TY  - CHAP
AU  - Opačić, Miloš
AU  - Ristic, Aleksandar J
AU  - Savic, Danijela
AU  - Selih, Vid Simon
AU  - Zivin, Marko
AU  - Sokic, Dragoslav
AU  - Raičević, Savo
AU  - Bascarevic, Vladimir
AU  - Spasojević, Ivan
PY  - 2017
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/2938
AB  - Mesial temporal lobe epilepsy (mTLE) represents the most common subtype of human
focal epilepsies and perhaps the best-characterized disorder of this type 1
. Hippocampal
sclerosis (HS) is the most common histopathologic abnormality found in adults with drugresistant mTLE 2
. The histopathologic hallmark of HS is segmental pyramidal cell loss,
which can affect any field of the cornu Ammonis (CA1-4). Hippocampal neuronal cell loss
is always associated with a severe pattern of astrogliosis 3
. Therewithal, disturbed
homeostasis of metals is implicated in the pathology of mTLE-HS. Zinc has been
considered to play a major role in epileptogenesis in relation to its involvement in the
modulation of excitability and synaptic plasticity 4,5. Further, it has been shown that
epileptogenic hippocampi are exposed to oxidative stress and that the development of prooxidative conditions in the CNS usually involves the loss of homeostasis of iron 6,7. Low
brain levels of copper and manganese have been reported in patients with Menkes disease
and in animal models of epilepsy, and linked to seizure development 8,9. Ristić et al. were
the first to conduct a case-control study of total concentration of metals in tissue of human
HS, and report lower concentrations of copper and manganese 10.
PB  - Biohemijsko društvo Srbije
T2  - Biochemistry of Control in Life and Technology
T1  - Imaging and regional distribution of copper, zinc, manganese and iron in sclerotic hippocampi of patients with mesial temporal lobe epilepsy
EP  - 181
SP  - 179
UR  - https://hdl.handle.net/21.15107/rcub_rimsi_2938
ER  - 

@inbook{
author = "Opačić, Miloš and Ristic, Aleksandar J and Savic, Danijela and Selih, Vid Simon and Zivin, Marko and Sokic, Dragoslav and Raičević, Savo and Bascarevic, Vladimir and Spasojević, Ivan",
year = "2017",
abstract = "Mesial temporal lobe epilepsy (mTLE) represents the most common subtype of human
focal epilepsies and perhaps the best-characterized disorder of this type 1
. Hippocampal
sclerosis (HS) is the most common histopathologic abnormality found in adults with drugresistant mTLE 2
. The histopathologic hallmark of HS is segmental pyramidal cell loss,
which can affect any field of the cornu Ammonis (CA1-4). Hippocampal neuronal cell loss
is always associated with a severe pattern of astrogliosis 3
. Therewithal, disturbed
homeostasis of metals is implicated in the pathology of mTLE-HS. Zinc has been
considered to play a major role in epileptogenesis in relation to its involvement in the
modulation of excitability and synaptic plasticity 4,5. Further, it has been shown that
epileptogenic hippocampi are exposed to oxidative stress and that the development of prooxidative conditions in the CNS usually involves the loss of homeostasis of iron 6,7. Low
brain levels of copper and manganese have been reported in patients with Menkes disease
and in animal models of epilepsy, and linked to seizure development 8,9. Ristić et al. were
the first to conduct a case-control study of total concentration of metals in tissue of human
HS, and report lower concentrations of copper and manganese 10.",
publisher = "Biohemijsko društvo Srbije",
journal = "Biochemistry of Control in Life and Technology",
booktitle = "Imaging and regional distribution of copper, zinc, manganese and iron in sclerotic hippocampi of patients with mesial temporal lobe epilepsy",
pages = "181-179",
url = "https://hdl.handle.net/21.15107/rcub_rimsi_2938"
}

Opačić, M., Ristic, A. J., Savic, D., Selih, V. S., Zivin, M., Sokic, D., Raičević, S., Bascarevic, V.,& Spasojević, I.. (2017). Imaging and regional distribution of copper, zinc, manganese and iron in sclerotic hippocampi of patients with mesial temporal lobe epilepsy. in Biochemistry of Control in Life and Technology
Biohemijsko društvo Srbije., 179-181.
https://hdl.handle.net/21.15107/rcub_rimsi_2938

Opačić M, Ristic AJ, Savic D, Selih VS, Zivin M, Sokic D, Raičević S, Bascarevic V, Spasojević I. Imaging and regional distribution of copper, zinc, manganese and iron in sclerotic hippocampi of patients with mesial temporal lobe epilepsy. in Biochemistry of Control in Life and Technology. 2017;:179-181.
https://hdl.handle.net/21.15107/rcub_rimsi_2938 .

Opačić, Miloš, Ristic, Aleksandar J, Savic, Danijela, Selih, Vid Simon, Zivin, Marko, Sokic, Dragoslav, Raičević, Savo, Bascarevic, Vladimir, Spasojević, Ivan, "Imaging and regional distribution of copper, zinc, manganese and iron in sclerotic hippocampi of patients with mesial temporal lobe epilepsy" in Biochemistry of Control in Life and Technology (2017):179-181,
https://hdl.handle.net/21.15107/rcub_rimsi_2938 .