, Andriy
AU  - Djurović, Mirko
AU  - Jesionowski, Teofil
AU  - Ehrlich, Hermann
PY  - 2020
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/1324
AB  - Studies on the identification, properties and function of chitin in sponges (Porifera), which are recognized as the first multicellular organisms on Earth, continue to be of fundamental scientific interest. The occurrence of chitin has so far been reported in 21 marine sponge species and only in two inhabiting fresh water. In this study, we present the discovery of alpha-chitin in the endemic demosponge Ochridaspongia rotunda, found in Lake Ohrid, which dates from the Tertiary. The presence of chitin in this species was confirmed using special staining, a chitinase test, FTIR, Raman and NEXAFS spectroscopy, and electrospray ionization mass spectrometry (ESIMS). In contrast to the case of marine sponges, chitin in O. rotunda has been found only within its holdfast, suggesting a role of chitin in the attachment of the sponge to the hard substratum. Isolated fibrous matter strongly resemble the shape and size of the sponge holdfast with membrane-like structure.
PB  - Elsevier, Amsterdam
T2  - International Journal of Biological Macromolecules
T1  - Identification and first insights into the structure of chitin from the endemic freshwater demosponge Ochridaspongia rotunda (Arndt, 1937)
EP  - 1194
SP  - 1187
VL  - 162
DO  - 10.1016/j.ijbiomac.2020.06.247
ER  - 

@article{
author = "Talevski, Trajce and Talevska-Leshoska, Aleksandra and Pejoski, Elena and Pejin, Boris and Machalowski, Tomasz and Wysokowski, Marcin and Tsurkan, Mikhail, V and Petrova, Olga and Sivkov, Viktor and Martinović, Rajko and Pantović, Snežana and Khrunyk, Yuliya and Trylis, Volodymyr and Fursov, Andriy and Djurović, Mirko and Jesionowski, Teofil and Ehrlich, Hermann",
year = "2020",
abstract = "Studies on the identification, properties and function of chitin in sponges (Porifera), which are recognized as the first multicellular organisms on Earth, continue to be of fundamental scientific interest. The occurrence of chitin has so far been reported in 21 marine sponge species and only in two inhabiting fresh water. In this study, we present the discovery of alpha-chitin in the endemic demosponge Ochridaspongia rotunda, found in Lake Ohrid, which dates from the Tertiary. The presence of chitin in this species was confirmed using special staining, a chitinase test, FTIR, Raman and NEXAFS spectroscopy, and electrospray ionization mass spectrometry (ESIMS). In contrast to the case of marine sponges, chitin in O. rotunda has been found only within its holdfast, suggesting a role of chitin in the attachment of the sponge to the hard substratum. Isolated fibrous matter strongly resemble the shape and size of the sponge holdfast with membrane-like structure.",
publisher = "Elsevier, Amsterdam",
journal = "International Journal of Biological Macromolecules",
title = "Identification and first insights into the structure of chitin from the endemic freshwater demosponge Ochridaspongia rotunda (Arndt, 1937)",
pages = "1194-1187",
volume = "162",
doi = "10.1016/j.ijbiomac.2020.06.247"
}

Talevski, T., Talevska-Leshoska, A., Pejoski, E., Pejin, B., Machalowski, T., Wysokowski, M., Tsurkan, M. V., Petrova, O., Sivkov, V., Martinović, R., Pantović, S., Khrunyk, Y., Trylis, V., Fursov, A., Djurović, M., Jesionowski, T.,& Ehrlich, H.. (2020). Identification and first insights into the structure of chitin from the endemic freshwater demosponge Ochridaspongia rotunda (Arndt, 1937). in International Journal of Biological Macromolecules
Elsevier, Amsterdam., 162, 1187-1194.
https://doi.org/10.1016/j.ijbiomac.2020.06.247

Talevski T, Talevska-Leshoska A, Pejoski E, Pejin B, Machalowski T, Wysokowski M, Tsurkan MV, Petrova O, Sivkov V, Martinović R, Pantović S, Khrunyk Y, Trylis V, Fursov A, Djurović M, Jesionowski T, Ehrlich H. Identification and first insights into the structure of chitin from the endemic freshwater demosponge Ochridaspongia rotunda (Arndt, 1937). in International Journal of Biological Macromolecules. 2020;162:1187-1194.
doi:10.1016/j.ijbiomac.2020.06.247 .

Talevski, Trajce, Talevska-Leshoska, Aleksandra, Pejoski, Elena, Pejin, Boris, Machalowski, Tomasz, Wysokowski, Marcin, Tsurkan, Mikhail, V, Petrova, Olga, Sivkov, Viktor, Martinović, Rajko, Pantović, Snežana, Khrunyk, Yuliya, Trylis, Volodymyr, Fursov, Andriy, Djurović, Mirko, Jesionowski, Teofil, Ehrlich, Hermann, "Identification and first insights into the structure of chitin from the endemic freshwater demosponge Ochridaspongia rotunda (Arndt, 1937)" in International Journal of Biological Macromolecules, 162 (2020):1187-1194,
https://doi.org/10.1016/j.ijbiomac.2020.06.247 . .

TY  - JOUR
AU  - Nakarada, Dura
AU  - Pejin, Boris
AU  - Tommonaro, Giuseppina
AU  - Mojović, Miloš
PY  - 2020
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/1340
AB  - The liposomal integration method, in conjunction with electron paramagnetic resonance (EPR) spectroscopy, has been presented for the investigation of antioxidant activity of selected water-insoluble compound towards biologically relevant free radicals. This method was applied to avarol, a sesquiterpenoid hydroquinone isolated from the marine sponge Dysidea avara. The antioxidant activity of water-insoluble avarol towards (OH)-O-center dot, O-2(center dot-) and NO center dot radicals was attained by its incorporation into the DPPC liposomes bilayer, and towards ascorbyl radicals in the organic solvent. Avarol's activity towards (OH)-O-center dot, O-2(center dot-), NO center dot and ascorbyl radicals was 86.2%, 50.9%, 23.6% and 61.8%, respectively, showing its significant radical scavenging potential.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Journal of Liposome Research
T1  - Liposomal integration method for assessing antioxidative activity of water insoluble compounds towards biologically relevant free radicals: example of avarol
EP  - 226
IS  - 3
SP  - 218
VL  - 30
DO  - 10.1080/08982104.2019.1625378
ER  - 

@article{
author = "Nakarada, Dura and Pejin, Boris and Tommonaro, Giuseppina and Mojović, Miloš",
year = "2020",
abstract = "The liposomal integration method, in conjunction with electron paramagnetic resonance (EPR) spectroscopy, has been presented for the investigation of antioxidant activity of selected water-insoluble compound towards biologically relevant free radicals. This method was applied to avarol, a sesquiterpenoid hydroquinone isolated from the marine sponge Dysidea avara. The antioxidant activity of water-insoluble avarol towards (OH)-O-center dot, O-2(center dot-) and NO center dot radicals was attained by its incorporation into the DPPC liposomes bilayer, and towards ascorbyl radicals in the organic solvent. Avarol's activity towards (OH)-O-center dot, O-2(center dot-), NO center dot and ascorbyl radicals was 86.2%, 50.9%, 23.6% and 61.8%, respectively, showing its significant radical scavenging potential.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Journal of Liposome Research",
title = "Liposomal integration method for assessing antioxidative activity of water insoluble compounds towards biologically relevant free radicals: example of avarol",
pages = "226-218",
number = "3",
volume = "30",
doi = "10.1080/08982104.2019.1625378"
}

Nakarada, D., Pejin, B., Tommonaro, G.,& Mojović, M.. (2020). Liposomal integration method for assessing antioxidative activity of water insoluble compounds towards biologically relevant free radicals: example of avarol. in Journal of Liposome Research
Taylor & Francis Ltd, Abingdon., 30(3), 218-226.
https://doi.org/10.1080/08982104.2019.1625378

Nakarada D, Pejin B, Tommonaro G, Mojović M. Liposomal integration method for assessing antioxidative activity of water insoluble compounds towards biologically relevant free radicals: example of avarol. in Journal of Liposome Research. 2020;30(3):218-226.
doi:10.1080/08982104.2019.1625378 .

Nakarada, Dura, Pejin, Boris, Tommonaro, Giuseppina, Mojović, Miloš, "Liposomal integration method for assessing antioxidative activity of water insoluble compounds towards biologically relevant free radicals: example of avarol" in Journal of Liposome Research, 30, no. 3 (2020):218-226,
https://doi.org/10.1080/08982104.2019.1625378 . .

TY  - JOUR
AU  - Stanimirović, Bojana
AU  - Vujović, Dragan
AU  - Pejin, Boris
AU  - Popovic-Đorđević, Jelena
AU  - Maletic, Radojka
AU  - Raicević, Petar
AU  - Tesic, Zivoslav
PY  - 2019
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/1282
AB  - The elemental profile of the leaf samples of three Cabernet Franc clone candidates recently developed in Serbia (Nos. 02, 010 and 012) obtained in the last phase of clonal selection was examined within this study by ICP-OES. Optimal content of Al, Fe, Cu and Zn, the metals well known for their links with a number of neurodegenerative disorders including Alzheimer's disease, has actually highlighted the potential of the leaf sample No. 10 to afford a novel food supplement of natural origin possessing well balanced metal ingredients. Furthermore, lower content of some other elements (Cr, Mn, Ni and Pb) thoroughly supports such a claiming. Finally, the most favourable K/Na ratio observed for the aforementioned sample points out its likely cardioprotectivity. However, two other Cabernet Franc clone candidates might also be recommended for breeding in the same or similar viticultural conditions, since all obtained values were below toxic ones for human consumption. [GRAPHICS] .
PB  - Taylor & Francis Ltd, Abingdon
T2  - Natural Product Research
T1  - A contribution to the elemental profile of the leaf samples of newly developed Cabernet Franc varieties
EP  - 1213
IS  - 8
SP  - 1209
VL  - 33
DO  - 10.1080/14786419.2018.1457671
ER  - 

@article{
author = "Stanimirović, Bojana and Vujović, Dragan and Pejin, Boris and Popovic-Đorđević, Jelena and Maletic, Radojka and Raicević, Petar and Tesic, Zivoslav",
year = "2019",
abstract = "The elemental profile of the leaf samples of three Cabernet Franc clone candidates recently developed in Serbia (Nos. 02, 010 and 012) obtained in the last phase of clonal selection was examined within this study by ICP-OES. Optimal content of Al, Fe, Cu and Zn, the metals well known for their links with a number of neurodegenerative disorders including Alzheimer's disease, has actually highlighted the potential of the leaf sample No. 10 to afford a novel food supplement of natural origin possessing well balanced metal ingredients. Furthermore, lower content of some other elements (Cr, Mn, Ni and Pb) thoroughly supports such a claiming. Finally, the most favourable K/Na ratio observed for the aforementioned sample points out its likely cardioprotectivity. However, two other Cabernet Franc clone candidates might also be recommended for breeding in the same or similar viticultural conditions, since all obtained values were below toxic ones for human consumption. [GRAPHICS] .",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Natural Product Research",
title = "A contribution to the elemental profile of the leaf samples of newly developed Cabernet Franc varieties",
pages = "1213-1209",
number = "8",
volume = "33",
doi = "10.1080/14786419.2018.1457671"
}

Stanimirović, B., Vujović, D., Pejin, B., Popovic-Đorđević, J., Maletic, R., Raicević, P.,& Tesic, Z.. (2019). A contribution to the elemental profile of the leaf samples of newly developed Cabernet Franc varieties. in Natural Product Research
Taylor & Francis Ltd, Abingdon., 33(8), 1209-1213.
https://doi.org/10.1080/14786419.2018.1457671

Stanimirović B, Vujović D, Pejin B, Popovic-Đorđević J, Maletic R, Raicević P, Tesic Z. A contribution to the elemental profile of the leaf samples of newly developed Cabernet Franc varieties. in Natural Product Research. 2019;33(8):1209-1213.
doi:10.1080/14786419.2018.1457671 .

Stanimirović, Bojana, Vujović, Dragan, Pejin, Boris, Popovic-Đorđević, Jelena, Maletic, Radojka, Raicević, Petar, Tesic, Zivoslav, "A contribution to the elemental profile of the leaf samples of newly developed Cabernet Franc varieties" in Natural Product Research, 33, no. 8 (2019):1209-1213,
https://doi.org/10.1080/14786419.2018.1457671 . .

TY  - JOUR
AU  - Simonović, Mladen
AU  - Simonović, Branislav R.
AU  - Ostojic, Sanja
AU  - Pezo, Lato
AU  - Micic, Darko
AU  - Stanisavljević, Nemanja
AU  - Pejin, Boris
PY  - 2019
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/1219
AB  - This study aimed to estimate the quality (in terms of standard chemical parameters, total antioxidative activity /AO/ and thermal properties) of the fresh strawberry (Fragaria xananassa L. Duch.), raspberry (Rubus idaeus L.) and blackberry (Rubus fruticosusL.) samples grown in the Western Serbia. The examined blackberry variety was found to exhibit the most potent AO (DPPH /2,2-diphenyl-1-picrylhydrazyl/ assay, EC50 4.05 +/- 0.22 mu g and ARP 0.25 +/- 0.03 mu g(-1); Hydroxo-Perhydroxyl Mercury(II) Complex /HPMC/ assay, 0.072 +/- 0.007%/mu L), due to the enriched contents of both total phenolics and anthocyanins. It was actually followed by the raspberry and strawberry samples. Unlike the aforementioned trend for AO, thermal behaviour of all samples was similar. This is first time ever that a DC polarographic HPMC assay has been applied for the characterisation of the fresh berry fruits. Further studies aiming to screen total AO of the soft fruit during growth, storage and processing might be well facilitated by the application of this low cost, rapid, easy-to-handle and reliable electrochemical assay.
PB  - Elsevier, Amsterdam
T2  - Scientia Horticulturae
T1  - A contribution to the estimation of berry fruits quality
VL  - 258
DO  - 10.1016/j.scienta.2019.108776
ER  - 

@article{
author = "Simonović, Mladen and Simonović, Branislav R. and Ostojic, Sanja and Pezo, Lato and Micic, Darko and Stanisavljević, Nemanja and Pejin, Boris",
year = "2019",
abstract = "This study aimed to estimate the quality (in terms of standard chemical parameters, total antioxidative activity /AO/ and thermal properties) of the fresh strawberry (Fragaria xananassa L. Duch.), raspberry (Rubus idaeus L.) and blackberry (Rubus fruticosusL.) samples grown in the Western Serbia. The examined blackberry variety was found to exhibit the most potent AO (DPPH /2,2-diphenyl-1-picrylhydrazyl/ assay, EC50 4.05 +/- 0.22 mu g and ARP 0.25 +/- 0.03 mu g(-1); Hydroxo-Perhydroxyl Mercury(II) Complex /HPMC/ assay, 0.072 +/- 0.007%/mu L), due to the enriched contents of both total phenolics and anthocyanins. It was actually followed by the raspberry and strawberry samples. Unlike the aforementioned trend for AO, thermal behaviour of all samples was similar. This is first time ever that a DC polarographic HPMC assay has been applied for the characterisation of the fresh berry fruits. Further studies aiming to screen total AO of the soft fruit during growth, storage and processing might be well facilitated by the application of this low cost, rapid, easy-to-handle and reliable electrochemical assay.",
publisher = "Elsevier, Amsterdam",
journal = "Scientia Horticulturae",
title = "A contribution to the estimation of berry fruits quality",
volume = "258",
doi = "10.1016/j.scienta.2019.108776"
}

Simonović, M., Simonović, B. R., Ostojic, S., Pezo, L., Micic, D., Stanisavljević, N.,& Pejin, B.. (2019). A contribution to the estimation of berry fruits quality. in Scientia Horticulturae
Elsevier, Amsterdam., 258.
https://doi.org/10.1016/j.scienta.2019.108776

Simonović M, Simonović BR, Ostojic S, Pezo L, Micic D, Stanisavljević N, Pejin B. A contribution to the estimation of berry fruits quality. in Scientia Horticulturae. 2019;258.
doi:10.1016/j.scienta.2019.108776 .

Simonović, Mladen, Simonović, Branislav R., Ostojic, Sanja, Pezo, Lato, Micic, Darko, Stanisavljević, Nemanja, Pejin, Boris, "A contribution to the estimation of berry fruits quality" in Scientia Horticulturae, 258 (2019),
https://doi.org/10.1016/j.scienta.2019.108776 . .

TY  - JOUR
AU  - Simonović, Mladen
AU  - Ostojic, Sanja
AU  - Micic, Darko
AU  - Pesaković, Marijana
AU  - Pejin, Boris
PY  - 2019
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/1204
AB  - This study aimed to produce low-energy strawberries of the Joly cultivar by breeding them under different growing conditions. The efficacy of such a process was screened by the means of common physico-chemical parameters underpinned with the findings of elementary chemical analysis. The preferred strawberry breed line (treated with microbiological fertiliser of choice) showed both a decreased energy value (130 +/- 6 kJ/100 g or 31.07 kcal) and an increased water content (91.0 +/- 7.3 g/100 g). Due to a rich content of phenolic compounds (Total Phenolic Content/TPC/4184 +/- 39 mg GAE/kg; Total Anthocyanin Content/TAC/394 +/- 4 mg C3GE/kg), it also exhibited potent antioxidant activity (0.110 +/- 0.008 %/mu L, HPMC /Hydroxo-Perhydroxyl Mercury(II) Complex/) assay; EC50 = 2.01 +/- 0.10 mu g and ARP = 0.50 +/- 0.05 mu g(-1), DPPH assay). Finally, the polyphenolic extract of the same breed line showed high anti-alpha, glucosidase activity (IC50 = 19 +/- 1 mu g/mL), being more than four-fold active compared to acarbose (IC50 = 78 +/- 4 mu g/mL), the anti-diabetic drug used as a positive control. Taken all together, the utilisation of microbiological fertiliser (Bacillus sp.) in tunnels might be recommended for the breeding of low-energy strawberries of the Joly cultivar (the starting point for developing of novel functional foods targeting the obese population) in the same or similar agricultural conditions, if further studies confirm its likely potential and credibility.
PB  - MDPI, Basel
T2  - Applied Sciences-Basel
T1  - Low-Energy Strawberry Fruits of Joly Cultivar, the First Step Towards a Novel, Food-Based Solution for the Obese Population
IS  - 23
VL  - 9
DO  - 10.3390/app9235140
ER  - 

@article{
author = "Simonović, Mladen and Ostojic, Sanja and Micic, Darko and Pesaković, Marijana and Pejin, Boris",
year = "2019",
abstract = "This study aimed to produce low-energy strawberries of the Joly cultivar by breeding them under different growing conditions. The efficacy of such a process was screened by the means of common physico-chemical parameters underpinned with the findings of elementary chemical analysis. The preferred strawberry breed line (treated with microbiological fertiliser of choice) showed both a decreased energy value (130 +/- 6 kJ/100 g or 31.07 kcal) and an increased water content (91.0 +/- 7.3 g/100 g). Due to a rich content of phenolic compounds (Total Phenolic Content/TPC/4184 +/- 39 mg GAE/kg; Total Anthocyanin Content/TAC/394 +/- 4 mg C3GE/kg), it also exhibited potent antioxidant activity (0.110 +/- 0.008 %/mu L, HPMC /Hydroxo-Perhydroxyl Mercury(II) Complex/) assay; EC50 = 2.01 +/- 0.10 mu g and ARP = 0.50 +/- 0.05 mu g(-1), DPPH assay). Finally, the polyphenolic extract of the same breed line showed high anti-alpha, glucosidase activity (IC50 = 19 +/- 1 mu g/mL), being more than four-fold active compared to acarbose (IC50 = 78 +/- 4 mu g/mL), the anti-diabetic drug used as a positive control. Taken all together, the utilisation of microbiological fertiliser (Bacillus sp.) in tunnels might be recommended for the breeding of low-energy strawberries of the Joly cultivar (the starting point for developing of novel functional foods targeting the obese population) in the same or similar agricultural conditions, if further studies confirm its likely potential and credibility.",
publisher = "MDPI, Basel",
journal = "Applied Sciences-Basel",
title = "Low-Energy Strawberry Fruits of Joly Cultivar, the First Step Towards a Novel, Food-Based Solution for the Obese Population",
number = "23",
volume = "9",
doi = "10.3390/app9235140"
}

Simonović, M., Ostojic, S., Micic, D., Pesaković, M.,& Pejin, B.. (2019). Low-Energy Strawberry Fruits of Joly Cultivar, the First Step Towards a Novel, Food-Based Solution for the Obese Population. in Applied Sciences-Basel
MDPI, Basel., 9(23).
https://doi.org/10.3390/app9235140

Simonović M, Ostojic S, Micic D, Pesaković M, Pejin B. Low-Energy Strawberry Fruits of Joly Cultivar, the First Step Towards a Novel, Food-Based Solution for the Obese Population. in Applied Sciences-Basel. 2019;9(23).
doi:10.3390/app9235140 .

Simonović, Mladen, Ostojic, Sanja, Micic, Darko, Pesaković, Marijana, Pejin, Boris, "Low-Energy Strawberry Fruits of Joly Cultivar, the First Step Towards a Novel, Food-Based Solution for the Obese Population" in Applied Sciences-Basel, 9, no. 23 (2019),
https://doi.org/10.3390/app9235140 . .

TY  - JOUR
AU  - Karaman, Maja
AU  - Atlagic, Kristina
AU  - Novaković, Aleksandra
AU  - Sibul, Filip
AU  - Zivić, Miroslav
AU  - Stevanović, Katarina
AU  - Pejin, Boris
PY  - 2019
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/1198
AB  - Compared to plants, nowadays mushrooms attract more attention as functional foods, due to a number of advantages in manipulating them. This study aimed to screen the chemical composition (fatty acids and phenolics) and antioxidant potential (OH center dot, 2,2-diphenyl-1-picrylhydrazyl (DPPH center dot) and ferric reducing ability of plasma (FRAP)) of two edible mushrooms, Coprinus comatus and Coprinellus truncorum, collected from nature and submerged cultivation. Partial least square regression analysis has pointed out the importance of some fatty acids-more precisely, unsaturated fatty acids (UFAs) followed by fatty acids possessing both short (C6:0 and C8:0) and long (C23:0 and C24:0) saturated chains-and phenolic compounds (such as protocatechuic acid, daidzein, p-hydroxybenzoic acid, genistein and vanillic acid) for promising anti-OH center dot, FRAP and anti-DPPH center dot activities, respectively. However, other fatty acids (C16:0, C18:0 and C18:3n3) along with the flavonol isorhamnetin are actually suspected to negatively affect (by acting pro-oxidative) the aforementioned parameters, respectively. Taken together, design of new food supplements targeting oxidative stress might be predominantly based on the various UFAs combinations (C18:2n6, C20:1, C20:2, C20:4n6, C22:2, C22:1n9, etc.), particularly if OH center dot is suspected to play an important role.
PB  - MDPI, Basel
T2  - Antioxidants
T1  - Fatty Acids Predominantly Affect Anti-Hydroxyl Radical Activity and FRAP Value: The Case Study of Two Edible Mushrooms
IS  - 10
VL  - 8
DO  - 10.3390/antiox8100480
ER  - 

@article{
author = "Karaman, Maja and Atlagic, Kristina and Novaković, Aleksandra and Sibul, Filip and Zivić, Miroslav and Stevanović, Katarina and Pejin, Boris",
year = "2019",
abstract = "Compared to plants, nowadays mushrooms attract more attention as functional foods, due to a number of advantages in manipulating them. This study aimed to screen the chemical composition (fatty acids and phenolics) and antioxidant potential (OH center dot, 2,2-diphenyl-1-picrylhydrazyl (DPPH center dot) and ferric reducing ability of plasma (FRAP)) of two edible mushrooms, Coprinus comatus and Coprinellus truncorum, collected from nature and submerged cultivation. Partial least square regression analysis has pointed out the importance of some fatty acids-more precisely, unsaturated fatty acids (UFAs) followed by fatty acids possessing both short (C6:0 and C8:0) and long (C23:0 and C24:0) saturated chains-and phenolic compounds (such as protocatechuic acid, daidzein, p-hydroxybenzoic acid, genistein and vanillic acid) for promising anti-OH center dot, FRAP and anti-DPPH center dot activities, respectively. However, other fatty acids (C16:0, C18:0 and C18:3n3) along with the flavonol isorhamnetin are actually suspected to negatively affect (by acting pro-oxidative) the aforementioned parameters, respectively. Taken together, design of new food supplements targeting oxidative stress might be predominantly based on the various UFAs combinations (C18:2n6, C20:1, C20:2, C20:4n6, C22:2, C22:1n9, etc.), particularly if OH center dot is suspected to play an important role.",
publisher = "MDPI, Basel",
journal = "Antioxidants",
title = "Fatty Acids Predominantly Affect Anti-Hydroxyl Radical Activity and FRAP Value: The Case Study of Two Edible Mushrooms",
number = "10",
volume = "8",
doi = "10.3390/antiox8100480"
}

Karaman, M., Atlagic, K., Novaković, A., Sibul, F., Zivić, M., Stevanović, K.,& Pejin, B.. (2019). Fatty Acids Predominantly Affect Anti-Hydroxyl Radical Activity and FRAP Value: The Case Study of Two Edible Mushrooms. in Antioxidants
MDPI, Basel., 8(10).
https://doi.org/10.3390/antiox8100480

Karaman M, Atlagic K, Novaković A, Sibul F, Zivić M, Stevanović K, Pejin B. Fatty Acids Predominantly Affect Anti-Hydroxyl Radical Activity and FRAP Value: The Case Study of Two Edible Mushrooms. in Antioxidants. 2019;8(10).
doi:10.3390/antiox8100480 .

Karaman, Maja, Atlagic, Kristina, Novaković, Aleksandra, Sibul, Filip, Zivić, Miroslav, Stevanović, Katarina, Pejin, Boris, "Fatty Acids Predominantly Affect Anti-Hydroxyl Radical Activity and FRAP Value: The Case Study of Two Edible Mushrooms" in Antioxidants, 8, no. 10 (2019),
https://doi.org/10.3390/antiox8100480 . .

TY  - JOUR
AU  - Cakar, Uros
AU  - Petrović, Aleksandar
AU  - Pejin, Boris
AU  - Cakar, Mira
AU  - Živković, Marijana
AU  - Vajs, Vlatka E
AU  - Đorđević, Brizita
PY  - 2019
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/1254
AB  - This study aimed to estimate the potential of the selected berry (strawberry) and drupe (apricot, plum and sweet cherry) fruits as the substrates for the production of new fruit wines enriched with phenolic compounds. Sweet cherry wine (cultivar Burlat) stood out both for the profound content of phenolics (followed by their chemical profile) and potent anti-DPPH radical activity. The same fruit wine samples exhibited high redox potentials, slightly lower than strawberry and plum wine samples. Therefore, sweet cherry cultivar Burlat may be well recommended for development of novel fruit-based products endowed with naturally occurring phenolics. In any case, the remaining four cultivars are also worth further research efforts, particularly apricot cultivar Keckemetska ruza, which is one of the representatives of greatly underestimated fruit type thus far as a substrate for the production of the relevant fruit wines.
PB  - Elsevier, Amsterdam
T2  - Scientia Horticulturae
T1  - Fruit as a substrate for a wine: A case study of selected berry and drupe fruit wines
EP  - 49
SP  - 42
VL  - 244
DO  - 10.1016/j.scienta.2018.09.020
ER  - 

@article{
author = "Cakar, Uros and Petrović, Aleksandar and Pejin, Boris and Cakar, Mira and Živković, Marijana and Vajs, Vlatka E and Đorđević, Brizita",
year = "2019",
abstract = "This study aimed to estimate the potential of the selected berry (strawberry) and drupe (apricot, plum and sweet cherry) fruits as the substrates for the production of new fruit wines enriched with phenolic compounds. Sweet cherry wine (cultivar Burlat) stood out both for the profound content of phenolics (followed by their chemical profile) and potent anti-DPPH radical activity. The same fruit wine samples exhibited high redox potentials, slightly lower than strawberry and plum wine samples. Therefore, sweet cherry cultivar Burlat may be well recommended for development of novel fruit-based products endowed with naturally occurring phenolics. In any case, the remaining four cultivars are also worth further research efforts, particularly apricot cultivar Keckemetska ruza, which is one of the representatives of greatly underestimated fruit type thus far as a substrate for the production of the relevant fruit wines.",
publisher = "Elsevier, Amsterdam",
journal = "Scientia Horticulturae",
title = "Fruit as a substrate for a wine: A case study of selected berry and drupe fruit wines",
pages = "49-42",
volume = "244",
doi = "10.1016/j.scienta.2018.09.020"
}

Cakar, U., Petrović, A., Pejin, B., Cakar, M., Živković, M., Vajs, V. E.,& Đorđević, B.. (2019). Fruit as a substrate for a wine: A case study of selected berry and drupe fruit wines. in Scientia Horticulturae
Elsevier, Amsterdam., 244, 42-49.
https://doi.org/10.1016/j.scienta.2018.09.020

Cakar U, Petrović A, Pejin B, Cakar M, Živković M, Vajs VE, Đorđević B. Fruit as a substrate for a wine: A case study of selected berry and drupe fruit wines. in Scientia Horticulturae. 2019;244:42-49.
doi:10.1016/j.scienta.2018.09.020 .

Cakar, Uros, Petrović, Aleksandar, Pejin, Boris, Cakar, Mira, Živković, Marijana, Vajs, Vlatka E, Đorđević, Brizita, "Fruit as a substrate for a wine: A case study of selected berry and drupe fruit wines" in Scientia Horticulturae, 244 (2019):42-49,
https://doi.org/10.1016/j.scienta.2018.09.020 . .

TY  - JOUR
AU  - Nakarada, Dura
AU  - Pejin, Boris
AU  - Dimic, Dusan
AU  - Ivanovic-Sasic, Ana
AU  - Mojović, Zorica
AU  - Mojović, Miloš
PY  - 2019
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/1206
AB  - The electrochemistry of catecholamine neurotransmitters and their precursor l-dopa has been widely studied due to their relevance as biologically important compounds. The detection of these compounds from aqueous solution is hindered by the coexistence of quinone or hydroquinone. However, it was suggested that quinones adsorbed on the electrode surface can enhance catechol detection. In order to estimate the degree of interaction between quinones and l-dopa, cyclic voltammetry and UV-Vis spectroscopic study was performed. A sesquiterpenoid hydroquinone, isolated from the marine sponge Dysidea avara (avarol), has been used in this study. The change of apparent heterogeneous rate constant with different avarol/l-dopa ratio indicated that charge transfer could be enhanced at some extent. In addition to this, the obtained results for avarol and hydroquinone (its structural element) were compared. UV-Vis spectroscopic analysis confirmed interaction between l-dopa and avarol or hydroquinone. Taken all together, the interaction of l-dopa was stronger with hydroquinone than with avarol, presumably reflecting the conformational restrains of avarol caused by its terpenoid moiety.
PB  - Springer, Dordrecht
T2  - Reaction Kinetics Mechanisms and Catalysis
T1  - Electrochemical and spectroscopic study of l-dopa interaction with avarol
EP  - 229
IS  - 1
SP  - 219
VL  - 127
DO  - 10.1007/s11144-019-01575-z
ER  - 

@article{
author = "Nakarada, Dura and Pejin, Boris and Dimic, Dusan and Ivanovic-Sasic, Ana and Mojović, Zorica and Mojović, Miloš",
year = "2019",
abstract = "The electrochemistry of catecholamine neurotransmitters and their precursor l-dopa has been widely studied due to their relevance as biologically important compounds. The detection of these compounds from aqueous solution is hindered by the coexistence of quinone or hydroquinone. However, it was suggested that quinones adsorbed on the electrode surface can enhance catechol detection. In order to estimate the degree of interaction between quinones and l-dopa, cyclic voltammetry and UV-Vis spectroscopic study was performed. A sesquiterpenoid hydroquinone, isolated from the marine sponge Dysidea avara (avarol), has been used in this study. The change of apparent heterogeneous rate constant with different avarol/l-dopa ratio indicated that charge transfer could be enhanced at some extent. In addition to this, the obtained results for avarol and hydroquinone (its structural element) were compared. UV-Vis spectroscopic analysis confirmed interaction between l-dopa and avarol or hydroquinone. Taken all together, the interaction of l-dopa was stronger with hydroquinone than with avarol, presumably reflecting the conformational restrains of avarol caused by its terpenoid moiety.",
publisher = "Springer, Dordrecht",
journal = "Reaction Kinetics Mechanisms and Catalysis",
title = "Electrochemical and spectroscopic study of l-dopa interaction with avarol",
pages = "229-219",
number = "1",
volume = "127",
doi = "10.1007/s11144-019-01575-z"
}

Nakarada, D., Pejin, B., Dimic, D., Ivanovic-Sasic, A., Mojović, Z.,& Mojović, M.. (2019). Electrochemical and spectroscopic study of l-dopa interaction with avarol. in Reaction Kinetics Mechanisms and Catalysis
Springer, Dordrecht., 127(1), 219-229.
https://doi.org/10.1007/s11144-019-01575-z

Nakarada D, Pejin B, Dimic D, Ivanovic-Sasic A, Mojović Z, Mojović M. Electrochemical and spectroscopic study of l-dopa interaction with avarol. in Reaction Kinetics Mechanisms and Catalysis. 2019;127(1):219-229.
doi:10.1007/s11144-019-01575-z .

Nakarada, Dura, Pejin, Boris, Dimic, Dusan, Ivanovic-Sasic, Ana, Mojović, Zorica, Mojović, Miloš, "Electrochemical and spectroscopic study of l-dopa interaction with avarol" in Reaction Kinetics Mechanisms and Catalysis, 127, no. 1 (2019):219-229,
https://doi.org/10.1007/s11144-019-01575-z . .

TY  - JOUR
AU  - Pejin, Boris
AU  - Tesanović, Kristina
AU  - Jakovljević, Dragica
AU  - Kaisarević, Sonja
AU  - Sibul, Filip
AU  - Raseta, Milena
AU  - Karaman, Maja
PY  - 2019
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/1277
AB  - The polysaccharide (PSH) extracts from the edible mushroom species Coprinus comatus and Coprinellus truncorum were screened in liquid for their acetylcholinesterase inhibitory (AChE) activity. Both extracts were found to display inhibition of the aforementioned enzyme reaching similar IC50 values of 0.62 +/- 0.07 and 0.61 +/- 0.03 mg/mL, respectively. According to the means of FTIR spectroscopy, these PSH extracts mostly contained beta-glucans. However, the presence of some proteins and polyphenolics as minor ingredients were also detected. Compared with existing literature data for anti-AChE activity of the sugar samples, the findings within this study may be treated as a profound bioactivity. Consequently, this study puts some light on the possible use of the screened macrofungi in the palliative treatment of Alzheimer's disease. [GRAPHICS] .
PB  - Taylor & Francis Ltd, Abingdon
T2  - Natural Product Research
T1  - The polysaccharide extracts from the fungi Coprinus comatus and Coprinellus truncorum do exhibit AChE inhibitory activity
EP  - 754
IS  - 5
SP  - 750
VL  - 33
DO  - 10.1080/14786419.2017.1405417
ER  - 

@article{
author = "Pejin, Boris and Tesanović, Kristina and Jakovljević, Dragica and Kaisarević, Sonja and Sibul, Filip and Raseta, Milena and Karaman, Maja",
year = "2019",
abstract = "The polysaccharide (PSH) extracts from the edible mushroom species Coprinus comatus and Coprinellus truncorum were screened in liquid for their acetylcholinesterase inhibitory (AChE) activity. Both extracts were found to display inhibition of the aforementioned enzyme reaching similar IC50 values of 0.62 +/- 0.07 and 0.61 +/- 0.03 mg/mL, respectively. According to the means of FTIR spectroscopy, these PSH extracts mostly contained beta-glucans. However, the presence of some proteins and polyphenolics as minor ingredients were also detected. Compared with existing literature data for anti-AChE activity of the sugar samples, the findings within this study may be treated as a profound bioactivity. Consequently, this study puts some light on the possible use of the screened macrofungi in the palliative treatment of Alzheimer's disease. [GRAPHICS] .",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Natural Product Research",
title = "The polysaccharide extracts from the fungi Coprinus comatus and Coprinellus truncorum do exhibit AChE inhibitory activity",
pages = "754-750",
number = "5",
volume = "33",
doi = "10.1080/14786419.2017.1405417"
}

Pejin, B., Tesanović, K., Jakovljević, D., Kaisarević, S., Sibul, F., Raseta, M.,& Karaman, M.. (2019). The polysaccharide extracts from the fungi Coprinus comatus and Coprinellus truncorum do exhibit AChE inhibitory activity. in Natural Product Research
Taylor & Francis Ltd, Abingdon., 33(5), 750-754.
https://doi.org/10.1080/14786419.2017.1405417

Pejin B, Tesanović K, Jakovljević D, Kaisarević S, Sibul F, Raseta M, Karaman M. The polysaccharide extracts from the fungi Coprinus comatus and Coprinellus truncorum do exhibit AChE inhibitory activity. in Natural Product Research. 2019;33(5):750-754.
doi:10.1080/14786419.2017.1405417 .

Pejin, Boris, Tesanović, Kristina, Jakovljević, Dragica, Kaisarević, Sonja, Sibul, Filip, Raseta, Milena, Karaman, Maja, "The polysaccharide extracts from the fungi Coprinus comatus and Coprinellus truncorum do exhibit AChE inhibitory activity" in Natural Product Research, 33, no. 5 (2019):750-754,
https://doi.org/10.1080/14786419.2017.1405417 . .

TY  - JOUR
AU  - Pejin, Boris
AU  - Glumac, Miodrag
PY  - 2019
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/1209
AB  - Nowadays, the mangrove biome is considered to be a profound resource of natural products usually possessing cytotoxicity of a broader range. Covering the period 2007-2015, a total of 21 new naturally occurring compounds has stood out. For example, xylogranin B and swietephragmin C were found to exhibit very potent cytotoxic activity against the colon HCT-116 cells reaching IC50 values of 0.05 and 0.06 mu M, respectively. Bearing in mind the efficacy of the majority compounds in the preliminary in vitro screens, these studies should be expanded to both ex vivo and in vivo screens including the evaluation of the relevant toxicological profiles. [GRAPHICS] .
PB  - Taylor & Francis Ltd, Abingdon
T2  - Natural Product Research
T1  - New cytotoxic natural products from the mangrove biome: covering the period 2007-2015
EP  - 1628
IS  - 11
SP  - 1624
VL  - 33
DO  - 10.1080/14786419.2018.1425854
ER  - 

@article{
author = "Pejin, Boris and Glumac, Miodrag",
year = "2019",
abstract = "Nowadays, the mangrove biome is considered to be a profound resource of natural products usually possessing cytotoxicity of a broader range. Covering the period 2007-2015, a total of 21 new naturally occurring compounds has stood out. For example, xylogranin B and swietephragmin C were found to exhibit very potent cytotoxic activity against the colon HCT-116 cells reaching IC50 values of 0.05 and 0.06 mu M, respectively. Bearing in mind the efficacy of the majority compounds in the preliminary in vitro screens, these studies should be expanded to both ex vivo and in vivo screens including the evaluation of the relevant toxicological profiles. [GRAPHICS] .",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Natural Product Research",
title = "New cytotoxic natural products from the mangrove biome: covering the period 2007-2015",
pages = "1628-1624",
number = "11",
volume = "33",
doi = "10.1080/14786419.2018.1425854"
}

Pejin, B.,& Glumac, M.. (2019). New cytotoxic natural products from the mangrove biome: covering the period 2007-2015. in Natural Product Research
Taylor & Francis Ltd, Abingdon., 33(11), 1624-1628.
https://doi.org/10.1080/14786419.2018.1425854

Pejin B, Glumac M. New cytotoxic natural products from the mangrove biome: covering the period 2007-2015. in Natural Product Research. 2019;33(11):1624-1628.
doi:10.1080/14786419.2018.1425854 .

Pejin, Boris, Glumac, Miodrag, "New cytotoxic natural products from the mangrove biome: covering the period 2007-2015" in Natural Product Research, 33, no. 11 (2019):1624-1628,
https://doi.org/10.1080/14786419.2018.1425854 . .

TY  - JOUR
AU  - Karaman, Maja
AU  - Janjusević, Ljiljana
AU  - Jakovljević, Dragica
AU  - Sibul, Filip
AU  - Pejin, Boris
PY  - 2019
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/1200
AB  - This study outlines antioxidant and anti-AChE activities of the polysaccharide (PSH) extract from the mushroom species Amanita strobiliformis. Both the presence of alpha and ss glucans within the aforementioned extract was recorded. PSH extract displayed a profound scavenging activity of OH radicals (IC50 value, 11.86 +/- 0.59 mu g/mL) and high potential for reduction of Fe3+ ions (174.11 +/- 8.70 mg eq. AA/g d.w.) being almost 48- and 5-fold more effective than mannitol and butylated hydroxytoluene used as a positive control, respectively. Compared with galanthamine (0.001 mu g), the same extract exhibited a moderate anti-AChE activity (10 mu g) in solid. Since purified PSH extract exhibited higher bioactivity (IC50 value 7.27 +/- 0.31 mu g/mL, 197.68 +/- 9.47 mg eq. AA/g d.w. and 0.1 mu g, respectively), it can be predominantly ascribed to the polysaccharide compounds. A. strobiliformis PSH extract may be considered as a promising resource of potent bioactive polysaccharides of natural origin successfully addressing both oxidative stress and lack of acetylcholine.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Natural Product Research
T1  - Anti-hydroxyl radical activity, redox potential and anti-AChE activity of Amanita strobiliformis polysaccharide extract
EP  - 1526
IS  - 10
SP  - 1522
VL  - 33
DO  - 10.1080/14786419.2017.1422183
ER  - 

@article{
author = "Karaman, Maja and Janjusević, Ljiljana and Jakovljević, Dragica and Sibul, Filip and Pejin, Boris",
year = "2019",
abstract = "This study outlines antioxidant and anti-AChE activities of the polysaccharide (PSH) extract from the mushroom species Amanita strobiliformis. Both the presence of alpha and ss glucans within the aforementioned extract was recorded. PSH extract displayed a profound scavenging activity of OH radicals (IC50 value, 11.86 +/- 0.59 mu g/mL) and high potential for reduction of Fe3+ ions (174.11 +/- 8.70 mg eq. AA/g d.w.) being almost 48- and 5-fold more effective than mannitol and butylated hydroxytoluene used as a positive control, respectively. Compared with galanthamine (0.001 mu g), the same extract exhibited a moderate anti-AChE activity (10 mu g) in solid. Since purified PSH extract exhibited higher bioactivity (IC50 value 7.27 +/- 0.31 mu g/mL, 197.68 +/- 9.47 mg eq. AA/g d.w. and 0.1 mu g, respectively), it can be predominantly ascribed to the polysaccharide compounds. A. strobiliformis PSH extract may be considered as a promising resource of potent bioactive polysaccharides of natural origin successfully addressing both oxidative stress and lack of acetylcholine.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Natural Product Research",
title = "Anti-hydroxyl radical activity, redox potential and anti-AChE activity of Amanita strobiliformis polysaccharide extract",
pages = "1526-1522",
number = "10",
volume = "33",
doi = "10.1080/14786419.2017.1422183"
}

Karaman, M., Janjusević, L., Jakovljević, D., Sibul, F.,& Pejin, B.. (2019). Anti-hydroxyl radical activity, redox potential and anti-AChE activity of Amanita strobiliformis polysaccharide extract. in Natural Product Research
Taylor & Francis Ltd, Abingdon., 33(10), 1522-1526.
https://doi.org/10.1080/14786419.2017.1422183

Karaman M, Janjusević L, Jakovljević D, Sibul F, Pejin B. Anti-hydroxyl radical activity, redox potential and anti-AChE activity of Amanita strobiliformis polysaccharide extract. in Natural Product Research. 2019;33(10):1522-1526.
doi:10.1080/14786419.2017.1422183 .

Karaman, Maja, Janjusević, Ljiljana, Jakovljević, Dragica, Sibul, Filip, Pejin, Boris, "Anti-hydroxyl radical activity, redox potential and anti-AChE activity of Amanita strobiliformis polysaccharide extract" in Natural Product Research, 33, no. 10 (2019):1522-1526,
https://doi.org/10.1080/14786419.2017.1422183 . .

TY  - JOUR
AU  - Talevska, Aleksandra
AU  - Pejin, Boris
AU  - Kojić, Vesna
AU  - Berić, Tanja
AU  - Stanković, Slaviša
PY  - 2018
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/1149
AB  - In vitro anti-tumour and anti-radical activities of the acetone extract of the freshwater sponge Ochridaspongia rotunda were the subject of this study. The extract was found to be highly cytotoxic to human lung tumour cell line A-549 reaching IC50 value of 5.01 +/- 0.21 mu g/mL. Indeed, it displayed only 2-fold less anti-tumour activity than doxorubicin (IC50 value 2.42 +/- 0.13 mu g/mL) used as a positive control. The same extract was also found to be almost 37-fold more selective against A-549 vs. MRC-5 (normal) lung cells, in difference to weak selectivity of doxorubicin (less than 3-fold). Its profound anti-DPPH radical activity comparable to that of quercetin (IC50 values 3.68 +/- 0.19 and 3.14 +/- 0.09 mu g/mL, respectively) coupled with no signs of genotoxicity in the comet assay (MRC-5 cell line, vs. doxorubicin) has actually implicated the importance of this animal bioresource in searching for pharmaceutically useful bioactive compounds of natural origin. [GRAPHICS] .
PB  - Taylor & Francis Ltd, Abingdon
T2  - Natural Product Research
T1  - A contribution to pharmaceutical biology of freshwater sponges
EP  - 571
IS  - 5
SP  - 568
VL  - 32
DO  - 10.1080/14786419.2017.1315719
ER  - 

@article{
author = "Talevska, Aleksandra and Pejin, Boris and Kojić, Vesna and Berić, Tanja and Stanković, Slaviša",
year = "2018",
abstract = "In vitro anti-tumour and anti-radical activities of the acetone extract of the freshwater sponge Ochridaspongia rotunda were the subject of this study. The extract was found to be highly cytotoxic to human lung tumour cell line A-549 reaching IC50 value of 5.01 +/- 0.21 mu g/mL. Indeed, it displayed only 2-fold less anti-tumour activity than doxorubicin (IC50 value 2.42 +/- 0.13 mu g/mL) used as a positive control. The same extract was also found to be almost 37-fold more selective against A-549 vs. MRC-5 (normal) lung cells, in difference to weak selectivity of doxorubicin (less than 3-fold). Its profound anti-DPPH radical activity comparable to that of quercetin (IC50 values 3.68 +/- 0.19 and 3.14 +/- 0.09 mu g/mL, respectively) coupled with no signs of genotoxicity in the comet assay (MRC-5 cell line, vs. doxorubicin) has actually implicated the importance of this animal bioresource in searching for pharmaceutically useful bioactive compounds of natural origin. [GRAPHICS] .",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Natural Product Research",
title = "A contribution to pharmaceutical biology of freshwater sponges",
pages = "571-568",
number = "5",
volume = "32",
doi = "10.1080/14786419.2017.1315719"
}

Talevska, A., Pejin, B., Kojić, V., Berić, T.,& Stanković, S.. (2018). A contribution to pharmaceutical biology of freshwater sponges. in Natural Product Research
Taylor & Francis Ltd, Abingdon., 32(5), 568-571.
https://doi.org/10.1080/14786419.2017.1315719

Talevska A, Pejin B, Kojić V, Berić T, Stanković S. A contribution to pharmaceutical biology of freshwater sponges. in Natural Product Research. 2018;32(5):568-571.
doi:10.1080/14786419.2017.1315719 .

Talevska, Aleksandra, Pejin, Boris, Kojić, Vesna, Berić, Tanja, Stanković, Slaviša, "A contribution to pharmaceutical biology of freshwater sponges" in Natural Product Research, 32, no. 5 (2018):568-571,
https://doi.org/10.1080/14786419.2017.1315719 . .

TY  - JOUR
AU  - Stanimirović, Bojana
AU  - Popovic-Đorđević, Jelena
AU  - Pejin, Boris
AU  - Maletic, Radojka
AU  - Vujović, Dragan
AU  - Raicević, Petar
AU  - Tesic, Zivoslav
PY  - 2018
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/1166
AB  - Three Cabernet Franc (CF) clones (Nos. 02,010 and 012; not yet commercial) obtained in the last phase of clonal selection were examined within this study. Indeed, the content of 27 chemical elements in the vineyard soil along with CF grape and wine samples were determined by inductively coupled plasma - optical emission spectroscopy. The relative dependence of the selected elements in all samples were estimated using correlation matrices. While elemental profiles of both CF grape and wine samples were highly variable among the analysed clones, bioaccumulation factors (grape/soil) of Mg, Na and Sr were found to be specific for each single clone. Applying principal component analysis, the grape clones were differentiated among each other according to the content of 10 elements (Al, B, Ca, Cu, Fe, K, Mg, Mn, Na and Sr). Finally, hierarchical cluster analysis of CF grape and wine samples pointed out the similarity of the clones Nos. 010 and 012, since they were grouped within the same subcluster.
PB  - Elsevier Science Bv, Amsterdam
T2  - Scientia Horticulturae
T1  - Impact of clonal selection on Cabernet Franc Grape and wine elemental profiles
EP  - 80
SP  - 74
VL  - 237
DO  - 10.1016/j.scienta.2018.03.043
ER  - 

@article{
author = "Stanimirović, Bojana and Popovic-Đorđević, Jelena and Pejin, Boris and Maletic, Radojka and Vujović, Dragan and Raicević, Petar and Tesic, Zivoslav",
year = "2018",
abstract = "Three Cabernet Franc (CF) clones (Nos. 02,010 and 012; not yet commercial) obtained in the last phase of clonal selection were examined within this study. Indeed, the content of 27 chemical elements in the vineyard soil along with CF grape and wine samples were determined by inductively coupled plasma - optical emission spectroscopy. The relative dependence of the selected elements in all samples were estimated using correlation matrices. While elemental profiles of both CF grape and wine samples were highly variable among the analysed clones, bioaccumulation factors (grape/soil) of Mg, Na and Sr were found to be specific for each single clone. Applying principal component analysis, the grape clones were differentiated among each other according to the content of 10 elements (Al, B, Ca, Cu, Fe, K, Mg, Mn, Na and Sr). Finally, hierarchical cluster analysis of CF grape and wine samples pointed out the similarity of the clones Nos. 010 and 012, since they were grouped within the same subcluster.",
publisher = "Elsevier Science Bv, Amsterdam",
journal = "Scientia Horticulturae",
title = "Impact of clonal selection on Cabernet Franc Grape and wine elemental profiles",
pages = "80-74",
volume = "237",
doi = "10.1016/j.scienta.2018.03.043"
}

Stanimirović, B., Popovic-Đorđević, J., Pejin, B., Maletic, R., Vujović, D., Raicević, P.,& Tesic, Z.. (2018). Impact of clonal selection on Cabernet Franc Grape and wine elemental profiles. in Scientia Horticulturae
Elsevier Science Bv, Amsterdam., 237, 74-80.
https://doi.org/10.1016/j.scienta.2018.03.043

Stanimirović B, Popovic-Đorđević J, Pejin B, Maletic R, Vujović D, Raicević P, Tesic Z. Impact of clonal selection on Cabernet Franc Grape and wine elemental profiles. in Scientia Horticulturae. 2018;237:74-80.
doi:10.1016/j.scienta.2018.03.043 .

Stanimirović, Bojana, Popovic-Đorđević, Jelena, Pejin, Boris, Maletic, Radojka, Vujović, Dragan, Raicević, Petar, Tesic, Zivoslav, "Impact of clonal selection on Cabernet Franc Grape and wine elemental profiles" in Scientia Horticulturae, 237 (2018):74-80,
https://doi.org/10.1016/j.scienta.2018.03.043 . .

TY  - JOUR
AU  - Pejin, Boris
AU  - Tommonaro, Giuseppina
AU  - Glumac, Miodrag
AU  - Jakimov, Dimitar
AU  - Kojić, Vesna
PY  - 2018
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/1194
AB  - This study aimed to screen in vitro antitumour activity of the redox couple avarol/avarone against the human malignant glioma cell line U-251 MG for the first time. Compared both with avarol and positive controls used (temozolomide and doxorubicin), avarone was found to be the most active compound with IC50 value below 1 mu M (IC50 0.68 +/- 0.04 mu M, 96 h). Considerable less DNA damage in the cells treated with avarol and avarone vs. doxorubicin (105 & 123% vs. 299%, respectively; untreated U-251 MG cells were used as a control, 100%), coupled with no sign of cytotoxicity against the normal human foetal lung fibroblast MRC-5 cells (IC50 > 100 mu M), has actually pointed out the importance of this marine sesquiterpenoid quinone structure as a promising lead compound in development of novel brain chemotherapeutics. [GRAPHICS] .
PB  - Taylor & Francis Ltd, Abingdon
T2  - Natural Product Research
T1  - The redox couple avarol/avarone in the fight with malignant gliomas: the case study of U-251 MG cells
EP  - 620
IS  - 5
SP  - 616
VL  - 32
DO  - 10.1080/14786419.2017.1327959
ER  - 

@article{
author = "Pejin, Boris and Tommonaro, Giuseppina and Glumac, Miodrag and Jakimov, Dimitar and Kojić, Vesna",
year = "2018",
abstract = "This study aimed to screen in vitro antitumour activity of the redox couple avarol/avarone against the human malignant glioma cell line U-251 MG for the first time. Compared both with avarol and positive controls used (temozolomide and doxorubicin), avarone was found to be the most active compound with IC50 value below 1 mu M (IC50 0.68 +/- 0.04 mu M, 96 h). Considerable less DNA damage in the cells treated with avarol and avarone vs. doxorubicin (105 & 123% vs. 299%, respectively; untreated U-251 MG cells were used as a control, 100%), coupled with no sign of cytotoxicity against the normal human foetal lung fibroblast MRC-5 cells (IC50 > 100 mu M), has actually pointed out the importance of this marine sesquiterpenoid quinone structure as a promising lead compound in development of novel brain chemotherapeutics. [GRAPHICS] .",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Natural Product Research",
title = "The redox couple avarol/avarone in the fight with malignant gliomas: the case study of U-251 MG cells",
pages = "620-616",
number = "5",
volume = "32",
doi = "10.1080/14786419.2017.1327959"
}

Pejin, B., Tommonaro, G., Glumac, M., Jakimov, D.,& Kojić, V.. (2018). The redox couple avarol/avarone in the fight with malignant gliomas: the case study of U-251 MG cells. in Natural Product Research
Taylor & Francis Ltd, Abingdon., 32(5), 616-620.
https://doi.org/10.1080/14786419.2017.1327959

Pejin B, Tommonaro G, Glumac M, Jakimov D, Kojić V. The redox couple avarol/avarone in the fight with malignant gliomas: the case study of U-251 MG cells. in Natural Product Research. 2018;32(5):616-620.
doi:10.1080/14786419.2017.1327959 .

Pejin, Boris, Tommonaro, Giuseppina, Glumac, Miodrag, Jakimov, Dimitar, Kojić, Vesna, "The redox couple avarol/avarone in the fight with malignant gliomas: the case study of U-251 MG cells" in Natural Product Research, 32, no. 5 (2018):616-620,
https://doi.org/10.1080/14786419.2017.1327959 . .

TY  - JOUR
AU  - Janjusević, Ljiljana
AU  - Pejin, Boris
AU  - Kaisarević, Sonja
AU  - Gorjanović, Stanislava
AU  - Pastor, Ferenc
AU  - Tesanović, Kristina
AU  - Karaman, Maja
PY  - 2018
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/1154
AB  - This study aimed to estimate antiradical, antioxidant (AO) and cytotoxic activities of the fungus Trametes versicolor ethanol fruiting body extract. The extract was found to effectively scavenge both O-2(center dot-) and NO center dot (29.62 and 52.48g/mL, respectively). It also showed a good AO activity in the polarographic HPMC assay (950%/mL). p-Hydroxybenzoic acid may be one of the responsible compounds for the afore-mentioned activities. The same extract also exhibited a concentration-dependent cytotoxicity against MCF-7 and HepG2 tumour cell lines reaching IC50 values of 123.51 and 134.29g/mL, respectively with no cytotoxic activity against normal MRC-5 cells. Gentisic, syringic and protocatechuic acids may be among the bioactive principles for the observed cytotoxicity. Taken all together, T. versicolor ethanol extract can be considered as a promising candidate for development of health promoting food supplement. [GRAPHICS] .
PB  - Taylor & Francis Ltd, Abingdon
T2  - Natural Product Research
T1  - Trametes versicolor ethanol extract, a promising candidate for health-promoting food supplement
EP  - 967
IS  - 8
SP  - 963
VL  - 32
DO  - 10.1080/14786419.2017.1366484
ER  - 

@article{
author = "Janjusević, Ljiljana and Pejin, Boris and Kaisarević, Sonja and Gorjanović, Stanislava and Pastor, Ferenc and Tesanović, Kristina and Karaman, Maja",
year = "2018",
abstract = "This study aimed to estimate antiradical, antioxidant (AO) and cytotoxic activities of the fungus Trametes versicolor ethanol fruiting body extract. The extract was found to effectively scavenge both O-2(center dot-) and NO center dot (29.62 and 52.48g/mL, respectively). It also showed a good AO activity in the polarographic HPMC assay (950%/mL). p-Hydroxybenzoic acid may be one of the responsible compounds for the afore-mentioned activities. The same extract also exhibited a concentration-dependent cytotoxicity against MCF-7 and HepG2 tumour cell lines reaching IC50 values of 123.51 and 134.29g/mL, respectively with no cytotoxic activity against normal MRC-5 cells. Gentisic, syringic and protocatechuic acids may be among the bioactive principles for the observed cytotoxicity. Taken all together, T. versicolor ethanol extract can be considered as a promising candidate for development of health promoting food supplement. [GRAPHICS] .",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Natural Product Research",
title = "Trametes versicolor ethanol extract, a promising candidate for health-promoting food supplement",
pages = "967-963",
number = "8",
volume = "32",
doi = "10.1080/14786419.2017.1366484"
}

Janjusević, L., Pejin, B., Kaisarević, S., Gorjanović, S., Pastor, F., Tesanović, K.,& Karaman, M.. (2018). Trametes versicolor ethanol extract, a promising candidate for health-promoting food supplement. in Natural Product Research
Taylor & Francis Ltd, Abingdon., 32(8), 963-967.
https://doi.org/10.1080/14786419.2017.1366484

Janjusević L, Pejin B, Kaisarević S, Gorjanović S, Pastor F, Tesanović K, Karaman M. Trametes versicolor ethanol extract, a promising candidate for health-promoting food supplement. in Natural Product Research. 2018;32(8):963-967.
doi:10.1080/14786419.2017.1366484 .

Janjusević, Ljiljana, Pejin, Boris, Kaisarević, Sonja, Gorjanović, Stanislava, Pastor, Ferenc, Tesanović, Kristina, Karaman, Maja, "Trametes versicolor ethanol extract, a promising candidate for health-promoting food supplement" in Natural Product Research, 32, no. 8 (2018):963-967,
https://doi.org/10.1080/14786419.2017.1366484 . .

TY  - JOUR
AU  - Cakar, Uros
AU  - Grozdanic, Nada
AU  - Pejin, Boris
AU  - Vasic, Vesna
AU  - Cakar, Mira
AU  - Petrović, Aleksandar
AU  - Đorđević, Brizita
PY  - 2018
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/1158
AB  - alpha-Glucosidase inhibitory activity (AGL) of fruit wine samples made from blueberry, black chokeberry, blackberry, raspberry and sour cherry cultivars grown in Serbia was studied using an microvinification procedure. More precisely, both sugar and enzyme were added to the fruit must before fermentation for half of the samples. This increased the extraction of phenolic compounds. All the samples showed higher bioactivity compared to acarbose, the compound used as a positive control. Blueberry (IC50 similar to 27 +/- 1 mu g/ml) and black chokeberry (IC50 similar to 28 +/- 1 mu g/ml) wine samples had the highest values regardless of the vinification method. In addition to this, chlorogenic and caffeic acids were recognised as their key AGL bioactives. Taken all together, the fruit wine samples or their lyophilised extracts may be considered as complementary medicine supplements of potential interest for the control of postprandial hyperglycemia.
PB  - Elsevier Science Bv, Amsterdam
T2  - Food Bioscience
T1  - Impact of vinification procedure on fruit wine inhibitory activity against alpha-glucosidase
EP  - 7
SP  - 1
VL  - 25
DO  - 10.1016/j.fbio.2018.06.009
ER  - 

@article{
author = "Cakar, Uros and Grozdanic, Nada and Pejin, Boris and Vasic, Vesna and Cakar, Mira and Petrović, Aleksandar and Đorđević, Brizita",
year = "2018",
abstract = "alpha-Glucosidase inhibitory activity (AGL) of fruit wine samples made from blueberry, black chokeberry, blackberry, raspberry and sour cherry cultivars grown in Serbia was studied using an microvinification procedure. More precisely, both sugar and enzyme were added to the fruit must before fermentation for half of the samples. This increased the extraction of phenolic compounds. All the samples showed higher bioactivity compared to acarbose, the compound used as a positive control. Blueberry (IC50 similar to 27 +/- 1 mu g/ml) and black chokeberry (IC50 similar to 28 +/- 1 mu g/ml) wine samples had the highest values regardless of the vinification method. In addition to this, chlorogenic and caffeic acids were recognised as their key AGL bioactives. Taken all together, the fruit wine samples or their lyophilised extracts may be considered as complementary medicine supplements of potential interest for the control of postprandial hyperglycemia.",
publisher = "Elsevier Science Bv, Amsterdam",
journal = "Food Bioscience",
title = "Impact of vinification procedure on fruit wine inhibitory activity against alpha-glucosidase",
pages = "7-1",
volume = "25",
doi = "10.1016/j.fbio.2018.06.009"
}

Cakar, U., Grozdanic, N., Pejin, B., Vasic, V., Cakar, M., Petrović, A.,& Đorđević, B.. (2018). Impact of vinification procedure on fruit wine inhibitory activity against alpha-glucosidase. in Food Bioscience
Elsevier Science Bv, Amsterdam., 25, 1-7.
https://doi.org/10.1016/j.fbio.2018.06.009

Cakar U, Grozdanic N, Pejin B, Vasic V, Cakar M, Petrović A, Đorđević B. Impact of vinification procedure on fruit wine inhibitory activity against alpha-glucosidase. in Food Bioscience. 2018;25:1-7.
doi:10.1016/j.fbio.2018.06.009 .

Cakar, Uros, Grozdanic, Nada, Pejin, Boris, Vasic, Vesna, Cakar, Mira, Petrović, Aleksandar, Đorđević, Brizita, "Impact of vinification procedure on fruit wine inhibitory activity against alpha-glucosidase" in Food Bioscience, 25 (2018):1-7,
https://doi.org/10.1016/j.fbio.2018.06.009 . .

TY  - JOUR
AU  - Pejin, Boris
AU  - Glumac, Miodrag
PY  - 2018
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/1193
AB  - This review covers the 1994-2014 literature data published for anti-CNS tumour natural products isolated from marine sponges. The focus was on highly potent antitumourics. It describes only eight promising bioactives (screened on even less number of the respective cell lines) suggesting that brain tumours actually represent quite a hot topic for the natural product research community worldwide. [GRAPHICS] .
PB  - Taylor & Francis Ltd, Abingdon
T2  - Natural Product Research
T1  - A brief review of potent anti-CNS tumourics from marine sponges: covering the period from 1994 to 2014
EP  - 384
IS  - 4
SP  - 375
VL  - 32
DO  - 10.1080/14786419.2017.1309400
ER  - 

@article{
author = "Pejin, Boris and Glumac, Miodrag",
year = "2018",
abstract = "This review covers the 1994-2014 literature data published for anti-CNS tumour natural products isolated from marine sponges. The focus was on highly potent antitumourics. It describes only eight promising bioactives (screened on even less number of the respective cell lines) suggesting that brain tumours actually represent quite a hot topic for the natural product research community worldwide. [GRAPHICS] .",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Natural Product Research",
title = "A brief review of potent anti-CNS tumourics from marine sponges: covering the period from 1994 to 2014",
pages = "384-375",
number = "4",
volume = "32",
doi = "10.1080/14786419.2017.1309400"
}

Pejin, B.,& Glumac, M.. (2018). A brief review of potent anti-CNS tumourics from marine sponges: covering the period from 1994 to 2014. in Natural Product Research
Taylor & Francis Ltd, Abingdon., 32(4), 375-384.
https://doi.org/10.1080/14786419.2017.1309400

Pejin B, Glumac M. A brief review of potent anti-CNS tumourics from marine sponges: covering the period from 1994 to 2014. in Natural Product Research. 2018;32(4):375-384.
doi:10.1080/14786419.2017.1309400 .

Pejin, Boris, Glumac, Miodrag, "A brief review of potent anti-CNS tumourics from marine sponges: covering the period from 1994 to 2014" in Natural Product Research, 32, no. 4 (2018):375-384,
https://doi.org/10.1080/14786419.2017.1309400 . .