Effects of xanthine derivatives on electroretinographic responsiveness
Само за регистроване кориснике
2000
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
In view of the use of synthetic propentofylline (PPF) as a protective agent in brain ischemia, its possible side effects on vision capacities have been explored by electroretinography in comparative experiments with theophylline. We used eyecup preparations of small-spotted dogfish sharks and of European eels, particularly ly suitable for long-lasting experiments. The drug exerted profound but reversible modifications of ERG records: (1) a dose-dependent increase of the amplitude and duration of the chemically isolated late receptor potential (LRP), (2) a partial unmasking of LRP, (3) a strong potentiation of the LRP-unmasking effect of low temperature, (3) a potentiation of light adaptation effects, and (5) a strong potentiation of the post-illumination hyperexcitability. The effects were explicable as due to a strong phosphodiesterase (PDE) inhibiting, cyclic guanosine monophosphate (cGMP) promoting, action of the drug. The effects were considerably stronger, or even of opposite sign..., in comparison to those of the chemically related theophylline. PPF did not seriously affect the ERG c-wave originating in the pigment epithelium. The results suggested that the effects of PPF on vision may not seriously hamper the therapeutic use of the drug. They indicated, on the other hand, that PPF was a retinoactive drug of potential usefulness in the exploration of the complex biochemical events underlying visual transduction.
Кључне речи:
xanthines / vision / theophylline / propentofylline / electroretinography (ERG)Извор:
Brain Research, 2000, 868, 2, 176-190Издавач:
- Elsevier, Amsterdam
DOI: 10.1016/S0006-8993(00)02328-3
ISSN: 0006-8993
PubMed: 10854570
WoS: 000087789300002
Scopus: 2-s2.0-0034705740
Институција/група
Institut za multidisciplinarna istraživanjaTY - JOUR AU - Andjus, RK AU - Konjević, D AU - Damjanović, Ilija AU - Gačić, Zoran PY - 2000 UR - http://rimsi.imsi.bg.ac.rs/handle/123456789/56 AB - In view of the use of synthetic propentofylline (PPF) as a protective agent in brain ischemia, its possible side effects on vision capacities have been explored by electroretinography in comparative experiments with theophylline. We used eyecup preparations of small-spotted dogfish sharks and of European eels, particularly ly suitable for long-lasting experiments. The drug exerted profound but reversible modifications of ERG records: (1) a dose-dependent increase of the amplitude and duration of the chemically isolated late receptor potential (LRP), (2) a partial unmasking of LRP, (3) a strong potentiation of the LRP-unmasking effect of low temperature, (3) a potentiation of light adaptation effects, and (5) a strong potentiation of the post-illumination hyperexcitability. The effects were explicable as due to a strong phosphodiesterase (PDE) inhibiting, cyclic guanosine monophosphate (cGMP) promoting, action of the drug. The effects were considerably stronger, or even of opposite sign, in comparison to those of the chemically related theophylline. PPF did not seriously affect the ERG c-wave originating in the pigment epithelium. The results suggested that the effects of PPF on vision may not seriously hamper the therapeutic use of the drug. They indicated, on the other hand, that PPF was a retinoactive drug of potential usefulness in the exploration of the complex biochemical events underlying visual transduction. PB - Elsevier, Amsterdam T2 - Brain Research T1 - Effects of xanthine derivatives on electroretinographic responsiveness EP - 190 IS - 2 SP - 176 VL - 868 DO - 10.1016/S0006-8993(00)02328-3 ER -
@article{ author = "Andjus, RK and Konjević, D and Damjanović, Ilija and Gačić, Zoran", year = "2000", abstract = "In view of the use of synthetic propentofylline (PPF) as a protective agent in brain ischemia, its possible side effects on vision capacities have been explored by electroretinography in comparative experiments with theophylline. We used eyecup preparations of small-spotted dogfish sharks and of European eels, particularly ly suitable for long-lasting experiments. The drug exerted profound but reversible modifications of ERG records: (1) a dose-dependent increase of the amplitude and duration of the chemically isolated late receptor potential (LRP), (2) a partial unmasking of LRP, (3) a strong potentiation of the LRP-unmasking effect of low temperature, (3) a potentiation of light adaptation effects, and (5) a strong potentiation of the post-illumination hyperexcitability. The effects were explicable as due to a strong phosphodiesterase (PDE) inhibiting, cyclic guanosine monophosphate (cGMP) promoting, action of the drug. The effects were considerably stronger, or even of opposite sign, in comparison to those of the chemically related theophylline. PPF did not seriously affect the ERG c-wave originating in the pigment epithelium. The results suggested that the effects of PPF on vision may not seriously hamper the therapeutic use of the drug. They indicated, on the other hand, that PPF was a retinoactive drug of potential usefulness in the exploration of the complex biochemical events underlying visual transduction.", publisher = "Elsevier, Amsterdam", journal = "Brain Research", title = "Effects of xanthine derivatives on electroretinographic responsiveness", pages = "190-176", number = "2", volume = "868", doi = "10.1016/S0006-8993(00)02328-3" }
Andjus, R., Konjević, D., Damjanović, I.,& Gačić, Z.. (2000). Effects of xanthine derivatives on electroretinographic responsiveness. in Brain Research Elsevier, Amsterdam., 868(2), 176-190. https://doi.org/10.1016/S0006-8993(00)02328-3
Andjus R, Konjević D, Damjanović I, Gačić Z. Effects of xanthine derivatives on electroretinographic responsiveness. in Brain Research. 2000;868(2):176-190. doi:10.1016/S0006-8993(00)02328-3 .
Andjus, RK, Konjević, D, Damjanović, Ilija, Gačić, Zoran, "Effects of xanthine derivatives on electroretinographic responsiveness" in Brain Research, 868, no. 2 (2000):176-190, https://doi.org/10.1016/S0006-8993(00)02328-3 . .