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Comparison of the effects of methanethiol and sodium sulphide on uterine contractile activity
dc.creator | Mijusković, Ana | |
dc.creator | Oreščanin-Dušić, Zorana | |
dc.creator | Nikolić-Kokić, Aleksandra | |
dc.creator | Slavić, Marija | |
dc.creator | Spasić, Mihajlo | |
dc.creator | Spasojević, Ivan | |
dc.creator | Blagojević, Duško P | |
dc.date.accessioned | 2022-04-05T14:50:49Z | |
dc.date.available | 2022-04-05T14:50:49Z | |
dc.date.issued | 2014 | |
dc.identifier.issn | 1734-1140 | |
dc.identifier.uri | http://rimsi.imsi.bg.ac.rs/handle/123456789/787 | |
dc.description.abstract | Background: Our aim was to investigate the effect of methanethiol (CH3SH) on contractility of rat uterus and activities of redox-active enzymes, and to compare them with the effect of sodium sulphide (Na2S), a hydrogen sulphide (H2S/HS-) donor. Methods: Uteri were isolated from virgin Wistar rats, divided into six groups, controls (untreated uteri allowed to contract spontaneously and in the presence of Ca2+(6 mM)), CH3SH treated (spontaneously active and Ca2+ induced) and Na2S treated (spontaneously active and Ca2+ induced). Underlying antioxidative enzyme activities (superoxide dismutase - SOD, glutathione peroxidase - GSHPx, glutathione reductase - GR) in CH3SH- or Na2S-treated uteri were compared to controls. Results: Our experiments showed that CH3SH and Na2S provoked reversible relaxation of both spontaneous and Ca2+ induced uterine contractions. The dose-response curves differed in shape, and CH3SH curve was shifted to higher concentration compared to H2S/HS-. The effects of Na2S fitted sigmoid curve, whereas those of CH3SH fitted linearly. CH3SH provoked increased SOD activity and decreased GR activity. However, Na2S (H2S/HS-) provoked an increase in SOD activity exclusively in Ca2+ stimulated uteri, while the activity of GSHPx was increased in both types of active uteri. Conclusion: Our results imply that CH3SH may have a constructive role in the control of muscle function and metabolism. Observed differences between CH3SH and H2S/HS- could be attributed to a larger moiety that is present in CH3SH compared to H2S, but they are more likely to be a consequence of the specific actions of HS-, in relation to its negative charge. | en |
dc.publisher | Polish Acad Sciences Inst Pharmacology, Krakow | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173014/RS// | |
dc.rights | restrictedAccess | |
dc.source | Pharmacological Reports | |
dc.subject | SOD | en |
dc.subject | Relaxation | en |
dc.subject | Reactive oxygen species | en |
dc.subject | Methanethiol | en |
dc.subject | Hydrogen sulfide | en |
dc.title | Comparison of the effects of methanethiol and sodium sulphide on uterine contractile activity | en |
dc.type | article | |
dc.rights.license | ARR | |
dc.citation.epage | 379 | |
dc.citation.issue | 3 | |
dc.citation.other | 66(3): 373-379 | |
dc.citation.rank | M23 | |
dc.citation.spage | 373 | |
dc.citation.volume | 66 | |
dc.identifier.doi | 10.1016/j.pharep.2013.12.012 | |
dc.identifier.pmid | 24905511 | |
dc.identifier.scopus | 2-s2.0-84901450234 | |
dc.identifier.wos | 000336948900005 | |
dc.type.version | publishedVersion |
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