Sedative and anxiolytic-like activities of the moss Rhodobryum ontariense water extract in rodents: a preliminary study
Abstract
This is the first study designed to explore behavioral effects of the water extract of the moss Rhodobryum ontariense (ROE). Experimental adult animals received intraperitoneal injections of ROE (50-400 mg/kg; vs. saline) 45 min before behavioural evaluation. Motor effects of ROE were estimated in male mice using the open field test (OFT), whereas the elevated plus maze (EPM) model of anxiety was applied on male rats. Single ROE treatments significantly decreased motor activity of mice in OFT (p lt 0.001) by reducing both the percentage of activity time and the distance travelled in 15 min Also, ROE in rats significantly increased (p lt 0.05) the percentage of time spent in open arms and the number of open-arm-entries during 5 min, which was similar to the actions of diazepam in rats (1 mg/kg). These results demonstrated that ROE produced motor sedation and anxiolytic-like effects in rodents.
Keywords:
Water extract / Sedation / Rhodobryum ontariense / Open field test / Elevated plus mazeSource:
Cryptogamie Bryologie, 2013, 34, 1, 49-54Publisher:
- Adac-Cryptogamie, Paris
Funding / projects:
- Biological effects, nutritional intake and status of folate and polysaturate fatty acid (PUFA): improvement of nutrition in Serbia (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41030)
- The membranes as sites of interaction between the intracellular and apoplastic environments: studies of the bioenergetics and signaling using biophysical and biochemical techniques. (RS-MESTD-Basic Research (BR or ON)-173040)
DOI: 10.7872/cryb.v34.iss1.2013.49
ISSN: 1290-0796
WoS: 000315174900005
Scopus: 2-s2.0-84874632116
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Institution/Community
Institut za multidisciplinarna istraživanjaTY - JOUR AU - Pejin, Boris AU - Tovilović, Gordana I AU - Ignjatović, Djurdjica S AU - Kien-Thai, Yong AU - Tomic, Mirko D PY - 2013 UR - http://rimsi.imsi.bg.ac.rs/handle/123456789/635 AB - This is the first study designed to explore behavioral effects of the water extract of the moss Rhodobryum ontariense (ROE). Experimental adult animals received intraperitoneal injections of ROE (50-400 mg/kg; vs. saline) 45 min before behavioural evaluation. Motor effects of ROE were estimated in male mice using the open field test (OFT), whereas the elevated plus maze (EPM) model of anxiety was applied on male rats. Single ROE treatments significantly decreased motor activity of mice in OFT (p lt 0.001) by reducing both the percentage of activity time and the distance travelled in 15 min Also, ROE in rats significantly increased (p lt 0.05) the percentage of time spent in open arms and the number of open-arm-entries during 5 min, which was similar to the actions of diazepam in rats (1 mg/kg). These results demonstrated that ROE produced motor sedation and anxiolytic-like effects in rodents. PB - Adac-Cryptogamie, Paris T2 - Cryptogamie Bryologie T1 - Sedative and anxiolytic-like activities of the moss Rhodobryum ontariense water extract in rodents: a preliminary study EP - 54 IS - 1 SP - 49 VL - 34 DO - 10.7872/cryb.v34.iss1.2013.49 ER -
@article{ author = "Pejin, Boris and Tovilović, Gordana I and Ignjatović, Djurdjica S and Kien-Thai, Yong and Tomic, Mirko D", year = "2013", abstract = "This is the first study designed to explore behavioral effects of the water extract of the moss Rhodobryum ontariense (ROE). Experimental adult animals received intraperitoneal injections of ROE (50-400 mg/kg; vs. saline) 45 min before behavioural evaluation. Motor effects of ROE were estimated in male mice using the open field test (OFT), whereas the elevated plus maze (EPM) model of anxiety was applied on male rats. Single ROE treatments significantly decreased motor activity of mice in OFT (p lt 0.001) by reducing both the percentage of activity time and the distance travelled in 15 min Also, ROE in rats significantly increased (p lt 0.05) the percentage of time spent in open arms and the number of open-arm-entries during 5 min, which was similar to the actions of diazepam in rats (1 mg/kg). These results demonstrated that ROE produced motor sedation and anxiolytic-like effects in rodents.", publisher = "Adac-Cryptogamie, Paris", journal = "Cryptogamie Bryologie", title = "Sedative and anxiolytic-like activities of the moss Rhodobryum ontariense water extract in rodents: a preliminary study", pages = "54-49", number = "1", volume = "34", doi = "10.7872/cryb.v34.iss1.2013.49" }
Pejin, B., Tovilović, G. I., Ignjatović, D. S., Kien-Thai, Y.,& Tomic, M. D.. (2013). Sedative and anxiolytic-like activities of the moss Rhodobryum ontariense water extract in rodents: a preliminary study. in Cryptogamie Bryologie Adac-Cryptogamie, Paris., 34(1), 49-54. https://doi.org/10.7872/cryb.v34.iss1.2013.49
Pejin B, Tovilović GI, Ignjatović DS, Kien-Thai Y, Tomic MD. Sedative and anxiolytic-like activities of the moss Rhodobryum ontariense water extract in rodents: a preliminary study. in Cryptogamie Bryologie. 2013;34(1):49-54. doi:10.7872/cryb.v34.iss1.2013.49 .
Pejin, Boris, Tovilović, Gordana I, Ignjatović, Djurdjica S, Kien-Thai, Yong, Tomic, Mirko D, "Sedative and anxiolytic-like activities of the moss Rhodobryum ontariense water extract in rodents: a preliminary study" in Cryptogamie Bryologie, 34, no. 1 (2013):49-54, https://doi.org/10.7872/cryb.v34.iss1.2013.49 . .