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dc.creatorKracun-Kolarević, Margareta
dc.creatorKolarević, Stoimir
dc.creatorJovanović, Jovana
dc.creatorMarković, Vanja
dc.creatorIllic, Marija
dc.creatorSimonović, Predrag
dc.creatorSimic, Vladica
dc.creatorGačić, Zoran
dc.creatorDiamantini, Elena
dc.creatorStella, Elisa
dc.creatorPetrović, Mira
dc.creatorMajone, Bruno
dc.creatorBellin, Alberto
dc.creatorPaunović, Momir
dc.creatorVukovic-Gacic, Branka
dc.date.accessioned2022-04-05T15:03:28Z
dc.date.available2022-04-05T15:03:28Z
dc.date.issued2016
dc.identifier.issn0048-9697
dc.identifier.urihttp://rimsi.imsi.bg.ac.rs/handle/123456789/977
dc.description.abstractIn this study a comprehensive genotoxicological survey throughout the upper and middle stretches of Adige river basin is presented. The study was carried out at 7 sites located along the Adige main course and one the most significant tributaries, the Noce creek, both presenting different levels of pollution pressure. To give an insight into the nature of the genotoxic activity we employed the battery of prokaryotic and eukaryotic assays. Mutagenicity in water samples was evaluated by SOS/umuC test in Salmonella typhimurium TA1535/pSK1002. The level of DNA damage as a biomarker of exposure (comet assay) and biomarker of effect (micronucleus assay) and the level of oxidative stress as well (Fpg - modified comet assay) were studied in blood cells of Salmo cenerinus Nardo, 1847 and Salmo marmoratus Cuvier, 1829. Within the applied bioassays, comet assay showed the highest potential for discriminating the sampling sites which are under lesser extent of pressure (sampling sites 1-Barnes at Bresimo and 4-Noce downstream S. Giustina) from the sites under high pressure (sampling sites 5-Noce at Mezzolombardo and 6/7-Adige upstream and downstream municipality of Trento). Significant correlation between the standard and Fpg - modified comet assay indicated that oxidative stress could be a major contributor to observed DNA damage in collected specimens.en
dc.publisherElsevier Science Bv, Amsterdam
dc.relationinfo:eu-repo/grantAgreement/EC/FP7/603629/EU//
dc.relationMinistry of Education, Science and Technological Development of the Republic of Serbia
dc.relationbilateral project Serbia and Slovenia [BI-RS/14-15-013]
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceScience of the Total Environment
dc.subjectTrout Adige Riveren
dc.subjectMicronucleusen
dc.subjectEcogenotoxicologyen
dc.subjectComet assayen
dc.titleEvaluation of genotoxic potential throughout the upper and middle stretches of Adige river basinen
dc.typearticle
dc.rights.licenseBY-NC-ND
dc.citation.epage1391
dc.citation.other571: 1383-1391
dc.citation.rankaM21
dc.citation.spage1383
dc.citation.volume571
dc.identifier.doi10.1016/j.scitotenv.2016.07.099
dc.identifier.fulltexthttp://rimsi.imsi.bg.ac.rs/bitstream/id/1114/974.pdf
dc.identifier.pmid27450952
dc.identifier.scopus2-s2.0-84979519348
dc.identifier.wos000383930400138
dc.type.versionpublishedVersion


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