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dc.creatorKracun-Kolarević, Margareta
dc.creatorKolarević, Stoimir
dc.creatorAtanacković, Ana
dc.creatorMarković, Vanja
dc.creatorGačić, Zoran
dc.creatorPaunović, Momir
dc.creatorVukovic-Gacic, Branka
dc.date.accessioned2022-04-05T14:59:56Z
dc.date.available2022-04-05T14:59:56Z
dc.date.issued2015
dc.identifier.issn0049-6979
dc.identifier.urihttp://rimsi.imsi.bg.ac.rs/handle/123456789/925
dc.description.abstractGenotoxicity of 5-fluorouracil (5-FU), etoposide (ET) and cadmium chloride (CdCl2) was evaluated in Limnodrilus udekemianus, cosmopolitan tubificid species, by alkaline single-cell gel electrophoresis (comet assay). Groups of 50 individuals were exposed in vivo in water-only short-term (96 h) tests to 5-FU (0.004, 0.04, 0.4, 4 and 40 mu M), ET (0.004. 0.04, 0.4 and 4 mu M) and CdCl2 (0.004, 0.04, 0.4, 4 and 40 mu M). Mortality of worms was observed only for CdCl2 (4 and 40 mu M). Cell viability lower than 70 % was detected for 5-FU (0.4, 4 and 40 mu M), ET (4 mu M) and CdCl2 (0.4 and 4 mu M). All tested substances induced significant increase of DNA damage except 0.004 mu M of ET. L. udekemianus being sensitive to all tested substances indicates that it can be used in ecogenotoxicology studies. Concern should be raised to cytostatics, especially to 5-FU, since concentration of 0.004 mu M induced DNA damage is similar to ones detected in wastewaters.en
dc.publisherSpringer International Publishing Ag, Cham
dc.relationinfo:eu-repo/grantAgreement/EC/FP7/603629/EU//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Technological Development (TD or TR)/37009/RS//
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceWater Air and Soil Pollution
dc.subjectLimnodrilus udekemianusen
dc.subjectGenotoxicityen
dc.subjectEtoposideen
dc.subjectComet assayen
dc.subjectCdCl2en
dc.subject5-Fluorouracilen
dc.titleEffects of 5-Fluorouracil, Etoposide and CdCl2 in Aquatic Oligochaeta Limnodrilus udekemianus Claparede (Tubificidae) Measured by Comet Assayen
dc.typearticle
dc.rights.licenseBY
dc.citation.issue8
dc.citation.other226(8): -
dc.citation.rankM22
dc.citation.volume226
dc.identifier.doi10.1007/s11270-015-2511-6
dc.identifier.fulltexthttp://rimsi.imsi.bg.ac.rs/bitstream/id/1076/922.pdf
dc.identifier.pmid27546921
dc.identifier.scopus2-s2.0-84958057878
dc.identifier.wos000359369600022
dc.type.versionpublishedVersion


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Приказ основних података о документу