Imaging and regional distribution of copper, zinc, manganese and iron in sclerotic hippocampi of patients with mesial temporal lobe epilepsy
Аутори
Opačić, MilošRistic, Aleksandar J
Savic, Danijela
Selih, Vid Simon
Zivin, Marko
Sokic, Dragoslav
Raičević, Savo
Bascarevic, Vladimir
Spasojević, Ivan
Поглавље у монографији (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Mesial temporal lobe epilepsy (mTLE) represents the most common subtype of human
focal epilepsies and perhaps the best-characterized disorder of this type 1
. Hippocampal
sclerosis (HS) is the most common histopathologic abnormality found in adults with drugresistant mTLE 2
. The histopathologic hallmark of HS is segmental pyramidal cell loss,
which can affect any field of the cornu Ammonis (CA1-4). Hippocampal neuronal cell loss
is always associated with a severe pattern of astrogliosis 3
. Therewithal, disturbed
homeostasis of metals is implicated in the pathology of mTLE-HS. Zinc has been
considered to play a major role in epileptogenesis in relation to its involvement in the
modulation of excitability and synaptic plasticity 4,5. Further, it has been shown that
epileptogenic hippocampi are exposed to oxidative stress and that the development of prooxidative conditions in the CNS usually involves the loss of homeostasis of iron 6,7. Low
brain levels of copper and mangane...se have been reported in patients with Menkes disease
and in animal models of epilepsy, and linked to seizure development 8,9. Ristić et al. were
the first to conduct a case-control study of total concentration of metals in tissue of human
HS, and report lower concentrations of copper and manganese 10.
Кључне речи:
Hippocampus metal epilepsy microscopyИзвор:
Biochemistry of Control in Life and Technology, 2017, 179-181Издавач:
- Biohemijsko društvo Srbije
Институција/група
Institut za multidisciplinarna istraživanjaTY - CHAP AU - Opačić, Miloš AU - Ristic, Aleksandar J AU - Savic, Danijela AU - Selih, Vid Simon AU - Zivin, Marko AU - Sokic, Dragoslav AU - Raičević, Savo AU - Bascarevic, Vladimir AU - Spasojević, Ivan PY - 2017 UR - http://rimsi.imsi.bg.ac.rs/handle/123456789/2938 AB - Mesial temporal lobe epilepsy (mTLE) represents the most common subtype of human focal epilepsies and perhaps the best-characterized disorder of this type 1 . Hippocampal sclerosis (HS) is the most common histopathologic abnormality found in adults with drugresistant mTLE 2 . The histopathologic hallmark of HS is segmental pyramidal cell loss, which can affect any field of the cornu Ammonis (CA1-4). Hippocampal neuronal cell loss is always associated with a severe pattern of astrogliosis 3 . Therewithal, disturbed homeostasis of metals is implicated in the pathology of mTLE-HS. Zinc has been considered to play a major role in epileptogenesis in relation to its involvement in the modulation of excitability and synaptic plasticity 4,5. Further, it has been shown that epileptogenic hippocampi are exposed to oxidative stress and that the development of prooxidative conditions in the CNS usually involves the loss of homeostasis of iron 6,7. Low brain levels of copper and manganese have been reported in patients with Menkes disease and in animal models of epilepsy, and linked to seizure development 8,9. Ristić et al. were the first to conduct a case-control study of total concentration of metals in tissue of human HS, and report lower concentrations of copper and manganese 10. PB - Biohemijsko društvo Srbije T2 - Biochemistry of Control in Life and Technology T1 - Imaging and regional distribution of copper, zinc, manganese and iron in sclerotic hippocampi of patients with mesial temporal lobe epilepsy EP - 181 SP - 179 UR - https://hdl.handle.net/21.15107/rcub_rimsi_2938 ER -
@inbook{ author = "Opačić, Miloš and Ristic, Aleksandar J and Savic, Danijela and Selih, Vid Simon and Zivin, Marko and Sokic, Dragoslav and Raičević, Savo and Bascarevic, Vladimir and Spasojević, Ivan", year = "2017", abstract = "Mesial temporal lobe epilepsy (mTLE) represents the most common subtype of human focal epilepsies and perhaps the best-characterized disorder of this type 1 . Hippocampal sclerosis (HS) is the most common histopathologic abnormality found in adults with drugresistant mTLE 2 . The histopathologic hallmark of HS is segmental pyramidal cell loss, which can affect any field of the cornu Ammonis (CA1-4). Hippocampal neuronal cell loss is always associated with a severe pattern of astrogliosis 3 . Therewithal, disturbed homeostasis of metals is implicated in the pathology of mTLE-HS. Zinc has been considered to play a major role in epileptogenesis in relation to its involvement in the modulation of excitability and synaptic plasticity 4,5. Further, it has been shown that epileptogenic hippocampi are exposed to oxidative stress and that the development of prooxidative conditions in the CNS usually involves the loss of homeostasis of iron 6,7. Low brain levels of copper and manganese have been reported in patients with Menkes disease and in animal models of epilepsy, and linked to seizure development 8,9. Ristić et al. were the first to conduct a case-control study of total concentration of metals in tissue of human HS, and report lower concentrations of copper and manganese 10.", publisher = "Biohemijsko društvo Srbije", journal = "Biochemistry of Control in Life and Technology", booktitle = "Imaging and regional distribution of copper, zinc, manganese and iron in sclerotic hippocampi of patients with mesial temporal lobe epilepsy", pages = "181-179", url = "https://hdl.handle.net/21.15107/rcub_rimsi_2938" }
Opačić, M., Ristic, A. J., Savic, D., Selih, V. S., Zivin, M., Sokic, D., Raičević, S., Bascarevic, V.,& Spasojević, I.. (2017). Imaging and regional distribution of copper, zinc, manganese and iron in sclerotic hippocampi of patients with mesial temporal lobe epilepsy. in Biochemistry of Control in Life and Technology Biohemijsko društvo Srbije., 179-181. https://hdl.handle.net/21.15107/rcub_rimsi_2938
Opačić M, Ristic AJ, Savic D, Selih VS, Zivin M, Sokic D, Raičević S, Bascarevic V, Spasojević I. Imaging and regional distribution of copper, zinc, manganese and iron in sclerotic hippocampi of patients with mesial temporal lobe epilepsy. in Biochemistry of Control in Life and Technology. 2017;:179-181. https://hdl.handle.net/21.15107/rcub_rimsi_2938 .
Opačić, Miloš, Ristic, Aleksandar J, Savic, Danijela, Selih, Vid Simon, Zivin, Marko, Sokic, Dragoslav, Raičević, Savo, Bascarevic, Vladimir, Spasojević, Ivan, "Imaging and regional distribution of copper, zinc, manganese and iron in sclerotic hippocampi of patients with mesial temporal lobe epilepsy" in Biochemistry of Control in Life and Technology (2017):179-181, https://hdl.handle.net/21.15107/rcub_rimsi_2938 .