In vitro avarol does affect the growth of Candida sp.
Само за регистроване кориснике
2016
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
This work extends in vitro screening of antimicrobial activity of avarol, the marine natural product firstly isolated from the Mediterranean sponge Dysidea avara. Its anticandidial activity was evaluated by microdilution method against eight Candida strains, two ATCC and six clinical ones. At a different extent this compound was proven to be active against all the strains tested (MIC 0.8-6.0g/mL and MFC 1.6-12.0g/mL, respectively). According to the best of our knowledge, this is the first report on avarol activity towards any yeast strain which may be of relevance for Alzheimer's disease. Indeed, avarol derivatives showing moderate AChE activity should be screened for anticandidial activity both in vitro and in vivo. [GRAPHICS] .
Кључне речи:
oral pathogens / Marine sponge / Dysidea avara / avarol / anticandidial activity / Alzheimer's diseaseИзвор:
Natural Product Research, 2016, 30, 17, 1956-1960Издавач:
- Taylor & Francis Ltd, Abingdon
Финансирање / пројекти:
- Синтеза и биолошка испитивања нових миметика или деривата одабраних цитотоксичних лактона, антитуморског агенса тиазофурина и природних нафтних киселина (RS-MESTD-Basic Research (BR or ON)-172006)
- Биоактивни природни производи самониклих, гајених и јестивих биљака: одређивање структура и активности (RS-MESTD-Basic Research (BR or ON)-172053)
DOI: 10.1080/14786419.2015.1091454
ISSN: 1478-6419
PubMed: 26405848
WoS: 000382562400010
Scopus: 2-s2.0-84981285540
Институција/група
Institut za multidisciplinarna istraživanjaTY - JOUR AU - Pejin, Boris AU - Ciric, Ana AU - Marković, Dejan AU - Tommonaro, Giuseppina AU - Soković, Marina PY - 2016 UR - http://rimsi.imsi.bg.ac.rs/handle/123456789/997 AB - This work extends in vitro screening of antimicrobial activity of avarol, the marine natural product firstly isolated from the Mediterranean sponge Dysidea avara. Its anticandidial activity was evaluated by microdilution method against eight Candida strains, two ATCC and six clinical ones. At a different extent this compound was proven to be active against all the strains tested (MIC 0.8-6.0g/mL and MFC 1.6-12.0g/mL, respectively). According to the best of our knowledge, this is the first report on avarol activity towards any yeast strain which may be of relevance for Alzheimer's disease. Indeed, avarol derivatives showing moderate AChE activity should be screened for anticandidial activity both in vitro and in vivo. [GRAPHICS] . PB - Taylor & Francis Ltd, Abingdon T2 - Natural Product Research T1 - In vitro avarol does affect the growth of Candida sp. EP - 1960 IS - 17 SP - 1956 VL - 30 DO - 10.1080/14786419.2015.1091454 ER -
@article{ author = "Pejin, Boris and Ciric, Ana and Marković, Dejan and Tommonaro, Giuseppina and Soković, Marina", year = "2016", abstract = "This work extends in vitro screening of antimicrobial activity of avarol, the marine natural product firstly isolated from the Mediterranean sponge Dysidea avara. Its anticandidial activity was evaluated by microdilution method against eight Candida strains, two ATCC and six clinical ones. At a different extent this compound was proven to be active against all the strains tested (MIC 0.8-6.0g/mL and MFC 1.6-12.0g/mL, respectively). According to the best of our knowledge, this is the first report on avarol activity towards any yeast strain which may be of relevance for Alzheimer's disease. Indeed, avarol derivatives showing moderate AChE activity should be screened for anticandidial activity both in vitro and in vivo. [GRAPHICS] .", publisher = "Taylor & Francis Ltd, Abingdon", journal = "Natural Product Research", title = "In vitro avarol does affect the growth of Candida sp.", pages = "1960-1956", number = "17", volume = "30", doi = "10.1080/14786419.2015.1091454" }
Pejin, B., Ciric, A., Marković, D., Tommonaro, G.,& Soković, M.. (2016). In vitro avarol does affect the growth of Candida sp.. in Natural Product Research Taylor & Francis Ltd, Abingdon., 30(17), 1956-1960. https://doi.org/10.1080/14786419.2015.1091454
Pejin B, Ciric A, Marković D, Tommonaro G, Soković M. In vitro avarol does affect the growth of Candida sp.. in Natural Product Research. 2016;30(17):1956-1960. doi:10.1080/14786419.2015.1091454 .
Pejin, Boris, Ciric, Ana, Marković, Dejan, Tommonaro, Giuseppina, Soković, Marina, "In vitro avarol does affect the growth of Candida sp." in Natural Product Research, 30, no. 17 (2016):1956-1960, https://doi.org/10.1080/14786419.2015.1091454 . .