Bacterial cellulose-lignin composite hydrogel as a promising agent in chronic wound healing
2018
Аутори
Zmejkoski, DanicaSpasojević, Dragica
Orlovska, Irina
Kozyrovska, Natalia
Soković, Marina
Glamočlija, Jasmina
Dmitrović, Svetlana
Matović, Branko
Tasić, Nikola
Maksimović, Vuk
Sosnin, Mikhail
Radotić, Ksenija
Чланак у часопису (Рецензирана верзија)
Метаподаци
Приказ свих података о документуАпстракт
Lignins and lignin-derived compounds are known to have antibacterial properties. The wound healing agents in the form of dressings produce faster skin repair and decrease pain in patients. In order to create an efficient antimicrobial agent in the form of dressing in the treatment of chronic wounds, a composite hydrogel of bacterial cellulose (BC) and dehydrogenative polymer of coniferyl alcohol (DHP), BC-DHP, was designed. Novel composite showed inhibitory or bactericidal effects against selected pathogenic bacteria, including clinically isolated ones. The highest release rate of DHP was in the first hour, while after 24 h there was still slow release of small amounts of DHP from BC-DHP during 72 h monitoring. High-performance liquid chromatography coupled with mass-spectrometry showed that BC-DHP releases DHP oligomers, which are proposed to be antimicrobially active DHP fractions. Scanning electron microscopy and atomic force microscopy micrographs proved a dose-dependent interactio...n of DHP with BC, which resulted in a decrease of the pore number and size in the cellulose membrane. The Fourier-transform infrared absorption spectra of the BC-DHP showed that DHP was partly bound to the BC matrix. The swelling and crystallinity degree were dose-dependent. All obtained results confirmed BC-DHP composite as a promising hydrogel for wounds healing.
Кључне речи:
Lignin model polymer / Bacterial cellulose / Antimicrobial activityИзвор:
International Journal of Biological Macromolecules, 2018, 118, 494-503Издавач:
- Elsevier, Amsterdam
Финансирање / пројекти:
- National Academy of Sciences of Ukraine [47/2015-2016]
- Синтеза, процесирање и карактеризација наноструктурних материјала за примену у области енергије, механичког инжењерства, заштите животне стредине и биомедицине (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-45012)
- Испитивања односа структура-функција у ћелијском зиду биљака и измене структуре зида ензимским инжењерингом (RS-MESTD-Basic Research (BR or ON)-173017)
- 0-3D наноструктуре за примену у електроници и обновљивим изворима енергије: синтеза, карактеризација и процесирање (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-45007)
- Интеракције мембрана са унутарћелијским и апопластичним простором: изучавања биоенергетике и сингализације користећи биофизичке и биохемијске методе (RS-MESTD-Basic Research (BR or ON)-173040)
- Карактеризација и примена метаболита гљива и утврђивање потенцијала нових биофунгицида (RS-MESTD-Basic Research (BR or ON)-173032)
Напомена:
- This is the peered review of the paper: Zmejkoski, D., Spasojević, D., Orlovska, I., Kozyrovska, N., Soković, M., Glamoclija, J., Dmitrović, S., Matović, B., Tasić, N., Maksimović, V., Sosnin, M.,& Radotić, K.. (2018). Bacterial cellulose-lignin composite hydrogel as a promising agent in chronic wound healing. in International Journal of Biological Macromolecules Elsevier, Amsterdam., 118, 494-503. https://doi.org/10.1016/j.ijbiomac.2018.06.067 conv_590
DOI: 10.1016/j.ijbiomac.2018.06.067
ISSN: 0141-8130
PubMed: 29909035
WoS: 000445170200057
Scopus: 2-s2.0-85049108073
Институција/група
Institut za multidisciplinarna istraživanjaTY - JOUR AU - Zmejkoski, Danica AU - Spasojević, Dragica AU - Orlovska, Irina AU - Kozyrovska, Natalia AU - Soković, Marina AU - Glamočlija, Jasmina AU - Dmitrović, Svetlana AU - Matović, Branko AU - Tasić, Nikola AU - Maksimović, Vuk AU - Sosnin, Mikhail AU - Radotić, Ksenija PY - 2018 UR - http://rimsi.imsi.bg.ac.rs/handle/123456789/1157 AB - Lignins and lignin-derived compounds are known to have antibacterial properties. The wound healing agents in the form of dressings produce faster skin repair and decrease pain in patients. In order to create an efficient antimicrobial agent in the form of dressing in the treatment of chronic wounds, a composite hydrogel of bacterial cellulose (BC) and dehydrogenative polymer of coniferyl alcohol (DHP), BC-DHP, was designed. Novel composite showed inhibitory or bactericidal effects against selected pathogenic bacteria, including clinically isolated ones. The highest release rate of DHP was in the first hour, while after 24 h there was still slow release of small amounts of DHP from BC-DHP during 72 h monitoring. High-performance liquid chromatography coupled with mass-spectrometry showed that BC-DHP releases DHP oligomers, which are proposed to be antimicrobially active DHP fractions. Scanning electron microscopy and atomic force microscopy micrographs proved a dose-dependent interaction of DHP with BC, which resulted in a decrease of the pore number and size in the cellulose membrane. The Fourier-transform infrared absorption spectra of the BC-DHP showed that DHP was partly bound to the BC matrix. The swelling and crystallinity degree were dose-dependent. All obtained results confirmed BC-DHP composite as a promising hydrogel for wounds healing. PB - Elsevier, Amsterdam T2 - International Journal of Biological Macromolecules T1 - Bacterial cellulose-lignin composite hydrogel as a promising agent in chronic wound healing EP - 503 SP - 494 VL - 118 DO - 10.1016/j.ijbiomac.2018.06.067 ER -
@article{ author = "Zmejkoski, Danica and Spasojević, Dragica and Orlovska, Irina and Kozyrovska, Natalia and Soković, Marina and Glamočlija, Jasmina and Dmitrović, Svetlana and Matović, Branko and Tasić, Nikola and Maksimović, Vuk and Sosnin, Mikhail and Radotić, Ksenija", year = "2018", abstract = "Lignins and lignin-derived compounds are known to have antibacterial properties. The wound healing agents in the form of dressings produce faster skin repair and decrease pain in patients. In order to create an efficient antimicrobial agent in the form of dressing in the treatment of chronic wounds, a composite hydrogel of bacterial cellulose (BC) and dehydrogenative polymer of coniferyl alcohol (DHP), BC-DHP, was designed. Novel composite showed inhibitory or bactericidal effects against selected pathogenic bacteria, including clinically isolated ones. The highest release rate of DHP was in the first hour, while after 24 h there was still slow release of small amounts of DHP from BC-DHP during 72 h monitoring. High-performance liquid chromatography coupled with mass-spectrometry showed that BC-DHP releases DHP oligomers, which are proposed to be antimicrobially active DHP fractions. Scanning electron microscopy and atomic force microscopy micrographs proved a dose-dependent interaction of DHP with BC, which resulted in a decrease of the pore number and size in the cellulose membrane. The Fourier-transform infrared absorption spectra of the BC-DHP showed that DHP was partly bound to the BC matrix. The swelling and crystallinity degree were dose-dependent. All obtained results confirmed BC-DHP composite as a promising hydrogel for wounds healing.", publisher = "Elsevier, Amsterdam", journal = "International Journal of Biological Macromolecules", title = "Bacterial cellulose-lignin composite hydrogel as a promising agent in chronic wound healing", pages = "503-494", volume = "118", doi = "10.1016/j.ijbiomac.2018.06.067" }
Zmejkoski, D., Spasojević, D., Orlovska, I., Kozyrovska, N., Soković, M., Glamočlija, J., Dmitrović, S., Matović, B., Tasić, N., Maksimović, V., Sosnin, M.,& Radotić, K.. (2018). Bacterial cellulose-lignin composite hydrogel as a promising agent in chronic wound healing. in International Journal of Biological Macromolecules Elsevier, Amsterdam., 118, 494-503. https://doi.org/10.1016/j.ijbiomac.2018.06.067
Zmejkoski D, Spasojević D, Orlovska I, Kozyrovska N, Soković M, Glamočlija J, Dmitrović S, Matović B, Tasić N, Maksimović V, Sosnin M, Radotić K. Bacterial cellulose-lignin composite hydrogel as a promising agent in chronic wound healing. in International Journal of Biological Macromolecules. 2018;118:494-503. doi:10.1016/j.ijbiomac.2018.06.067 .
Zmejkoski, Danica, Spasojević, Dragica, Orlovska, Irina, Kozyrovska, Natalia, Soković, Marina, Glamočlija, Jasmina, Dmitrović, Svetlana, Matović, Branko, Tasić, Nikola, Maksimović, Vuk, Sosnin, Mikhail, Radotić, Ksenija, "Bacterial cellulose-lignin composite hydrogel as a promising agent in chronic wound healing" in International Journal of Biological Macromolecules, 118 (2018):494-503, https://doi.org/10.1016/j.ijbiomac.2018.06.067 . .