A perspective view on the nanomotion detection of living organisms and its features
Samo za registrovane korisnike
2020
Autori
Venturelli, LeonardoKohler, Anne-Celine
Stupar, Petar
Villalba, Maria, I
Kalauzi, Aleksandar
Radotić, Ksenija
Bertacchi, Massimiliano
Dinarelli, Simone
Girasole, Marco
Pesic, Milica
Banković, Jasna
Vela, Maria E.
Yantorno, Osvaldo
Willaert, Ronnie
Dietler, Giovanni
Longo, Giovanni
Kasas, Sandor
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
The insurgence of newly arising, rapidly developing health threats, such as drug-resistant bacteria and cancers, is one of the most urgent public-health issues of modern times. This menace calls for the development of sensitive and reliable diagnostic tools to monitor the response of single cells to chemical or pharmaceutical stimuli. Recently, it has been demonstrated that all living organisms oscillate at a nanometric scale and that these oscillations stop as soon as the organisms die. These nanometric scale oscillations can be detected by depositing living cells onto a micro-fabricated cantilever and by monitoring its displacements with an atomic force microscope-based electronics. Such devices, named nanomotion sensors, have been employed to determine the resistance profiles of life-threatening bacteria within minutes, to evaluate, among others, the effect of chemicals on yeast, neurons, and cancer cells. The data obtained so far demonstrate the advantages of nanomotion sensing dev...ices in rapidly characterizing microorganism susceptibility to pharmaceutical agents. Here, we review the key aspects of this technique, presenting its major applications. and detailing its working protocols.
Ključne reči:
single cell investigation / nanomotion / nanomechanical sensors / nanobiosensors / cellular metabolism / antibiotic susceptibility test / AFMIzvor:
Journal of Molecular Recognition, 2020, 33, 12Izdavač:
- Wiley, Hoboken
Finansiranje / projekti:
- Agencia Nacional de Promocion Cientifica y TecnologicaANPCyT [PICT 2016-0679, PICT 2017-2444, PUE 22920170100100CO]
- European Space AgencyEuropean Space AgencyEuropean Commission [PRODEX]
- Gebert Ruf Stiftung [GRS-024/14]
- Ministero della SaluteMinistry of Health, Italy [GR-2009-1605007]
- NASA Exoplanet Science Institute [NNH16ZDA001N-CLDTCH]
- Schweizerischer Nationalfonds zur Forderung der Wissenschaftlichen ForschungAustrian Science Fund (FWF) [200021-144321, 407240-167137, CRSII5_173863]
- Federaal Wetenschapsbeleid
- Identifikacija molekularnih markera za predikciju progresije tumora, odgovora na terapiju i ishoda bolesti (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-41031)
- Ispitivanja odnosa struktura-funkcija u ćelijskom zidu biljaka i izmene strukture zida enzimskim inženjeringom (RS-MESTD-Basic Research (BR or ON)-173017)
DOI: 10.1002/jmr.2849
ISSN: 0952-3499
PubMed: 32227521
WoS: 000522282700001
Scopus: 2-s2.0-85082526069
Institucija/grupa
Institut za multidisciplinarna istraživanjaTY - JOUR AU - Venturelli, Leonardo AU - Kohler, Anne-Celine AU - Stupar, Petar AU - Villalba, Maria, I AU - Kalauzi, Aleksandar AU - Radotić, Ksenija AU - Bertacchi, Massimiliano AU - Dinarelli, Simone AU - Girasole, Marco AU - Pesic, Milica AU - Banković, Jasna AU - Vela, Maria E. AU - Yantorno, Osvaldo AU - Willaert, Ronnie AU - Dietler, Giovanni AU - Longo, Giovanni AU - Kasas, Sandor PY - 2020 UR - http://rimsi.imsi.bg.ac.rs/handle/123456789/1338 AB - The insurgence of newly arising, rapidly developing health threats, such as drug-resistant bacteria and cancers, is one of the most urgent public-health issues of modern times. This menace calls for the development of sensitive and reliable diagnostic tools to monitor the response of single cells to chemical or pharmaceutical stimuli. Recently, it has been demonstrated that all living organisms oscillate at a nanometric scale and that these oscillations stop as soon as the organisms die. These nanometric scale oscillations can be detected by depositing living cells onto a micro-fabricated cantilever and by monitoring its displacements with an atomic force microscope-based electronics. Such devices, named nanomotion sensors, have been employed to determine the resistance profiles of life-threatening bacteria within minutes, to evaluate, among others, the effect of chemicals on yeast, neurons, and cancer cells. The data obtained so far demonstrate the advantages of nanomotion sensing devices in rapidly characterizing microorganism susceptibility to pharmaceutical agents. Here, we review the key aspects of this technique, presenting its major applications. and detailing its working protocols. PB - Wiley, Hoboken T2 - Journal of Molecular Recognition T1 - A perspective view on the nanomotion detection of living organisms and its features IS - 12 VL - 33 DO - 10.1002/jmr.2849 ER -
@article{ author = "Venturelli, Leonardo and Kohler, Anne-Celine and Stupar, Petar and Villalba, Maria, I and Kalauzi, Aleksandar and Radotić, Ksenija and Bertacchi, Massimiliano and Dinarelli, Simone and Girasole, Marco and Pesic, Milica and Banković, Jasna and Vela, Maria E. and Yantorno, Osvaldo and Willaert, Ronnie and Dietler, Giovanni and Longo, Giovanni and Kasas, Sandor", year = "2020", abstract = "The insurgence of newly arising, rapidly developing health threats, such as drug-resistant bacteria and cancers, is one of the most urgent public-health issues of modern times. This menace calls for the development of sensitive and reliable diagnostic tools to monitor the response of single cells to chemical or pharmaceutical stimuli. Recently, it has been demonstrated that all living organisms oscillate at a nanometric scale and that these oscillations stop as soon as the organisms die. These nanometric scale oscillations can be detected by depositing living cells onto a micro-fabricated cantilever and by monitoring its displacements with an atomic force microscope-based electronics. Such devices, named nanomotion sensors, have been employed to determine the resistance profiles of life-threatening bacteria within minutes, to evaluate, among others, the effect of chemicals on yeast, neurons, and cancer cells. The data obtained so far demonstrate the advantages of nanomotion sensing devices in rapidly characterizing microorganism susceptibility to pharmaceutical agents. Here, we review the key aspects of this technique, presenting its major applications. and detailing its working protocols.", publisher = "Wiley, Hoboken", journal = "Journal of Molecular Recognition", title = "A perspective view on the nanomotion detection of living organisms and its features", number = "12", volume = "33", doi = "10.1002/jmr.2849" }
Venturelli, L., Kohler, A., Stupar, P., Villalba, M. I., Kalauzi, A., Radotić, K., Bertacchi, M., Dinarelli, S., Girasole, M., Pesic, M., Banković, J., Vela, M. E., Yantorno, O., Willaert, R., Dietler, G., Longo, G.,& Kasas, S.. (2020). A perspective view on the nanomotion detection of living organisms and its features. in Journal of Molecular Recognition Wiley, Hoboken., 33(12). https://doi.org/10.1002/jmr.2849
Venturelli L, Kohler A, Stupar P, Villalba MI, Kalauzi A, Radotić K, Bertacchi M, Dinarelli S, Girasole M, Pesic M, Banković J, Vela ME, Yantorno O, Willaert R, Dietler G, Longo G, Kasas S. A perspective view on the nanomotion detection of living organisms and its features. in Journal of Molecular Recognition. 2020;33(12). doi:10.1002/jmr.2849 .
Venturelli, Leonardo, Kohler, Anne-Celine, Stupar, Petar, Villalba, Maria, I, Kalauzi, Aleksandar, Radotić, Ksenija, Bertacchi, Massimiliano, Dinarelli, Simone, Girasole, Marco, Pesic, Milica, Banković, Jasna, Vela, Maria E., Yantorno, Osvaldo, Willaert, Ronnie, Dietler, Giovanni, Longo, Giovanni, Kasas, Sandor, "A perspective view on the nanomotion detection of living organisms and its features" in Journal of Molecular Recognition, 33, no. 12 (2020), https://doi.org/10.1002/jmr.2849 . .