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In vitro antibiofilm activity of the freshwater bryozoan Hyalinella punctata: a case study of Pseudomonas aeruginosa PAO1

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Authors
Pejin, Boris
Ciric, Ana
Karaman, Ivo
Horvatović, Mladen
Glamočlija, Jasmina
Nikolic, Milos
Soković, Marina
Article (Published version)
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Abstract
The antibiofilm and possible antiquorum sensing effects against the strain Pseudomonas aeruginosa PAO1 of five crude extracts of the freshwater bryozoan Hyalinella punctata (Hancock, 1850) were evaluated in vitro for the first time. H. punctata ethyl acetate extract (HpEtAc) exhibited the highest antibiofilm activity reducing the biofilm formation of P. aeruginosa PAO1 in the range of 80.63-88.13%. While all tested extracts reduced the twitching motility of the aforementioned bacterial strain, HpEtAc showed to be the most effective. Finally, at a concentration of 0.5 MIC, the same extract mostly inhibited the production of pyocyanin by P. aeruginosa PAO1 (71.53%). In comparison both with the positive controls used (streptomycin and ampicillin, 67.13 and 69.77%, respectively), HpEtAc was found to inhibit pyocyanin in a higher extent. An extensive chemical characterisation of this particular extract may result in isolation and identification of novel lead compounds targeting P. aeruginos...a, an opportunistic human pathogen. [GRAPHCIS].

Keywords:
extracts / Bryozoa / antiquorum sensing activity / antibiofilm activity
Source:
Natural Product Research, 2016, 30, 16, 1847-1850
Publisher:
  • Taylor & Francis Ltd, Abingdon
Funding / projects:
  • Natural products of wild, cultivated and edible plants: structure and bioactivity determination (RS-172053)
  • Characterization and application of fungal metabolites and assessment of new biofungicides potential (RS-173032)

DOI: 10.1080/14786419.2015.1072714

ISSN: 1478-6419

PubMed: 26264659

WoS: 000382554700012

Scopus: 2-s2.0-84939180206
[ Google Scholar ]
10
5
URI
http://rimsi.imsi.bg.ac.rs/handle/123456789/954
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Institut za multidisciplinarna istraživanja
TY  - JOUR
AU  - Pejin, Boris
AU  - Ciric, Ana
AU  - Karaman, Ivo
AU  - Horvatović, Mladen
AU  - Glamočlija, Jasmina
AU  - Nikolic, Milos
AU  - Soković, Marina
PY  - 2016
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/954
AB  - The antibiofilm and possible antiquorum sensing effects against the strain Pseudomonas aeruginosa PAO1 of five crude extracts of the freshwater bryozoan Hyalinella punctata (Hancock, 1850) were evaluated in vitro for the first time. H. punctata ethyl acetate extract (HpEtAc) exhibited the highest antibiofilm activity reducing the biofilm formation of P. aeruginosa PAO1 in the range of 80.63-88.13%. While all tested extracts reduced the twitching motility of the aforementioned bacterial strain, HpEtAc showed to be the most effective. Finally, at a concentration of 0.5 MIC, the same extract mostly inhibited the production of pyocyanin by P. aeruginosa PAO1 (71.53%). In comparison both with the positive controls used (streptomycin and ampicillin, 67.13 and 69.77%, respectively), HpEtAc was found to inhibit pyocyanin in a higher extent. An extensive chemical characterisation of this particular extract may result in isolation and identification of novel lead compounds targeting P. aeruginosa, an opportunistic human pathogen. [GRAPHCIS].
PB  - Taylor & Francis Ltd, Abingdon
T2  - Natural Product Research
T1  - In vitro antibiofilm activity of the freshwater bryozoan Hyalinella punctata: a case study of Pseudomonas aeruginosa PAO1
EP  - 1850
IS  - 16
SP  - 1847
VL  - 30
DO  - 10.1080/14786419.2015.1072714
ER  - 
@article{
author = "Pejin, Boris and Ciric, Ana and Karaman, Ivo and Horvatović, Mladen and Glamočlija, Jasmina and Nikolic, Milos and Soković, Marina",
year = "2016",
abstract = "The antibiofilm and possible antiquorum sensing effects against the strain Pseudomonas aeruginosa PAO1 of five crude extracts of the freshwater bryozoan Hyalinella punctata (Hancock, 1850) were evaluated in vitro for the first time. H. punctata ethyl acetate extract (HpEtAc) exhibited the highest antibiofilm activity reducing the biofilm formation of P. aeruginosa PAO1 in the range of 80.63-88.13%. While all tested extracts reduced the twitching motility of the aforementioned bacterial strain, HpEtAc showed to be the most effective. Finally, at a concentration of 0.5 MIC, the same extract mostly inhibited the production of pyocyanin by P. aeruginosa PAO1 (71.53%). In comparison both with the positive controls used (streptomycin and ampicillin, 67.13 and 69.77%, respectively), HpEtAc was found to inhibit pyocyanin in a higher extent. An extensive chemical characterisation of this particular extract may result in isolation and identification of novel lead compounds targeting P. aeruginosa, an opportunistic human pathogen. [GRAPHCIS].",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Natural Product Research",
title = "In vitro antibiofilm activity of the freshwater bryozoan Hyalinella punctata: a case study of Pseudomonas aeruginosa PAO1",
pages = "1850-1847",
number = "16",
volume = "30",
doi = "10.1080/14786419.2015.1072714"
}
Pejin, B., Ciric, A., Karaman, I., Horvatović, M., Glamočlija, J., Nikolic, M.,& Soković, M.. (2016). In vitro antibiofilm activity of the freshwater bryozoan Hyalinella punctata: a case study of Pseudomonas aeruginosa PAO1. in Natural Product Research
Taylor & Francis Ltd, Abingdon., 30(16), 1847-1850.
https://doi.org/10.1080/14786419.2015.1072714
Pejin B, Ciric A, Karaman I, Horvatović M, Glamočlija J, Nikolic M, Soković M. In vitro antibiofilm activity of the freshwater bryozoan Hyalinella punctata: a case study of Pseudomonas aeruginosa PAO1. in Natural Product Research. 2016;30(16):1847-1850.
doi:10.1080/14786419.2015.1072714 .
Pejin, Boris, Ciric, Ana, Karaman, Ivo, Horvatović, Mladen, Glamočlija, Jasmina, Nikolic, Milos, Soković, Marina, "In vitro antibiofilm activity of the freshwater bryozoan Hyalinella punctata: a case study of Pseudomonas aeruginosa PAO1" in Natural Product Research, 30, no. 16 (2016):1847-1850,
https://doi.org/10.1080/14786419.2015.1072714 . .

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