Приказ основних података о документу
Diethyldithiocarbamate potentiates the effects of protamine sulphate in the isolated rat uterus
dc.creator | Oreščanin-Dušić, Zorana | |
dc.creator | Milovanović, Slobodan | |
dc.creator | Blagojević, Duško | |
dc.creator | Nikolić-Kokić, Aleksandra | |
dc.creator | Radojicic, Ratko | |
dc.creator | Spasojević, Ivan | |
dc.creator | Spasić, Mihajlo | |
dc.date.accessioned | 2022-04-05T14:20:54Z | |
dc.date.available | 2022-04-05T14:20:54Z | |
dc.date.issued | 2009 | |
dc.identifier.issn | 1351-0002 | |
dc.identifier.uri | http://rimsi.imsi.bg.ac.rs/handle/123456789/335 | |
dc.description.abstract | Protamine sulphate causes potassium ion channel-mediated relaxation of spontaneous and calcium ion-induced contractions of the isolated rat uterus. Diethyldithiocarbamate (DDC) potentiated the effect of protamine sulphate. A mechanism for DDC's action was postulated on the basis of its interactions with divalent iron ions and Cui Zn-SOD. DDC chelates divalent iron ions creating DDC-iron (Fe-DDC) complexes. Fe-DDC forms stable NO-Fe-DDC2 complexes by NO scavenging and de-nitrosylation processes, which in combination with DDC (5 mM) provoke inhibition of Cui Zn-SOD resulting in specific oxidative conditions culminating in potassium ion channel opening, membrane hyperpolarisation, inhibition of calcium ion influx and subsequent muscle relaxation. As Fe-DDC and NO-Fe-DDC2 complexes exclude divalent iron ions from participating in the hydroxy radical generating Fenton reaction, DDC can also prevent iron-related pathophysiological manifestations. Such permissive roles of DDC open the possibility for application of its pharmacological form (disulfiram) to a wider spectrum of pathophysiological conditions related to smooth muscles. | en |
dc.publisher | Taylor & Francis Ltd, Abingdon | |
dc.relation | info:eu-repo/grantAgreement/MESTD/MPN2006-2010/143034/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/MPN2006-2010/143016/RS// | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | |
dc.source | Redox Report | |
dc.subject | uterus | en |
dc.subject | protamine sulphate | en |
dc.subject | nitric oxide | en |
dc.subject | diethyldithiocarbamate | en |
dc.title | Diethyldithiocarbamate potentiates the effects of protamine sulphate in the isolated rat uterus | en |
dc.type | article | |
dc.rights.license | BY-NC | |
dc.citation.epage | 54 | |
dc.citation.issue | 2 | |
dc.citation.other | 14(2): 48-54 | |
dc.citation.rank | M23 | |
dc.citation.spage | 48 | |
dc.citation.volume | 14 | |
dc.identifier.doi | 10.1179/135100009X392476 | |
dc.identifier.fulltext | http://rimsi.imsi.bg.ac.rs/bitstream/id/583/332.pdf | |
dc.identifier.pmid | 19389271 | |
dc.identifier.scopus | 2-s2.0-69249116672 | |
dc.identifier.wos | 000265636800001 | |
dc.type.version | publishedVersion |