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Starosne promene u sadržaju insulin - sličnom faktora rasta i u mozgu pacova
Age-related changes in the content of insulin: Like growth factor-l in rat brain
dc.creator | Culic, M | |
dc.creator | Grbic, G | |
dc.creator | Martać, Ljiljana | |
dc.creator | Todorović, V | |
dc.creator | Drndarević, N | |
dc.creator | Nikolic, JA | |
dc.creator | Kalauzi, Aleksandar | |
dc.creator | Spasić, Slađana | |
dc.date.accessioned | 2022-04-05T14:02:39Z | |
dc.date.available | 2022-04-05T14:02:39Z | |
dc.date.issued | 2002 | |
dc.identifier.issn | 0567-8315 | |
dc.identifier.uri | http://rimsi.imsi.bg.ac.rs/handle/123456789/71 | |
dc.description.abstract | Vršena su istraživanja insulinu sličnog faktora rasta (IGF-I) na mišićno i koštano tkivo, ali je posvećena mala pažnja efektu na mozak u toku starenja. Mi smo ispitivali sadržaj IGF-I u moždanom tkivu pacova različite starosti. Nađeno je da su IGF-I koncentracije u kori malog mozga kao i velikog mozga mladih pacova (4-5 dana starih) više u poređenju sa sadržajima grupe tek-odraslih pacova starosti 2,5 meseca i grupe nešto starijih odraslih pacova (7,5-9 meseci starih). Međutim, smanjenje koncentracije IGF-I sadržaja samo u kori malog mozga nešto starijih pacova (7,5-9 meseci) bilo je značajno u odnosu na vrednosti u novorođenih (4-5 dana starih pacova). Naši rezultati ukazuju da IGF-I opada tokom života i moguće - selektivno u određenim moždanim regionima. | sr |
dc.description.abstract | Although there has been extensive research on the effect of IGF-I on muscles and bone tissue, the effect on brain aging has received little attention. We investigated the IGF-I content in brains of differently aged rats. The IGF-I contents in cerebellar and cerebral cortex were found to be higher in immature rats (4-5 days old) compared to young adult (2.5 months old) and middle-aged (7.5-9 months old) rats. However, the decrease of mean IGF-I in middle-aged rats compared to immature animals was statistically significant only in the cerebellar codex. Our results indicate that IGF-I content decreases through the lifespan and maybe selectively in some brain regions. | en |
dc.publisher | Univerzitet u Beogradu - Fakultet veterinarske medicine, Beograd | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.source | Acta Veterinaria-Beograd | |
dc.subject | rat | en |
dc.subject | IGF-I | en |
dc.subject | cerebellar cortex | en |
dc.subject | brain | en |
dc.subject | ageing | en |
dc.title | Starosne promene u sadržaju insulin - sličnom faktora rasta i u mozgu pacova | sr |
dc.title | Age-related changes in the content of insulin: Like growth factor-l in rat brain | en |
dc.type | article | |
dc.rights.license | BY-NC-ND | |
dc.citation.epage | 303 | |
dc.citation.issue | 5-6 | |
dc.citation.other | 52(5-6): 299-303 | |
dc.citation.rank | M23 | |
dc.citation.spage | 299 | |
dc.citation.volume | 52 | |
dc.identifier.doi | 10.2298/AVB0206299C | |
dc.identifier.fulltext | http://rimsi.imsi.bg.ac.rs/bitstream/id/870/68.pdf | |
dc.identifier.scopus | 2-s2.0-0036975950 | |
dc.identifier.wos | 000180300700002 | |
dc.type.version | publishedVersion |