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Further in vitro evaluation of cytotoxicity of the marine natural product derivative 4 '-leucine-avarone
dc.creator | Pejin, Boris | |
dc.creator | Iodice, Carmine | |
dc.creator | Tommonaro, Giuseppina | |
dc.creator | Bogdanović, Gordana | |
dc.creator | Kojić, Vesna | |
dc.creator | De Rosa, Salvatore | |
dc.date.accessioned | 2022-04-05T14:50:16Z | |
dc.date.available | 2022-04-05T14:50:16Z | |
dc.date.issued | 2014 | |
dc.identifier.issn | 1478-6419 | |
dc.identifier.uri | http://rimsi.imsi.bg.ac.rs/handle/123456789/779 | |
dc.description.abstract | The cytotoxicity of 4-leucine-avarone, amino derivative of the sponge Dysidea avara secondary metabolite avarone, was evaluated by 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide assay in vitro against seven human solid tumours for the first time. The compound tested induced dose-dependent cytotoxic response in all cancer cells showing better activity towards the lung A-549 and colon HT-29 cell lines (IC50 7.40M and 9.62M, respectively) than towards the breast adenocarcinoma ER positive MCF-7 and ER negative MDA-MB-231 cells (IC50 11.64M and 17.31M, respectively), the prostate adenocarcinoma PC-3 and epiteloid cervix carcinoma HeLa cells (IC50 14.24M and 15.54M, respectively). No toxicity was found towards the foetal lung fibroblast MRC-5 cell line at the concentrations used. According to experimental data obtained, the sesquiterpenoid quinone structure of avarone may inspire development of new drug-like substances with improved cytotoxicity on lung cancer in humans. | en |
dc.publisher | Taylor & Francis Ltd, Abingdon | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172006/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172053/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173040/RS// | |
dc.rights | restrictedAccess | |
dc.source | Natural Product Research | |
dc.subject | sesquiterpenoid quinone | en |
dc.subject | MTT assay | en |
dc.subject | Dysidea avara | en |
dc.subject | A-549 cells | en |
dc.title | Further in vitro evaluation of cytotoxicity of the marine natural product derivative 4 '-leucine-avarone | en |
dc.type | article | |
dc.rights.license | ARR | |
dc.citation.epage | 350 | |
dc.citation.issue | 5 | |
dc.citation.other | 28(5): 347-350 | |
dc.citation.rank | M23 | |
dc.citation.spage | 347 | |
dc.citation.volume | 28 | |
dc.identifier.doi | 10.1080/14786419.2013.863201 | |
dc.identifier.pmid | 24422776 | |
dc.identifier.scopus | 2-s2.0-84896392470 | |
dc.identifier.wos | 000333994100014 | |
dc.type.version | publishedVersion |
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