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Mechanisms of redox interactions of bilirubin with copper and the effects of penicillamine
dc.creator | Bozic, Bojana | |
dc.creator | Korać Jačić, Jelena | |
dc.creator | Stanković, Dalibor M. | |
dc.creator | Stanić, Marina | |
dc.creator | Popovic-Bijelic, Ana | |
dc.creator | Bogdanović Pristov, Jelena | |
dc.creator | Spasojević, Ivan | |
dc.creator | Bajčetić, Milica | |
dc.date.accessioned | 2022-04-05T15:07:57Z | |
dc.date.available | 2022-04-05T15:07:57Z | |
dc.date.issued | 2017 | |
dc.identifier.issn | 0009-2797 | |
dc.identifier.uri | http://rimsi.imsi.bg.ac.rs/handle/123456789/1044 | |
dc.description.abstract | Toxic effects of unconjugated bilirubin (BR) in neonatal hyperbilirubinemia have been related to redox and/or coordinate interactions with Cu2+. However, the development and mechanisms of such interactions at physiological pH have not been resolved. This study shows that BR reduces Cu2+ to Cu1+ in 1:1 stoichiometry. Apparently, BR undergoes degradation, i.e. BR and Cu2+ do not form stable complexes. The binding of Cu2+ to inorganic phosphates, liposomal phosphate groups, or to chelating drug penicillamine, impedes redox interactions with BR. Cu1+ undergoes spontaneous oxidation by O-2 resulting in hydrogen peroxide accumulation and hydroxyl radical production. In relation to this, copper and BR induced synergistic oxidative/damaging effects on erythrocytes membrane, which were alleviated by penicillamine. The production of reactive oxygen species by BR and copper represents a plausible cause of BR toxic effects and cell damage in hyperbilirubinemia. Further examination of therapeutic potentials of copper chelators in the treatment of severe neonatal hyperbilirubinemia is needed. | en |
dc.publisher | Elsevier Ireland Ltd, Clare | |
dc.relation | Magbiovin project (FP7-ERA Chairs-Pilot Call) [621375] | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173014/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173017/RS// | |
dc.rights | restrictedAccess | |
dc.source | Chemico-Biological Interactions | |
dc.subject | Superoxide | en |
dc.subject | Lipid peroxidation | en |
dc.subject | Hyperbilirubinemia | en |
dc.subject | Hydrogen peroxide | en |
dc.subject | Erythrocytes | en |
dc.title | Mechanisms of redox interactions of bilirubin with copper and the effects of penicillamine | en |
dc.type | article | |
dc.rights.license | ARR | |
dc.citation.epage | 134 | |
dc.citation.other | 278: 129-134 | |
dc.citation.rank | M21 | |
dc.citation.spage | 129 | |
dc.citation.volume | 278 | |
dc.identifier.doi | 10.1016/j.cbi.2017.10.022 | |
dc.identifier.pmid | 29079291 | |
dc.identifier.scopus | 2-s2.0-85032258652 | |
dc.identifier.wos | 000418302000016 | |
dc.type.version | publishedVersion |