TY  - CONF
AU  - Štrbac, Filip
AU  - Simin, Nataša
AU  - Orčić, Dejan
AU  - Krnjajić, Slobodan
AU  - Bosco, Antonio
AU  - Stojanović, Dragica
AU  - Ratajac, Radomir
AU  - Cringoli, Giuseppe
AU  - Rinaldi, Laura
PY  - 2023
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/2137
AB  - Plants of the genus Mentha are well-known for their various medicinal properties including anti-inflammatory, antiemetic, antispasmodic, analgesic and antiparasitic effects, which are used for the treatment of various gastrointestinal and respiratory diseases. The aim of this study was to determine the chemical composition of the essential oils (EOs) of two Mentha species, peppermint (M. piperita) and spearmint (M. spicata), and to evaluate their anthelmintic activity against gastrointestinal nematodes, parasites that have a significantly negative impact on modern sheep farming. The main compounds of peppermint EO, determined by GC-MS analyses, were menthol (32.6%), menthone (22.0%) and isomenthone (9.39%), and those of spearmint were carvone (64.4%), trans-4-caranone (8.67%) and limonene (4.37%). Their anthelmintic effects, assesed using the egg hatch test conducted at eight different concentrations (50, 12.5, 3.125, 0.781, 0.195, 0.049, 0.025 and 0.0125 mg/ml), were 20.0-90.3% and 13.0-93.7%, respectively. Although both tested samples showed high and dose-dependent (R2 = 0.93 and 0.96, respectively) anthelmintic
potential, their effect was significantly different at five concentrations (p<0.05). The obtained results suggest the high influence of differences in chemical composition of EOs on their pharmacological properties, although the samples were extracted from similar plant species. These should not be neglected during the preparation of formulation, which is important for finding alternatives to combat resistance in nematode.
PB  - Faculty of Chemistry, University of Belgrade; Serbian Biochemical Society
C3  - Serbian Biochemical Society Twelfth Conference (international scientific meeting) - “Biochemistry in Biotechnology”
T1  - Differences in Chemical Composition of the Essential Oils of Peppermint (Mentha x piperita L.) and Spearmint (Mentha spicata L.) and their Anthelmintic Properties
EP  - 113
SP  - 113
UR  - https://hdl.handle.net/21.15107/rcub_rimsi_2137
ER  - 

@conference{
author = "Štrbac, Filip and Simin, Nataša and Orčić, Dejan and Krnjajić, Slobodan and Bosco, Antonio and Stojanović, Dragica and Ratajac, Radomir and Cringoli, Giuseppe and Rinaldi, Laura",
year = "2023",
abstract = "Plants of the genus Mentha are well-known for their various medicinal properties including anti-inflammatory, antiemetic, antispasmodic, analgesic and antiparasitic effects, which are used for the treatment of various gastrointestinal and respiratory diseases. The aim of this study was to determine the chemical composition of the essential oils (EOs) of two Mentha species, peppermint (M. piperita) and spearmint (M. spicata), and to evaluate their anthelmintic activity against gastrointestinal nematodes, parasites that have a significantly negative impact on modern sheep farming. The main compounds of peppermint EO, determined by GC-MS analyses, were menthol (32.6%), menthone (22.0%) and isomenthone (9.39%), and those of spearmint were carvone (64.4%), trans-4-caranone (8.67%) and limonene (4.37%). Their anthelmintic effects, assesed using the egg hatch test conducted at eight different concentrations (50, 12.5, 3.125, 0.781, 0.195, 0.049, 0.025 and 0.0125 mg/ml), were 20.0-90.3% and 13.0-93.7%, respectively. Although both tested samples showed high and dose-dependent (R2 = 0.93 and 0.96, respectively) anthelmintic
potential, their effect was significantly different at five concentrations (p<0.05). The obtained results suggest the high influence of differences in chemical composition of EOs on their pharmacological properties, although the samples were extracted from similar plant species. These should not be neglected during the preparation of formulation, which is important for finding alternatives to combat resistance in nematode.",
publisher = "Faculty of Chemistry, University of Belgrade; Serbian Biochemical Society",
journal = "Serbian Biochemical Society Twelfth Conference (international scientific meeting) - “Biochemistry in Biotechnology”",
title = "Differences in Chemical Composition of the Essential Oils of Peppermint (Mentha x piperita L.) and Spearmint (Mentha spicata L.) and their Anthelmintic Properties",
pages = "113-113",
url = "https://hdl.handle.net/21.15107/rcub_rimsi_2137"
}

Štrbac, F., Simin, N., Orčić, D., Krnjajić, S., Bosco, A., Stojanović, D., Ratajac, R., Cringoli, G.,& Rinaldi, L.. (2023). Differences in Chemical Composition of the Essential Oils of Peppermint (Mentha x piperita L.) and Spearmint (Mentha spicata L.) and their Anthelmintic Properties. in Serbian Biochemical Society Twelfth Conference (international scientific meeting) - “Biochemistry in Biotechnology”
Faculty of Chemistry, University of Belgrade; Serbian Biochemical Society., 113-113.
https://hdl.handle.net/21.15107/rcub_rimsi_2137

Štrbac F, Simin N, Orčić D, Krnjajić S, Bosco A, Stojanović D, Ratajac R, Cringoli G, Rinaldi L. Differences in Chemical Composition of the Essential Oils of Peppermint (Mentha x piperita L.) and Spearmint (Mentha spicata L.) and their Anthelmintic Properties. in Serbian Biochemical Society Twelfth Conference (international scientific meeting) - “Biochemistry in Biotechnology”. 2023;:113-113.
https://hdl.handle.net/21.15107/rcub_rimsi_2137 .

Štrbac, Filip, Simin, Nataša, Orčić, Dejan, Krnjajić, Slobodan, Bosco, Antonio, Stojanović, Dragica, Ratajac, Radomir, Cringoli, Giuseppe, Rinaldi, Laura, "Differences in Chemical Composition of the Essential Oils of Peppermint (Mentha x piperita L.) and Spearmint (Mentha spicata L.) and their Anthelmintic Properties" in Serbian Biochemical Society Twelfth Conference (international scientific meeting) - “Biochemistry in Biotechnology” (2023):113-113,
https://hdl.handle.net/21.15107/rcub_rimsi_2137 .