This work extends in vitro screening of antimicrobial activity of avarol, the marine natural product firstly isolated from the Mediterranean sponge Dysidea avara. Its anticandidial activity was evaluated by microdilution method against eight Candida strains, two ATCC and six clinical ones. At a different extent this compound was proven to be active against all the strains tested (MIC 0.8-6.0g/mL and MFC 1.6-12.0g/mL, respectively). According to the best of our knowledge, this is the first report on avarol activity towards any yeast strain which may be of relevance for Alzheimer's disease. Indeed, avarol derivatives showing moderate AChE activity should be screened for anticandidial activity both in vitro and in vivo. [GRAPHICS] .
TY - JOUR
AU - Pejin, Boris
AU - Ciric, Ana
AU - Marković, Dejan
AU - Tommonaro, Giuseppina
AU - Soković, Marina
PY - 2016
UR - http://rimsi.imsi.bg.ac.rs/handle/123456789/997
AB - This work extends in vitro screening of antimicrobial activity of avarol, the marine natural product firstly isolated from the Mediterranean sponge Dysidea avara. Its anticandidial activity was evaluated by microdilution method against eight Candida strains, two ATCC and six clinical ones. At a different extent this compound was proven to be active against all the strains tested (MIC 0.8-6.0g/mL and MFC 1.6-12.0g/mL, respectively). According to the best of our knowledge, this is the first report on avarol activity towards any yeast strain which may be of relevance for Alzheimer's disease. Indeed, avarol derivatives showing moderate AChE activity should be screened for anticandidial activity both in vitro and in vivo. [GRAPHICS] .
PB - Taylor & Francis Ltd, Abingdon
T2 - Natural Product Research
T1 - In vitro avarol does affect the growth of Candida sp.
EP - 1960
IS - 17
SP - 1956
VL - 30
DO - 10.1080/14786419.2015.1091454
ER -
@article{
author = "Pejin, Boris and Ciric, Ana and Marković, Dejan and Tommonaro, Giuseppina and Soković, Marina",
year = "2016",
abstract = "This work extends in vitro screening of antimicrobial activity of avarol, the marine natural product firstly isolated from the Mediterranean sponge Dysidea avara. Its anticandidial activity was evaluated by microdilution method against eight Candida strains, two ATCC and six clinical ones. At a different extent this compound was proven to be active against all the strains tested (MIC 0.8-6.0g/mL and MFC 1.6-12.0g/mL, respectively). According to the best of our knowledge, this is the first report on avarol activity towards any yeast strain which may be of relevance for Alzheimer's disease. Indeed, avarol derivatives showing moderate AChE activity should be screened for anticandidial activity both in vitro and in vivo. [GRAPHICS] .",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Natural Product Research",
title = "In vitro avarol does affect the growth of Candida sp.",
pages = "1960-1956",
number = "17",
volume = "30",
doi = "10.1080/14786419.2015.1091454"
}
Pejin, B., Ciric, A., Marković, D., Tommonaro, G.,& Soković, M.. (2016). In vitro avarol does affect the growth of Candida sp.. in Natural Product Research
Taylor & Francis Ltd, Abingdon., 30(17), 1956-1960.
https://doi.org/10.1080/14786419.2015.1091454
Pejin B, Ciric A, Marković D, Tommonaro G, Soković M. In vitro avarol does affect the growth of Candida sp.. in Natural Product Research. 2016;30(17):1956-1960.
doi:10.1080/14786419.2015.1091454 .
Pejin, Boris, Ciric, Ana, Marković, Dejan, Tommonaro, Giuseppina, Soković, Marina, "In vitro avarol does affect the growth of Candida sp." in Natural Product Research, 30, no. 17 (2016):1956-1960,
https://doi.org/10.1080/14786419.2015.1091454 . .
