In vitro anti-quorum sensing activity of phytol
Apstrakt
Anti-quorum sensing activity of the diterpene phytol was evaluated in vitro for the first time. This compound (at three sub-MIC concentrations - 0.5, 0.25 and 0.125 MIC, respectively) reduced the formation of Pseudomonas aeruginosa PAO1 biofilm in the range of 74.00-84.33% exhibiting higher activity than the both positive controls used, streptomycin and ampicillin. Phytol (0.5 MIC) also effectively reduced P. aeruginosa twitching and flagella motility. Indeed, the bacteria treated were incapable of producing a twitching zone and had almost round, smooth and regular colony edges. Finally, the tested compound (0.5 MIC) exhibited good P. aeruginosa pyocyanin inhibitory activity (51.94%) practically to the same extent as streptomycin (52.09%). According to the experimental data obtained, this phytol property may inspire design of medical foods targeting P. aeruginosa quorum sensing activity.
Ključne reči:
twitching and flagella motility / pyocyanin / Pseudomonas aeruginosa PAO1 / diterpene alcohol / biofilmIzvor:
Natural Product Research, 2015, 29, 4, 374-377Izdavač:
- Taylor & Francis Ltd, Abingdon
Finansiranje / projekti:
- Bioaktivni prirodni proizvodi samoniklih, gajenih i jestivih biljaka: određivanje struktura i aktivnosti (RS-172053)
- Ispitivanja odnosa struktura-funkcija u ćelijskom zidu biljaka i izmene strukture zida enzimskim inženjeringom (RS-173017)
- Karakterizacija i primena metabolita gljiva i utvrđivanje potencijala novih biofungicida (RS-173032)
DOI: 10.1080/14786419.2014.945088
ISSN: 1478-6419
PubMed: 25103916
WoS: 000346850600016
Scopus: 2-s2.0-84920554798
Institucija/grupa
Institut za multidisciplinarna istraživanjaTY - JOUR AU - Pejin, Boris AU - Ciric, Ana AU - Glamočlija, Jasmina AU - Nikolic, Milos AU - Soković, Marina PY - 2015 UR - http://rimsi.imsi.bg.ac.rs/handle/123456789/832 AB - Anti-quorum sensing activity of the diterpene phytol was evaluated in vitro for the first time. This compound (at three sub-MIC concentrations - 0.5, 0.25 and 0.125 MIC, respectively) reduced the formation of Pseudomonas aeruginosa PAO1 biofilm in the range of 74.00-84.33% exhibiting higher activity than the both positive controls used, streptomycin and ampicillin. Phytol (0.5 MIC) also effectively reduced P. aeruginosa twitching and flagella motility. Indeed, the bacteria treated were incapable of producing a twitching zone and had almost round, smooth and regular colony edges. Finally, the tested compound (0.5 MIC) exhibited good P. aeruginosa pyocyanin inhibitory activity (51.94%) practically to the same extent as streptomycin (52.09%). According to the experimental data obtained, this phytol property may inspire design of medical foods targeting P. aeruginosa quorum sensing activity. PB - Taylor & Francis Ltd, Abingdon T2 - Natural Product Research T1 - In vitro anti-quorum sensing activity of phytol EP - 377 IS - 4 SP - 374 VL - 29 DO - 10.1080/14786419.2014.945088 ER -
@article{ author = "Pejin, Boris and Ciric, Ana and Glamočlija, Jasmina and Nikolic, Milos and Soković, Marina", year = "2015", abstract = "Anti-quorum sensing activity of the diterpene phytol was evaluated in vitro for the first time. This compound (at three sub-MIC concentrations - 0.5, 0.25 and 0.125 MIC, respectively) reduced the formation of Pseudomonas aeruginosa PAO1 biofilm in the range of 74.00-84.33% exhibiting higher activity than the both positive controls used, streptomycin and ampicillin. Phytol (0.5 MIC) also effectively reduced P. aeruginosa twitching and flagella motility. Indeed, the bacteria treated were incapable of producing a twitching zone and had almost round, smooth and regular colony edges. Finally, the tested compound (0.5 MIC) exhibited good P. aeruginosa pyocyanin inhibitory activity (51.94%) practically to the same extent as streptomycin (52.09%). According to the experimental data obtained, this phytol property may inspire design of medical foods targeting P. aeruginosa quorum sensing activity.", publisher = "Taylor & Francis Ltd, Abingdon", journal = "Natural Product Research", title = "In vitro anti-quorum sensing activity of phytol", pages = "377-374", number = "4", volume = "29", doi = "10.1080/14786419.2014.945088" }
Pejin, B., Ciric, A., Glamočlija, J., Nikolic, M.,& Soković, M.. (2015). In vitro anti-quorum sensing activity of phytol. in Natural Product Research Taylor & Francis Ltd, Abingdon., 29(4), 374-377. https://doi.org/10.1080/14786419.2014.945088
Pejin B, Ciric A, Glamočlija J, Nikolic M, Soković M. In vitro anti-quorum sensing activity of phytol. in Natural Product Research. 2015;29(4):374-377. doi:10.1080/14786419.2014.945088 .
Pejin, Boris, Ciric, Ana, Glamočlija, Jasmina, Nikolic, Milos, Soković, Marina, "In vitro anti-quorum sensing activity of phytol" in Natural Product Research, 29, no. 4 (2015):374-377, https://doi.org/10.1080/14786419.2014.945088 . .