TY  - JOUR
AU  - Anicic, Neda
AU  - Gasic, Uros
AU  - Lu, Feng
AU  - Ciric, Ana
AU  - Ivanov, Marija
AU  - Jevtic, Bojan
AU  - Dimitrijević, Milena
AU  - Anđelković, Boban
AU  - Skoric, Marijana
AU  - Nestorović-Živković, Jasmina M
AU  - Mao, Yingle
AU  - Liu, Jia
AU  - Tang, Chunping
AU  - Soković, Marina
AU  - Ye, Yang
AU  - Misic, Danijela
PY  - 2021
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/1485
AB  - Two Balkan Peninsula endemics, Nepeta rtanjensis and N. argolica subsp. argolica, both characterized by specialized metabolite profiles predominated by iridoids and phenolics, are differentiated according to the stereochemistry of major iridoid aglycone nepetalactone (NL). For the first time, the present study provides a comparative analysis of antimicrobial and immunomodulating activities of the two Nepeta species and their major iridoids isolated from natural sources-cis,trans-NL, trans,cis-NL, and 1,5,9-epideoxyloganic acid (1,5,9-eDLA), as well as of phenolic acid rosmarinic acid (RA). Methanol extracts and pure iridoids displayed excellent antimicrobial activity against eight strains of bacteria and seven strains of fungi. They were especially potent against food-borne pathogens such as L. monocytogenes, E. coli, S. aureus, Penicillium sp., and Aspergillus sp. Targeted iridoids were efficient agents in preventing biofilm formation of resistant P. aeruginosa strain, and they displayed additive antimicrobial interaction. Iridoids are, to a great extent, responsible for the prominent antimicrobial activities of the two Nepeta species, although are probably minor contributors to the moderate immunomodulatory effects. The analyzed iridoids and RA, individually or in mixtures, have the potential to be used in the pharmaceutical industry as potent antimicrobials, and in the food industry to increase the shelf life and safety of food products.
PB  - MDPI, Basel
T2  - Pharmaceuticals
T1  - Antimicrobial and Immunomodulating Activities of Two Endemic Nepeta Species and Their Major Iridoids Isolated from Natural Sources
IS  - 5
VL  - 14
DO  - 10.3390/ph14050414
ER  - 

@article{
author = "Anicic, Neda and Gasic, Uros and Lu, Feng and Ciric, Ana and Ivanov, Marija and Jevtic, Bojan and Dimitrijević, Milena and Anđelković, Boban and Skoric, Marijana and Nestorović-Živković, Jasmina M and Mao, Yingle and Liu, Jia and Tang, Chunping and Soković, Marina and Ye, Yang and Misic, Danijela",
year = "2021",
abstract = "Two Balkan Peninsula endemics, Nepeta rtanjensis and N. argolica subsp. argolica, both characterized by specialized metabolite profiles predominated by iridoids and phenolics, are differentiated according to the stereochemistry of major iridoid aglycone nepetalactone (NL). For the first time, the present study provides a comparative analysis of antimicrobial and immunomodulating activities of the two Nepeta species and their major iridoids isolated from natural sources-cis,trans-NL, trans,cis-NL, and 1,5,9-epideoxyloganic acid (1,5,9-eDLA), as well as of phenolic acid rosmarinic acid (RA). Methanol extracts and pure iridoids displayed excellent antimicrobial activity against eight strains of bacteria and seven strains of fungi. They were especially potent against food-borne pathogens such as L. monocytogenes, E. coli, S. aureus, Penicillium sp., and Aspergillus sp. Targeted iridoids were efficient agents in preventing biofilm formation of resistant P. aeruginosa strain, and they displayed additive antimicrobial interaction. Iridoids are, to a great extent, responsible for the prominent antimicrobial activities of the two Nepeta species, although are probably minor contributors to the moderate immunomodulatory effects. The analyzed iridoids and RA, individually or in mixtures, have the potential to be used in the pharmaceutical industry as potent antimicrobials, and in the food industry to increase the shelf life and safety of food products.",
publisher = "MDPI, Basel",
journal = "Pharmaceuticals",
title = "Antimicrobial and Immunomodulating Activities of Two Endemic Nepeta Species and Their Major Iridoids Isolated from Natural Sources",
number = "5",
volume = "14",
doi = "10.3390/ph14050414"
}

Anicic, N., Gasic, U., Lu, F., Ciric, A., Ivanov, M., Jevtic, B., Dimitrijević, M., Anđelković, B., Skoric, M., Nestorović-Živković, J. M., Mao, Y., Liu, J., Tang, C., Soković, M., Ye, Y.,& Misic, D.. (2021). Antimicrobial and Immunomodulating Activities of Two Endemic Nepeta Species and Their Major Iridoids Isolated from Natural Sources. in Pharmaceuticals
MDPI, Basel., 14(5).
https://doi.org/10.3390/ph14050414

Anicic N, Gasic U, Lu F, Ciric A, Ivanov M, Jevtic B, Dimitrijević M, Anđelković B, Skoric M, Nestorović-Živković JM, Mao Y, Liu J, Tang C, Soković M, Ye Y, Misic D. Antimicrobial and Immunomodulating Activities of Two Endemic Nepeta Species and Their Major Iridoids Isolated from Natural Sources. in Pharmaceuticals. 2021;14(5).
doi:10.3390/ph14050414 .

Anicic, Neda, Gasic, Uros, Lu, Feng, Ciric, Ana, Ivanov, Marija, Jevtic, Bojan, Dimitrijević, Milena, Anđelković, Boban, Skoric, Marijana, Nestorović-Živković, Jasmina M, Mao, Yingle, Liu, Jia, Tang, Chunping, Soković, Marina, Ye, Yang, Misic, Danijela, "Antimicrobial and Immunomodulating Activities of Two Endemic Nepeta Species and Their Major Iridoids Isolated from Natural Sources" in Pharmaceuticals, 14, no. 5 (2021),
https://doi.org/10.3390/ph14050414 . .

TY  - CONF
AU  - Zmejkoski, Danica Z.
AU  - Spasojević, Dragica
AU  - Soković, Marina
AU  - Glamočlija, Jasmina
AU  - Orlovska, Irina
AU  - Kozirovska, Natalia
AU  - Radotić, Ksenija
PY  - 2018
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/2913
AB  - Biofilm-forming bacteria are recognized as a major impediment to wound healing. The aim of this study was to improve design of the formulations used for care of biofilm-infected wounds. Since lignins and lignin-derived compounds are known to have antibacterial properties especially efficient against biofilm-forming pathogens, the gel and membrane type of materials of enzymatically synthesized lignin model compound, dehydrogenative polymer of coniferyl alcohol (DHP) with alginate (Alg) and bacterial cellulose (BC) synthesized by culture Komagataeibacter intermedius IMBG180, were composed. The hydrogels were tested on Gram-negative P. aeruginosa (ATCC 27853) and S. typhimurium (ATCC 13311), Gram-positive bacteria L. monocytogenes (NCTC 7973) and S. aureus (ATCC 6538), as well as S. aureus #1*, S. aureus #2*, P. aeruginosa* and Serratia sp.* clinical human isolates obtained from patients’ wounds. DHP-Alg showed activity against all ofthe tested bacteria with minimal inhibitory concentrations (MICs) of 0.002–0.45 mg/mL and minimal bactericidal concentrations (MBCs) of 0.004–0.90 mg/mL. L. monocytogenes was the most susceptible. DHP-BC exhibited antibacterial activity on all tested bacteria, with exception of P. aeruginosa and S. aureus #1*. MICs and MBCs were in range of 0.22-0.42 mg/mL and 0.22-0.88 mg/mL, respectively. DHP-Alg gel and DHP-BC membranes, after initial release in the first hour of 34% and 19.26% of DHP, respectively, allowed the slow and continuous release of DHP in PBS solution. After 24 hours the amount of released antimicrobial substance from DHP-Alg and DHP-BC were 42.13% and 46.2%, respectively. Based on all obtained results, both hydrogels have the potential to be used in medical treatments as antibacterial agents.
PB  - Национална и универзитетска библиотека „Св. Климент Охридски“, Скопје
C3  - 25th Congress of SCTM
T1  - Antimicrobial composite polymers as potential agents in chronic wound healing
SP  - 223
UR  - https://hdl.handle.net/21.15107/rcub_rimsi_2913
ER  - 

@conference{
author = "Zmejkoski, Danica Z. and Spasojević, Dragica and Soković, Marina and Glamočlija, Jasmina and Orlovska, Irina and Kozirovska, Natalia and Radotić, Ksenija",
year = "2018",
abstract = "Biofilm-forming bacteria are recognized as a major impediment to wound healing. The aim of this study was to improve design of the formulations used for care of biofilm-infected wounds. Since lignins and lignin-derived compounds are known to have antibacterial properties especially efficient against biofilm-forming pathogens, the gel and membrane type of materials of enzymatically synthesized lignin model compound, dehydrogenative polymer of coniferyl alcohol (DHP) with alginate (Alg) and bacterial cellulose (BC) synthesized by culture Komagataeibacter intermedius IMBG180, were composed. The hydrogels were tested on Gram-negative P. aeruginosa (ATCC 27853) and S. typhimurium (ATCC 13311), Gram-positive bacteria L. monocytogenes (NCTC 7973) and S. aureus (ATCC 6538), as well as S. aureus #1*, S. aureus #2*, P. aeruginosa* and Serratia sp.* clinical human isolates obtained from patients’ wounds. DHP-Alg showed activity against all ofthe tested bacteria with minimal inhibitory concentrations (MICs) of 0.002–0.45 mg/mL and minimal bactericidal concentrations (MBCs) of 0.004–0.90 mg/mL. L. monocytogenes was the most susceptible. DHP-BC exhibited antibacterial activity on all tested bacteria, with exception of P. aeruginosa and S. aureus #1*. MICs and MBCs were in range of 0.22-0.42 mg/mL and 0.22-0.88 mg/mL, respectively. DHP-Alg gel and DHP-BC membranes, after initial release in the first hour of 34% and 19.26% of DHP, respectively, allowed the slow and continuous release of DHP in PBS solution. After 24 hours the amount of released antimicrobial substance from DHP-Alg and DHP-BC were 42.13% and 46.2%, respectively. Based on all obtained results, both hydrogels have the potential to be used in medical treatments as antibacterial agents.",
publisher = "Национална и универзитетска библиотека „Св. Климент Охридски“, Скопје",
journal = "25th Congress of SCTM",
title = "Antimicrobial composite polymers as potential agents in chronic wound healing",
pages = "223",
url = "https://hdl.handle.net/21.15107/rcub_rimsi_2913"
}

Zmejkoski, D. Z., Spasojević, D., Soković, M., Glamočlija, J., Orlovska, I., Kozirovska, N.,& Radotić, K.. (2018). Antimicrobial composite polymers as potential agents in chronic wound healing. in 25th Congress of SCTM
Национална и универзитетска библиотека „Св. Климент Охридски“, Скопје., 223.
https://hdl.handle.net/21.15107/rcub_rimsi_2913

Zmejkoski DZ, Spasojević D, Soković M, Glamočlija J, Orlovska I, Kozirovska N, Radotić K. Antimicrobial composite polymers as potential agents in chronic wound healing. in 25th Congress of SCTM. 2018;:223.
https://hdl.handle.net/21.15107/rcub_rimsi_2913 .

Zmejkoski, Danica Z., Spasojević, Dragica, Soković, Marina, Glamočlija, Jasmina, Orlovska, Irina, Kozirovska, Natalia, Radotić, Ksenija, "Antimicrobial composite polymers as potential agents in chronic wound healing" in 25th Congress of SCTM (2018):223,
https://hdl.handle.net/21.15107/rcub_rimsi_2913 .

TY  - JOUR
AU  - Zmejkoski, Danica
AU  - Spasojević, Dragica
AU  - Orlovska, Irina
AU  - Kozyrovska, Natalia
AU  - Soković, Marina
AU  - Glamočlija, Jasmina
AU  - Dmitrović, Svetlana
AU  - Matović, Branko
AU  - Tasić, Nikola
AU  - Maksimović, Vuk
AU  - Sosnin, Mikhail
AU  - Radotić, Ksenija
PY  - 2018
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/1157
AB  - Lignins and lignin-derived compounds are known to have antibacterial properties. The wound healing agents in the form of dressings produce faster skin repair and decrease pain in patients. In order to create an efficient antimicrobial agent in the form of dressing in the treatment of chronic wounds, a composite hydrogel of bacterial cellulose (BC) and dehydrogenative polymer of coniferyl alcohol (DHP), BC-DHP, was designed. Novel composite showed inhibitory or bactericidal effects against selected pathogenic bacteria, including clinically isolated ones. The highest release rate of DHP was in the first hour, while after 24 h there was still slow release of small amounts of DHP from BC-DHP during 72 h monitoring. High-performance liquid chromatography coupled with mass-spectrometry showed that BC-DHP releases DHP oligomers, which are proposed to be antimicrobially active DHP fractions. Scanning electron microscopy and atomic force microscopy micrographs proved a dose-dependent interaction of DHP with BC, which resulted in a decrease of the pore number and size in the cellulose membrane. The Fourier-transform infrared absorption spectra of the BC-DHP showed that DHP was partly bound to the BC matrix. The swelling and crystallinity degree were dose-dependent. All obtained results confirmed BC-DHP composite as a promising hydrogel for wounds healing.
PB  - Elsevier, Amsterdam
T2  - International Journal of Biological Macromolecules
T1  - Bacterial cellulose-lignin composite hydrogel as a promising agent in chronic wound healing
EP  - 503
SP  - 494
VL  - 118
DO  - 10.1016/j.ijbiomac.2018.06.067
ER  - 

@article{
author = "Zmejkoski, Danica and Spasojević, Dragica and Orlovska, Irina and Kozyrovska, Natalia and Soković, Marina and Glamočlija, Jasmina and Dmitrović, Svetlana and Matović, Branko and Tasić, Nikola and Maksimović, Vuk and Sosnin, Mikhail and Radotić, Ksenija",
year = "2018",
abstract = "Lignins and lignin-derived compounds are known to have antibacterial properties. The wound healing agents in the form of dressings produce faster skin repair and decrease pain in patients. In order to create an efficient antimicrobial agent in the form of dressing in the treatment of chronic wounds, a composite hydrogel of bacterial cellulose (BC) and dehydrogenative polymer of coniferyl alcohol (DHP), BC-DHP, was designed. Novel composite showed inhibitory or bactericidal effects against selected pathogenic bacteria, including clinically isolated ones. The highest release rate of DHP was in the first hour, while after 24 h there was still slow release of small amounts of DHP from BC-DHP during 72 h monitoring. High-performance liquid chromatography coupled with mass-spectrometry showed that BC-DHP releases DHP oligomers, which are proposed to be antimicrobially active DHP fractions. Scanning electron microscopy and atomic force microscopy micrographs proved a dose-dependent interaction of DHP with BC, which resulted in a decrease of the pore number and size in the cellulose membrane. The Fourier-transform infrared absorption spectra of the BC-DHP showed that DHP was partly bound to the BC matrix. The swelling and crystallinity degree were dose-dependent. All obtained results confirmed BC-DHP composite as a promising hydrogel for wounds healing.",
publisher = "Elsevier, Amsterdam",
journal = "International Journal of Biological Macromolecules",
title = "Bacterial cellulose-lignin composite hydrogel as a promising agent in chronic wound healing",
pages = "503-494",
volume = "118",
doi = "10.1016/j.ijbiomac.2018.06.067"
}

Zmejkoski, D., Spasojević, D., Orlovska, I., Kozyrovska, N., Soković, M., Glamočlija, J., Dmitrović, S., Matović, B., Tasić, N., Maksimović, V., Sosnin, M.,& Radotić, K.. (2018). Bacterial cellulose-lignin composite hydrogel as a promising agent in chronic wound healing. in International Journal of Biological Macromolecules
Elsevier, Amsterdam., 118, 494-503.
https://doi.org/10.1016/j.ijbiomac.2018.06.067

Zmejkoski D, Spasojević D, Orlovska I, Kozyrovska N, Soković M, Glamočlija J, Dmitrović S, Matović B, Tasić N, Maksimović V, Sosnin M, Radotić K. Bacterial cellulose-lignin composite hydrogel as a promising agent in chronic wound healing. in International Journal of Biological Macromolecules. 2018;118:494-503.
doi:10.1016/j.ijbiomac.2018.06.067 .

Zmejkoski, Danica, Spasojević, Dragica, Orlovska, Irina, Kozyrovska, Natalia, Soković, Marina, Glamočlija, Jasmina, Dmitrović, Svetlana, Matović, Branko, Tasić, Nikola, Maksimović, Vuk, Sosnin, Mikhail, Radotić, Ksenija, "Bacterial cellulose-lignin composite hydrogel as a promising agent in chronic wound healing" in International Journal of Biological Macromolecules, 118 (2018):494-503,
https://doi.org/10.1016/j.ijbiomac.2018.06.067 . .

TY  - JOUR
AU  - Pejin, Boris
AU  - Ciric, Ana
AU  - Dimitrić-Marković, Jasmina
AU  - Glamočlija, Jasmina
AU  - Nikolic, Milos
AU  - Soković, Marina
PY  - 2017
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/1090
AB  - Anti-biofilm activity of three anthocyanidins (pelargonidin, cyanidin and delphinidin) was evaluated for the first time at in vitro conditions. All the compounds reduced the formation of Pseudomonas aeruginosa PAO1 biofilm at low sub-MIC (0.125 MIC) with delphinidin (c 56.25g/mL) being the most active (43%). In comparison, ampicillin (c 93.75g/mL) and streptomycin (c 21.25g/mL) (used as positive controls) were considerably less effective at the same sub-MIC (8 and 12%, respectively). Furthermore, at 0.5 MIC (c 225g/mL) this anthocyanidin molecule partly reduced the bacterial protrusions. However, no any of the aforementioned compounds inhibited the production of pyocyanin by the bacterial strain P. aeruginosa PAO1. Taken all together, the delphinidin scaffold could be taken into consideration for the design of the novel and more effective anti-biofilm agents inspired by the anthocyanidins.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Natural Product Research
T1  - An insight into anti-biofilm and anti-quorum sensing activities of the selected anthocyanidins: the case study of Pseudomonas aeruginosa PAO1
EP  - 1180
IS  - 10
SP  - 1177
VL  - 31
DO  - 10.1080/14786419.2016.1222386
ER  - 

@article{
author = "Pejin, Boris and Ciric, Ana and Dimitrić-Marković, Jasmina and Glamočlija, Jasmina and Nikolic, Milos and Soković, Marina",
year = "2017",
abstract = "Anti-biofilm activity of three anthocyanidins (pelargonidin, cyanidin and delphinidin) was evaluated for the first time at in vitro conditions. All the compounds reduced the formation of Pseudomonas aeruginosa PAO1 biofilm at low sub-MIC (0.125 MIC) with delphinidin (c 56.25g/mL) being the most active (43%). In comparison, ampicillin (c 93.75g/mL) and streptomycin (c 21.25g/mL) (used as positive controls) were considerably less effective at the same sub-MIC (8 and 12%, respectively). Furthermore, at 0.5 MIC (c 225g/mL) this anthocyanidin molecule partly reduced the bacterial protrusions. However, no any of the aforementioned compounds inhibited the production of pyocyanin by the bacterial strain P. aeruginosa PAO1. Taken all together, the delphinidin scaffold could be taken into consideration for the design of the novel and more effective anti-biofilm agents inspired by the anthocyanidins.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Natural Product Research",
title = "An insight into anti-biofilm and anti-quorum sensing activities of the selected anthocyanidins: the case study of Pseudomonas aeruginosa PAO1",
pages = "1180-1177",
number = "10",
volume = "31",
doi = "10.1080/14786419.2016.1222386"
}

Pejin, B., Ciric, A., Dimitrić-Marković, J., Glamočlija, J., Nikolic, M.,& Soković, M.. (2017). An insight into anti-biofilm and anti-quorum sensing activities of the selected anthocyanidins: the case study of Pseudomonas aeruginosa PAO1. in Natural Product Research
Taylor & Francis Ltd, Abingdon., 31(10), 1177-1180.
https://doi.org/10.1080/14786419.2016.1222386

Pejin B, Ciric A, Dimitrić-Marković J, Glamočlija J, Nikolic M, Soković M. An insight into anti-biofilm and anti-quorum sensing activities of the selected anthocyanidins: the case study of Pseudomonas aeruginosa PAO1. in Natural Product Research. 2017;31(10):1177-1180.
doi:10.1080/14786419.2016.1222386 .

Pejin, Boris, Ciric, Ana, Dimitrić-Marković, Jasmina, Glamočlija, Jasmina, Nikolic, Milos, Soković, Marina, "An insight into anti-biofilm and anti-quorum sensing activities of the selected anthocyanidins: the case study of Pseudomonas aeruginosa PAO1" in Natural Product Research, 31, no. 10 (2017):1177-1180,
https://doi.org/10.1080/14786419.2016.1222386 . .

TY  - JOUR
AU  - Spasojević, Dragica
AU  - Zmejkoski, Danica
AU  - Glamočlija, Jasmina
AU  - Nikolic, Milos
AU  - Soković, Marina
AU  - Milošević, Verica Lj.
AU  - Jaric, Ivana
AU  - Stojanović, Marijana
AU  - Marinković, Emilija
AU  - Barisani-Asenbauer, Talin
AU  - Prodanović, Radivoje
AU  - Jovanović, Milos
AU  - Radotić, Ksenija
PY  - 2016
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/983
AB  - Nowadays bacterial resistance to known antibiotics is a serious health problem. In order to achieve more efficient treatment, lately there is an effort to find new substances, such as certain biomaterials, that are non-toxic to humans with antibiotic potential. Lignins and lignin-derived compounds have been proposed to be good candidates for use in medicine and health maintenance. In this study, the antibacterial activity of the lignin model polymer dehydrogenate polymer (DHP) in alginate hydrogel (Alg) was studied. The obtained results show that DHP-Alg has strong antimicrobial activity against several bacterial strains and biofilms and does not have a toxic effect on human epithelial cells. These results strongly suggest its application as a wound healing agent or as an adjunct substance for wound treatments.
PB  - Elsevier, Amsterdam
T2  - International Journal of Antimicrobial Agents
T1  - Lignin model compound in alginate hydrogel: a strong antimicrobial agent with high potential in wound treatment
EP  - 735
IS  - 6
SP  - 732
VL  - 48
DO  - 10.1016/j.ijantimicag.2016.08.014
ER  - 

@article{
author = "Spasojević, Dragica and Zmejkoski, Danica and Glamočlija, Jasmina and Nikolic, Milos and Soković, Marina and Milošević, Verica Lj. and Jaric, Ivana and Stojanović, Marijana and Marinković, Emilija and Barisani-Asenbauer, Talin and Prodanović, Radivoje and Jovanović, Milos and Radotić, Ksenija",
year = "2016",
abstract = "Nowadays bacterial resistance to known antibiotics is a serious health problem. In order to achieve more efficient treatment, lately there is an effort to find new substances, such as certain biomaterials, that are non-toxic to humans with antibiotic potential. Lignins and lignin-derived compounds have been proposed to be good candidates for use in medicine and health maintenance. In this study, the antibacterial activity of the lignin model polymer dehydrogenate polymer (DHP) in alginate hydrogel (Alg) was studied. The obtained results show that DHP-Alg has strong antimicrobial activity against several bacterial strains and biofilms and does not have a toxic effect on human epithelial cells. These results strongly suggest its application as a wound healing agent or as an adjunct substance for wound treatments.",
publisher = "Elsevier, Amsterdam",
journal = "International Journal of Antimicrobial Agents",
title = "Lignin model compound in alginate hydrogel: a strong antimicrobial agent with high potential in wound treatment",
pages = "735-732",
number = "6",
volume = "48",
doi = "10.1016/j.ijantimicag.2016.08.014"
}

Spasojević, D., Zmejkoski, D., Glamočlija, J., Nikolic, M., Soković, M., Milošević, V. Lj., Jaric, I., Stojanović, M., Marinković, E., Barisani-Asenbauer, T., Prodanović, R., Jovanović, M.,& Radotić, K.. (2016). Lignin model compound in alginate hydrogel: a strong antimicrobial agent with high potential in wound treatment. in International Journal of Antimicrobial Agents
Elsevier, Amsterdam., 48(6), 732-735.
https://doi.org/10.1016/j.ijantimicag.2016.08.014

Spasojević D, Zmejkoski D, Glamočlija J, Nikolic M, Soković M, Milošević VL, Jaric I, Stojanović M, Marinković E, Barisani-Asenbauer T, Prodanović R, Jovanović M, Radotić K. Lignin model compound in alginate hydrogel: a strong antimicrobial agent with high potential in wound treatment. in International Journal of Antimicrobial Agents. 2016;48(6):732-735.
doi:10.1016/j.ijantimicag.2016.08.014 .

Spasojević, Dragica, Zmejkoski, Danica, Glamočlija, Jasmina, Nikolic, Milos, Soković, Marina, Milošević, Verica Lj., Jaric, Ivana, Stojanović, Marijana, Marinković, Emilija, Barisani-Asenbauer, Talin, Prodanović, Radivoje, Jovanović, Milos, Radotić, Ksenija, "Lignin model compound in alginate hydrogel: a strong antimicrobial agent with high potential in wound treatment" in International Journal of Antimicrobial Agents, 48, no. 6 (2016):732-735,
https://doi.org/10.1016/j.ijantimicag.2016.08.014 . .

TY  - JOUR
AU  - Pejin, Boris
AU  - Ciric, Ana
AU  - Horvatović, Mladen
AU  - Jurca, Tamara
AU  - Glamočlija, Jasmina
AU  - Nikolic, Milos
AU  - Soković, Marina
PY  - 2016
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/955
AB  - The antimicrobial activity of five crude extracts of the freshwater bryozoan Pectinatella magnifica (Leidy, 1851) was evaluated in vitro for the first time. P. magnifica acetone extract exhibited the highest antibacterial activity (minimum inhibitory concentrations (MIC) 0.004-0.350mg/mL and MBC 0.007-0.500mg/mL), while its methanol extract showed the most promising antifungal activity (MIC 0.03-0.12mg/mL and MFC 0.06-0.25mg/mL). Furthermore, at a concentration of 0.25 MIC, the methanol extract reduced biofilm formation of the bacterial strain Pseudomonas aeruginosa PAO1 in a considerable extent (59.14%). FTIR spectra of the most active extracts indicate the presence of carbonyl compounds, long-chain alcohols and/or sterols. According to the experimental data obtained, P. magnifica methanol extract may be considered as a good resource of novel natural products with potent antibiofilm activity against the bacterium well known for its resistance. [GRAPHCIS].
PB  - Taylor & Francis Ltd, Abingdon
T2  - Natural Product Research
T1  - An insight into antimicrobial activity of the freshwater bryozoan Pectinatella magnifica
EP  - 1843
IS  - 16
SP  - 1839
VL  - 30
DO  - 10.1080/14786419.2015.1068773
ER  - 

@article{
author = "Pejin, Boris and Ciric, Ana and Horvatović, Mladen and Jurca, Tamara and Glamočlija, Jasmina and Nikolic, Milos and Soković, Marina",
year = "2016",
abstract = "The antimicrobial activity of five crude extracts of the freshwater bryozoan Pectinatella magnifica (Leidy, 1851) was evaluated in vitro for the first time. P. magnifica acetone extract exhibited the highest antibacterial activity (minimum inhibitory concentrations (MIC) 0.004-0.350mg/mL and MBC 0.007-0.500mg/mL), while its methanol extract showed the most promising antifungal activity (MIC 0.03-0.12mg/mL and MFC 0.06-0.25mg/mL). Furthermore, at a concentration of 0.25 MIC, the methanol extract reduced biofilm formation of the bacterial strain Pseudomonas aeruginosa PAO1 in a considerable extent (59.14%). FTIR spectra of the most active extracts indicate the presence of carbonyl compounds, long-chain alcohols and/or sterols. According to the experimental data obtained, P. magnifica methanol extract may be considered as a good resource of novel natural products with potent antibiofilm activity against the bacterium well known for its resistance. [GRAPHCIS].",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Natural Product Research",
title = "An insight into antimicrobial activity of the freshwater bryozoan Pectinatella magnifica",
pages = "1843-1839",
number = "16",
volume = "30",
doi = "10.1080/14786419.2015.1068773"
}

Pejin, B., Ciric, A., Horvatović, M., Jurca, T., Glamočlija, J., Nikolic, M.,& Soković, M.. (2016). An insight into antimicrobial activity of the freshwater bryozoan Pectinatella magnifica. in Natural Product Research
Taylor & Francis Ltd, Abingdon., 30(16), 1839-1843.
https://doi.org/10.1080/14786419.2015.1068773

Pejin B, Ciric A, Horvatović M, Jurca T, Glamočlija J, Nikolic M, Soković M. An insight into antimicrobial activity of the freshwater bryozoan Pectinatella magnifica. in Natural Product Research. 2016;30(16):1839-1843.
doi:10.1080/14786419.2015.1068773 .

Pejin, Boris, Ciric, Ana, Horvatović, Mladen, Jurca, Tamara, Glamočlija, Jasmina, Nikolic, Milos, Soković, Marina, "An insight into antimicrobial activity of the freshwater bryozoan Pectinatella magnifica" in Natural Product Research, 30, no. 16 (2016):1839-1843,
https://doi.org/10.1080/14786419.2015.1068773 . .

TY  - JOUR
AU  - Pejin, Boris
AU  - Ciric, Ana
AU  - Karaman, Ivo
AU  - Horvatović, Mladen
AU  - Glamočlija, Jasmina
AU  - Nikolic, Milos
AU  - Soković, Marina
PY  - 2016
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/954
AB  - The antibiofilm and possible antiquorum sensing effects against the strain Pseudomonas aeruginosa PAO1 of five crude extracts of the freshwater bryozoan Hyalinella punctata (Hancock, 1850) were evaluated in vitro for the first time. H. punctata ethyl acetate extract (HpEtAc) exhibited the highest antibiofilm activity reducing the biofilm formation of P. aeruginosa PAO1 in the range of 80.63-88.13%. While all tested extracts reduced the twitching motility of the aforementioned bacterial strain, HpEtAc showed to be the most effective. Finally, at a concentration of 0.5 MIC, the same extract mostly inhibited the production of pyocyanin by P. aeruginosa PAO1 (71.53%). In comparison both with the positive controls used (streptomycin and ampicillin, 67.13 and 69.77%, respectively), HpEtAc was found to inhibit pyocyanin in a higher extent. An extensive chemical characterisation of this particular extract may result in isolation and identification of novel lead compounds targeting P. aeruginosa, an opportunistic human pathogen. [GRAPHCIS].
PB  - Taylor & Francis Ltd, Abingdon
T2  - Natural Product Research
T1  - In vitro antibiofilm activity of the freshwater bryozoan Hyalinella punctata: a case study of Pseudomonas aeruginosa PAO1
EP  - 1850
IS  - 16
SP  - 1847
VL  - 30
DO  - 10.1080/14786419.2015.1072714
ER  - 

@article{
author = "Pejin, Boris and Ciric, Ana and Karaman, Ivo and Horvatović, Mladen and Glamočlija, Jasmina and Nikolic, Milos and Soković, Marina",
year = "2016",
abstract = "The antibiofilm and possible antiquorum sensing effects against the strain Pseudomonas aeruginosa PAO1 of five crude extracts of the freshwater bryozoan Hyalinella punctata (Hancock, 1850) were evaluated in vitro for the first time. H. punctata ethyl acetate extract (HpEtAc) exhibited the highest antibiofilm activity reducing the biofilm formation of P. aeruginosa PAO1 in the range of 80.63-88.13%. While all tested extracts reduced the twitching motility of the aforementioned bacterial strain, HpEtAc showed to be the most effective. Finally, at a concentration of 0.5 MIC, the same extract mostly inhibited the production of pyocyanin by P. aeruginosa PAO1 (71.53%). In comparison both with the positive controls used (streptomycin and ampicillin, 67.13 and 69.77%, respectively), HpEtAc was found to inhibit pyocyanin in a higher extent. An extensive chemical characterisation of this particular extract may result in isolation and identification of novel lead compounds targeting P. aeruginosa, an opportunistic human pathogen. [GRAPHCIS].",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Natural Product Research",
title = "In vitro antibiofilm activity of the freshwater bryozoan Hyalinella punctata: a case study of Pseudomonas aeruginosa PAO1",
pages = "1850-1847",
number = "16",
volume = "30",
doi = "10.1080/14786419.2015.1072714"
}

Pejin, B., Ciric, A., Karaman, I., Horvatović, M., Glamočlija, J., Nikolic, M.,& Soković, M.. (2016). In vitro antibiofilm activity of the freshwater bryozoan Hyalinella punctata: a case study of Pseudomonas aeruginosa PAO1. in Natural Product Research
Taylor & Francis Ltd, Abingdon., 30(16), 1847-1850.
https://doi.org/10.1080/14786419.2015.1072714

Pejin B, Ciric A, Karaman I, Horvatović M, Glamočlija J, Nikolic M, Soković M. In vitro antibiofilm activity of the freshwater bryozoan Hyalinella punctata: a case study of Pseudomonas aeruginosa PAO1. in Natural Product Research. 2016;30(16):1847-1850.
doi:10.1080/14786419.2015.1072714 .

Pejin, Boris, Ciric, Ana, Karaman, Ivo, Horvatović, Mladen, Glamočlija, Jasmina, Nikolic, Milos, Soković, Marina, "In vitro antibiofilm activity of the freshwater bryozoan Hyalinella punctata: a case study of Pseudomonas aeruginosa PAO1" in Natural Product Research, 30, no. 16 (2016):1847-1850,
https://doi.org/10.1080/14786419.2015.1072714 . .

TY  - JOUR
AU  - Pejin, Boris
AU  - Ciric, Ana
AU  - Marković, Dejan
AU  - Tommonaro, Giuseppina
AU  - Soković, Marina
PY  - 2016
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/997
AB  - This work extends in vitro screening of antimicrobial activity of avarol, the marine natural product firstly isolated from the Mediterranean sponge Dysidea avara. Its anticandidial activity was evaluated by microdilution method against eight Candida strains, two ATCC and six clinical ones. At a different extent this compound was proven to be active against all the strains tested (MIC 0.8-6.0g/mL and MFC 1.6-12.0g/mL, respectively). According to the best of our knowledge, this is the first report on avarol activity towards any yeast strain which may be of relevance for Alzheimer's disease. Indeed, avarol derivatives showing moderate AChE activity should be screened for anticandidial activity both in vitro and in vivo. [GRAPHICS] .
PB  - Taylor & Francis Ltd, Abingdon
T2  - Natural Product Research
T1  - In vitro avarol does affect the growth of Candida sp.
EP  - 1960
IS  - 17
SP  - 1956
VL  - 30
DO  - 10.1080/14786419.2015.1091454
ER  - 

@article{
author = "Pejin, Boris and Ciric, Ana and Marković, Dejan and Tommonaro, Giuseppina and Soković, Marina",
year = "2016",
abstract = "This work extends in vitro screening of antimicrobial activity of avarol, the marine natural product firstly isolated from the Mediterranean sponge Dysidea avara. Its anticandidial activity was evaluated by microdilution method against eight Candida strains, two ATCC and six clinical ones. At a different extent this compound was proven to be active against all the strains tested (MIC 0.8-6.0g/mL and MFC 1.6-12.0g/mL, respectively). According to the best of our knowledge, this is the first report on avarol activity towards any yeast strain which may be of relevance for Alzheimer's disease. Indeed, avarol derivatives showing moderate AChE activity should be screened for anticandidial activity both in vitro and in vivo. [GRAPHICS] .",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Natural Product Research",
title = "In vitro avarol does affect the growth of Candida sp.",
pages = "1960-1956",
number = "17",
volume = "30",
doi = "10.1080/14786419.2015.1091454"
}

Pejin, B., Ciric, A., Marković, D., Tommonaro, G.,& Soković, M.. (2016). In vitro avarol does affect the growth of Candida sp.. in Natural Product Research
Taylor & Francis Ltd, Abingdon., 30(17), 1956-1960.
https://doi.org/10.1080/14786419.2015.1091454

Pejin B, Ciric A, Marković D, Tommonaro G, Soković M. In vitro avarol does affect the growth of Candida sp.. in Natural Product Research. 2016;30(17):1956-1960.
doi:10.1080/14786419.2015.1091454 .

Pejin, Boris, Ciric, Ana, Marković, Dejan, Tommonaro, Giuseppina, Soković, Marina, "In vitro avarol does affect the growth of Candida sp." in Natural Product Research, 30, no. 17 (2016):1956-1960,
https://doi.org/10.1080/14786419.2015.1091454 . .

TY  - JOUR
AU  - Pejin, Boris
AU  - Ciric, Ana
AU  - Dimitrić-Marković, Jasmina
AU  - Glamočlija, Jasmina
AU  - Nikolic, Milos
AU  - Stanimirović, Bojana
AU  - Soković, Marina
PY  - 2015
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/852
AB  - This work was focused on in vitro evaluation of anti-biofilm and anti-quorum sensing effects of four selected flavonoid compounds /(+)-catechin, caffeic acid, quercetin and morin/using the strain Pseudomonas aeruginosa PAO1. At a concentration of 0.5 MIC quercetin was the only compound found to potently reduce both P. aeruginosa biofilm formation (95%) and its twitching motility. The chemical scaffold of quercetin, a common dietary polyphenol, may actually inspire development of novel and more effective medicinal agents targeting P. aeruginosa, the bacterium well known for its resistance.
PB  - Bentham Science Publ Ltd, Sharjah
T2  - Current Pharmaceutical Biotechnology
T1  - Quercetin Potently Reduces Biofilm Formation of the Strain Pseudomonas aeruginosa PAO1 in vitro
EP  - 737
IS  - 8
SP  - 733
VL  - 16
DO  - 10.2174/1389201016666150505121951
ER  - 

@article{
author = "Pejin, Boris and Ciric, Ana and Dimitrić-Marković, Jasmina and Glamočlija, Jasmina and Nikolic, Milos and Stanimirović, Bojana and Soković, Marina",
year = "2015",
abstract = "This work was focused on in vitro evaluation of anti-biofilm and anti-quorum sensing effects of four selected flavonoid compounds /(+)-catechin, caffeic acid, quercetin and morin/using the strain Pseudomonas aeruginosa PAO1. At a concentration of 0.5 MIC quercetin was the only compound found to potently reduce both P. aeruginosa biofilm formation (95%) and its twitching motility. The chemical scaffold of quercetin, a common dietary polyphenol, may actually inspire development of novel and more effective medicinal agents targeting P. aeruginosa, the bacterium well known for its resistance.",
publisher = "Bentham Science Publ Ltd, Sharjah",
journal = "Current Pharmaceutical Biotechnology",
title = "Quercetin Potently Reduces Biofilm Formation of the Strain Pseudomonas aeruginosa PAO1 in vitro",
pages = "737-733",
number = "8",
volume = "16",
doi = "10.2174/1389201016666150505121951"
}

Pejin, B., Ciric, A., Dimitrić-Marković, J., Glamočlija, J., Nikolic, M., Stanimirović, B.,& Soković, M.. (2015). Quercetin Potently Reduces Biofilm Formation of the Strain Pseudomonas aeruginosa PAO1 in vitro. in Current Pharmaceutical Biotechnology
Bentham Science Publ Ltd, Sharjah., 16(8), 733-737.
https://doi.org/10.2174/1389201016666150505121951

Pejin B, Ciric A, Dimitrić-Marković J, Glamočlija J, Nikolic M, Stanimirović B, Soković M. Quercetin Potently Reduces Biofilm Formation of the Strain Pseudomonas aeruginosa PAO1 in vitro. in Current Pharmaceutical Biotechnology. 2015;16(8):733-737.
doi:10.2174/1389201016666150505121951 .

Pejin, Boris, Ciric, Ana, Dimitrić-Marković, Jasmina, Glamočlija, Jasmina, Nikolic, Milos, Stanimirović, Bojana, Soković, Marina, "Quercetin Potently Reduces Biofilm Formation of the Strain Pseudomonas aeruginosa PAO1 in vitro" in Current Pharmaceutical Biotechnology, 16, no. 8 (2015):733-737,
https://doi.org/10.2174/1389201016666150505121951 . .

TY  - JOUR
AU  - Pejin, Boris
AU  - Ciric, Ana
AU  - Glamočlija, Jasmina
AU  - Nikolic, Milos
AU  - Soković, Marina
PY  - 2015
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/832
AB  - Anti-quorum sensing activity of the diterpene phytol was evaluated in vitro for the first time. This compound (at three sub-MIC concentrations - 0.5, 0.25 and 0.125 MIC, respectively) reduced the formation of Pseudomonas aeruginosa PAO1 biofilm in the range of 74.00-84.33% exhibiting higher activity than the both positive controls used, streptomycin and ampicillin. Phytol (0.5 MIC) also effectively reduced P. aeruginosa twitching and flagella motility. Indeed, the bacteria treated were incapable of producing a twitching zone and had almost round, smooth and regular colony edges. Finally, the tested compound (0.5 MIC) exhibited good P. aeruginosa pyocyanin inhibitory activity (51.94%) practically to the same extent as streptomycin (52.09%). According to the experimental data obtained, this phytol property may inspire design of medical foods targeting P. aeruginosa quorum sensing activity.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Natural Product Research
T1  - In vitro anti-quorum sensing activity of phytol
EP  - 377
IS  - 4
SP  - 374
VL  - 29
DO  - 10.1080/14786419.2014.945088
ER  - 

@article{
author = "Pejin, Boris and Ciric, Ana and Glamočlija, Jasmina and Nikolic, Milos and Soković, Marina",
year = "2015",
abstract = "Anti-quorum sensing activity of the diterpene phytol was evaluated in vitro for the first time. This compound (at three sub-MIC concentrations - 0.5, 0.25 and 0.125 MIC, respectively) reduced the formation of Pseudomonas aeruginosa PAO1 biofilm in the range of 74.00-84.33% exhibiting higher activity than the both positive controls used, streptomycin and ampicillin. Phytol (0.5 MIC) also effectively reduced P. aeruginosa twitching and flagella motility. Indeed, the bacteria treated were incapable of producing a twitching zone and had almost round, smooth and regular colony edges. Finally, the tested compound (0.5 MIC) exhibited good P. aeruginosa pyocyanin inhibitory activity (51.94%) practically to the same extent as streptomycin (52.09%). According to the experimental data obtained, this phytol property may inspire design of medical foods targeting P. aeruginosa quorum sensing activity.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Natural Product Research",
title = "In vitro anti-quorum sensing activity of phytol",
pages = "377-374",
number = "4",
volume = "29",
doi = "10.1080/14786419.2014.945088"
}

Pejin, B., Ciric, A., Glamočlija, J., Nikolic, M.,& Soković, M.. (2015). In vitro anti-quorum sensing activity of phytol. in Natural Product Research
Taylor & Francis Ltd, Abingdon., 29(4), 374-377.
https://doi.org/10.1080/14786419.2014.945088

Pejin B, Ciric A, Glamočlija J, Nikolic M, Soković M. In vitro anti-quorum sensing activity of phytol. in Natural Product Research. 2015;29(4):374-377.
doi:10.1080/14786419.2014.945088 .

Pejin, Boris, Ciric, Ana, Glamočlija, Jasmina, Nikolic, Milos, Soković, Marina, "In vitro anti-quorum sensing activity of phytol" in Natural Product Research, 29, no. 4 (2015):374-377,
https://doi.org/10.1080/14786419.2014.945088 . .

TY  - JOUR
AU  - Pejin, Boris
AU  - Savić, Aleksandar G
AU  - Soković, Marina
AU  - Glamočlija, Jasmina
AU  - Ciric, Ana D
AU  - Nikolic, Milos MN
AU  - Radotić, Ksenija
AU  - Mojović, Miloš
PY  - 2014
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/759
AB  - The antiradical activity of phytol was evaluated by electron paramagnetic resonance towards hydroxyl radical (root OH), superoxide anion radical (), methoxy radical (root CH2OH), carbon-dioxide anion radical (), as well as towards nitric-oxide radical (root NO) and 2,2-diphenyl-1-picrylhydrazyl (root DPPH) radical. It reduced the production of all tested radicals showing more promising activity against , root CH2OH and root DPPH radicals (56%, 50% and 48%, respectively) in comparison with root NO, and root OH radicals (38%, 23% and 15%, respectively). The antimicrobial activity of phytol was evaluated by the microdilution method against eight bacterial and eight fungal strains. To varying degrees, it was proven to be active against all tested bacteria and fungi (MIC 0.003-0.038mg/mL and MBC 0.013-0.052mg/mL, MIC 0.008-0.016mg/mL and MFC 0.090-0.520mg/mL, respectively). According to the obtained results, medical foods containing phytol may support development of new therapies for heart disease.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Natural Product Research
T1  - Further in vitro evaluation of antiradical and antimicrobial activities of phytol
EP  - 376
IS  - 6
SP  - 372
VL  - 28
DO  - 10.1080/14786419.2013.869692
ER  - 

@article{
author = "Pejin, Boris and Savić, Aleksandar G and Soković, Marina and Glamočlija, Jasmina and Ciric, Ana D and Nikolic, Milos MN and Radotić, Ksenija and Mojović, Miloš",
year = "2014",
abstract = "The antiradical activity of phytol was evaluated by electron paramagnetic resonance towards hydroxyl radical (root OH), superoxide anion radical (), methoxy radical (root CH2OH), carbon-dioxide anion radical (), as well as towards nitric-oxide radical (root NO) and 2,2-diphenyl-1-picrylhydrazyl (root DPPH) radical. It reduced the production of all tested radicals showing more promising activity against , root CH2OH and root DPPH radicals (56%, 50% and 48%, respectively) in comparison with root NO, and root OH radicals (38%, 23% and 15%, respectively). The antimicrobial activity of phytol was evaluated by the microdilution method against eight bacterial and eight fungal strains. To varying degrees, it was proven to be active against all tested bacteria and fungi (MIC 0.003-0.038mg/mL and MBC 0.013-0.052mg/mL, MIC 0.008-0.016mg/mL and MFC 0.090-0.520mg/mL, respectively). According to the obtained results, medical foods containing phytol may support development of new therapies for heart disease.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Natural Product Research",
title = "Further in vitro evaluation of antiradical and antimicrobial activities of phytol",
pages = "376-372",
number = "6",
volume = "28",
doi = "10.1080/14786419.2013.869692"
}

Pejin, B., Savić, A. G., Soković, M., Glamočlija, J., Ciric, A. D., Nikolic, M. M., Radotić, K.,& Mojović, M.. (2014). Further in vitro evaluation of antiradical and antimicrobial activities of phytol. in Natural Product Research
Taylor & Francis Ltd, Abingdon., 28(6), 372-376.
https://doi.org/10.1080/14786419.2013.869692

Pejin B, Savić AG, Soković M, Glamočlija J, Ciric AD, Nikolic MM, Radotić K, Mojović M. Further in vitro evaluation of antiradical and antimicrobial activities of phytol. in Natural Product Research. 2014;28(6):372-376.
doi:10.1080/14786419.2013.869692 .

Pejin, Boris, Savić, Aleksandar G, Soković, Marina, Glamočlija, Jasmina, Ciric, Ana D, Nikolic, Milos MN, Radotić, Ksenija, Mojović, Miloš, "Further in vitro evaluation of antiradical and antimicrobial activities of phytol" in Natural Product Research, 28, no. 6 (2014):372-376,
https://doi.org/10.1080/14786419.2013.869692 . .

TY  - JOUR
AU  - Pejin, Boris
AU  - Talevska, Aleksandra
AU  - Ciric, Ana
AU  - Glamočlija, Jasmina
AU  - Nikolic, Milos
AU  - Talevski, Trajce
AU  - Soković, Marina
PY  - 2014
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/806
AB  - The anti-quorum sensing activities towards the bacterium Pseudomonas aeruginosa PA01 (pyocyanin production, biofilm formation and twitching and flagella motility) of two crude extracts (methanol and acetone) of the freshwater sponge Ochridaspongia rotunda (Arndt, 1937) were evaluated in vitro for the first time. Both extracts demonstrated P. aeruginosa pyocyanin inhibitory activity, reducing its production for 49.90% and 42.44%, respectively. In addition, they both showed higher anti-biofilm activity (48.29% and 53.99%, respectively) than ampicillin (30.84%). Finally, O. rotunda extracts effectively reduced twitching and flagella motility of P. aeruginosa. Taken all together, these results suggest that endemic sponge species from the oldest lake in Europe may offer novel bioactive natural products with promising medicinal potential towards P. aeruginosa infections.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Natural Product Research
T1  - Anti-quorum sensing activity of selected sponge extracts: a case study of Pseudomonas aeruginosa
EP  - 2333
IS  - 24
SP  - 2330
VL  - 28
DO  - 10.1080/14786419.2014.934239
ER  - 

@article{
author = "Pejin, Boris and Talevska, Aleksandra and Ciric, Ana and Glamočlija, Jasmina and Nikolic, Milos and Talevski, Trajce and Soković, Marina",
year = "2014",
abstract = "The anti-quorum sensing activities towards the bacterium Pseudomonas aeruginosa PA01 (pyocyanin production, biofilm formation and twitching and flagella motility) of two crude extracts (methanol and acetone) of the freshwater sponge Ochridaspongia rotunda (Arndt, 1937) were evaluated in vitro for the first time. Both extracts demonstrated P. aeruginosa pyocyanin inhibitory activity, reducing its production for 49.90% and 42.44%, respectively. In addition, they both showed higher anti-biofilm activity (48.29% and 53.99%, respectively) than ampicillin (30.84%). Finally, O. rotunda extracts effectively reduced twitching and flagella motility of P. aeruginosa. Taken all together, these results suggest that endemic sponge species from the oldest lake in Europe may offer novel bioactive natural products with promising medicinal potential towards P. aeruginosa infections.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Natural Product Research",
title = "Anti-quorum sensing activity of selected sponge extracts: a case study of Pseudomonas aeruginosa",
pages = "2333-2330",
number = "24",
volume = "28",
doi = "10.1080/14786419.2014.934239"
}

Pejin, B., Talevska, A., Ciric, A., Glamočlija, J., Nikolic, M., Talevski, T.,& Soković, M.. (2014). Anti-quorum sensing activity of selected sponge extracts: a case study of Pseudomonas aeruginosa. in Natural Product Research
Taylor & Francis Ltd, Abingdon., 28(24), 2330-2333.
https://doi.org/10.1080/14786419.2014.934239

Pejin B, Talevska A, Ciric A, Glamočlija J, Nikolic M, Talevski T, Soković M. Anti-quorum sensing activity of selected sponge extracts: a case study of Pseudomonas aeruginosa. in Natural Product Research. 2014;28(24):2330-2333.
doi:10.1080/14786419.2014.934239 .

Pejin, Boris, Talevska, Aleksandra, Ciric, Ana, Glamočlija, Jasmina, Nikolic, Milos, Talevski, Trajce, Soković, Marina, "Anti-quorum sensing activity of selected sponge extracts: a case study of Pseudomonas aeruginosa" in Natural Product Research, 28, no. 24 (2014):2330-2333,
https://doi.org/10.1080/14786419.2014.934239 . .

TY  - JOUR
AU  - Pejin, Boris
AU  - Talevska, Aleksandra
AU  - Ciric, Ana
AU  - Glamočlija, Jasmina
AU  - Nikolic, Milos
AU  - Talevski, Trajce
AU  - Soković, Marina
PY  - 2014
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/784
AB  - The antimicrobial activity of five crude extracts (aqueous, methanol, ethyl acetate, acetone and methylene chloride) of the freshwater sponge Ochridaspongia rotunda (Arndt, 1937) was evaluated in vitro by using microdilution method against eight bacterial and eight fungal strains for the first time. The extracts were proven to be active in varying degrees against all the bacteria and fungi tested. O. rotunda methanol extract exhibited the highest antibacterial activity (minimum inhibitory concentration (MIC) 7.5-15.0 mu g/mL and minimum bactericidal concentration 15-30 mu g/mL), while its acetone extract exhibited the most promising antifungal activity (MIC 7.5-45.0 mu g/mL and minimum fungicidal concentration 15-60 mu g/mL). The extracts were more effective against the bacteria and fungi screened compared with the positive controls (streptomycin and ampicillin for bacteria and bifonazole and ketoconazole for fungi, respectively). According to the experimental data obtained, this deepwater sponge species may be considered as a gold mine of new antimicrobial substances with significant and broad-range activity.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Natural Product Research
T1  - In vitro evaluation of antimicrobial activity of the freshwater sponge Ochridaspongia rotunda (Arndt, 1937)
EP  - 1494
IS  - 18
SP  - 1489
VL  - 28
DO  - 10.1080/14786419.2014.911297
ER  - 

@article{
author = "Pejin, Boris and Talevska, Aleksandra and Ciric, Ana and Glamočlija, Jasmina and Nikolic, Milos and Talevski, Trajce and Soković, Marina",
year = "2014",
abstract = "The antimicrobial activity of five crude extracts (aqueous, methanol, ethyl acetate, acetone and methylene chloride) of the freshwater sponge Ochridaspongia rotunda (Arndt, 1937) was evaluated in vitro by using microdilution method against eight bacterial and eight fungal strains for the first time. The extracts were proven to be active in varying degrees against all the bacteria and fungi tested. O. rotunda methanol extract exhibited the highest antibacterial activity (minimum inhibitory concentration (MIC) 7.5-15.0 mu g/mL and minimum bactericidal concentration 15-30 mu g/mL), while its acetone extract exhibited the most promising antifungal activity (MIC 7.5-45.0 mu g/mL and minimum fungicidal concentration 15-60 mu g/mL). The extracts were more effective against the bacteria and fungi screened compared with the positive controls (streptomycin and ampicillin for bacteria and bifonazole and ketoconazole for fungi, respectively). According to the experimental data obtained, this deepwater sponge species may be considered as a gold mine of new antimicrobial substances with significant and broad-range activity.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Natural Product Research",
title = "In vitro evaluation of antimicrobial activity of the freshwater sponge Ochridaspongia rotunda (Arndt, 1937)",
pages = "1494-1489",
number = "18",
volume = "28",
doi = "10.1080/14786419.2014.911297"
}

Pejin, B., Talevska, A., Ciric, A., Glamočlija, J., Nikolic, M., Talevski, T.,& Soković, M.. (2014). In vitro evaluation of antimicrobial activity of the freshwater sponge Ochridaspongia rotunda (Arndt, 1937). in Natural Product Research
Taylor & Francis Ltd, Abingdon., 28(18), 1489-1494.
https://doi.org/10.1080/14786419.2014.911297

Pejin B, Talevska A, Ciric A, Glamočlija J, Nikolic M, Talevski T, Soković M. In vitro evaluation of antimicrobial activity of the freshwater sponge Ochridaspongia rotunda (Arndt, 1937). in Natural Product Research. 2014;28(18):1489-1494.
doi:10.1080/14786419.2014.911297 .

Pejin, Boris, Talevska, Aleksandra, Ciric, Ana, Glamočlija, Jasmina, Nikolic, Milos, Talevski, Trajce, Soković, Marina, "In vitro evaluation of antimicrobial activity of the freshwater sponge Ochridaspongia rotunda (Arndt, 1937)" in Natural Product Research, 28, no. 18 (2014):1489-1494,
https://doi.org/10.1080/14786419.2014.911297 . .

TY  - JOUR
AU  - Pejin, Boris
AU  - Iodice, Carmine
AU  - Tommonaro, Giuseppina
AU  - Stanimirović, Bojana
AU  - Ciric, Ana
AU  - Glamočlija, Jasmina
AU  - Nikolic, Milos
AU  - De Rosa, Salvatore
AU  - Soković, Marina
PY  - 2014
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/776
AB  - This work extends in vitro screening of antimicrobial activity of the sesquiterpene hydroquinone avarol, a main secondary metabolite of the Mediterranean sponge species Dysidea avara. The antimicrobial activity was in part evaluated by microdilution method against selected bacterial and fungal strains. Additionally, the screening included evaluation of anti-quorum sensing (anti-QS) effects. At a different extent avarol was proven to be active against all the microorganisms tested (MIC 0.002-0.008 mg/mL and MBC 0.004-0.016 mg/mL; MIC 0.004-0.015 mg/mL and MFC 0.008-0.030 mg/mL; respectively). This marine natural product also showed moderate anti-QS effects, reducing Pseudomonas aeruginosa PAO1 biofilm formation (75%), its twitching and protrusions motilities as well as pyocianin production (39%). According to the best of our knowledge, this is the first report both on avarol anti Gram-negative bacterial activity and anti-QS effects.
PB  - Bentham Science Publ Ltd, Sharjah
T2  - Current Pharmaceutical Biotechnology
T1  - Further in vitro Evaluation of Antimicrobial Activity of the Marine Sesquiterpene Hydroquinone Avarol
EP  - 588
IS  - 6
SP  - 583
VL  - 15
DO  - 10.2174/138920101506140910152253
ER  - 

@article{
author = "Pejin, Boris and Iodice, Carmine and Tommonaro, Giuseppina and Stanimirović, Bojana and Ciric, Ana and Glamočlija, Jasmina and Nikolic, Milos and De Rosa, Salvatore and Soković, Marina",
year = "2014",
abstract = "This work extends in vitro screening of antimicrobial activity of the sesquiterpene hydroquinone avarol, a main secondary metabolite of the Mediterranean sponge species Dysidea avara. The antimicrobial activity was in part evaluated by microdilution method against selected bacterial and fungal strains. Additionally, the screening included evaluation of anti-quorum sensing (anti-QS) effects. At a different extent avarol was proven to be active against all the microorganisms tested (MIC 0.002-0.008 mg/mL and MBC 0.004-0.016 mg/mL; MIC 0.004-0.015 mg/mL and MFC 0.008-0.030 mg/mL; respectively). This marine natural product also showed moderate anti-QS effects, reducing Pseudomonas aeruginosa PAO1 biofilm formation (75%), its twitching and protrusions motilities as well as pyocianin production (39%). According to the best of our knowledge, this is the first report both on avarol anti Gram-negative bacterial activity and anti-QS effects.",
publisher = "Bentham Science Publ Ltd, Sharjah",
journal = "Current Pharmaceutical Biotechnology",
title = "Further in vitro Evaluation of Antimicrobial Activity of the Marine Sesquiterpene Hydroquinone Avarol",
pages = "588-583",
number = "6",
volume = "15",
doi = "10.2174/138920101506140910152253"
}

Pejin, B., Iodice, C., Tommonaro, G., Stanimirović, B., Ciric, A., Glamočlija, J., Nikolic, M., De Rosa, S.,& Soković, M.. (2014). Further in vitro Evaluation of Antimicrobial Activity of the Marine Sesquiterpene Hydroquinone Avarol. in Current Pharmaceutical Biotechnology
Bentham Science Publ Ltd, Sharjah., 15(6), 583-588.
https://doi.org/10.2174/138920101506140910152253

Pejin B, Iodice C, Tommonaro G, Stanimirović B, Ciric A, Glamočlija J, Nikolic M, De Rosa S, Soković M. Further in vitro Evaluation of Antimicrobial Activity of the Marine Sesquiterpene Hydroquinone Avarol. in Current Pharmaceutical Biotechnology. 2014;15(6):583-588.
doi:10.2174/138920101506140910152253 .

Pejin, Boris, Iodice, Carmine, Tommonaro, Giuseppina, Stanimirović, Bojana, Ciric, Ana, Glamočlija, Jasmina, Nikolic, Milos, De Rosa, Salvatore, Soković, Marina, "Further in vitro Evaluation of Antimicrobial Activity of the Marine Sesquiterpene Hydroquinone Avarol" in Current Pharmaceutical Biotechnology, 15, no. 6 (2014):583-588,
https://doi.org/10.2174/138920101506140910152253 . .

TY  - JOUR
AU  - Bukvicki, Danka R
AU  - Stojković, Dejan S
AU  - Soković, Marina
AU  - Vannini, Lucia
AU  - Montanari, Chiara
AU  - Pejin, Boris
AU  - Savić, Aleksandar G
AU  - Veljic, Milan M
AU  - Grujic, Slavica
AU  - Marin, Petar D.
PY  - 2014
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/760
AB  - The dominant compounds in Satureja horvatii oil were p-cymene (33.14%), thymol (26.11%) and thymol methyl ether (15.08%). The minimum inhibitory concentration (MIC) varied from 0.03 to 0.57 mg/mL for bacteria, and from 0.56 to 2.23 mg/mL for yeast strains, while minimum bactericidal/yeast-cidal concentration (MBC/MYC) varied from 0.07 to 1.15 mg/mL and 1.11 to 5.57 mg/mL for bacteria and yeasts, respectively. The antiradical potential of the essential oil was evaluated using hydroxyl radical (center dot OH) generated in Fenton reaction. The meat preserving potential of essential oil from Satureja horvatii was investigated against L monocytogenes. Essential oil successfully inhibited development of L monocytogenes in pork meat. Sensorial evaluation on flavor and color of meat was performed. The color and flavor of meat treated with essential oil improved after 4 days of storage. S. horvatii essential oil can act as a potent inhibitor of food spoiling microorganisms, in meat products and also can be a useful source of natural antioxidants.
PB  - Elsevier Sci Ltd, Oxford
T2  - Meat Science
T1  - Satureja horvatii essential oil: In vitro antimicrobial and antiradical properties and in situ control of Listeria monocytogenes in pork meat
EP  - 1360
IS  - 3
SP  - 1355
VL  - 96
DO  - 10.1016/j.meatsci.2013.11.024
ER  - 

@article{
author = "Bukvicki, Danka R and Stojković, Dejan S and Soković, Marina and Vannini, Lucia and Montanari, Chiara and Pejin, Boris and Savić, Aleksandar G and Veljic, Milan M and Grujic, Slavica and Marin, Petar D.",
year = "2014",
abstract = "The dominant compounds in Satureja horvatii oil were p-cymene (33.14%), thymol (26.11%) and thymol methyl ether (15.08%). The minimum inhibitory concentration (MIC) varied from 0.03 to 0.57 mg/mL for bacteria, and from 0.56 to 2.23 mg/mL for yeast strains, while minimum bactericidal/yeast-cidal concentration (MBC/MYC) varied from 0.07 to 1.15 mg/mL and 1.11 to 5.57 mg/mL for bacteria and yeasts, respectively. The antiradical potential of the essential oil was evaluated using hydroxyl radical (center dot OH) generated in Fenton reaction. The meat preserving potential of essential oil from Satureja horvatii was investigated against L monocytogenes. Essential oil successfully inhibited development of L monocytogenes in pork meat. Sensorial evaluation on flavor and color of meat was performed. The color and flavor of meat treated with essential oil improved after 4 days of storage. S. horvatii essential oil can act as a potent inhibitor of food spoiling microorganisms, in meat products and also can be a useful source of natural antioxidants.",
publisher = "Elsevier Sci Ltd, Oxford",
journal = "Meat Science",
title = "Satureja horvatii essential oil: In vitro antimicrobial and antiradical properties and in situ control of Listeria monocytogenes in pork meat",
pages = "1360-1355",
number = "3",
volume = "96",
doi = "10.1016/j.meatsci.2013.11.024"
}

Bukvicki, D. R., Stojković, D. S., Soković, M., Vannini, L., Montanari, C., Pejin, B., Savić, A. G., Veljic, M. M., Grujic, S.,& Marin, P. D.. (2014). Satureja horvatii essential oil: In vitro antimicrobial and antiradical properties and in situ control of Listeria monocytogenes in pork meat. in Meat Science
Elsevier Sci Ltd, Oxford., 96(3), 1355-1360.
https://doi.org/10.1016/j.meatsci.2013.11.024

Bukvicki DR, Stojković DS, Soković M, Vannini L, Montanari C, Pejin B, Savić AG, Veljic MM, Grujic S, Marin PD. Satureja horvatii essential oil: In vitro antimicrobial and antiradical properties and in situ control of Listeria monocytogenes in pork meat. in Meat Science. 2014;96(3):1355-1360.
doi:10.1016/j.meatsci.2013.11.024 .

Bukvicki, Danka R, Stojković, Dejan S, Soković, Marina, Vannini, Lucia, Montanari, Chiara, Pejin, Boris, Savić, Aleksandar G, Veljic, Milan M, Grujic, Slavica, Marin, Petar D., "Satureja horvatii essential oil: In vitro antimicrobial and antiradical properties and in situ control of Listeria monocytogenes in pork meat" in Meat Science, 96, no. 3 (2014):1355-1360,
https://doi.org/10.1016/j.meatsci.2013.11.024 . .

TY  - JOUR
AU  - Pejin, Boris
AU  - Glamočlija, Jasmina
AU  - Ciric, A.
AU  - Yong, H.-T.
AU  - Soković, Marina
PY  - 2013
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/639
AB  - The antimicrobial activity of the moss Rhodobryum ontariense tea was evaluated by microdilution method against eight bacterial (Bacillus cereus, Enterobacter cloacae, Escherichia coli, Listeria monocytogens, Micrococcus flavus, Pseudomonas aeruginosa, Salmonella typhimurium and Staphylococcus aureus) and eight fungal species (Aspergillus fumigatus, Aspergillus niger, Aspergillus ochraceus, Aspergillus versicolor, Candida albicans, Penicillium funiculosum, Penicillium ochrochloron and Trichoderma viride). The investigated water extract was proven to be active against all the bacteria and majority of the fungi tested, but to varying degrees. E. cloacae was the most sensitive bacterium (MIC 0.62 mg/mL and MBC 2.50 mg/mL while C. albicans was the most sensitive micro fungus (MIC 0.20 mg/mL and MFC 1.00 mg/mL). On the other hand, at tested concentration the extract did not show any activity against the fungi A. fumigatus and A. niger. These findings indicated a good potential of R. ontariense tea in searching for new antifungals against C. albicans, the fungus which have become a cause of major health concerns in hospital due to hospital-acquired infections.
PB  - Syscom 18 SRL
T2  - Revista de Chimie
T1  - The Moss Rhodobryum ontariense Tea, a Good Source of Natural Antifungals Against Candida albicans
EP  - 554
IS  - 5
SP  - 552
VL  - 64
UR  - https://hdl.handle.net/21.15107/rcub_rimsi_639
ER  - 

@article{
author = "Pejin, Boris and Glamočlija, Jasmina and Ciric, A. and Yong, H.-T. and Soković, Marina",
year = "2013",
abstract = "The antimicrobial activity of the moss Rhodobryum ontariense tea was evaluated by microdilution method against eight bacterial (Bacillus cereus, Enterobacter cloacae, Escherichia coli, Listeria monocytogens, Micrococcus flavus, Pseudomonas aeruginosa, Salmonella typhimurium and Staphylococcus aureus) and eight fungal species (Aspergillus fumigatus, Aspergillus niger, Aspergillus ochraceus, Aspergillus versicolor, Candida albicans, Penicillium funiculosum, Penicillium ochrochloron and Trichoderma viride). The investigated water extract was proven to be active against all the bacteria and majority of the fungi tested, but to varying degrees. E. cloacae was the most sensitive bacterium (MIC 0.62 mg/mL and MBC 2.50 mg/mL while C. albicans was the most sensitive micro fungus (MIC 0.20 mg/mL and MFC 1.00 mg/mL). On the other hand, at tested concentration the extract did not show any activity against the fungi A. fumigatus and A. niger. These findings indicated a good potential of R. ontariense tea in searching for new antifungals against C. albicans, the fungus which have become a cause of major health concerns in hospital due to hospital-acquired infections.",
publisher = "Syscom 18 SRL",
journal = "Revista de Chimie",
title = "The Moss Rhodobryum ontariense Tea, a Good Source of Natural Antifungals Against Candida albicans",
pages = "554-552",
number = "5",
volume = "64",
url = "https://hdl.handle.net/21.15107/rcub_rimsi_639"
}

Pejin, B., Glamočlija, J., Ciric, A., Yong, H.-T.,& Soković, M.. (2013). The Moss Rhodobryum ontariense Tea, a Good Source of Natural Antifungals Against Candida albicans. in Revista de Chimie
Syscom 18 SRL., 64(5), 552-554.
https://hdl.handle.net/21.15107/rcub_rimsi_639

Pejin B, Glamočlija J, Ciric A, Yong H, Soković M. The Moss Rhodobryum ontariense Tea, a Good Source of Natural Antifungals Against Candida albicans. in Revista de Chimie. 2013;64(5):552-554.
https://hdl.handle.net/21.15107/rcub_rimsi_639 .

Pejin, Boris, Glamočlija, Jasmina, Ciric, A., Yong, H.-T., Soković, Marina, "The Moss Rhodobryum ontariense Tea, a Good Source of Natural Antifungals Against Candida albicans" in Revista de Chimie, 64, no. 5 (2013):552-554,
https://hdl.handle.net/21.15107/rcub_rimsi_639 .

TY  - JOUR
AU  - Nikolic, Milos MN
AU  - Marković, Tatjana
AU  - Mojović, Miloš
AU  - Pejin, Boris
AU  - Savić, Aleksandar G
AU  - Peric, Tamara O
AU  - Marković, Dejan Lj
AU  - Stević, Tatjana R
AU  - Soković, Marina
PY  - 2013
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/675
AB  - The aim of this study was to examine chemical composition and biological activity of Gaultheria procumbens L essential oil (EO) against food spoilage and oral microorganisms. The components of EO were identified by GC-MS. Antimicrobial activity was determined against food spoilage (five bacteria and six fungal species) and oral microorganisms (eight bacteria and thirty two fungal species) by microdilution and microplate biofilm assay, antioxidant activity was tested using the persistent free radical 2,2-diphenyl-1-picryl hydrazyl (DPPH), while antiradical activity was examined by fluorescence spectroscopy and electron paramagnetic resonance spectroscopy (EPR). GC-MS analysis showed that methyl salicylate (96.90%) was the main component of the oil. Essential oil inhibited the growth of all microorganisms tested, i.e. food and oral bacteria and fungi, respectively (MIC 0.18-3.00 mg/ml and MBC 1.25-4.00 mg/ml; MIC 0.73-5.00 mg/ml and MFC 2.92-26.67 mg/ml); The oil effectively inhibited the biofilm formation of oral Streptococcus mutans and Candida albicans as well (MIC 25.00 MBC 50.00 mg/ml; MIC 12.50, MFC 50.00 mg/ml). In addition, oil exhibited a dose-dependent DPPH-radical-scavenging activity with IC50 value of 30.61 mg/ml. The specific fluorescence probe 2-[6-(4'-amino)phenoxy-3H-xanten-3-on-9-yl] benzoic acid (APP) and the the spin trap 5-(Diethoxyphosphoryl)-5-methyl-1-pyrroline-N-oxide (DEPMPO), capable for simultaneous detection of different free radical specie were used in antiradical activity of the oil measurements. Oil showed a moderate antiradical activity, reducing quantity of produced hydroxyl radicals to about 20% of initial value. This study succeeds in creating directly comparable and quantitative data for the oil unsufficiently examined so far.
PB  - Elsevier, Amsterdam
T2  - Industrial Crops and Products
T1  - Chemical composition and biological activity of Gaultheria procumbens L. essential oil
EP  - 567
SP  - 561
VL  - 49
DO  - 10.1016/j.indcrop.2013.06.002
ER  - 

@article{
author = "Nikolic, Milos MN and Marković, Tatjana and Mojović, Miloš and Pejin, Boris and Savić, Aleksandar G and Peric, Tamara O and Marković, Dejan Lj and Stević, Tatjana R and Soković, Marina",
year = "2013",
abstract = "The aim of this study was to examine chemical composition and biological activity of Gaultheria procumbens L essential oil (EO) against food spoilage and oral microorganisms. The components of EO were identified by GC-MS. Antimicrobial activity was determined against food spoilage (five bacteria and six fungal species) and oral microorganisms (eight bacteria and thirty two fungal species) by microdilution and microplate biofilm assay, antioxidant activity was tested using the persistent free radical 2,2-diphenyl-1-picryl hydrazyl (DPPH), while antiradical activity was examined by fluorescence spectroscopy and electron paramagnetic resonance spectroscopy (EPR). GC-MS analysis showed that methyl salicylate (96.90%) was the main component of the oil. Essential oil inhibited the growth of all microorganisms tested, i.e. food and oral bacteria and fungi, respectively (MIC 0.18-3.00 mg/ml and MBC 1.25-4.00 mg/ml; MIC 0.73-5.00 mg/ml and MFC 2.92-26.67 mg/ml); The oil effectively inhibited the biofilm formation of oral Streptococcus mutans and Candida albicans as well (MIC 25.00 MBC 50.00 mg/ml; MIC 12.50, MFC 50.00 mg/ml). In addition, oil exhibited a dose-dependent DPPH-radical-scavenging activity with IC50 value of 30.61 mg/ml. The specific fluorescence probe 2-[6-(4'-amino)phenoxy-3H-xanten-3-on-9-yl] benzoic acid (APP) and the the spin trap 5-(Diethoxyphosphoryl)-5-methyl-1-pyrroline-N-oxide (DEPMPO), capable for simultaneous detection of different free radical specie were used in antiradical activity of the oil measurements. Oil showed a moderate antiradical activity, reducing quantity of produced hydroxyl radicals to about 20% of initial value. This study succeeds in creating directly comparable and quantitative data for the oil unsufficiently examined so far.",
publisher = "Elsevier, Amsterdam",
journal = "Industrial Crops and Products",
title = "Chemical composition and biological activity of Gaultheria procumbens L. essential oil",
pages = "567-561",
volume = "49",
doi = "10.1016/j.indcrop.2013.06.002"
}

Nikolic, M. M., Marković, T., Mojović, M., Pejin, B., Savić, A. G., Peric, T. O., Marković, D. L., Stević, T. R.,& Soković, M.. (2013). Chemical composition and biological activity of Gaultheria procumbens L. essential oil. in Industrial Crops and Products
Elsevier, Amsterdam., 49, 561-567.
https://doi.org/10.1016/j.indcrop.2013.06.002

Nikolic MM, Marković T, Mojović M, Pejin B, Savić AG, Peric TO, Marković DL, Stević TR, Soković M. Chemical composition and biological activity of Gaultheria procumbens L. essential oil. in Industrial Crops and Products. 2013;49:561-567.
doi:10.1016/j.indcrop.2013.06.002 .

Nikolic, Milos MN, Marković, Tatjana, Mojović, Miloš, Pejin, Boris, Savić, Aleksandar G, Peric, Tamara O, Marković, Dejan Lj, Stević, Tatjana R, Soković, Marina, "Chemical composition and biological activity of Gaultheria procumbens L. essential oil" in Industrial Crops and Products, 49 (2013):561-567,
https://doi.org/10.1016/j.indcrop.2013.06.002 . .

TY  - JOUR
AU  - Pejin, Boris
AU  - Glamočlija, Jasmina
AU  - Ciric, A.
AU  - Radotić, Ksenija
AU  - Vajs, Vlatka E
AU  - Tešević, Vele
AU  - Hegediš, Aleksandar
AU  - Karaman, I.
AU  - Horvatović, Mladen
AU  - Soković, Marina
PY  - 2012
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/614
AB  - The antimicrobial activity of the freshwater bryozoan Hyalinella punctata (Hancock, 1850) was tested by microdilution method against eight bacteria and eight fungi for the first time. All five crude extracts (hexane, acetone, dimethyl sulfoxide, methanol and water) showed good antibacterial and antifungal potential in vitro wherein the acetone extract was the most active (MICs 0.50-7.00 mu g/ml and MBCs 2.50-10.00 mu g/ml).
PB  - Inst Materials Physics
T2  - Digest Journal of Nanomaterials and Biostructures
T1  - Antimicrobial activity of the freshwater bryozoan hyalinella punctata (Hancock, 1850)
EP  - 1026
IS  - 3
SP  - 1021
VL  - 7
UR  - https://hdl.handle.net/21.15107/rcub_cherry_1565
ER  - 

@article{
author = "Pejin, Boris and Glamočlija, Jasmina and Ciric, A. and Radotić, Ksenija and Vajs, Vlatka E and Tešević, Vele and Hegediš, Aleksandar and Karaman, I. and Horvatović, Mladen and Soković, Marina",
year = "2012",
abstract = "The antimicrobial activity of the freshwater bryozoan Hyalinella punctata (Hancock, 1850) was tested by microdilution method against eight bacteria and eight fungi for the first time. All five crude extracts (hexane, acetone, dimethyl sulfoxide, methanol and water) showed good antibacterial and antifungal potential in vitro wherein the acetone extract was the most active (MICs 0.50-7.00 mu g/ml and MBCs 2.50-10.00 mu g/ml).",
publisher = "Inst Materials Physics",
journal = "Digest Journal of Nanomaterials and Biostructures",
title = "Antimicrobial activity of the freshwater bryozoan hyalinella punctata (Hancock, 1850)",
pages = "1026-1021",
number = "3",
volume = "7",
url = "https://hdl.handle.net/21.15107/rcub_cherry_1565"
}

Pejin, B., Glamočlija, J., Ciric, A., Radotić, K., Vajs, V. E., Tešević, V., Hegediš, A., Karaman, I., Horvatović, M.,& Soković, M.. (2012). Antimicrobial activity of the freshwater bryozoan hyalinella punctata (Hancock, 1850). in Digest Journal of Nanomaterials and Biostructures
Inst Materials Physics., 7(3), 1021-1026.
https://hdl.handle.net/21.15107/rcub_cherry_1565

Pejin B, Glamočlija J, Ciric A, Radotić K, Vajs VE, Tešević V, Hegediš A, Karaman I, Horvatović M, Soković M. Antimicrobial activity of the freshwater bryozoan hyalinella punctata (Hancock, 1850). in Digest Journal of Nanomaterials and Biostructures. 2012;7(3):1021-1026.
https://hdl.handle.net/21.15107/rcub_cherry_1565 .

Pejin, Boris, Glamočlija, Jasmina, Ciric, A., Radotić, Ksenija, Vajs, Vlatka E, Tešević, Vele, Hegediš, Aleksandar, Karaman, I., Horvatović, Mladen, Soković, Marina, "Antimicrobial activity of the freshwater bryozoan hyalinella punctata (Hancock, 1850)" in Digest Journal of Nanomaterials and Biostructures, 7, no. 3 (2012):1021-1026,
https://hdl.handle.net/21.15107/rcub_cherry_1565 .

TY  - JOUR
AU  - Pejin, Boris
AU  - Sabovljević, Aneta
AU  - Soković, Marina
AU  - Glamočlija, Jasmina
AU  - Ciric, Ana D
AU  - Vujicic, Milorad
AU  - Sabovljević, Marko S
PY  - 2012
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/530
AB  - U in vitro ispitivanju antimikrobne aktivnosti dimetil-sulfoksidnog ekstrakta mahovine Rhodobryum ontariense na osam bakterijskih (Escherichia coli, Pseudomonas aeruginosa, Salmonella typhimurium, Enterobacter cloacae, Listeria monocytogenes, Bacillus cereus, Micrococcus flavus i Staphylococcus aureus) i pet gljivičnih sojeva (Aspergillus versicolor, Aspergillus fumigatus, Penicillium funiculosum, Penicillium ochrochloron i Trichoderma viride) korišćena je modifikovana mikrodiluciona tehnika. Dati ekstrakt u različitoj meri pokazao je aktivnost na sve testirane organizme. Njegova aktivnost na gljivu T. viride bila je jača od aktivnosti koju je pokazao antifungalni lek bifonazol upotrebljen kao pozitivna kontrola (MIK 100 i 200 μg/ml, redom). Ovaj rad ukazuje na činjenicu da R. ontariense predstavlja obećavajući izvor prirodnih proizvoda sa antifungalnom aktivnošću.
AB  - The antimicrobial activity of dimethyl sulfoxide extract of moss Rhodobryum ontariense (Kindb.) Kindb. was evaluated by microdilution method against eight bacterial (Escherichia coli, Pseudomonas aeruginosa, Salmonella typhimurium, Enterobacter cloacae, Listeria monocytogenes, Bacillus cereus, Micrococcus flavus and Staphylococcus aureus) and five fungal species (Aspergillus versicolor, Aspergillus fumigatus, Penicillium funiculosum, Penicillium ochrochloron and Trichoderma viride). The extract was proven to be active against all the bacteria and fungi tested but to varying degrees. It showed better inhibitory activity compared to the known antifungal drug against T. viride (MIC 100 and 200 μg/ml, respectively). This finding implies that R. ontariense could be considered as a promising material for natural antifungal products.
PB  - Savez hemijskih inženjera, Beograd
T2  - Hemijska Industrija
T1  - Antimikrobna aktivnost Rhodobryum ontariense
T1  - Antimicrobial activity of Rhodobryum ontariense
EP  - 384
IS  - 3
SP  - 381
VL  - 66
DO  - 10.2298/HEMIND111107100P
ER  - 

@article{
author = "Pejin, Boris and Sabovljević, Aneta and Soković, Marina and Glamočlija, Jasmina and Ciric, Ana D and Vujicic, Milorad and Sabovljević, Marko S",
year = "2012",
abstract = "U in vitro ispitivanju antimikrobne aktivnosti dimetil-sulfoksidnog ekstrakta mahovine Rhodobryum ontariense na osam bakterijskih (Escherichia coli, Pseudomonas aeruginosa, Salmonella typhimurium, Enterobacter cloacae, Listeria monocytogenes, Bacillus cereus, Micrococcus flavus i Staphylococcus aureus) i pet gljivičnih sojeva (Aspergillus versicolor, Aspergillus fumigatus, Penicillium funiculosum, Penicillium ochrochloron i Trichoderma viride) korišćena je modifikovana mikrodiluciona tehnika. Dati ekstrakt u različitoj meri pokazao je aktivnost na sve testirane organizme. Njegova aktivnost na gljivu T. viride bila je jača od aktivnosti koju je pokazao antifungalni lek bifonazol upotrebljen kao pozitivna kontrola (MIK 100 i 200 μg/ml, redom). Ovaj rad ukazuje na činjenicu da R. ontariense predstavlja obećavajući izvor prirodnih proizvoda sa antifungalnom aktivnošću., The antimicrobial activity of dimethyl sulfoxide extract of moss Rhodobryum ontariense (Kindb.) Kindb. was evaluated by microdilution method against eight bacterial (Escherichia coli, Pseudomonas aeruginosa, Salmonella typhimurium, Enterobacter cloacae, Listeria monocytogenes, Bacillus cereus, Micrococcus flavus and Staphylococcus aureus) and five fungal species (Aspergillus versicolor, Aspergillus fumigatus, Penicillium funiculosum, Penicillium ochrochloron and Trichoderma viride). The extract was proven to be active against all the bacteria and fungi tested but to varying degrees. It showed better inhibitory activity compared to the known antifungal drug against T. viride (MIC 100 and 200 μg/ml, respectively). This finding implies that R. ontariense could be considered as a promising material for natural antifungal products.",
publisher = "Savez hemijskih inženjera, Beograd",
journal = "Hemijska Industrija",
title = "Antimikrobna aktivnost Rhodobryum ontariense, Antimicrobial activity of Rhodobryum ontariense",
pages = "384-381",
number = "3",
volume = "66",
doi = "10.2298/HEMIND111107100P"
}

Pejin, B., Sabovljević, A., Soković, M., Glamočlija, J., Ciric, A. D., Vujicic, M.,& Sabovljević, M. S.. (2012). Antimikrobna aktivnost Rhodobryum ontariense. in Hemijska Industrija
Savez hemijskih inženjera, Beograd., 66(3), 381-384.
https://doi.org/10.2298/HEMIND111107100P

Pejin B, Sabovljević A, Soković M, Glamočlija J, Ciric AD, Vujicic M, Sabovljević MS. Antimikrobna aktivnost Rhodobryum ontariense. in Hemijska Industrija. 2012;66(3):381-384.
doi:10.2298/HEMIND111107100P .

Pejin, Boris, Sabovljević, Aneta, Soković, Marina, Glamočlija, Jasmina, Ciric, Ana D, Vujicic, Milorad, Sabovljević, Marko S, "Antimikrobna aktivnost Rhodobryum ontariense" in Hemijska Industrija, 66, no. 3 (2012):381-384,
https://doi.org/10.2298/HEMIND111107100P . .

TY  - JOUR
AU  - Sabovljević, Aneta
AU  - Soković, Marina
AU  - Glamočlija, Jasmina
AU  - Ciric, Ana D
AU  - Vujicic, Milorad
AU  - Pejin, Boris
AU  - Sabovljević, Marko S
PY  - 2011
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/485
AB  - The antifungal activity of dimethyl sulfoxide (DMSO) extracts of three bryophyte species, two mosses (Atrichum undulatum (Hedw.) P. Beauv., Physcomitrella patens (Hedw.) Bruch and Schimp) and a liverwort (Marchantia polymorpha L. ssp. ruderalis Bischl. and Boisselier), grown in nature and in axenic culture was evaluated by microdilution method against five fungal species (Aspergillus versicolor, Aspergillus fumigatus, Penicillium funiculosum, Penicillium ochrochloron and Trichoderma viride). All the investigated bryophyte extracts have been proved to be active against all fungi tested. In general, extracts made from material grown in the laboratory (in vitro) conditions express better antifungal activity comparing to those made from material grown in the nature. Some of the fungi tested react similarly to both extracts.
PB  - Academic Journals, Victoria Island
T2  - Journal of Medicinal Plants Research
T1  - Bio-activities of extracts from some axenically farmed and naturally grown bryophytes
EP  - 571
IS  - 4
SP  - 565
VL  - 5
UR  - https://hdl.handle.net/21.15107/rcub_rimsi_485
ER  - 

@article{
author = "Sabovljević, Aneta and Soković, Marina and Glamočlija, Jasmina and Ciric, Ana D and Vujicic, Milorad and Pejin, Boris and Sabovljević, Marko S",
year = "2011",
abstract = "The antifungal activity of dimethyl sulfoxide (DMSO) extracts of three bryophyte species, two mosses (Atrichum undulatum (Hedw.) P. Beauv., Physcomitrella patens (Hedw.) Bruch and Schimp) and a liverwort (Marchantia polymorpha L. ssp. ruderalis Bischl. and Boisselier), grown in nature and in axenic culture was evaluated by microdilution method against five fungal species (Aspergillus versicolor, Aspergillus fumigatus, Penicillium funiculosum, Penicillium ochrochloron and Trichoderma viride). All the investigated bryophyte extracts have been proved to be active against all fungi tested. In general, extracts made from material grown in the laboratory (in vitro) conditions express better antifungal activity comparing to those made from material grown in the nature. Some of the fungi tested react similarly to both extracts.",
publisher = "Academic Journals, Victoria Island",
journal = "Journal of Medicinal Plants Research",
title = "Bio-activities of extracts from some axenically farmed and naturally grown bryophytes",
pages = "571-565",
number = "4",
volume = "5",
url = "https://hdl.handle.net/21.15107/rcub_rimsi_485"
}

Sabovljević, A., Soković, M., Glamočlija, J., Ciric, A. D., Vujicic, M., Pejin, B.,& Sabovljević, M. S.. (2011). Bio-activities of extracts from some axenically farmed and naturally grown bryophytes. in Journal of Medicinal Plants Research
Academic Journals, Victoria Island., 5(4), 565-571.
https://hdl.handle.net/21.15107/rcub_rimsi_485

Sabovljević A, Soković M, Glamočlija J, Ciric AD, Vujicic M, Pejin B, Sabovljević MS. Bio-activities of extracts from some axenically farmed and naturally grown bryophytes. in Journal of Medicinal Plants Research. 2011;5(4):565-571.
https://hdl.handle.net/21.15107/rcub_rimsi_485 .

Sabovljević, Aneta, Soković, Marina, Glamočlija, Jasmina, Ciric, Ana D, Vujicic, Milorad, Pejin, Boris, Sabovljević, Marko S, "Bio-activities of extracts from some axenically farmed and naturally grown bryophytes" in Journal of Medicinal Plants Research, 5, no. 4 (2011):565-571,
https://hdl.handle.net/21.15107/rcub_rimsi_485 .

TY  - JOUR
AU  - Nestorović, Jasmina M
AU  - Misic, Danijela
AU  - Siler, Branislav
AU  - Soković, Marina
AU  - Glamočlija, Jasmina
AU  - Ciric, Ana D
AU  - Maksimović, Vuk
AU  - Grubisic, Dragoljub V
PY  - 2010
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/372
AB  - Rapid micropropagation of Nepeta rtanjensis, N. sibirica and N. nervosa was performed. Qualitative and quantitative nepetalactone content in methanol extracts of in vitro grown plants was analysed by reverse-phase HPLC coupled with UV and MS detection. Only trans,cis-nepetalactone was detected in shoots of N. rtanjensis, while cis,trans-nepetalactone stereoisomer was present in N. sibirica. No nepetalactone was observed in shoots of N. nervosa. The antimicrobial activity of methanol extracts, against eight bacterial and eight fungal species, was evaluated. All the tested extracts showed significant antibacterial and strong antifungal activity. However, N. rtanjensis extract exhibited the best antimicrobial potential.
PB  - Elsevier, Amsterdam
T2  - Fitoterapia
T1  - Nepetalactone content in shoot cultures of three endemic Nepeta species and the evaluation of their antimicrobial activity
EP  - 626
IS  - 6
SP  - 621
VL  - 81
DO  - 10.1016/j.fitote.2010.03.007
ER  - 

@article{
author = "Nestorović, Jasmina M and Misic, Danijela and Siler, Branislav and Soković, Marina and Glamočlija, Jasmina and Ciric, Ana D and Maksimović, Vuk and Grubisic, Dragoljub V",
year = "2010",
abstract = "Rapid micropropagation of Nepeta rtanjensis, N. sibirica and N. nervosa was performed. Qualitative and quantitative nepetalactone content in methanol extracts of in vitro grown plants was analysed by reverse-phase HPLC coupled with UV and MS detection. Only trans,cis-nepetalactone was detected in shoots of N. rtanjensis, while cis,trans-nepetalactone stereoisomer was present in N. sibirica. No nepetalactone was observed in shoots of N. nervosa. The antimicrobial activity of methanol extracts, against eight bacterial and eight fungal species, was evaluated. All the tested extracts showed significant antibacterial and strong antifungal activity. However, N. rtanjensis extract exhibited the best antimicrobial potential.",
publisher = "Elsevier, Amsterdam",
journal = "Fitoterapia",
title = "Nepetalactone content in shoot cultures of three endemic Nepeta species and the evaluation of their antimicrobial activity",
pages = "626-621",
number = "6",
volume = "81",
doi = "10.1016/j.fitote.2010.03.007"
}

Nestorović, J. M., Misic, D., Siler, B., Soković, M., Glamočlija, J., Ciric, A. D., Maksimović, V.,& Grubisic, D. V.. (2010). Nepetalactone content in shoot cultures of three endemic Nepeta species and the evaluation of their antimicrobial activity. in Fitoterapia
Elsevier, Amsterdam., 81(6), 621-626.
https://doi.org/10.1016/j.fitote.2010.03.007

Nestorović JM, Misic D, Siler B, Soković M, Glamočlija J, Ciric AD, Maksimović V, Grubisic DV. Nepetalactone content in shoot cultures of three endemic Nepeta species and the evaluation of their antimicrobial activity. in Fitoterapia. 2010;81(6):621-626.
doi:10.1016/j.fitote.2010.03.007 .

Nestorović, Jasmina M, Misic, Danijela, Siler, Branislav, Soković, Marina, Glamočlija, Jasmina, Ciric, Ana D, Maksimović, Vuk, Grubisic, Dragoljub V, "Nepetalactone content in shoot cultures of three endemic Nepeta species and the evaluation of their antimicrobial activity" in Fitoterapia, 81, no. 6 (2010):621-626,
https://doi.org/10.1016/j.fitote.2010.03.007 . .

TY  - JOUR
AU  - Grbic, G.
AU  - Culic, M.
AU  - Martać, Ljiljana
AU  - Soković, Marina
AU  - Spasić, Slađana
AU  - Doković, D.
PY  - 2008
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/239
AB  - The aim of our study was to investigate the effect of camphor essential oil on rat cerebral cortex activity by fractal analysis. Fractal dimension (FD) values of the parietal electrocortical activity were calculated before and after intraperitoneal administration of camphor essential oil (450-675 mu l/kg) in anesthetized rats. Camphor oil induced seizure-like activity with single and multiple spiking of high amplitudes in the parietal electrocorticogram and occasional clonic limb convulsions. The FD values of cortical activity after camphor oil administration increased on the average. Only FD values of ictal ECoG sequences were lower than those before camphor oil administration.
PB  - Srpsko biološko društvo, Beograd, i dr.
T2  - Archives of Biological Sciences
T1  - Effect of camphor essential oil on rat cerebral cortex activity as manifested by fractal dimension changes
EP  - 553
IS  - 4
SP  - 547
VL  - 60
DO  - 10.2298/ABS0804547G
ER  - 

@article{
author = "Grbic, G. and Culic, M. and Martać, Ljiljana and Soković, Marina and Spasić, Slađana and Doković, D.",
year = "2008",
abstract = "The aim of our study was to investigate the effect of camphor essential oil on rat cerebral cortex activity by fractal analysis. Fractal dimension (FD) values of the parietal electrocortical activity were calculated before and after intraperitoneal administration of camphor essential oil (450-675 mu l/kg) in anesthetized rats. Camphor oil induced seizure-like activity with single and multiple spiking of high amplitudes in the parietal electrocorticogram and occasional clonic limb convulsions. The FD values of cortical activity after camphor oil administration increased on the average. Only FD values of ictal ECoG sequences were lower than those before camphor oil administration.",
publisher = "Srpsko biološko društvo, Beograd, i dr.",
journal = "Archives of Biological Sciences",
title = "Effect of camphor essential oil on rat cerebral cortex activity as manifested by fractal dimension changes",
pages = "553-547",
number = "4",
volume = "60",
doi = "10.2298/ABS0804547G"
}

Grbic, G., Culic, M., Martać, L., Soković, M., Spasić, S.,& Doković, D.. (2008). Effect of camphor essential oil on rat cerebral cortex activity as manifested by fractal dimension changes. in Archives of Biological Sciences
Srpsko biološko društvo, Beograd, i dr.., 60(4), 547-553.
https://doi.org/10.2298/ABS0804547G

Grbic G, Culic M, Martać L, Soković M, Spasić S, Doković D. Effect of camphor essential oil on rat cerebral cortex activity as manifested by fractal dimension changes. in Archives of Biological Sciences. 2008;60(4):547-553.
doi:10.2298/ABS0804547G .

Grbic, G., Culic, M., Martać, Ljiljana, Soković, Marina, Spasić, Slađana, Doković, D., "Effect of camphor essential oil on rat cerebral cortex activity as manifested by fractal dimension changes" in Archives of Biological Sciences, 60, no. 4 (2008):547-553,
https://doi.org/10.2298/ABS0804547G . .

TY  - JOUR
AU  - Grbić, Gordana
AU  - Ćulić, Milka
AU  - Martać, Ljiljana
AU  - Kesić, Srđan Ž.
AU  - Soković, Marina
AU  - Spasić, Slađana
AU  - Đoković, Dejan
PY  - 2006
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/2945
AB  - We have decided to detect the seizure brain activity induced by camphor essential oil in rats, as there are still reports of severe intoxication in humans by camphor. The experiments were performed on adult Wistar male rats. The surgery and the acute electrophysiological recordings were done under pentobarbital sodium anesthesia. Local field potentials of cerebral parietal cortex were recorded. The rats were injected by camphor essential oil (150-675 μl/kg b.w., in 1 ml of saline, i.p). We analyzed by Fast Fourier Transform the digitized electrocortical signals before and up 2-3 h after essential oil administration at the sampling rate of 256 Hz. There was a great increase of the mean total power spectra, a relative increase of the power in delta range and decreases of theta and beta ranges when seizural activity with spikes and waves of large amplitude occurred at the level of cerebral cortex 5-30 min after administration of camphor oil at doses >300 μl/kg b.w. It is necessary to investigate further the dose dependent effectiveness of each terpenoid constituent of camphor essential oil on brain activity in order to elucidate the relative safety of the usage of essential oils with these terpenoids.
PB  - Serbian Union of Biological Sciences
T2  - Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica
T1  - Trovanje kamforom - spektralna analiza aktivnosti mozga pacova
T1  - Camphor oil poisoning: Spectral analysis of rat brain activity
EP  - 238
IS  - 3
SP  - 233
VL  - 42
UR  - https://hdl.handle.net/21.15107/rcub_rimsi_2945
ER  - 

@article{
author = "Grbić, Gordana and Ćulić, Milka and Martać, Ljiljana and Kesić, Srđan Ž. and Soković, Marina and Spasić, Slađana and Đoković, Dejan",
year = "2006",
abstract = "We have decided to detect the seizure brain activity induced by camphor essential oil in rats, as there are still reports of severe intoxication in humans by camphor. The experiments were performed on adult Wistar male rats. The surgery and the acute electrophysiological recordings were done under pentobarbital sodium anesthesia. Local field potentials of cerebral parietal cortex were recorded. The rats were injected by camphor essential oil (150-675 μl/kg b.w., in 1 ml of saline, i.p). We analyzed by Fast Fourier Transform the digitized electrocortical signals before and up 2-3 h after essential oil administration at the sampling rate of 256 Hz. There was a great increase of the mean total power spectra, a relative increase of the power in delta range and decreases of theta and beta ranges when seizural activity with spikes and waves of large amplitude occurred at the level of cerebral cortex 5-30 min after administration of camphor oil at doses >300 μl/kg b.w. It is necessary to investigate further the dose dependent effectiveness of each terpenoid constituent of camphor essential oil on brain activity in order to elucidate the relative safety of the usage of essential oils with these terpenoids.",
publisher = "Serbian Union of Biological Sciences",
journal = "Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica",
title = "Trovanje kamforom - spektralna analiza aktivnosti mozga pacova, Camphor oil poisoning: Spectral analysis of rat brain activity",
pages = "238-233",
number = "3",
volume = "42",
url = "https://hdl.handle.net/21.15107/rcub_rimsi_2945"
}

Grbić, G., Ćulić, M., Martać, L., Kesić, S. Ž., Soković, M., Spasić, S.,& Đoković, D.. (2006). Trovanje kamforom - spektralna analiza aktivnosti mozga pacova. in Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica
Serbian Union of Biological Sciences., 42(3), 233-238.
https://hdl.handle.net/21.15107/rcub_rimsi_2945

Grbić G, Ćulić M, Martać L, Kesić SŽ, Soković M, Spasić S, Đoković D. Trovanje kamforom - spektralna analiza aktivnosti mozga pacova. in Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica. 2006;42(3):233-238.
https://hdl.handle.net/21.15107/rcub_rimsi_2945 .

Grbić, Gordana, Ćulić, Milka, Martać, Ljiljana, Kesić, Srđan Ž., Soković, Marina, Spasić, Slađana, Đoković, Dejan, "Trovanje kamforom - spektralna analiza aktivnosti mozga pacova" in Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica, 42, no. 3 (2006):233-238,
https://hdl.handle.net/21.15107/rcub_rimsi_2945 .