Mitochondria-Targeted Antioxidants: Future Perspectives in Kidney Ischemia Reperfusion Injury
Апстракт
Kidney ischemia/reperfusion injury emerges in various clinical settings as a great problem complicating the course and outcome. Ischemia/reperfusion injury is still an unsolved puzzle with a great diversity of investigational approaches, putting the focus on oxidative stress and mitochondria. Mitochondria are both sources and targets of ROS. They participate in initiation and progression of kidney ischemia/reperfusion injury linking oxidative stress, inflammation, and cell death. The dependence of kidney proximal tubule cells on oxidative mitochondrial metabolism makes them particularly prone to harmful effects of mitochondrial damage. The administration of antioxidants has been used as a way to prevent and treat kidney ischemia/reperfusion injury for a long time. Recently a new method based on mitochondria-targeted antioxidants has become the focus of interest. Here we review the current status of results achieved in numerous studies investigating these novel compounds in ischemia/rep...erfusion injury which specifically target mitochondria such asMitoQ, Szeto-Schiller (SS) peptides (Bendavia), SkQ1 and SkQR1, and superoxide dismutase mimics. Based on the favorable results obtained in the studies that have examined myocardial ischemia/reperfusion injury, ongoing clinical trials investigate the efficacy of some novel therapeutics in preventing myocardial infarct. This also implies future strategies in preventing kidney ischemia/reperfusion injury.
Кључне речи:
kidney / autophagy / oxidative stress / xanthine oxidaseИзвор:
Oxidative Medicine and Cellular Longevity, 2016, 2016Издавач:
- Hindawi Ltd, London
DOI: 10.1155/2016/2950503
ISSN: 1942-0900
PubMed: 27313826
WoS: 000377911900001
Scopus: 2-s2.0-84975109034
Институција/група
Institut za multidisciplinarna istraživanjaTY - JOUR AU - Kezic, Aleksandra AU - Spasojević, Ivan AU - Lezaic, Visnja AU - Bajčetić, Milica PY - 2016 UR - http://rimsi.imsi.bg.ac.rs/handle/123456789/993 AB - Kidney ischemia/reperfusion injury emerges in various clinical settings as a great problem complicating the course and outcome. Ischemia/reperfusion injury is still an unsolved puzzle with a great diversity of investigational approaches, putting the focus on oxidative stress and mitochondria. Mitochondria are both sources and targets of ROS. They participate in initiation and progression of kidney ischemia/reperfusion injury linking oxidative stress, inflammation, and cell death. The dependence of kidney proximal tubule cells on oxidative mitochondrial metabolism makes them particularly prone to harmful effects of mitochondrial damage. The administration of antioxidants has been used as a way to prevent and treat kidney ischemia/reperfusion injury for a long time. Recently a new method based on mitochondria-targeted antioxidants has become the focus of interest. Here we review the current status of results achieved in numerous studies investigating these novel compounds in ischemia/reperfusion injury which specifically target mitochondria such asMitoQ, Szeto-Schiller (SS) peptides (Bendavia), SkQ1 and SkQR1, and superoxide dismutase mimics. Based on the favorable results obtained in the studies that have examined myocardial ischemia/reperfusion injury, ongoing clinical trials investigate the efficacy of some novel therapeutics in preventing myocardial infarct. This also implies future strategies in preventing kidney ischemia/reperfusion injury. PB - Hindawi Ltd, London T2 - Oxidative Medicine and Cellular Longevity T1 - Mitochondria-Targeted Antioxidants: Future Perspectives in Kidney Ischemia Reperfusion Injury VL - 2016 DO - 10.1155/2016/2950503 ER -
@article{ author = "Kezic, Aleksandra and Spasojević, Ivan and Lezaic, Visnja and Bajčetić, Milica", year = "2016", abstract = "Kidney ischemia/reperfusion injury emerges in various clinical settings as a great problem complicating the course and outcome. Ischemia/reperfusion injury is still an unsolved puzzle with a great diversity of investigational approaches, putting the focus on oxidative stress and mitochondria. Mitochondria are both sources and targets of ROS. They participate in initiation and progression of kidney ischemia/reperfusion injury linking oxidative stress, inflammation, and cell death. The dependence of kidney proximal tubule cells on oxidative mitochondrial metabolism makes them particularly prone to harmful effects of mitochondrial damage. The administration of antioxidants has been used as a way to prevent and treat kidney ischemia/reperfusion injury for a long time. Recently a new method based on mitochondria-targeted antioxidants has become the focus of interest. Here we review the current status of results achieved in numerous studies investigating these novel compounds in ischemia/reperfusion injury which specifically target mitochondria such asMitoQ, Szeto-Schiller (SS) peptides (Bendavia), SkQ1 and SkQR1, and superoxide dismutase mimics. Based on the favorable results obtained in the studies that have examined myocardial ischemia/reperfusion injury, ongoing clinical trials investigate the efficacy of some novel therapeutics in preventing myocardial infarct. This also implies future strategies in preventing kidney ischemia/reperfusion injury.", publisher = "Hindawi Ltd, London", journal = "Oxidative Medicine and Cellular Longevity", title = "Mitochondria-Targeted Antioxidants: Future Perspectives in Kidney Ischemia Reperfusion Injury", volume = "2016", doi = "10.1155/2016/2950503" }
Kezic, A., Spasojević, I., Lezaic, V.,& Bajčetić, M.. (2016). Mitochondria-Targeted Antioxidants: Future Perspectives in Kidney Ischemia Reperfusion Injury. in Oxidative Medicine and Cellular Longevity Hindawi Ltd, London., 2016. https://doi.org/10.1155/2016/2950503
Kezic A, Spasojević I, Lezaic V, Bajčetić M. Mitochondria-Targeted Antioxidants: Future Perspectives in Kidney Ischemia Reperfusion Injury. in Oxidative Medicine and Cellular Longevity. 2016;2016. doi:10.1155/2016/2950503 .
Kezic, Aleksandra, Spasojević, Ivan, Lezaic, Visnja, Bajčetić, Milica, "Mitochondria-Targeted Antioxidants: Future Perspectives in Kidney Ischemia Reperfusion Injury" in Oxidative Medicine and Cellular Longevity, 2016 (2016), https://doi.org/10.1155/2016/2950503 . .