TY  - JOUR
AU  - Baralic, Marko
AU  - Spasojević, Ivan
AU  - Miljus, Goran
AU  - Šunderić, Miloš
AU  - Robajac, Dragana
AU  - Dobrijević, Zorana
AU  - Gligorijević, Nikola
AU  - Nedic, Olgica
AU  - Penezic, Ana
PY  - 2022
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/2985
AB  - Albumin (HSA) is a multifunctional protein and due to its free Cys34 thiol group, represents a main source of free
thiols in the circulation. This property of HSA, combined with its ability to sequester redox active Cu(II) ions,
makes HSA a dominant circulatory antioxidant. End stage kidney disease (ESRD) is a condition accompanied by
elevated oxidative stress. The aim of the present study was to examine changes in the antioxidative capacity of
HSA and Cu(II) binding affinity in patients on peritoneal dialysis (PD), and relate it to the Cys34 thiol group
content and other structural changes of this molecule.
HSA molecules are modified in ESRD patients subjected to PD, having significantly lower thiol group and
bound Cu(II) content, reduced antioxidant capacity, an increased content of advanced glycation end-products
and altered conformation. Also, Cu(II) binding capacity of HSA in these patients is impaired, since a significant
portion of the high-affinity metal-binding site is unable to interact with Cu(II).
Taking into account that the concentration of Cu(II) in the circulation of ESRD patients is much higher than in
healthy persons and that Cu(II) binding capacity of HSA in these patients is significantly impaired, HSA may be
considered as a novel circulatory pro-oxidant, thus exacerbating oxidative stress.
PB  - Elsevier
T2  - Free radical biology and medicine
T1  - Albumin at the intersection between antioxidant and pro-oxidant in patients on peritoneal dialysis
EP  - 112
SP  - 105
VL  - 187
DO  - 10.1016/j.freeradbiomed.2022.05.019
ER  - 

@article{
author = "Baralic, Marko and Spasojević, Ivan and Miljus, Goran and Šunderić, Miloš and Robajac, Dragana and Dobrijević, Zorana and Gligorijević, Nikola and Nedic, Olgica and Penezic, Ana",
year = "2022",
abstract = "Albumin (HSA) is a multifunctional protein and due to its free Cys34 thiol group, represents a main source of free
thiols in the circulation. This property of HSA, combined with its ability to sequester redox active Cu(II) ions,
makes HSA a dominant circulatory antioxidant. End stage kidney disease (ESRD) is a condition accompanied by
elevated oxidative stress. The aim of the present study was to examine changes in the antioxidative capacity of
HSA and Cu(II) binding affinity in patients on peritoneal dialysis (PD), and relate it to the Cys34 thiol group
content and other structural changes of this molecule.
HSA molecules are modified in ESRD patients subjected to PD, having significantly lower thiol group and
bound Cu(II) content, reduced antioxidant capacity, an increased content of advanced glycation end-products
and altered conformation. Also, Cu(II) binding capacity of HSA in these patients is impaired, since a significant
portion of the high-affinity metal-binding site is unable to interact with Cu(II).
Taking into account that the concentration of Cu(II) in the circulation of ESRD patients is much higher than in
healthy persons and that Cu(II) binding capacity of HSA in these patients is significantly impaired, HSA may be
considered as a novel circulatory pro-oxidant, thus exacerbating oxidative stress.",
publisher = "Elsevier",
journal = "Free radical biology and medicine",
title = "Albumin at the intersection between antioxidant and pro-oxidant in patients on peritoneal dialysis",
pages = "112-105",
volume = "187",
doi = "10.1016/j.freeradbiomed.2022.05.019"
}

Baralic, M., Spasojević, I., Miljus, G., Šunderić, M., Robajac, D., Dobrijević, Z., Gligorijević, N., Nedic, O.,& Penezic, A.. (2022). Albumin at the intersection between antioxidant and pro-oxidant in patients on peritoneal dialysis. in Free radical biology and medicine
Elsevier., 187, 105-112.
https://doi.org/10.1016/j.freeradbiomed.2022.05.019

Baralic M, Spasojević I, Miljus G, Šunderić M, Robajac D, Dobrijević Z, Gligorijević N, Nedic O, Penezic A. Albumin at the intersection between antioxidant and pro-oxidant in patients on peritoneal dialysis. in Free radical biology and medicine. 2022;187:105-112.
doi:10.1016/j.freeradbiomed.2022.05.019 .

Baralic, Marko, Spasojević, Ivan, Miljus, Goran, Šunderić, Miloš, Robajac, Dragana, Dobrijević, Zorana, Gligorijević, Nikola, Nedic, Olgica, Penezic, Ana, "Albumin at the intersection between antioxidant and pro-oxidant in patients on peritoneal dialysis" in Free radical biology and medicine, 187 (2022):105-112,
https://doi.org/10.1016/j.freeradbiomed.2022.05.019 . .