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Effects of 5-Fluorouracil, Etoposide and CdCl2 in Aquatic Oligochaeta Limnodrilus udekemianus Claparede (Tubificidae) Measured by Comet Assay
dc.creator | Kracun-Kolarević, Margareta | |
dc.creator | Kolarević, Stoimir | |
dc.creator | Atanacković, Ana | |
dc.creator | Marković, Vanja | |
dc.creator | Gačić, Zoran | |
dc.creator | Paunović, Momir | |
dc.creator | Vukovic-Gacic, Branka | |
dc.date.accessioned | 2022-04-05T14:59:56Z | |
dc.date.available | 2022-04-05T14:59:56Z | |
dc.date.issued | 2015 | |
dc.identifier.issn | 0049-6979 | |
dc.identifier.uri | http://rimsi.imsi.bg.ac.rs/handle/123456789/925 | |
dc.description.abstract | Genotoxicity of 5-fluorouracil (5-FU), etoposide (ET) and cadmium chloride (CdCl2) was evaluated in Limnodrilus udekemianus, cosmopolitan tubificid species, by alkaline single-cell gel electrophoresis (comet assay). Groups of 50 individuals were exposed in vivo in water-only short-term (96 h) tests to 5-FU (0.004, 0.04, 0.4, 4 and 40 mu M), ET (0.004. 0.04, 0.4 and 4 mu M) and CdCl2 (0.004, 0.04, 0.4, 4 and 40 mu M). Mortality of worms was observed only for CdCl2 (4 and 40 mu M). Cell viability lower than 70 % was detected for 5-FU (0.4, 4 and 40 mu M), ET (4 mu M) and CdCl2 (0.4 and 4 mu M). All tested substances induced significant increase of DNA damage except 0.004 mu M of ET. L. udekemianus being sensitive to all tested substances indicates that it can be used in ecogenotoxicology studies. Concern should be raised to cytostatics, especially to 5-FU, since concentration of 0.004 mu M induced DNA damage is similar to ones detected in wastewaters. | en |
dc.publisher | Springer International Publishing Ag, Cham | |
dc.relation | info:eu-repo/grantAgreement/EC/FP7/603629/EU// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Technological Development (TD or TR)/37009/RS// | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | |
dc.source | Water Air and Soil Pollution | |
dc.subject | Limnodrilus udekemianus | en |
dc.subject | Genotoxicity | en |
dc.subject | Etoposide | en |
dc.subject | Comet assay | en |
dc.subject | CdCl2 | en |
dc.subject | 5-Fluorouracil | en |
dc.title | Effects of 5-Fluorouracil, Etoposide and CdCl2 in Aquatic Oligochaeta Limnodrilus udekemianus Claparede (Tubificidae) Measured by Comet Assay | en |
dc.type | article | |
dc.rights.license | BY | |
dc.citation.issue | 8 | |
dc.citation.other | 226(8): - | |
dc.citation.rank | M22 | |
dc.citation.volume | 226 | |
dc.identifier.doi | 10.1007/s11270-015-2511-6 | |
dc.identifier.fulltext | http://rimsi.imsi.bg.ac.rs/bitstream/id/1076/922.pdf | |
dc.identifier.pmid | 27546921 | |
dc.identifier.scopus | 2-s2.0-84958057878 | |
dc.identifier.wos | 000359369600022 | |
dc.type.version | publishedVersion |