The effects of wild-type and mutant sod1 on smooth muscle contraction
2015
Autori
Nikolić-Kokić, AleksandraOreščanin-Dušić, Zorana
Spasojević, Ivan
Blagojević, Duško
Stević, Zorica D
Andjus, Pavle R.
Spasić, Mihajlo
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
In this work we compared the mutated liver copper zinc-containing superoxide dismutase (SOD1) protein G93A of the transgenic rat model of familial amyotrophic lateral sclerosis (FALS), to wild-type (WT) rat SOD1. We examined their enzymatic activities and effects on isometric contractions of uteri of healthy virgin rats. G93A SOD1 showed a slightly higher activity than WT SOD1 and, in contrast to WT SOD1, G93A SOD1 did not induce smooth muscle relaxation. This result indicates that effects on smooth muscles are not related to SOD1 enzyme activity and suggest that heterodimers of G93A SOD1 form an ion-conducting pore that diminishes the relaxatory effects of SOD1. We propose that this type of pathogenic feedback affects neurons in FALS.
Ključne reči:
WT SOD1 / mutation / muscle relaxation / G93A SOD1 / FALSIzvor:
Archives of Biological Sciences, 2015, 67, 1, 187-192Izdavač:
- Srpsko biološko društvo, Beograd, i dr.
Finansiranje / projekti:
- Molekularni mehanizmi redoks signalinga u homeostazi, adaptaciji i patologiji (RS-173014)
- Ispitivanje molekularno-genetskih, patohistoloških i biohemijskih karakteristika neuromišićnih bolesti (RS-175083)
DOI: 10.2298/ABS141006023N
ISSN: 0354-4664
WoS: 000352003500020
Scopus: 2-s2.0-84937410301
Institucija/grupa
Institut za multidisciplinarna istraživanjaTY - JOUR AU - Nikolić-Kokić, Aleksandra AU - Oreščanin-Dušić, Zorana AU - Spasojević, Ivan AU - Blagojević, Duško AU - Stević, Zorica D AU - Andjus, Pavle R. AU - Spasić, Mihajlo PY - 2015 UR - http://rimsi.imsi.bg.ac.rs/handle/123456789/902 AB - In this work we compared the mutated liver copper zinc-containing superoxide dismutase (SOD1) protein G93A of the transgenic rat model of familial amyotrophic lateral sclerosis (FALS), to wild-type (WT) rat SOD1. We examined their enzymatic activities and effects on isometric contractions of uteri of healthy virgin rats. G93A SOD1 showed a slightly higher activity than WT SOD1 and, in contrast to WT SOD1, G93A SOD1 did not induce smooth muscle relaxation. This result indicates that effects on smooth muscles are not related to SOD1 enzyme activity and suggest that heterodimers of G93A SOD1 form an ion-conducting pore that diminishes the relaxatory effects of SOD1. We propose that this type of pathogenic feedback affects neurons in FALS. PB - Srpsko biološko društvo, Beograd, i dr. T2 - Archives of Biological Sciences T1 - The effects of wild-type and mutant sod1 on smooth muscle contraction EP - 192 IS - 1 SP - 187 VL - 67 DO - 10.2298/ABS141006023N ER -
@article{ author = "Nikolić-Kokić, Aleksandra and Oreščanin-Dušić, Zorana and Spasojević, Ivan and Blagojević, Duško and Stević, Zorica D and Andjus, Pavle R. and Spasić, Mihajlo", year = "2015", abstract = "In this work we compared the mutated liver copper zinc-containing superoxide dismutase (SOD1) protein G93A of the transgenic rat model of familial amyotrophic lateral sclerosis (FALS), to wild-type (WT) rat SOD1. We examined their enzymatic activities and effects on isometric contractions of uteri of healthy virgin rats. G93A SOD1 showed a slightly higher activity than WT SOD1 and, in contrast to WT SOD1, G93A SOD1 did not induce smooth muscle relaxation. This result indicates that effects on smooth muscles are not related to SOD1 enzyme activity and suggest that heterodimers of G93A SOD1 form an ion-conducting pore that diminishes the relaxatory effects of SOD1. We propose that this type of pathogenic feedback affects neurons in FALS.", publisher = "Srpsko biološko društvo, Beograd, i dr.", journal = "Archives of Biological Sciences", title = "The effects of wild-type and mutant sod1 on smooth muscle contraction", pages = "192-187", number = "1", volume = "67", doi = "10.2298/ABS141006023N" }
Nikolić-Kokić, A., Oreščanin-Dušić, Z., Spasojević, I., Blagojević, D., Stević, Z. D., Andjus, P. R.,& Spasić, M.. (2015). The effects of wild-type and mutant sod1 on smooth muscle contraction. in Archives of Biological Sciences Srpsko biološko društvo, Beograd, i dr.., 67(1), 187-192. https://doi.org/10.2298/ABS141006023N
Nikolić-Kokić A, Oreščanin-Dušić Z, Spasojević I, Blagojević D, Stević ZD, Andjus PR, Spasić M. The effects of wild-type and mutant sod1 on smooth muscle contraction. in Archives of Biological Sciences. 2015;67(1):187-192. doi:10.2298/ABS141006023N .
Nikolić-Kokić, Aleksandra, Oreščanin-Dušić, Zorana, Spasojević, Ivan, Blagojević, Duško, Stević, Zorica D, Andjus, Pavle R., Spasić, Mihajlo, "The effects of wild-type and mutant sod1 on smooth muscle contraction" in Archives of Biological Sciences, 67, no. 1 (2015):187-192, https://doi.org/10.2298/ABS141006023N . .