TY  - JOUR
AU  - Pejin, Boris
AU  - Ciric, Ana
AU  - Dimitrić-Marković, Jasmina
AU  - Glamočlija, Jasmina
AU  - Nikolic, Milos
AU  - Soković, Marina
PY  - 2017
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/1090
AB  - Anti-biofilm activity of three anthocyanidins (pelargonidin, cyanidin and delphinidin) was evaluated for the first time at in vitro conditions. All the compounds reduced the formation of Pseudomonas aeruginosa PAO1 biofilm at low sub-MIC (0.125 MIC) with delphinidin (c 56.25g/mL) being the most active (43%). In comparison, ampicillin (c 93.75g/mL) and streptomycin (c 21.25g/mL) (used as positive controls) were considerably less effective at the same sub-MIC (8 and 12%, respectively). Furthermore, at 0.5 MIC (c 225g/mL) this anthocyanidin molecule partly reduced the bacterial protrusions. However, no any of the aforementioned compounds inhibited the production of pyocyanin by the bacterial strain P. aeruginosa PAO1. Taken all together, the delphinidin scaffold could be taken into consideration for the design of the novel and more effective anti-biofilm agents inspired by the anthocyanidins.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Natural Product Research
T1  - An insight into anti-biofilm and anti-quorum sensing activities of the selected anthocyanidins: the case study of Pseudomonas aeruginosa PAO1
EP  - 1180
IS  - 10
SP  - 1177
VL  - 31
DO  - 10.1080/14786419.2016.1222386
ER  - 

@article{
author = "Pejin, Boris and Ciric, Ana and Dimitrić-Marković, Jasmina and Glamočlija, Jasmina and Nikolic, Milos and Soković, Marina",
year = "2017",
abstract = "Anti-biofilm activity of three anthocyanidins (pelargonidin, cyanidin and delphinidin) was evaluated for the first time at in vitro conditions. All the compounds reduced the formation of Pseudomonas aeruginosa PAO1 biofilm at low sub-MIC (0.125 MIC) with delphinidin (c 56.25g/mL) being the most active (43%). In comparison, ampicillin (c 93.75g/mL) and streptomycin (c 21.25g/mL) (used as positive controls) were considerably less effective at the same sub-MIC (8 and 12%, respectively). Furthermore, at 0.5 MIC (c 225g/mL) this anthocyanidin molecule partly reduced the bacterial protrusions. However, no any of the aforementioned compounds inhibited the production of pyocyanin by the bacterial strain P. aeruginosa PAO1. Taken all together, the delphinidin scaffold could be taken into consideration for the design of the novel and more effective anti-biofilm agents inspired by the anthocyanidins.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Natural Product Research",
title = "An insight into anti-biofilm and anti-quorum sensing activities of the selected anthocyanidins: the case study of Pseudomonas aeruginosa PAO1",
pages = "1180-1177",
number = "10",
volume = "31",
doi = "10.1080/14786419.2016.1222386"
}

Pejin, B., Ciric, A., Dimitrić-Marković, J., Glamočlija, J., Nikolic, M.,& Soković, M.. (2017). An insight into anti-biofilm and anti-quorum sensing activities of the selected anthocyanidins: the case study of Pseudomonas aeruginosa PAO1. in Natural Product Research
Taylor & Francis Ltd, Abingdon., 31(10), 1177-1180.
https://doi.org/10.1080/14786419.2016.1222386

Pejin B, Ciric A, Dimitrić-Marković J, Glamočlija J, Nikolic M, Soković M. An insight into anti-biofilm and anti-quorum sensing activities of the selected anthocyanidins: the case study of Pseudomonas aeruginosa PAO1. in Natural Product Research. 2017;31(10):1177-1180.
doi:10.1080/14786419.2016.1222386 .

Pejin, Boris, Ciric, Ana, Dimitrić-Marković, Jasmina, Glamočlija, Jasmina, Nikolic, Milos, Soković, Marina, "An insight into anti-biofilm and anti-quorum sensing activities of the selected anthocyanidins: the case study of Pseudomonas aeruginosa PAO1" in Natural Product Research, 31, no. 10 (2017):1177-1180,
https://doi.org/10.1080/14786419.2016.1222386 . .

TY  - JOUR
AU  - Spasojević, Dragica
AU  - Zmejkoski, Danica
AU  - Glamočlija, Jasmina
AU  - Nikolic, Milos
AU  - Soković, Marina
AU  - Milošević, Verica Lj.
AU  - Jaric, Ivana
AU  - Stojanović, Marijana
AU  - Marinković, Emilija
AU  - Barisani-Asenbauer, Talin
AU  - Prodanović, Radivoje
AU  - Jovanović, Milos
AU  - Radotić, Ksenija
PY  - 2016
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/983
AB  - Nowadays bacterial resistance to known antibiotics is a serious health problem. In order to achieve more efficient treatment, lately there is an effort to find new substances, such as certain biomaterials, that are non-toxic to humans with antibiotic potential. Lignins and lignin-derived compounds have been proposed to be good candidates for use in medicine and health maintenance. In this study, the antibacterial activity of the lignin model polymer dehydrogenate polymer (DHP) in alginate hydrogel (Alg) was studied. The obtained results show that DHP-Alg has strong antimicrobial activity against several bacterial strains and biofilms and does not have a toxic effect on human epithelial cells. These results strongly suggest its application as a wound healing agent or as an adjunct substance for wound treatments.
PB  - Elsevier, Amsterdam
T2  - International Journal of Antimicrobial Agents
T1  - Lignin model compound in alginate hydrogel: a strong antimicrobial agent with high potential in wound treatment
EP  - 735
IS  - 6
SP  - 732
VL  - 48
DO  - 10.1016/j.ijantimicag.2016.08.014
ER  - 

@article{
author = "Spasojević, Dragica and Zmejkoski, Danica and Glamočlija, Jasmina and Nikolic, Milos and Soković, Marina and Milošević, Verica Lj. and Jaric, Ivana and Stojanović, Marijana and Marinković, Emilija and Barisani-Asenbauer, Talin and Prodanović, Radivoje and Jovanović, Milos and Radotić, Ksenija",
year = "2016",
abstract = "Nowadays bacterial resistance to known antibiotics is a serious health problem. In order to achieve more efficient treatment, lately there is an effort to find new substances, such as certain biomaterials, that are non-toxic to humans with antibiotic potential. Lignins and lignin-derived compounds have been proposed to be good candidates for use in medicine and health maintenance. In this study, the antibacterial activity of the lignin model polymer dehydrogenate polymer (DHP) in alginate hydrogel (Alg) was studied. The obtained results show that DHP-Alg has strong antimicrobial activity against several bacterial strains and biofilms and does not have a toxic effect on human epithelial cells. These results strongly suggest its application as a wound healing agent or as an adjunct substance for wound treatments.",
publisher = "Elsevier, Amsterdam",
journal = "International Journal of Antimicrobial Agents",
title = "Lignin model compound in alginate hydrogel: a strong antimicrobial agent with high potential in wound treatment",
pages = "735-732",
number = "6",
volume = "48",
doi = "10.1016/j.ijantimicag.2016.08.014"
}

Spasojević, D., Zmejkoski, D., Glamočlija, J., Nikolic, M., Soković, M., Milošević, V. Lj., Jaric, I., Stojanović, M., Marinković, E., Barisani-Asenbauer, T., Prodanović, R., Jovanović, M.,& Radotić, K.. (2016). Lignin model compound in alginate hydrogel: a strong antimicrobial agent with high potential in wound treatment. in International Journal of Antimicrobial Agents
Elsevier, Amsterdam., 48(6), 732-735.
https://doi.org/10.1016/j.ijantimicag.2016.08.014

Spasojević D, Zmejkoski D, Glamočlija J, Nikolic M, Soković M, Milošević VL, Jaric I, Stojanović M, Marinković E, Barisani-Asenbauer T, Prodanović R, Jovanović M, Radotić K. Lignin model compound in alginate hydrogel: a strong antimicrobial agent with high potential in wound treatment. in International Journal of Antimicrobial Agents. 2016;48(6):732-735.
doi:10.1016/j.ijantimicag.2016.08.014 .

Spasojević, Dragica, Zmejkoski, Danica, Glamočlija, Jasmina, Nikolic, Milos, Soković, Marina, Milošević, Verica Lj., Jaric, Ivana, Stojanović, Marijana, Marinković, Emilija, Barisani-Asenbauer, Talin, Prodanović, Radivoje, Jovanović, Milos, Radotić, Ksenija, "Lignin model compound in alginate hydrogel: a strong antimicrobial agent with high potential in wound treatment" in International Journal of Antimicrobial Agents, 48, no. 6 (2016):732-735,
https://doi.org/10.1016/j.ijantimicag.2016.08.014 . .

TY  - JOUR
AU  - Pejin, Boris
AU  - Ciric, Ana
AU  - Horvatović, Mladen
AU  - Jurca, Tamara
AU  - Glamočlija, Jasmina
AU  - Nikolic, Milos
AU  - Soković, Marina
PY  - 2016
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/955
AB  - The antimicrobial activity of five crude extracts of the freshwater bryozoan Pectinatella magnifica (Leidy, 1851) was evaluated in vitro for the first time. P. magnifica acetone extract exhibited the highest antibacterial activity (minimum inhibitory concentrations (MIC) 0.004-0.350mg/mL and MBC 0.007-0.500mg/mL), while its methanol extract showed the most promising antifungal activity (MIC 0.03-0.12mg/mL and MFC 0.06-0.25mg/mL). Furthermore, at a concentration of 0.25 MIC, the methanol extract reduced biofilm formation of the bacterial strain Pseudomonas aeruginosa PAO1 in a considerable extent (59.14%). FTIR spectra of the most active extracts indicate the presence of carbonyl compounds, long-chain alcohols and/or sterols. According to the experimental data obtained, P. magnifica methanol extract may be considered as a good resource of novel natural products with potent antibiofilm activity against the bacterium well known for its resistance. [GRAPHCIS].
PB  - Taylor & Francis Ltd, Abingdon
T2  - Natural Product Research
T1  - An insight into antimicrobial activity of the freshwater bryozoan Pectinatella magnifica
EP  - 1843
IS  - 16
SP  - 1839
VL  - 30
DO  - 10.1080/14786419.2015.1068773
ER  - 

@article{
author = "Pejin, Boris and Ciric, Ana and Horvatović, Mladen and Jurca, Tamara and Glamočlija, Jasmina and Nikolic, Milos and Soković, Marina",
year = "2016",
abstract = "The antimicrobial activity of five crude extracts of the freshwater bryozoan Pectinatella magnifica (Leidy, 1851) was evaluated in vitro for the first time. P. magnifica acetone extract exhibited the highest antibacterial activity (minimum inhibitory concentrations (MIC) 0.004-0.350mg/mL and MBC 0.007-0.500mg/mL), while its methanol extract showed the most promising antifungal activity (MIC 0.03-0.12mg/mL and MFC 0.06-0.25mg/mL). Furthermore, at a concentration of 0.25 MIC, the methanol extract reduced biofilm formation of the bacterial strain Pseudomonas aeruginosa PAO1 in a considerable extent (59.14%). FTIR spectra of the most active extracts indicate the presence of carbonyl compounds, long-chain alcohols and/or sterols. According to the experimental data obtained, P. magnifica methanol extract may be considered as a good resource of novel natural products with potent antibiofilm activity against the bacterium well known for its resistance. [GRAPHCIS].",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Natural Product Research",
title = "An insight into antimicrobial activity of the freshwater bryozoan Pectinatella magnifica",
pages = "1843-1839",
number = "16",
volume = "30",
doi = "10.1080/14786419.2015.1068773"
}

Pejin, B., Ciric, A., Horvatović, M., Jurca, T., Glamočlija, J., Nikolic, M.,& Soković, M.. (2016). An insight into antimicrobial activity of the freshwater bryozoan Pectinatella magnifica. in Natural Product Research
Taylor & Francis Ltd, Abingdon., 30(16), 1839-1843.
https://doi.org/10.1080/14786419.2015.1068773

Pejin B, Ciric A, Horvatović M, Jurca T, Glamočlija J, Nikolic M, Soković M. An insight into antimicrobial activity of the freshwater bryozoan Pectinatella magnifica. in Natural Product Research. 2016;30(16):1839-1843.
doi:10.1080/14786419.2015.1068773 .

Pejin, Boris, Ciric, Ana, Horvatović, Mladen, Jurca, Tamara, Glamočlija, Jasmina, Nikolic, Milos, Soković, Marina, "An insight into antimicrobial activity of the freshwater bryozoan Pectinatella magnifica" in Natural Product Research, 30, no. 16 (2016):1839-1843,
https://doi.org/10.1080/14786419.2015.1068773 . .

TY  - JOUR
AU  - Pejin, Boris
AU  - Ciric, Ana
AU  - Karaman, Ivo
AU  - Horvatović, Mladen
AU  - Glamočlija, Jasmina
AU  - Nikolic, Milos
AU  - Soković, Marina
PY  - 2016
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/954
AB  - The antibiofilm and possible antiquorum sensing effects against the strain Pseudomonas aeruginosa PAO1 of five crude extracts of the freshwater bryozoan Hyalinella punctata (Hancock, 1850) were evaluated in vitro for the first time. H. punctata ethyl acetate extract (HpEtAc) exhibited the highest antibiofilm activity reducing the biofilm formation of P. aeruginosa PAO1 in the range of 80.63-88.13%. While all tested extracts reduced the twitching motility of the aforementioned bacterial strain, HpEtAc showed to be the most effective. Finally, at a concentration of 0.5 MIC, the same extract mostly inhibited the production of pyocyanin by P. aeruginosa PAO1 (71.53%). In comparison both with the positive controls used (streptomycin and ampicillin, 67.13 and 69.77%, respectively), HpEtAc was found to inhibit pyocyanin in a higher extent. An extensive chemical characterisation of this particular extract may result in isolation and identification of novel lead compounds targeting P. aeruginosa, an opportunistic human pathogen. [GRAPHCIS].
PB  - Taylor & Francis Ltd, Abingdon
T2  - Natural Product Research
T1  - In vitro antibiofilm activity of the freshwater bryozoan Hyalinella punctata: a case study of Pseudomonas aeruginosa PAO1
EP  - 1850
IS  - 16
SP  - 1847
VL  - 30
DO  - 10.1080/14786419.2015.1072714
ER  - 

@article{
author = "Pejin, Boris and Ciric, Ana and Karaman, Ivo and Horvatović, Mladen and Glamočlija, Jasmina and Nikolic, Milos and Soković, Marina",
year = "2016",
abstract = "The antibiofilm and possible antiquorum sensing effects against the strain Pseudomonas aeruginosa PAO1 of five crude extracts of the freshwater bryozoan Hyalinella punctata (Hancock, 1850) were evaluated in vitro for the first time. H. punctata ethyl acetate extract (HpEtAc) exhibited the highest antibiofilm activity reducing the biofilm formation of P. aeruginosa PAO1 in the range of 80.63-88.13%. While all tested extracts reduced the twitching motility of the aforementioned bacterial strain, HpEtAc showed to be the most effective. Finally, at a concentration of 0.5 MIC, the same extract mostly inhibited the production of pyocyanin by P. aeruginosa PAO1 (71.53%). In comparison both with the positive controls used (streptomycin and ampicillin, 67.13 and 69.77%, respectively), HpEtAc was found to inhibit pyocyanin in a higher extent. An extensive chemical characterisation of this particular extract may result in isolation and identification of novel lead compounds targeting P. aeruginosa, an opportunistic human pathogen. [GRAPHCIS].",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Natural Product Research",
title = "In vitro antibiofilm activity of the freshwater bryozoan Hyalinella punctata: a case study of Pseudomonas aeruginosa PAO1",
pages = "1850-1847",
number = "16",
volume = "30",
doi = "10.1080/14786419.2015.1072714"
}

Pejin, B., Ciric, A., Karaman, I., Horvatović, M., Glamočlija, J., Nikolic, M.,& Soković, M.. (2016). In vitro antibiofilm activity of the freshwater bryozoan Hyalinella punctata: a case study of Pseudomonas aeruginosa PAO1. in Natural Product Research
Taylor & Francis Ltd, Abingdon., 30(16), 1847-1850.
https://doi.org/10.1080/14786419.2015.1072714

Pejin B, Ciric A, Karaman I, Horvatović M, Glamočlija J, Nikolic M, Soković M. In vitro antibiofilm activity of the freshwater bryozoan Hyalinella punctata: a case study of Pseudomonas aeruginosa PAO1. in Natural Product Research. 2016;30(16):1847-1850.
doi:10.1080/14786419.2015.1072714 .

Pejin, Boris, Ciric, Ana, Karaman, Ivo, Horvatović, Mladen, Glamočlija, Jasmina, Nikolic, Milos, Soković, Marina, "In vitro antibiofilm activity of the freshwater bryozoan Hyalinella punctata: a case study of Pseudomonas aeruginosa PAO1" in Natural Product Research, 30, no. 16 (2016):1847-1850,
https://doi.org/10.1080/14786419.2015.1072714 . .

TY  - JOUR
AU  - Pejin, Boris
AU  - Ciric, Ana
AU  - Dimitrić-Marković, Jasmina
AU  - Glamočlija, Jasmina
AU  - Nikolic, Milos
AU  - Stanimirović, Bojana
AU  - Soković, Marina
PY  - 2015
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/852
AB  - This work was focused on in vitro evaluation of anti-biofilm and anti-quorum sensing effects of four selected flavonoid compounds /(+)-catechin, caffeic acid, quercetin and morin/using the strain Pseudomonas aeruginosa PAO1. At a concentration of 0.5 MIC quercetin was the only compound found to potently reduce both P. aeruginosa biofilm formation (95%) and its twitching motility. The chemical scaffold of quercetin, a common dietary polyphenol, may actually inspire development of novel and more effective medicinal agents targeting P. aeruginosa, the bacterium well known for its resistance.
PB  - Bentham Science Publ Ltd, Sharjah
T2  - Current Pharmaceutical Biotechnology
T1  - Quercetin Potently Reduces Biofilm Formation of the Strain Pseudomonas aeruginosa PAO1 in vitro
EP  - 737
IS  - 8
SP  - 733
VL  - 16
DO  - 10.2174/1389201016666150505121951
ER  - 

@article{
author = "Pejin, Boris and Ciric, Ana and Dimitrić-Marković, Jasmina and Glamočlija, Jasmina and Nikolic, Milos and Stanimirović, Bojana and Soković, Marina",
year = "2015",
abstract = "This work was focused on in vitro evaluation of anti-biofilm and anti-quorum sensing effects of four selected flavonoid compounds /(+)-catechin, caffeic acid, quercetin and morin/using the strain Pseudomonas aeruginosa PAO1. At a concentration of 0.5 MIC quercetin was the only compound found to potently reduce both P. aeruginosa biofilm formation (95%) and its twitching motility. The chemical scaffold of quercetin, a common dietary polyphenol, may actually inspire development of novel and more effective medicinal agents targeting P. aeruginosa, the bacterium well known for its resistance.",
publisher = "Bentham Science Publ Ltd, Sharjah",
journal = "Current Pharmaceutical Biotechnology",
title = "Quercetin Potently Reduces Biofilm Formation of the Strain Pseudomonas aeruginosa PAO1 in vitro",
pages = "737-733",
number = "8",
volume = "16",
doi = "10.2174/1389201016666150505121951"
}

Pejin, B., Ciric, A., Dimitrić-Marković, J., Glamočlija, J., Nikolic, M., Stanimirović, B.,& Soković, M.. (2015). Quercetin Potently Reduces Biofilm Formation of the Strain Pseudomonas aeruginosa PAO1 in vitro. in Current Pharmaceutical Biotechnology
Bentham Science Publ Ltd, Sharjah., 16(8), 733-737.
https://doi.org/10.2174/1389201016666150505121951

Pejin B, Ciric A, Dimitrić-Marković J, Glamočlija J, Nikolic M, Stanimirović B, Soković M. Quercetin Potently Reduces Biofilm Formation of the Strain Pseudomonas aeruginosa PAO1 in vitro. in Current Pharmaceutical Biotechnology. 2015;16(8):733-737.
doi:10.2174/1389201016666150505121951 .

Pejin, Boris, Ciric, Ana, Dimitrić-Marković, Jasmina, Glamočlija, Jasmina, Nikolic, Milos, Stanimirović, Bojana, Soković, Marina, "Quercetin Potently Reduces Biofilm Formation of the Strain Pseudomonas aeruginosa PAO1 in vitro" in Current Pharmaceutical Biotechnology, 16, no. 8 (2015):733-737,
https://doi.org/10.2174/1389201016666150505121951 . .

TY  - JOUR
AU  - Pejin, Boris
AU  - Ciric, Ana
AU  - Glamočlija, Jasmina
AU  - Nikolic, Milos
AU  - Soković, Marina
PY  - 2015
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/832
AB  - Anti-quorum sensing activity of the diterpene phytol was evaluated in vitro for the first time. This compound (at three sub-MIC concentrations - 0.5, 0.25 and 0.125 MIC, respectively) reduced the formation of Pseudomonas aeruginosa PAO1 biofilm in the range of 74.00-84.33% exhibiting higher activity than the both positive controls used, streptomycin and ampicillin. Phytol (0.5 MIC) also effectively reduced P. aeruginosa twitching and flagella motility. Indeed, the bacteria treated were incapable of producing a twitching zone and had almost round, smooth and regular colony edges. Finally, the tested compound (0.5 MIC) exhibited good P. aeruginosa pyocyanin inhibitory activity (51.94%) practically to the same extent as streptomycin (52.09%). According to the experimental data obtained, this phytol property may inspire design of medical foods targeting P. aeruginosa quorum sensing activity.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Natural Product Research
T1  - In vitro anti-quorum sensing activity of phytol
EP  - 377
IS  - 4
SP  - 374
VL  - 29
DO  - 10.1080/14786419.2014.945088
ER  - 

@article{
author = "Pejin, Boris and Ciric, Ana and Glamočlija, Jasmina and Nikolic, Milos and Soković, Marina",
year = "2015",
abstract = "Anti-quorum sensing activity of the diterpene phytol was evaluated in vitro for the first time. This compound (at three sub-MIC concentrations - 0.5, 0.25 and 0.125 MIC, respectively) reduced the formation of Pseudomonas aeruginosa PAO1 biofilm in the range of 74.00-84.33% exhibiting higher activity than the both positive controls used, streptomycin and ampicillin. Phytol (0.5 MIC) also effectively reduced P. aeruginosa twitching and flagella motility. Indeed, the bacteria treated were incapable of producing a twitching zone and had almost round, smooth and regular colony edges. Finally, the tested compound (0.5 MIC) exhibited good P. aeruginosa pyocyanin inhibitory activity (51.94%) practically to the same extent as streptomycin (52.09%). According to the experimental data obtained, this phytol property may inspire design of medical foods targeting P. aeruginosa quorum sensing activity.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Natural Product Research",
title = "In vitro anti-quorum sensing activity of phytol",
pages = "377-374",
number = "4",
volume = "29",
doi = "10.1080/14786419.2014.945088"
}

Pejin, B., Ciric, A., Glamočlija, J., Nikolic, M.,& Soković, M.. (2015). In vitro anti-quorum sensing activity of phytol. in Natural Product Research
Taylor & Francis Ltd, Abingdon., 29(4), 374-377.
https://doi.org/10.1080/14786419.2014.945088

Pejin B, Ciric A, Glamočlija J, Nikolic M, Soković M. In vitro anti-quorum sensing activity of phytol. in Natural Product Research. 2015;29(4):374-377.
doi:10.1080/14786419.2014.945088 .

Pejin, Boris, Ciric, Ana, Glamočlija, Jasmina, Nikolic, Milos, Soković, Marina, "In vitro anti-quorum sensing activity of phytol" in Natural Product Research, 29, no. 4 (2015):374-377,
https://doi.org/10.1080/14786419.2014.945088 . .

TY  - JOUR
AU  - Pejin, Boris
AU  - Talevska, Aleksandra
AU  - Ciric, Ana
AU  - Glamočlija, Jasmina
AU  - Nikolic, Milos
AU  - Talevski, Trajce
AU  - Soković, Marina
PY  - 2014
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/806
AB  - The anti-quorum sensing activities towards the bacterium Pseudomonas aeruginosa PA01 (pyocyanin production, biofilm formation and twitching and flagella motility) of two crude extracts (methanol and acetone) of the freshwater sponge Ochridaspongia rotunda (Arndt, 1937) were evaluated in vitro for the first time. Both extracts demonstrated P. aeruginosa pyocyanin inhibitory activity, reducing its production for 49.90% and 42.44%, respectively. In addition, they both showed higher anti-biofilm activity (48.29% and 53.99%, respectively) than ampicillin (30.84%). Finally, O. rotunda extracts effectively reduced twitching and flagella motility of P. aeruginosa. Taken all together, these results suggest that endemic sponge species from the oldest lake in Europe may offer novel bioactive natural products with promising medicinal potential towards P. aeruginosa infections.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Natural Product Research
T1  - Anti-quorum sensing activity of selected sponge extracts: a case study of Pseudomonas aeruginosa
EP  - 2333
IS  - 24
SP  - 2330
VL  - 28
DO  - 10.1080/14786419.2014.934239
ER  - 

@article{
author = "Pejin, Boris and Talevska, Aleksandra and Ciric, Ana and Glamočlija, Jasmina and Nikolic, Milos and Talevski, Trajce and Soković, Marina",
year = "2014",
abstract = "The anti-quorum sensing activities towards the bacterium Pseudomonas aeruginosa PA01 (pyocyanin production, biofilm formation and twitching and flagella motility) of two crude extracts (methanol and acetone) of the freshwater sponge Ochridaspongia rotunda (Arndt, 1937) were evaluated in vitro for the first time. Both extracts demonstrated P. aeruginosa pyocyanin inhibitory activity, reducing its production for 49.90% and 42.44%, respectively. In addition, they both showed higher anti-biofilm activity (48.29% and 53.99%, respectively) than ampicillin (30.84%). Finally, O. rotunda extracts effectively reduced twitching and flagella motility of P. aeruginosa. Taken all together, these results suggest that endemic sponge species from the oldest lake in Europe may offer novel bioactive natural products with promising medicinal potential towards P. aeruginosa infections.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Natural Product Research",
title = "Anti-quorum sensing activity of selected sponge extracts: a case study of Pseudomonas aeruginosa",
pages = "2333-2330",
number = "24",
volume = "28",
doi = "10.1080/14786419.2014.934239"
}

Pejin, B., Talevska, A., Ciric, A., Glamočlija, J., Nikolic, M., Talevski, T.,& Soković, M.. (2014). Anti-quorum sensing activity of selected sponge extracts: a case study of Pseudomonas aeruginosa. in Natural Product Research
Taylor & Francis Ltd, Abingdon., 28(24), 2330-2333.
https://doi.org/10.1080/14786419.2014.934239

Pejin B, Talevska A, Ciric A, Glamočlija J, Nikolic M, Talevski T, Soković M. Anti-quorum sensing activity of selected sponge extracts: a case study of Pseudomonas aeruginosa. in Natural Product Research. 2014;28(24):2330-2333.
doi:10.1080/14786419.2014.934239 .

Pejin, Boris, Talevska, Aleksandra, Ciric, Ana, Glamočlija, Jasmina, Nikolic, Milos, Talevski, Trajce, Soković, Marina, "Anti-quorum sensing activity of selected sponge extracts: a case study of Pseudomonas aeruginosa" in Natural Product Research, 28, no. 24 (2014):2330-2333,
https://doi.org/10.1080/14786419.2014.934239 . .

TY  - JOUR
AU  - Pejin, Boris
AU  - Talevska, Aleksandra
AU  - Ciric, Ana
AU  - Glamočlija, Jasmina
AU  - Nikolic, Milos
AU  - Talevski, Trajce
AU  - Soković, Marina
PY  - 2014
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/784
AB  - The antimicrobial activity of five crude extracts (aqueous, methanol, ethyl acetate, acetone and methylene chloride) of the freshwater sponge Ochridaspongia rotunda (Arndt, 1937) was evaluated in vitro by using microdilution method against eight bacterial and eight fungal strains for the first time. The extracts were proven to be active in varying degrees against all the bacteria and fungi tested. O. rotunda methanol extract exhibited the highest antibacterial activity (minimum inhibitory concentration (MIC) 7.5-15.0 mu g/mL and minimum bactericidal concentration 15-30 mu g/mL), while its acetone extract exhibited the most promising antifungal activity (MIC 7.5-45.0 mu g/mL and minimum fungicidal concentration 15-60 mu g/mL). The extracts were more effective against the bacteria and fungi screened compared with the positive controls (streptomycin and ampicillin for bacteria and bifonazole and ketoconazole for fungi, respectively). According to the experimental data obtained, this deepwater sponge species may be considered as a gold mine of new antimicrobial substances with significant and broad-range activity.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Natural Product Research
T1  - In vitro evaluation of antimicrobial activity of the freshwater sponge Ochridaspongia rotunda (Arndt, 1937)
EP  - 1494
IS  - 18
SP  - 1489
VL  - 28
DO  - 10.1080/14786419.2014.911297
ER  - 

@article{
author = "Pejin, Boris and Talevska, Aleksandra and Ciric, Ana and Glamočlija, Jasmina and Nikolic, Milos and Talevski, Trajce and Soković, Marina",
year = "2014",
abstract = "The antimicrobial activity of five crude extracts (aqueous, methanol, ethyl acetate, acetone and methylene chloride) of the freshwater sponge Ochridaspongia rotunda (Arndt, 1937) was evaluated in vitro by using microdilution method against eight bacterial and eight fungal strains for the first time. The extracts were proven to be active in varying degrees against all the bacteria and fungi tested. O. rotunda methanol extract exhibited the highest antibacterial activity (minimum inhibitory concentration (MIC) 7.5-15.0 mu g/mL and minimum bactericidal concentration 15-30 mu g/mL), while its acetone extract exhibited the most promising antifungal activity (MIC 7.5-45.0 mu g/mL and minimum fungicidal concentration 15-60 mu g/mL). The extracts were more effective against the bacteria and fungi screened compared with the positive controls (streptomycin and ampicillin for bacteria and bifonazole and ketoconazole for fungi, respectively). According to the experimental data obtained, this deepwater sponge species may be considered as a gold mine of new antimicrobial substances with significant and broad-range activity.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Natural Product Research",
title = "In vitro evaluation of antimicrobial activity of the freshwater sponge Ochridaspongia rotunda (Arndt, 1937)",
pages = "1494-1489",
number = "18",
volume = "28",
doi = "10.1080/14786419.2014.911297"
}

Pejin, B., Talevska, A., Ciric, A., Glamočlija, J., Nikolic, M., Talevski, T.,& Soković, M.. (2014). In vitro evaluation of antimicrobial activity of the freshwater sponge Ochridaspongia rotunda (Arndt, 1937). in Natural Product Research
Taylor & Francis Ltd, Abingdon., 28(18), 1489-1494.
https://doi.org/10.1080/14786419.2014.911297

Pejin B, Talevska A, Ciric A, Glamočlija J, Nikolic M, Talevski T, Soković M. In vitro evaluation of antimicrobial activity of the freshwater sponge Ochridaspongia rotunda (Arndt, 1937). in Natural Product Research. 2014;28(18):1489-1494.
doi:10.1080/14786419.2014.911297 .

Pejin, Boris, Talevska, Aleksandra, Ciric, Ana, Glamočlija, Jasmina, Nikolic, Milos, Talevski, Trajce, Soković, Marina, "In vitro evaluation of antimicrobial activity of the freshwater sponge Ochridaspongia rotunda (Arndt, 1937)" in Natural Product Research, 28, no. 18 (2014):1489-1494,
https://doi.org/10.1080/14786419.2014.911297 . .

TY  - JOUR
AU  - Pejin, Boris
AU  - Iodice, Carmine
AU  - Tommonaro, Giuseppina
AU  - Stanimirović, Bojana
AU  - Ciric, Ana
AU  - Glamočlija, Jasmina
AU  - Nikolic, Milos
AU  - De Rosa, Salvatore
AU  - Soković, Marina
PY  - 2014
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/776
AB  - This work extends in vitro screening of antimicrobial activity of the sesquiterpene hydroquinone avarol, a main secondary metabolite of the Mediterranean sponge species Dysidea avara. The antimicrobial activity was in part evaluated by microdilution method against selected bacterial and fungal strains. Additionally, the screening included evaluation of anti-quorum sensing (anti-QS) effects. At a different extent avarol was proven to be active against all the microorganisms tested (MIC 0.002-0.008 mg/mL and MBC 0.004-0.016 mg/mL; MIC 0.004-0.015 mg/mL and MFC 0.008-0.030 mg/mL; respectively). This marine natural product also showed moderate anti-QS effects, reducing Pseudomonas aeruginosa PAO1 biofilm formation (75%), its twitching and protrusions motilities as well as pyocianin production (39%). According to the best of our knowledge, this is the first report both on avarol anti Gram-negative bacterial activity and anti-QS effects.
PB  - Bentham Science Publ Ltd, Sharjah
T2  - Current Pharmaceutical Biotechnology
T1  - Further in vitro Evaluation of Antimicrobial Activity of the Marine Sesquiterpene Hydroquinone Avarol
EP  - 588
IS  - 6
SP  - 583
VL  - 15
DO  - 10.2174/138920101506140910152253
ER  - 

@article{
author = "Pejin, Boris and Iodice, Carmine and Tommonaro, Giuseppina and Stanimirović, Bojana and Ciric, Ana and Glamočlija, Jasmina and Nikolic, Milos and De Rosa, Salvatore and Soković, Marina",
year = "2014",
abstract = "This work extends in vitro screening of antimicrobial activity of the sesquiterpene hydroquinone avarol, a main secondary metabolite of the Mediterranean sponge species Dysidea avara. The antimicrobial activity was in part evaluated by microdilution method against selected bacterial and fungal strains. Additionally, the screening included evaluation of anti-quorum sensing (anti-QS) effects. At a different extent avarol was proven to be active against all the microorganisms tested (MIC 0.002-0.008 mg/mL and MBC 0.004-0.016 mg/mL; MIC 0.004-0.015 mg/mL and MFC 0.008-0.030 mg/mL; respectively). This marine natural product also showed moderate anti-QS effects, reducing Pseudomonas aeruginosa PAO1 biofilm formation (75%), its twitching and protrusions motilities as well as pyocianin production (39%). According to the best of our knowledge, this is the first report both on avarol anti Gram-negative bacterial activity and anti-QS effects.",
publisher = "Bentham Science Publ Ltd, Sharjah",
journal = "Current Pharmaceutical Biotechnology",
title = "Further in vitro Evaluation of Antimicrobial Activity of the Marine Sesquiterpene Hydroquinone Avarol",
pages = "588-583",
number = "6",
volume = "15",
doi = "10.2174/138920101506140910152253"
}

Pejin, B., Iodice, C., Tommonaro, G., Stanimirović, B., Ciric, A., Glamočlija, J., Nikolic, M., De Rosa, S.,& Soković, M.. (2014). Further in vitro Evaluation of Antimicrobial Activity of the Marine Sesquiterpene Hydroquinone Avarol. in Current Pharmaceutical Biotechnology
Bentham Science Publ Ltd, Sharjah., 15(6), 583-588.
https://doi.org/10.2174/138920101506140910152253

Pejin B, Iodice C, Tommonaro G, Stanimirović B, Ciric A, Glamočlija J, Nikolic M, De Rosa S, Soković M. Further in vitro Evaluation of Antimicrobial Activity of the Marine Sesquiterpene Hydroquinone Avarol. in Current Pharmaceutical Biotechnology. 2014;15(6):583-588.
doi:10.2174/138920101506140910152253 .

Pejin, Boris, Iodice, Carmine, Tommonaro, Giuseppina, Stanimirović, Bojana, Ciric, Ana, Glamočlija, Jasmina, Nikolic, Milos, De Rosa, Salvatore, Soković, Marina, "Further in vitro Evaluation of Antimicrobial Activity of the Marine Sesquiterpene Hydroquinone Avarol" in Current Pharmaceutical Biotechnology, 15, no. 6 (2014):583-588,
https://doi.org/10.2174/138920101506140910152253 . .

TY  - JOUR
AU  - Milivojević, Jasminka M
AU  - Maksimović, Vuk
AU  - Nikolic, Milos
AU  - Bogdanović Pristov, Jelena
AU  - Maletic, Radojka
AU  - Milatović, Dragan P
PY  - 2011
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/439
AB  - Content of individual sugars, organic acids, total phenolics (TPH), some important phenolic compounds (kaempferol, myricetin, quercetin, and ellagic acid) and total antioxidant capacity (TAC) in the fruits of strawberry, raspberry and blackberry were studied. A comparison was made between cultivars and wild relatives of each species (Fragaria vesca L., Rubus idaeus L. and Rubus fruticosus L.). The main sugars found were fructose and glucose both in the fruits of wild species and the studied cultivars. Citric acid was determined to be the major organic acid in most of tested berries with the exception of blackberry cultivars, where malic acid was dominant. The content of individual phenolic compounds varied among the wild species, as well as among the studied cultivars. Ellagic acid content was higher in F. vesca, R. idaeus and R. fruticosus (122.5 mu g/g FW, 12.71 mu g/g FW and 61.7 mu g/g FW, respectively) than that obtained in analyzed cultivars. Overall, TPH expressed higher values in the wild strawberry and blackberry species in comparison to the studied cultivars, and consequently, the highest levels of TAC were recorded in F. vesca (5.78 mg asc/g FW), followed by R. fruticosus (4.95 mg asc/g FW).
PB  - Wiley-Hindawi, London
T2  - Journal of Food Quality
T1  - Chemical and antioxidant properties of cultivated and wild fragaria and rubus berries
EP  - 9
IS  - 1
SP  - 1
VL  - 34
DO  - 10.1111/j.1745-4557.2010.00360.x
ER  - 

@article{
author = "Milivojević, Jasminka M and Maksimović, Vuk and Nikolic, Milos and Bogdanović Pristov, Jelena and Maletic, Radojka and Milatović, Dragan P",
year = "2011",
abstract = "Content of individual sugars, organic acids, total phenolics (TPH), some important phenolic compounds (kaempferol, myricetin, quercetin, and ellagic acid) and total antioxidant capacity (TAC) in the fruits of strawberry, raspberry and blackberry were studied. A comparison was made between cultivars and wild relatives of each species (Fragaria vesca L., Rubus idaeus L. and Rubus fruticosus L.). The main sugars found were fructose and glucose both in the fruits of wild species and the studied cultivars. Citric acid was determined to be the major organic acid in most of tested berries with the exception of blackberry cultivars, where malic acid was dominant. The content of individual phenolic compounds varied among the wild species, as well as among the studied cultivars. Ellagic acid content was higher in F. vesca, R. idaeus and R. fruticosus (122.5 mu g/g FW, 12.71 mu g/g FW and 61.7 mu g/g FW, respectively) than that obtained in analyzed cultivars. Overall, TPH expressed higher values in the wild strawberry and blackberry species in comparison to the studied cultivars, and consequently, the highest levels of TAC were recorded in F. vesca (5.78 mg asc/g FW), followed by R. fruticosus (4.95 mg asc/g FW).",
publisher = "Wiley-Hindawi, London",
journal = "Journal of Food Quality",
title = "Chemical and antioxidant properties of cultivated and wild fragaria and rubus berries",
pages = "9-1",
number = "1",
volume = "34",
doi = "10.1111/j.1745-4557.2010.00360.x"
}

Milivojević, J. M., Maksimović, V., Nikolic, M., Bogdanović Pristov, J., Maletic, R.,& Milatović, D. P.. (2011). Chemical and antioxidant properties of cultivated and wild fragaria and rubus berries. in Journal of Food Quality
Wiley-Hindawi, London., 34(1), 1-9.
https://doi.org/10.1111/j.1745-4557.2010.00360.x

Milivojević JM, Maksimović V, Nikolic M, Bogdanović Pristov J, Maletic R, Milatović DP. Chemical and antioxidant properties of cultivated and wild fragaria and rubus berries. in Journal of Food Quality. 2011;34(1):1-9.
doi:10.1111/j.1745-4557.2010.00360.x .

Milivojević, Jasminka M, Maksimović, Vuk, Nikolic, Milos, Bogdanović Pristov, Jelena, Maletic, Radojka, Milatović, Dragan P, "Chemical and antioxidant properties of cultivated and wild fragaria and rubus berries" in Journal of Food Quality, 34, no. 1 (2011):1-9,
https://doi.org/10.1111/j.1745-4557.2010.00360.x . .