Bacterial cellulose-lignin composite hydrogel as a promising agent in chronic wound healing
2018
Autori
Zmejkoski, DanicaSpasojević, Dragica
Orlovska, Irina
Kozyrovska, Natalia
Soković, Marina
Glamočlija, Jasmina
Dmitrović, Svetlana
Matović, Branko
Tasić, Nikola
Maksimović, Vuk
Sosnin, Mikhail
Radotić, Ksenija
Članak u časopisu (Recenzirana verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Lignins and lignin-derived compounds are known to have antibacterial properties. The wound healing agents in the form of dressings produce faster skin repair and decrease pain in patients. In order to create an efficient antimicrobial agent in the form of dressing in the treatment of chronic wounds, a composite hydrogel of bacterial cellulose (BC) and dehydrogenative polymer of coniferyl alcohol (DHP), BC-DHP, was designed. Novel composite showed inhibitory or bactericidal effects against selected pathogenic bacteria, including clinically isolated ones. The highest release rate of DHP was in the first hour, while after 24 h there was still slow release of small amounts of DHP from BC-DHP during 72 h monitoring. High-performance liquid chromatography coupled with mass-spectrometry showed that BC-DHP releases DHP oligomers, which are proposed to be antimicrobially active DHP fractions. Scanning electron microscopy and atomic force microscopy micrographs proved a dose-dependent interactio...n of DHP with BC, which resulted in a decrease of the pore number and size in the cellulose membrane. The Fourier-transform infrared absorption spectra of the BC-DHP showed that DHP was partly bound to the BC matrix. The swelling and crystallinity degree were dose-dependent. All obtained results confirmed BC-DHP composite as a promising hydrogel for wounds healing.
Ključne reči:
Lignin model polymer / Bacterial cellulose / Antimicrobial activityIzvor:
International Journal of Biological Macromolecules, 2018, 118, 494-503Izdavač:
- Elsevier, Amsterdam
Finansiranje / projekti:
- National Academy of Sciences of Ukraine [47/2015-2016]
- Sinteza, procesiranje i karakterizacija nanostrukturnih materijala za primenu u oblasti energije, mehaničkog inženjerstva, zaštite životne stredine i biomedicine (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-45012)
- Ispitivanja odnosa struktura-funkcija u ćelijskom zidu biljaka i izmene strukture zida enzimskim inženjeringom (RS-MESTD-Basic Research (BR or ON)-173017)
- 0-3D nanostrukture za primenu u elektronici i obnovljivim izvorima energije: sinteza, karakterizacija i procesiranje (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-45007)
- Interakcije membrana sa unutarćelijskim i apoplastičnim prostorom: izučavanja bioenergetike i singalizacije koristeći biofizičke i biohemijske metode (RS-MESTD-Basic Research (BR or ON)-173040)
- Karakterizacija i primena metabolita gljiva i utvrđivanje potencijala novih biofungicida (RS-MESTD-Basic Research (BR or ON)-173032)
Napomena:
- This is the peered review of the paper: Zmejkoski, D., Spasojević, D., Orlovska, I., Kozyrovska, N., Soković, M., Glamoclija, J., Dmitrović, S., Matović, B., Tasić, N., Maksimović, V., Sosnin, M.,& Radotić, K.. (2018). Bacterial cellulose-lignin composite hydrogel as a promising agent in chronic wound healing. in International Journal of Biological Macromolecules Elsevier, Amsterdam., 118, 494-503. https://doi.org/10.1016/j.ijbiomac.2018.06.067 conv_590
DOI: 10.1016/j.ijbiomac.2018.06.067
ISSN: 0141-8130
PubMed: 29909035
WoS: 000445170200057
Scopus: 2-s2.0-85049108073
Institucija/grupa
Institut za multidisciplinarna istraživanjaTY - JOUR AU - Zmejkoski, Danica AU - Spasojević, Dragica AU - Orlovska, Irina AU - Kozyrovska, Natalia AU - Soković, Marina AU - Glamočlija, Jasmina AU - Dmitrović, Svetlana AU - Matović, Branko AU - Tasić, Nikola AU - Maksimović, Vuk AU - Sosnin, Mikhail AU - Radotić, Ksenija PY - 2018 UR - http://rimsi.imsi.bg.ac.rs/handle/123456789/1157 AB - Lignins and lignin-derived compounds are known to have antibacterial properties. The wound healing agents in the form of dressings produce faster skin repair and decrease pain in patients. In order to create an efficient antimicrobial agent in the form of dressing in the treatment of chronic wounds, a composite hydrogel of bacterial cellulose (BC) and dehydrogenative polymer of coniferyl alcohol (DHP), BC-DHP, was designed. Novel composite showed inhibitory or bactericidal effects against selected pathogenic bacteria, including clinically isolated ones. The highest release rate of DHP was in the first hour, while after 24 h there was still slow release of small amounts of DHP from BC-DHP during 72 h monitoring. High-performance liquid chromatography coupled with mass-spectrometry showed that BC-DHP releases DHP oligomers, which are proposed to be antimicrobially active DHP fractions. Scanning electron microscopy and atomic force microscopy micrographs proved a dose-dependent interaction of DHP with BC, which resulted in a decrease of the pore number and size in the cellulose membrane. The Fourier-transform infrared absorption spectra of the BC-DHP showed that DHP was partly bound to the BC matrix. The swelling and crystallinity degree were dose-dependent. All obtained results confirmed BC-DHP composite as a promising hydrogel for wounds healing. PB - Elsevier, Amsterdam T2 - International Journal of Biological Macromolecules T1 - Bacterial cellulose-lignin composite hydrogel as a promising agent in chronic wound healing EP - 503 SP - 494 VL - 118 DO - 10.1016/j.ijbiomac.2018.06.067 ER -
@article{ author = "Zmejkoski, Danica and Spasojević, Dragica and Orlovska, Irina and Kozyrovska, Natalia and Soković, Marina and Glamočlija, Jasmina and Dmitrović, Svetlana and Matović, Branko and Tasić, Nikola and Maksimović, Vuk and Sosnin, Mikhail and Radotić, Ksenija", year = "2018", abstract = "Lignins and lignin-derived compounds are known to have antibacterial properties. The wound healing agents in the form of dressings produce faster skin repair and decrease pain in patients. In order to create an efficient antimicrobial agent in the form of dressing in the treatment of chronic wounds, a composite hydrogel of bacterial cellulose (BC) and dehydrogenative polymer of coniferyl alcohol (DHP), BC-DHP, was designed. Novel composite showed inhibitory or bactericidal effects against selected pathogenic bacteria, including clinically isolated ones. The highest release rate of DHP was in the first hour, while after 24 h there was still slow release of small amounts of DHP from BC-DHP during 72 h monitoring. High-performance liquid chromatography coupled with mass-spectrometry showed that BC-DHP releases DHP oligomers, which are proposed to be antimicrobially active DHP fractions. Scanning electron microscopy and atomic force microscopy micrographs proved a dose-dependent interaction of DHP with BC, which resulted in a decrease of the pore number and size in the cellulose membrane. The Fourier-transform infrared absorption spectra of the BC-DHP showed that DHP was partly bound to the BC matrix. The swelling and crystallinity degree were dose-dependent. All obtained results confirmed BC-DHP composite as a promising hydrogel for wounds healing.", publisher = "Elsevier, Amsterdam", journal = "International Journal of Biological Macromolecules", title = "Bacterial cellulose-lignin composite hydrogel as a promising agent in chronic wound healing", pages = "503-494", volume = "118", doi = "10.1016/j.ijbiomac.2018.06.067" }
Zmejkoski, D., Spasojević, D., Orlovska, I., Kozyrovska, N., Soković, M., Glamočlija, J., Dmitrović, S., Matović, B., Tasić, N., Maksimović, V., Sosnin, M.,& Radotić, K.. (2018). Bacterial cellulose-lignin composite hydrogel as a promising agent in chronic wound healing. in International Journal of Biological Macromolecules Elsevier, Amsterdam., 118, 494-503. https://doi.org/10.1016/j.ijbiomac.2018.06.067
Zmejkoski D, Spasojević D, Orlovska I, Kozyrovska N, Soković M, Glamočlija J, Dmitrović S, Matović B, Tasić N, Maksimović V, Sosnin M, Radotić K. Bacterial cellulose-lignin composite hydrogel as a promising agent in chronic wound healing. in International Journal of Biological Macromolecules. 2018;118:494-503. doi:10.1016/j.ijbiomac.2018.06.067 .
Zmejkoski, Danica, Spasojević, Dragica, Orlovska, Irina, Kozyrovska, Natalia, Soković, Marina, Glamočlija, Jasmina, Dmitrović, Svetlana, Matović, Branko, Tasić, Nikola, Maksimović, Vuk, Sosnin, Mikhail, Radotić, Ksenija, "Bacterial cellulose-lignin composite hydrogel as a promising agent in chronic wound healing" in International Journal of Biological Macromolecules, 118 (2018):494-503, https://doi.org/10.1016/j.ijbiomac.2018.06.067 . .