TY  - JOUR
AU  - Simonović, Mladen
AU  - Mix, Thorsten
AU  - Glumac, Miodrag
AU  - Pejin, Boris
PY  - 2022
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/1547
AB  - A new protein detector of 2,4,6-trinitrophenol (TNP, picric acid) is concisely reported herein for the first time. In brief, the gene of a specific scFv fragment, namely 3.5, was fused separately with the gene of beta-lactamase and, subsequently, expressed in the periplasmic space of Escherichia coli, affording in such a way the recombinant fusion protein 3.5-scFv-beta-lactamase. This bifunctional immunoreagent tool was further convincingly demonstrated for being capable to directly detect trinitrophenol-tris(hydroxymethyl)aminomethane (TNP-Tris), a less toxic TNP derivative of choice compared to TNP itself, with competitive sensitivity (50 +/- 2 fmol or 175 +/- 6 pg/mL).
PB  - Taylor & Francis Ltd, Abingdon
T2  - Natural Product Research
T1  - 3.5-scFv-beta-lactamase, a new protein detector of picric acid, the highly nitrated organic explosive
EP  - 1320
IS  - 5
SP  - 1317
VL  - 36
DO  - 10.1080/14786419.2020.1860977
ER  - 

@article{
author = "Simonović, Mladen and Mix, Thorsten and Glumac, Miodrag and Pejin, Boris",
year = "2022",
abstract = "A new protein detector of 2,4,6-trinitrophenol (TNP, picric acid) is concisely reported herein for the first time. In brief, the gene of a specific scFv fragment, namely 3.5, was fused separately with the gene of beta-lactamase and, subsequently, expressed in the periplasmic space of Escherichia coli, affording in such a way the recombinant fusion protein 3.5-scFv-beta-lactamase. This bifunctional immunoreagent tool was further convincingly demonstrated for being capable to directly detect trinitrophenol-tris(hydroxymethyl)aminomethane (TNP-Tris), a less toxic TNP derivative of choice compared to TNP itself, with competitive sensitivity (50 +/- 2 fmol or 175 +/- 6 pg/mL).",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Natural Product Research",
title = "3.5-scFv-beta-lactamase, a new protein detector of picric acid, the highly nitrated organic explosive",
pages = "1320-1317",
number = "5",
volume = "36",
doi = "10.1080/14786419.2020.1860977"
}

Simonović, M., Mix, T., Glumac, M.,& Pejin, B.. (2022). 3.5-scFv-beta-lactamase, a new protein detector of picric acid, the highly nitrated organic explosive. in Natural Product Research
Taylor & Francis Ltd, Abingdon., 36(5), 1317-1320.
https://doi.org/10.1080/14786419.2020.1860977

Simonović M, Mix T, Glumac M, Pejin B. 3.5-scFv-beta-lactamase, a new protein detector of picric acid, the highly nitrated organic explosive. in Natural Product Research. 2022;36(5):1317-1320.
doi:10.1080/14786419.2020.1860977 .

Simonović, Mladen, Mix, Thorsten, Glumac, Miodrag, Pejin, Boris, "3.5-scFv-beta-lactamase, a new protein detector of picric acid, the highly nitrated organic explosive" in Natural Product Research, 36, no. 5 (2022):1317-1320,
https://doi.org/10.1080/14786419.2020.1860977 . .

TY  - JOUR
AU  - Simonović, Mladen
AU  - Ostojic, Sanja
AU  - Micic, Darko
AU  - Bisercic-Savić, Marjetka
AU  - Mix, Thorsten
AU  - Glumac, Miodrag
AU  - Pejin, Boris
PY  - 2022
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/1537
AB  - This study aimed to develop a fast and reliable protocol for Trinitrophenol-Tris(hydroxymethyl)aminomethane (TNP-Tris) detection applying a beta-lactamase-fusion protein of choice, the natural product-based immunoreagent tool of competitive sensitivity developed herein for the first time. Since the fusion protein 11B3-scFv-beta-lactamase is constructed from a scFv-antibody (11B3) linked to an enzyme (beta-lactamase), the step related to the use of secondary antibody in the enzyme-linked immunosorbent assay (ELISA) is completely omitted. Indeed, this fusion protein itself serves both as binding mean of the antigen model and detecting agent, due to the presence of the naturally occurring enzyme. In such a way, it actually affords the one-step TNP-Tris detection reaching a promising LOD value of 45 +/- 2 fmol or 157 +/- 6 pg/mL. Taken all together, the current protocol does represent much cheaper and significantly less-time consuming alternative compared both to the recombinant antibodies and recombinant phages, previously designed means in our labs for the same purpose. [GRAPHICS] .
PB  - Taylor & Francis Ltd, Abingdon
T2  - Natural Product Research
T1  - A novel and effective natural product-based immunodetection tool for TNT-like compounds
EP  - 861
IS  - 3
SP  - 857
VL  - 36
DO  - 10.1080/14786419.2020.1806269
ER  - 

@article{
author = "Simonović, Mladen and Ostojic, Sanja and Micic, Darko and Bisercic-Savić, Marjetka and Mix, Thorsten and Glumac, Miodrag and Pejin, Boris",
year = "2022",
abstract = "This study aimed to develop a fast and reliable protocol for Trinitrophenol-Tris(hydroxymethyl)aminomethane (TNP-Tris) detection applying a beta-lactamase-fusion protein of choice, the natural product-based immunoreagent tool of competitive sensitivity developed herein for the first time. Since the fusion protein 11B3-scFv-beta-lactamase is constructed from a scFv-antibody (11B3) linked to an enzyme (beta-lactamase), the step related to the use of secondary antibody in the enzyme-linked immunosorbent assay (ELISA) is completely omitted. Indeed, this fusion protein itself serves both as binding mean of the antigen model and detecting agent, due to the presence of the naturally occurring enzyme. In such a way, it actually affords the one-step TNP-Tris detection reaching a promising LOD value of 45 +/- 2 fmol or 157 +/- 6 pg/mL. Taken all together, the current protocol does represent much cheaper and significantly less-time consuming alternative compared both to the recombinant antibodies and recombinant phages, previously designed means in our labs for the same purpose. [GRAPHICS] .",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Natural Product Research",
title = "A novel and effective natural product-based immunodetection tool for TNT-like compounds",
pages = "861-857",
number = "3",
volume = "36",
doi = "10.1080/14786419.2020.1806269"
}

Simonović, M., Ostojic, S., Micic, D., Bisercic-Savić, M., Mix, T., Glumac, M.,& Pejin, B.. (2022). A novel and effective natural product-based immunodetection tool for TNT-like compounds. in Natural Product Research
Taylor & Francis Ltd, Abingdon., 36(3), 857-861.
https://doi.org/10.1080/14786419.2020.1806269

Simonović M, Ostojic S, Micic D, Bisercic-Savić M, Mix T, Glumac M, Pejin B. A novel and effective natural product-based immunodetection tool for TNT-like compounds. in Natural Product Research. 2022;36(3):857-861.
doi:10.1080/14786419.2020.1806269 .

Simonović, Mladen, Ostojic, Sanja, Micic, Darko, Bisercic-Savić, Marjetka, Mix, Thorsten, Glumac, Miodrag, Pejin, Boris, "A novel and effective natural product-based immunodetection tool for TNT-like compounds" in Natural Product Research, 36, no. 3 (2022):857-861,
https://doi.org/10.1080/14786419.2020.1806269 . .

TY  - JOUR
AU  - Simonović, Mladen
AU  - Kojić, Vesna
AU  - Jakimov, Dimitar
AU  - Glumac, Miodrag
AU  - Pejin, Boris
PY  - 2021
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/1513
AB  - This study was focused on in vitro cytotoxicity screening of the raspberry seeds methanol extract towards a number of cancer cell lines of human origin. The tested extract at the preferred concentrations (IC50  lt 30 mu g/mL) inhibited only the growth of the lung cancer A-549 cells (IC50 = 14.07 +/- 0.96 mu g/mL). At the same time, it was practically inactive (IC50 >300 mu g/mL) and non-mutagenic towards normal MRC-5 lung cells. Finally, the extract potently scavenged both OH center dot (IC50 = 20.11 +/- 1.77 mu g/mL) and O2-center dot (IC50 = 47.23 +/- 3.82 mu g/mL), the free radicals of proved relevance for cancer pathophysiology. Though seeds were enriched with phenolic compounds (TPC = 5.21 +/- 0.07 mg GAE/g), anthocyanins were present in traces only (TAC = 0.07 +/- 0.003 mg cyn-3-glu/g), while flavonoids were not detected at all. This is the first report on anti-lung cancer potential of the seeds of any soft fruit.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Natural Product Research
T1  - Raspberry seeds extract selectively inhibits the growth of human lung cancer cells in vitro
EP  - 2256
IS  - 13
SP  - 2253
VL  - 35
DO  - 10.1080/14786419.2019.1666391
ER  - 

@article{
author = "Simonović, Mladen and Kojić, Vesna and Jakimov, Dimitar and Glumac, Miodrag and Pejin, Boris",
year = "2021",
abstract = "This study was focused on in vitro cytotoxicity screening of the raspberry seeds methanol extract towards a number of cancer cell lines of human origin. The tested extract at the preferred concentrations (IC50  lt 30 mu g/mL) inhibited only the growth of the lung cancer A-549 cells (IC50 = 14.07 +/- 0.96 mu g/mL). At the same time, it was practically inactive (IC50 >300 mu g/mL) and non-mutagenic towards normal MRC-5 lung cells. Finally, the extract potently scavenged both OH center dot (IC50 = 20.11 +/- 1.77 mu g/mL) and O2-center dot (IC50 = 47.23 +/- 3.82 mu g/mL), the free radicals of proved relevance for cancer pathophysiology. Though seeds were enriched with phenolic compounds (TPC = 5.21 +/- 0.07 mg GAE/g), anthocyanins were present in traces only (TAC = 0.07 +/- 0.003 mg cyn-3-glu/g), while flavonoids were not detected at all. This is the first report on anti-lung cancer potential of the seeds of any soft fruit.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Natural Product Research",
title = "Raspberry seeds extract selectively inhibits the growth of human lung cancer cells in vitro",
pages = "2256-2253",
number = "13",
volume = "35",
doi = "10.1080/14786419.2019.1666391"
}

Simonović, M., Kojić, V., Jakimov, D., Glumac, M.,& Pejin, B.. (2021). Raspberry seeds extract selectively inhibits the growth of human lung cancer cells in vitro. in Natural Product Research
Taylor & Francis Ltd, Abingdon., 35(13), 2253-2256.
https://doi.org/10.1080/14786419.2019.1666391

Simonović M, Kojić V, Jakimov D, Glumac M, Pejin B. Raspberry seeds extract selectively inhibits the growth of human lung cancer cells in vitro. in Natural Product Research. 2021;35(13):2253-2256.
doi:10.1080/14786419.2019.1666391 .

Simonović, Mladen, Kojić, Vesna, Jakimov, Dimitar, Glumac, Miodrag, Pejin, Boris, "Raspberry seeds extract selectively inhibits the growth of human lung cancer cells in vitro" in Natural Product Research, 35, no. 13 (2021):2253-2256,
https://doi.org/10.1080/14786419.2019.1666391 . .

TY  - JOUR
AU  - Pejin, Boris
AU  - Simonović, Mladen
AU  - Talevska, Aleksandra
AU  - Glumac, Miodrag
AU  - Jakimov, Dimitar
AU  - Kojić, Vesna
PY  - 2021
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/1511
AB  - The cytotoxicity of the methanol extract of the freshwater sponge Ochridaspongia rotunda (Arndt, 1937) (Malawispongiidae) was evaluated by MTT assay at in vitro conditions against three brain tumour cell lines (Neuro-2A, U-251 MG and U-87 MG). The extract was actually found to be most effective against the malignant glioma U-251 MG cells reaching a promising IC50 value of 1.87 +/- 0.09 mu g/mL at 96 h. However, it exhibited only a bit of cytotoxicity (IC50 321.14 +/- 11.29 mu g/mL, 96 h) towards the normal cells. Also, this sponge extract was 5-fold more selective for U-251 MG versus U-87 MG cells. Finally, monitoring genotoxicity at chromosomal level using the micronucleus test practically revealed lack of any significant toxicity of O. rotunda extract, compared to doxorubicin. [GRAPHICS] .
PB  - Taylor & Francis Ltd, Abingdon
T2  - Natural Product Research
T1  - A neglected natural source for targeting glioblastoma
EP  - 1860
IS  - 11
SP  - 1856
VL  - 35
DO  - 10.1080/14786419.2019.1638386
ER  - 

@article{
author = "Pejin, Boris and Simonović, Mladen and Talevska, Aleksandra and Glumac, Miodrag and Jakimov, Dimitar and Kojić, Vesna",
year = "2021",
abstract = "The cytotoxicity of the methanol extract of the freshwater sponge Ochridaspongia rotunda (Arndt, 1937) (Malawispongiidae) was evaluated by MTT assay at in vitro conditions against three brain tumour cell lines (Neuro-2A, U-251 MG and U-87 MG). The extract was actually found to be most effective against the malignant glioma U-251 MG cells reaching a promising IC50 value of 1.87 +/- 0.09 mu g/mL at 96 h. However, it exhibited only a bit of cytotoxicity (IC50 321.14 +/- 11.29 mu g/mL, 96 h) towards the normal cells. Also, this sponge extract was 5-fold more selective for U-251 MG versus U-87 MG cells. Finally, monitoring genotoxicity at chromosomal level using the micronucleus test practically revealed lack of any significant toxicity of O. rotunda extract, compared to doxorubicin. [GRAPHICS] .",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Natural Product Research",
title = "A neglected natural source for targeting glioblastoma",
pages = "1860-1856",
number = "11",
volume = "35",
doi = "10.1080/14786419.2019.1638386"
}

Pejin, B., Simonović, M., Talevska, A., Glumac, M., Jakimov, D.,& Kojić, V.. (2021). A neglected natural source for targeting glioblastoma. in Natural Product Research
Taylor & Francis Ltd, Abingdon., 35(11), 1856-1860.
https://doi.org/10.1080/14786419.2019.1638386

Pejin B, Simonović M, Talevska A, Glumac M, Jakimov D, Kojić V. A neglected natural source for targeting glioblastoma. in Natural Product Research. 2021;35(11):1856-1860.
doi:10.1080/14786419.2019.1638386 .

Pejin, Boris, Simonović, Mladen, Talevska, Aleksandra, Glumac, Miodrag, Jakimov, Dimitar, Kojić, Vesna, "A neglected natural source for targeting glioblastoma" in Natural Product Research, 35, no. 11 (2021):1856-1860,
https://doi.org/10.1080/14786419.2019.1638386 . .

TY  - JOUR
AU  - Karaman, Maja
AU  - Tesanović, Kristina
AU  - Gorjanović, Stanislava
AU  - Pastor, Ferenc
AU  - Simonović, Mladen
AU  - Glumac, Miodrag
AU  - Pejin, Boris
PY  - 2021
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/1510
AB  - This study was focused on in vitro screening of the total antioxidant activity of the selected extracts of the mushroom Coprinus comatus and quinic acid, one of their antidiabetic ingredients, by an uncommon electrochemical assay. Indeed, direct current (DC) polarographic HydroxoPerhydroxo Mercury(II) Complex (HPMC) assay based on decrease of anodic limiting current originating from HPMC formation in alkaline solutions of hydrogen peroxide at potential of mercury dissolution, observed upon gradual addition of antioxidants, was applied herein for the estimation of the natural products' antioxidativity. Quinic acid was found to exhibit most promising antioxidant potential (4.0 +/- 0.2%mu L-1) being approximate to 2-fold more active than the screened C. comatus extract samples. Actually, such a finding puts some light on the antioxidativity of cyclic polyols, well understimated class of organic compounds, compared to aromatic (poly)phenolics. As a low cost, easy-to handle and accurate this polarographic assay may be thoroughly recommended for much broader use.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Natural Product Research
T1  - Polarography as a technique of choice for the evaluation of total antioxidant activity: The case study of selected Coprinus Comatus extracts and quinic acid, their antidiabetic ingredient
EP  - 1716
IS  - 10
SP  - 1711
VL  - 35
DO  - 10.1080/14786419.2019.1628753
ER  - 

@article{
author = "Karaman, Maja and Tesanović, Kristina and Gorjanović, Stanislava and Pastor, Ferenc and Simonović, Mladen and Glumac, Miodrag and Pejin, Boris",
year = "2021",
abstract = "This study was focused on in vitro screening of the total antioxidant activity of the selected extracts of the mushroom Coprinus comatus and quinic acid, one of their antidiabetic ingredients, by an uncommon electrochemical assay. Indeed, direct current (DC) polarographic HydroxoPerhydroxo Mercury(II) Complex (HPMC) assay based on decrease of anodic limiting current originating from HPMC formation in alkaline solutions of hydrogen peroxide at potential of mercury dissolution, observed upon gradual addition of antioxidants, was applied herein for the estimation of the natural products' antioxidativity. Quinic acid was found to exhibit most promising antioxidant potential (4.0 +/- 0.2%mu L-1) being approximate to 2-fold more active than the screened C. comatus extract samples. Actually, such a finding puts some light on the antioxidativity of cyclic polyols, well understimated class of organic compounds, compared to aromatic (poly)phenolics. As a low cost, easy-to handle and accurate this polarographic assay may be thoroughly recommended for much broader use.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Natural Product Research",
title = "Polarography as a technique of choice for the evaluation of total antioxidant activity: The case study of selected Coprinus Comatus extracts and quinic acid, their antidiabetic ingredient",
pages = "1716-1711",
number = "10",
volume = "35",
doi = "10.1080/14786419.2019.1628753"
}

Karaman, M., Tesanović, K., Gorjanović, S., Pastor, F., Simonović, M., Glumac, M.,& Pejin, B.. (2021). Polarography as a technique of choice for the evaluation of total antioxidant activity: The case study of selected Coprinus Comatus extracts and quinic acid, their antidiabetic ingredient. in Natural Product Research
Taylor & Francis Ltd, Abingdon., 35(10), 1711-1716.
https://doi.org/10.1080/14786419.2019.1628753

Karaman M, Tesanović K, Gorjanović S, Pastor F, Simonović M, Glumac M, Pejin B. Polarography as a technique of choice for the evaluation of total antioxidant activity: The case study of selected Coprinus Comatus extracts and quinic acid, their antidiabetic ingredient. in Natural Product Research. 2021;35(10):1711-1716.
doi:10.1080/14786419.2019.1628753 .

Karaman, Maja, Tesanović, Kristina, Gorjanović, Stanislava, Pastor, Ferenc, Simonović, Mladen, Glumac, Miodrag, Pejin, Boris, "Polarography as a technique of choice for the evaluation of total antioxidant activity: The case study of selected Coprinus Comatus extracts and quinic acid, their antidiabetic ingredient" in Natural Product Research, 35, no. 10 (2021):1711-1716,
https://doi.org/10.1080/14786419.2019.1628753 . .

TY  - JOUR
AU  - Pejin, Boris
AU  - Glumac, Miodrag
PY  - 2019
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/1209
AB  - Nowadays, the mangrove biome is considered to be a profound resource of natural products usually possessing cytotoxicity of a broader range. Covering the period 2007-2015, a total of 21 new naturally occurring compounds has stood out. For example, xylogranin B and swietephragmin C were found to exhibit very potent cytotoxic activity against the colon HCT-116 cells reaching IC50 values of 0.05 and 0.06 mu M, respectively. Bearing in mind the efficacy of the majority compounds in the preliminary in vitro screens, these studies should be expanded to both ex vivo and in vivo screens including the evaluation of the relevant toxicological profiles. [GRAPHICS] .
PB  - Taylor & Francis Ltd, Abingdon
T2  - Natural Product Research
T1  - New cytotoxic natural products from the mangrove biome: covering the period 2007-2015
EP  - 1628
IS  - 11
SP  - 1624
VL  - 33
DO  - 10.1080/14786419.2018.1425854
ER  - 

@article{
author = "Pejin, Boris and Glumac, Miodrag",
year = "2019",
abstract = "Nowadays, the mangrove biome is considered to be a profound resource of natural products usually possessing cytotoxicity of a broader range. Covering the period 2007-2015, a total of 21 new naturally occurring compounds has stood out. For example, xylogranin B and swietephragmin C were found to exhibit very potent cytotoxic activity against the colon HCT-116 cells reaching IC50 values of 0.05 and 0.06 mu M, respectively. Bearing in mind the efficacy of the majority compounds in the preliminary in vitro screens, these studies should be expanded to both ex vivo and in vivo screens including the evaluation of the relevant toxicological profiles. [GRAPHICS] .",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Natural Product Research",
title = "New cytotoxic natural products from the mangrove biome: covering the period 2007-2015",
pages = "1628-1624",
number = "11",
volume = "33",
doi = "10.1080/14786419.2018.1425854"
}

Pejin, B.,& Glumac, M.. (2019). New cytotoxic natural products from the mangrove biome: covering the period 2007-2015. in Natural Product Research
Taylor & Francis Ltd, Abingdon., 33(11), 1624-1628.
https://doi.org/10.1080/14786419.2018.1425854

Pejin B, Glumac M. New cytotoxic natural products from the mangrove biome: covering the period 2007-2015. in Natural Product Research. 2019;33(11):1624-1628.
doi:10.1080/14786419.2018.1425854 .

Pejin, Boris, Glumac, Miodrag, "New cytotoxic natural products from the mangrove biome: covering the period 2007-2015" in Natural Product Research, 33, no. 11 (2019):1624-1628,
https://doi.org/10.1080/14786419.2018.1425854 . .

TY  - JOUR
AU  - Pejin, Boris
AU  - Tommonaro, Giuseppina
AU  - Glumac, Miodrag
AU  - Jakimov, Dimitar
AU  - Kojić, Vesna
PY  - 2018
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/1194
AB  - This study aimed to screen in vitro antitumour activity of the redox couple avarol/avarone against the human malignant glioma cell line U-251 MG for the first time. Compared both with avarol and positive controls used (temozolomide and doxorubicin), avarone was found to be the most active compound with IC50 value below 1 mu M (IC50 0.68 +/- 0.04 mu M, 96 h). Considerable less DNA damage in the cells treated with avarol and avarone vs. doxorubicin (105 & 123% vs. 299%, respectively; untreated U-251 MG cells were used as a control, 100%), coupled with no sign of cytotoxicity against the normal human foetal lung fibroblast MRC-5 cells (IC50 > 100 mu M), has actually pointed out the importance of this marine sesquiterpenoid quinone structure as a promising lead compound in development of novel brain chemotherapeutics. [GRAPHICS] .
PB  - Taylor & Francis Ltd, Abingdon
T2  - Natural Product Research
T1  - The redox couple avarol/avarone in the fight with malignant gliomas: the case study of U-251 MG cells
EP  - 620
IS  - 5
SP  - 616
VL  - 32
DO  - 10.1080/14786419.2017.1327959
ER  - 

@article{
author = "Pejin, Boris and Tommonaro, Giuseppina and Glumac, Miodrag and Jakimov, Dimitar and Kojić, Vesna",
year = "2018",
abstract = "This study aimed to screen in vitro antitumour activity of the redox couple avarol/avarone against the human malignant glioma cell line U-251 MG for the first time. Compared both with avarol and positive controls used (temozolomide and doxorubicin), avarone was found to be the most active compound with IC50 value below 1 mu M (IC50 0.68 +/- 0.04 mu M, 96 h). Considerable less DNA damage in the cells treated with avarol and avarone vs. doxorubicin (105 & 123% vs. 299%, respectively; untreated U-251 MG cells were used as a control, 100%), coupled with no sign of cytotoxicity against the normal human foetal lung fibroblast MRC-5 cells (IC50 > 100 mu M), has actually pointed out the importance of this marine sesquiterpenoid quinone structure as a promising lead compound in development of novel brain chemotherapeutics. [GRAPHICS] .",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Natural Product Research",
title = "The redox couple avarol/avarone in the fight with malignant gliomas: the case study of U-251 MG cells",
pages = "620-616",
number = "5",
volume = "32",
doi = "10.1080/14786419.2017.1327959"
}

Pejin, B., Tommonaro, G., Glumac, M., Jakimov, D.,& Kojić, V.. (2018). The redox couple avarol/avarone in the fight with malignant gliomas: the case study of U-251 MG cells. in Natural Product Research
Taylor & Francis Ltd, Abingdon., 32(5), 616-620.
https://doi.org/10.1080/14786419.2017.1327959

Pejin B, Tommonaro G, Glumac M, Jakimov D, Kojić V. The redox couple avarol/avarone in the fight with malignant gliomas: the case study of U-251 MG cells. in Natural Product Research. 2018;32(5):616-620.
doi:10.1080/14786419.2017.1327959 .

Pejin, Boris, Tommonaro, Giuseppina, Glumac, Miodrag, Jakimov, Dimitar, Kojić, Vesna, "The redox couple avarol/avarone in the fight with malignant gliomas: the case study of U-251 MG cells" in Natural Product Research, 32, no. 5 (2018):616-620,
https://doi.org/10.1080/14786419.2017.1327959 . .

TY  - JOUR
AU  - Pejin, Boris
AU  - Glumac, Miodrag
PY  - 2018
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/1193
AB  - This review covers the 1994-2014 literature data published for anti-CNS tumour natural products isolated from marine sponges. The focus was on highly potent antitumourics. It describes only eight promising bioactives (screened on even less number of the respective cell lines) suggesting that brain tumours actually represent quite a hot topic for the natural product research community worldwide. [GRAPHICS] .
PB  - Taylor & Francis Ltd, Abingdon
T2  - Natural Product Research
T1  - A brief review of potent anti-CNS tumourics from marine sponges: covering the period from 1994 to 2014
EP  - 384
IS  - 4
SP  - 375
VL  - 32
DO  - 10.1080/14786419.2017.1309400
ER  - 

@article{
author = "Pejin, Boris and Glumac, Miodrag",
year = "2018",
abstract = "This review covers the 1994-2014 literature data published for anti-CNS tumour natural products isolated from marine sponges. The focus was on highly potent antitumourics. It describes only eight promising bioactives (screened on even less number of the respective cell lines) suggesting that brain tumours actually represent quite a hot topic for the natural product research community worldwide. [GRAPHICS] .",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Natural Product Research",
title = "A brief review of potent anti-CNS tumourics from marine sponges: covering the period from 1994 to 2014",
pages = "384-375",
number = "4",
volume = "32",
doi = "10.1080/14786419.2017.1309400"
}

Pejin, B.,& Glumac, M.. (2018). A brief review of potent anti-CNS tumourics from marine sponges: covering the period from 1994 to 2014. in Natural Product Research
Taylor & Francis Ltd, Abingdon., 32(4), 375-384.
https://doi.org/10.1080/14786419.2017.1309400

Pejin B, Glumac M. A brief review of potent anti-CNS tumourics from marine sponges: covering the period from 1994 to 2014. in Natural Product Research. 2018;32(4):375-384.
doi:10.1080/14786419.2017.1309400 .

Pejin, Boris, Glumac, Miodrag, "A brief review of potent anti-CNS tumourics from marine sponges: covering the period from 1994 to 2014" in Natural Product Research, 32, no. 4 (2018):375-384,
https://doi.org/10.1080/14786419.2017.1309400 . .

TY  - JOUR
AU  - Glumac, Miodrag
AU  - Pejin, Boris
AU  - Karaman, Maja
AU  - Mojović, Miloš
AU  - Matavulj, Milan
PY  - 2017
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/1093
AB  - In vitro evaluation of total phenolic contents and antiradical activities of the lignicolous fungi Fomes fomentarius and Schizophyllum commune hydrodistilled extracts was the subject of this study. This preliminary screening included four free radical species evaluated by UV-vis (DPPH center dot, ABTS(center dot) and (NO)-N-center dot) and EPR (Asc(center dot)), respectively. According to the experimental data obtained, both F. fomentarius and S. commune hydrodistilled extracts may be considered as promising sources of phenolic natural products (157 and 138mg GAE/g d.e., respectively) and other bioactives showing good anti-DPPH (1.31g/mL) and anti-Asc (70.40%) radical activities, respectively, at in vitro conditions.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Natural Product Research
T1  - Lignicolous fungi hydrodistilled extracts may represent a promising source of natural phenolics
EP  - 107
IS  - 1
SP  - 104
VL  - 31
DO  - 10.1080/14786419.2016.1212036
ER  - 

@article{
author = "Glumac, Miodrag and Pejin, Boris and Karaman, Maja and Mojović, Miloš and Matavulj, Milan",
year = "2017",
abstract = "In vitro evaluation of total phenolic contents and antiradical activities of the lignicolous fungi Fomes fomentarius and Schizophyllum commune hydrodistilled extracts was the subject of this study. This preliminary screening included four free radical species evaluated by UV-vis (DPPH center dot, ABTS(center dot) and (NO)-N-center dot) and EPR (Asc(center dot)), respectively. According to the experimental data obtained, both F. fomentarius and S. commune hydrodistilled extracts may be considered as promising sources of phenolic natural products (157 and 138mg GAE/g d.e., respectively) and other bioactives showing good anti-DPPH (1.31g/mL) and anti-Asc (70.40%) radical activities, respectively, at in vitro conditions.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Natural Product Research",
title = "Lignicolous fungi hydrodistilled extracts may represent a promising source of natural phenolics",
pages = "107-104",
number = "1",
volume = "31",
doi = "10.1080/14786419.2016.1212036"
}

Glumac, M., Pejin, B., Karaman, M., Mojović, M.,& Matavulj, M.. (2017). Lignicolous fungi hydrodistilled extracts may represent a promising source of natural phenolics. in Natural Product Research
Taylor & Francis Ltd, Abingdon., 31(1), 104-107.
https://doi.org/10.1080/14786419.2016.1212036

Glumac M, Pejin B, Karaman M, Mojović M, Matavulj M. Lignicolous fungi hydrodistilled extracts may represent a promising source of natural phenolics. in Natural Product Research. 2017;31(1):104-107.
doi:10.1080/14786419.2016.1212036 .

Glumac, Miodrag, Pejin, Boris, Karaman, Maja, Mojović, Miloš, Matavulj, Milan, "Lignicolous fungi hydrodistilled extracts may represent a promising source of natural phenolics" in Natural Product Research, 31, no. 1 (2017):104-107,
https://doi.org/10.1080/14786419.2016.1212036 . .