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dc.creatorTodorović, Tamara R.
dc.creatorGrubisic, Sonja
dc.creatorPregelj, Matej
dc.creatorJagodic, Marko
dc.creatorMisirlic-Dencic, Sonja
dc.creatorDulović, Marija
dc.creatorMarković, Ivanka
dc.creatorKlisuric, Olivera
dc.creatorMalešević, Aleksandar
dc.creatorMitic, Dragana
dc.creatorAnđelković, Katarina
dc.creatorFilipović, Nenad
dc.date.accessioned2022-04-05T14:59:35Z
dc.date.available2022-04-05T14:59:35Z
dc.date.issued2015
dc.identifier.issn1434-1948
dc.identifier.urihttp://rimsi.imsi.bg.ac.rs/handle/123456789/920
dc.description.abstractCopper(II) complexes with the condensation derivative of methyl hydrazinoacetate and 2-acetylpyridine were synthesized. The X-ray crystal structures for both complexes revealed that they are polymerized isomers. A common feature of both complexes is the bidentate coordination of the ligand by one hydrazone and one pyridine nitrogen atom. In the monomeric complex, the copper(II) center is tetracoordinate, whereas dimerization through chlorido bridges results in a pentacoordinate arrangement about the metal ions in the dimer. The electronic and magnetic properties of both complexes are discussed on the basis of their X-ray structures, electron paramagnetic resonance (EPR) spectroscopy studies, and superconducting quantum interference device (SQUID) magnetization measurements combined with DFT calculations. Magnetostructural comparisons with structurally similar copper(II) complexes are also provided, and a possible correlation has been established. The antitumor activities of the Cu-II complexes were investigated against six different cancer cell lines, and the results suggest that the antiglioma action of the dimeric species is based on oxidative-stress-mediated phosphatidylserine externalization and caspase activation, which indicate apoptosis.en
dc.publisherWiley-V C H Verlag Gmbh, Weinheim
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172055/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/41025/RS//
dc.rightsrestrictedAccess
dc.sourceEuropean Journal of Inorganic Chemistry
dc.subjectMedicinal chemistryen
dc.subjectMagnetic propertiesen
dc.subjectDensity functional calculationsen
dc.subjectCytotoxicityen
dc.subjectCopperen
dc.subjectApoptosisen
dc.titleStructural, Magnetic, DFT, and Biological Studies of Mononuclear and Dinuclear Cu-II Complexes with Bidentate N-Heteroaromatic Schiff Base Ligandsen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage3931
dc.citation.issue23
dc.citation.other(23): 3921-3931
dc.citation.rankM22
dc.citation.spage3921
dc.identifier.doi10.1002/ejic.201500349
dc.identifier.scopus2-s2.0-84939270154
dc.identifier.wos000359627100013
dc.type.versionpublishedVersion


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