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Synthesis, characterization and biological activity of platinum(II) and palladium(II) complexes with quinoline derivatives of thiosemicarbazones
dc.creator | Vukašinović, Jelena | |
dc.creator | Babic, Nikolina | |
dc.creator | Todorović, Tamara | |
dc.creator | Filipović, Nenad | |
dc.date.accessioned | 2023-08-16T17:30:44Z | |
dc.date.available | 2023-08-16T17:30:44Z | |
dc.date.issued | 2016 | |
dc.identifier.isbn | 978-86-7132-064-1 | |
dc.identifier.uri | http://rimsi.imsi.bg.ac.rs/handle/123456789/2079 | |
dc.description.abstract | The aim of this study was to elucidate the structure, geometry and biological activity of platinum(II) and palladium(II) complexes with different quinoline derivatives of thiosemicar-bazones. Four novel platinum(II) and palladium(II) complexes with 2-quinolinecarboxaldehyde thiosemikarbazone (H2QATSC) and 8-quinolinecarboxaldehyde thiosemikarbazone (H8QATSC) were synthesized. The complexes of platinum(II) and palladium(II) with H2QATSC ligand, [PtCl(2QATSC)] (1) and [PdCl(2QATSC)] (2), were synthesized by direct reaction and charac-terized by single crystal X-ray analysis. The complexes of platinum(II) and palladium(II) with H8QATSC ligand, [PtCl(8QATSC)] (3) and [PdCl(8QATSC)] (4), were characterized by NMR spectroscopy. In the complexes 1–4 ligands are coordinated tridentately via the quinoline and imine nitrogen atoms and thiosemicarbazone sulfur atom, forming two five-membered rings with metal ion. The geometry around metal ions is square-planar, where chloride ion occupies fourth coordination site. Antitumor activity of the complexes 1–4 was investigated and com-pared with the activity of cisplatin. | sr |
dc.language.iso | en | sr |
dc.publisher | Serbian Chemical Society | sr |
dc.relation | Ministry of Education, Science and Technological Development of the Republic of Serbia | sr |
dc.rights | openAccess | sr |
dc.source | 4th Conference of Young Chemists of Serbia, 5 November, 2016, Belgrade, Serbia | sr |
dc.subject | Biological activity | sr |
dc.subject | Platinum(II) | sr |
dc.subject | Palladium(II) | sr |
dc.subject | Quinoline derivatives of thiosemicarbazones | sr |
dc.subject | Antitumor activity | sr |
dc.title | Synthesis, characterization and biological activity of platinum(II) and palladium(II) complexes with quinoline derivatives of thiosemicarbazones | sr |
dc.type | conferenceObject | sr |
dc.rights.license | ARR | sr |
dc.citation.spage | 37 | |
dc.identifier.fulltext | http://rimsi.imsi.bg.ac.rs/bitstream/id/5466/bitstream_5466.pdf | |
dc.identifier.rcub | https://hdl.handle.net/21.15107/rcub_rimsi_2079 | |
dc.type.version | publishedVersion | sr |