dc.creator | Karaman, Maja | |
dc.creator | Tesanović, Kristina | |
dc.creator | Novaković, Aleksandra | |
dc.creator | Jakovljević, Dragica | |
dc.creator | Janjusević, Ljiljana | |
dc.creator | Sibul, Filip | |
dc.creator | Pejin, Boris | |
dc.date.accessioned | 2022-04-05T15:26:17Z | |
dc.date.available | 2022-04-05T15:26:17Z | |
dc.date.issued | 2020 | |
dc.identifier.issn | 1478-6419 | |
dc.identifier.uri | http://rimsi.imsi.bg.ac.rs/handle/123456789/1318 | |
dc.description.abstract | In vitroacetylholinesterase (AChE) inhibitory activity of an autochthonous sample of the mushroomCoprinus comatus(encompassing fruiting body FB, mycelia M and filtrate F from the submerged cultivation) was the subject of this study.C. comatusF extract exhibited rather potent anti-AChE activity (73.0 +/- 1.5%) atin liquidconditions, comparable to those of the conventional drug donepezil (80.6 +/- 1.4%). Also, the same extract exhibited high anti-AChE activity (1 mu g)in solid. While its FTIR spectrum indicated the presence of phenolic compounds, quercetin (28.1 mu g g(-1)d.w.) was found to affect the observed bioactivity (59.8 +/- 0.9%). This is the first report of profound anti-AChE activity of anyC. comatusextract, a medicinal mushroom that has been successfully cultivated in P.R. China, due to the demanding needs of food industry. | en |
dc.publisher | Taylor & Francis Ltd, Abingdon | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172053/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172058/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173040/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/43002/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/43010/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/46001/RS// | |
dc.rights | restrictedAccess | |
dc.source | Natural Product Research | |
dc.subject | quercetin | en |
dc.subject | polyphenolic profile | en |
dc.subject | new AD health promoting product | en |
dc.subject | Coprinus comatusfiltrate extract | en |
dc.subject | AChE inhibitory activity | en |
dc.title | Coprinus comatusfiltrate extract, a novel neuroprotective agent of natural origin | en |
dc.type | article | |
dc.rights.license | ARR | |
dc.citation.epage | 2350 | |
dc.citation.issue | 16 | |
dc.citation.other | 34(16): 2346-2350 | |
dc.citation.rank | M22 | |
dc.citation.spage | 2346 | |
dc.citation.volume | 34 | |
dc.identifier.doi | 10.1080/14786419.2018.1533831 | |
dc.identifier.pmid | 30450967 | |
dc.identifier.scopus | 2-s2.0-85057546516 | |
dc.identifier.wos | 000561132800017 | |
dc.type.version | publishedVersion | |