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Effect of long-term cyanide exposure on cyanide-sensitive respiration and phosphate metabolism in the fungus phycomyces blakesleeanus
dc.creator | Stanić, Marina | |
dc.creator | Zivić, Miroslav | |
dc.creator | Hadzibrahimović, Mirzeta | |
dc.creator | Pajdic, Aleksandra | |
dc.creator | Krizak, Strahinja | |
dc.creator | Žižić, Milan | |
dc.creator | Zakrzewska, Joanna | |
dc.date.accessioned | 2022-04-05T14:52:18Z | |
dc.date.available | 2022-04-05T14:52:18Z | |
dc.date.issued | 2014 | |
dc.identifier.issn | 0354-4664 | |
dc.identifier.uri | http://rimsi.imsi.bg.ac.rs/handle/123456789/809 | |
dc.description.abstract | The effects of long-term exposure (5 h) of Phycomyces blakesleeanus mycelium to 5 mM KCN on respiration and phosphate metabolites were tested. Exposure to cyanide, antimycin A and azide lead to a decrease in the activity of cyanide-sensitive respiration (CSR), and the ratio of core polyphosphates (PPc) and inorganic phosphates (Pi), which is a good indicator of the metabolic state of a cell. After 5 h of incubation, the activity of CSR returned to control values. For this, the recovery of cytochrome c oxid.ase (COX) was required. In addition, the PPc/Pi ratio started to recover shortly after initiation of COX recovery, but never reached control values. This led us to conclude that the regulation of polyphosphate (PPn) levels in the cell is tightly coupled to respiratory chain functioning. In addition, acutely applied cyanide caused two different responses, observed by P-31 NMR spectroscopy, that were probably mediated through the mechanism of glycolytic oscillations, triggered by the effect of cyanide on mitochondria. | en |
dc.publisher | Srpsko biološko društvo, Beograd, i dr. | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173040/RS// | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.source | Archives of Biological Sciences | |
dc.subject | sugar phosphates | en |
dc.subject | polyphosphates | en |
dc.subject | Phycomyces blakesleeanus | en |
dc.subject | P-31 NMR | en |
dc.subject | cyanide sensitive respiration | en |
dc.title | Effect of long-term cyanide exposure on cyanide-sensitive respiration and phosphate metabolism in the fungus phycomyces blakesleeanus | en |
dc.type | article | |
dc.rights.license | BY-NC-ND | |
dc.citation.epage | 857 | |
dc.citation.issue | 2 | |
dc.citation.other | 66(2): 847-857 | |
dc.citation.rank | M23 | |
dc.citation.spage | 847 | |
dc.citation.volume | 66 | |
dc.identifier.doi | 10.2298/ABS1402847S | |
dc.identifier.fulltext | http://rimsi.imsi.bg.ac.rs/bitstream/id/968/806.pdf | |
dc.identifier.scopus | 2-s2.0-84904015691 | |
dc.identifier.wos | 000342265800044 | |
dc.type.version | publishedVersion |