TY  - JOUR
AU  - Pejin, Boris
AU  - Tesanović, Kristina
AU  - Jakovljević, Dragica
AU  - Kaisarević, Sonja
AU  - Sibul, Filip
AU  - Raseta, Milena
AU  - Karaman, Maja
PY  - 2019
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/1277
AB  - The polysaccharide (PSH) extracts from the edible mushroom species Coprinus comatus and Coprinellus truncorum were screened in liquid for their acetylcholinesterase inhibitory (AChE) activity. Both extracts were found to display inhibition of the aforementioned enzyme reaching similar IC50 values of 0.62 +/- 0.07 and 0.61 +/- 0.03 mg/mL, respectively. According to the means of FTIR spectroscopy, these PSH extracts mostly contained beta-glucans. However, the presence of some proteins and polyphenolics as minor ingredients were also detected. Compared with existing literature data for anti-AChE activity of the sugar samples, the findings within this study may be treated as a profound bioactivity. Consequently, this study puts some light on the possible use of the screened macrofungi in the palliative treatment of Alzheimer's disease. [GRAPHICS] .
PB  - Taylor & Francis Ltd, Abingdon
T2  - Natural Product Research
T1  - The polysaccharide extracts from the fungi Coprinus comatus and Coprinellus truncorum do exhibit AChE inhibitory activity
EP  - 754
IS  - 5
SP  - 750
VL  - 33
DO  - 10.1080/14786419.2017.1405417
ER  - 

@article{
author = "Pejin, Boris and Tesanović, Kristina and Jakovljević, Dragica and Kaisarević, Sonja and Sibul, Filip and Raseta, Milena and Karaman, Maja",
year = "2019",
abstract = "The polysaccharide (PSH) extracts from the edible mushroom species Coprinus comatus and Coprinellus truncorum were screened in liquid for their acetylcholinesterase inhibitory (AChE) activity. Both extracts were found to display inhibition of the aforementioned enzyme reaching similar IC50 values of 0.62 +/- 0.07 and 0.61 +/- 0.03 mg/mL, respectively. According to the means of FTIR spectroscopy, these PSH extracts mostly contained beta-glucans. However, the presence of some proteins and polyphenolics as minor ingredients were also detected. Compared with existing literature data for anti-AChE activity of the sugar samples, the findings within this study may be treated as a profound bioactivity. Consequently, this study puts some light on the possible use of the screened macrofungi in the palliative treatment of Alzheimer's disease. [GRAPHICS] .",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Natural Product Research",
title = "The polysaccharide extracts from the fungi Coprinus comatus and Coprinellus truncorum do exhibit AChE inhibitory activity",
pages = "754-750",
number = "5",
volume = "33",
doi = "10.1080/14786419.2017.1405417"
}

Pejin, B., Tesanović, K., Jakovljević, D., Kaisarević, S., Sibul, F., Raseta, M.,& Karaman, M.. (2019). The polysaccharide extracts from the fungi Coprinus comatus and Coprinellus truncorum do exhibit AChE inhibitory activity. in Natural Product Research
Taylor & Francis Ltd, Abingdon., 33(5), 750-754.
https://doi.org/10.1080/14786419.2017.1405417

Pejin B, Tesanović K, Jakovljević D, Kaisarević S, Sibul F, Raseta M, Karaman M. The polysaccharide extracts from the fungi Coprinus comatus and Coprinellus truncorum do exhibit AChE inhibitory activity. in Natural Product Research. 2019;33(5):750-754.
doi:10.1080/14786419.2017.1405417 .

Pejin, Boris, Tesanović, Kristina, Jakovljević, Dragica, Kaisarević, Sonja, Sibul, Filip, Raseta, Milena, Karaman, Maja, "The polysaccharide extracts from the fungi Coprinus comatus and Coprinellus truncorum do exhibit AChE inhibitory activity" in Natural Product Research, 33, no. 5 (2019):750-754,
https://doi.org/10.1080/14786419.2017.1405417 . .

TY  - JOUR
AU  - Tesanović, Kristina
AU  - Pejin, Boris
AU  - Sibul, Filip
AU  - Matavulj, Milan
AU  - Raseta, Milena
AU  - Janjusević, Ljiljana
AU  - Karaman, Maja
PY  - 2017
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/1095
AB  - Bioactive properties of fungi considerably differ between the fruiting body (FB) and the submerged culture as regards mycelia (M) and the fermentation broth (F). Antioxidant properties of hot-water extracts obtained from three different fungal origins: FB, M and F of two autochthonous fungal species (Northern Serbia), Coprinus comatus and Coprinellus truncorum were investigated. Free radical scavenging capacity (RSC) was evaluated in vitro by the DPPH assay and reducing power ability (FRAP assay). Considering possible bioactive properties of different compounds present in fungal extracts, the content of total proteins (TP), phenols (TC) and flavonoids (TF) were investigated colorimetrically. The chemical characterisation of the examined extracts was evaluated using the HPLC-MS/MS method. C. comatus showed the strongest RSC activity; more precisely, fermentation broth extract (FCc) on DPPH radicals (IC50 = 5.06 mu g mL(-1)) and fruiting body extract (FBCc) for the FRAP assay (42.86 mg ascorbic acid equivalents (AAE)/g). Submerged M extract of both species showed the highest TC (MCc 81.95 mg gallic acid eq (GAE)/g d.w.; MCt 81.64 mg GAE/g d.w.), while FB extracts contained the highest content of TP. Comparing LC-MS phenolic profiles between species-interspecifically and among different fungal origins-intraspecifically (fruiting bodies and submerged cultures), high variations were noticed. In submerged M or F extracts of C. comatus, vanillic, gallic, gentisic and cinnamic acids were detected, as opposed to FB. Considering that diverse phenolic profiles of detected antioxidant compounds were obtained by submerged cultivation, this type of cultivation is promising for the production of antioxidant substances.
PB  - Springer India, New Delhi
T2  - Journal of Food Science and Technology-Mysore
T1  - A comparative overview of antioxidative properties and phenolic profiles of different fungal origins: fruiting bodies and submerged cultures of Coprinus comatus and Coprinellus truncorum
EP  - 438
IS  - 2
SP  - 430
VL  - 54
DO  - 10.1007/s13197-016-2479-2
ER  - 

@article{
author = "Tesanović, Kristina and Pejin, Boris and Sibul, Filip and Matavulj, Milan and Raseta, Milena and Janjusević, Ljiljana and Karaman, Maja",
year = "2017",
abstract = "Bioactive properties of fungi considerably differ between the fruiting body (FB) and the submerged culture as regards mycelia (M) and the fermentation broth (F). Antioxidant properties of hot-water extracts obtained from three different fungal origins: FB, M and F of two autochthonous fungal species (Northern Serbia), Coprinus comatus and Coprinellus truncorum were investigated. Free radical scavenging capacity (RSC) was evaluated in vitro by the DPPH assay and reducing power ability (FRAP assay). Considering possible bioactive properties of different compounds present in fungal extracts, the content of total proteins (TP), phenols (TC) and flavonoids (TF) were investigated colorimetrically. The chemical characterisation of the examined extracts was evaluated using the HPLC-MS/MS method. C. comatus showed the strongest RSC activity; more precisely, fermentation broth extract (FCc) on DPPH radicals (IC50 = 5.06 mu g mL(-1)) and fruiting body extract (FBCc) for the FRAP assay (42.86 mg ascorbic acid equivalents (AAE)/g). Submerged M extract of both species showed the highest TC (MCc 81.95 mg gallic acid eq (GAE)/g d.w.; MCt 81.64 mg GAE/g d.w.), while FB extracts contained the highest content of TP. Comparing LC-MS phenolic profiles between species-interspecifically and among different fungal origins-intraspecifically (fruiting bodies and submerged cultures), high variations were noticed. In submerged M or F extracts of C. comatus, vanillic, gallic, gentisic and cinnamic acids were detected, as opposed to FB. Considering that diverse phenolic profiles of detected antioxidant compounds were obtained by submerged cultivation, this type of cultivation is promising for the production of antioxidant substances.",
publisher = "Springer India, New Delhi",
journal = "Journal of Food Science and Technology-Mysore",
title = "A comparative overview of antioxidative properties and phenolic profiles of different fungal origins: fruiting bodies and submerged cultures of Coprinus comatus and Coprinellus truncorum",
pages = "438-430",
number = "2",
volume = "54",
doi = "10.1007/s13197-016-2479-2"
}

Tesanović, K., Pejin, B., Sibul, F., Matavulj, M., Raseta, M., Janjusević, L.,& Karaman, M.. (2017). A comparative overview of antioxidative properties and phenolic profiles of different fungal origins: fruiting bodies and submerged cultures of Coprinus comatus and Coprinellus truncorum. in Journal of Food Science and Technology-Mysore
Springer India, New Delhi., 54(2), 430-438.
https://doi.org/10.1007/s13197-016-2479-2

Tesanović K, Pejin B, Sibul F, Matavulj M, Raseta M, Janjusević L, Karaman M. A comparative overview of antioxidative properties and phenolic profiles of different fungal origins: fruiting bodies and submerged cultures of Coprinus comatus and Coprinellus truncorum. in Journal of Food Science and Technology-Mysore. 2017;54(2):430-438.
doi:10.1007/s13197-016-2479-2 .

Tesanović, Kristina, Pejin, Boris, Sibul, Filip, Matavulj, Milan, Raseta, Milena, Janjusević, Ljiljana, Karaman, Maja, "A comparative overview of antioxidative properties and phenolic profiles of different fungal origins: fruiting bodies and submerged cultures of Coprinus comatus and Coprinellus truncorum" in Journal of Food Science and Technology-Mysore, 54, no. 2 (2017):430-438,
https://doi.org/10.1007/s13197-016-2479-2 . .