Biological activities of phenolic compounds and ethanolic extract of Halacsya sendtneri (Boiss) Dorfler
Само за регистроване кориснике
2012
Аутори
Masković, Pavle ZDragišić Maksimović, Jelena
Maksimović, Vuk
Blagojević, Jelena
Vujosević, Mladen R
Manojlović, Nedeljko T
Radojković, Marija M
Cvijović, Milica S
Solujic, Slavica R
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
The objective of this study was to evaluate the efficacy of the ethanolic extract of endemic plant Halacsya sendtneri in inhibiting the growing of the test fungi and bacteria as well as to determine its genotoxic potential and toxicity using the Allium anaphase-telophase assay. Minimum inhibitory concentrations (MIC) were determined for 15 indicator strains of pathogens, representing both bacteria and fungi. The highest susceptibility to the ethanolic extract of H. sendtneri was exhibited by Pseudomonas glycinea (FSB4), (MIC=0.09 mg/ml) among the bacteria, and by Phialophora fastigiata (FSB81), (MIC=1.95 mg/ml) among the fungi. The composition of H. sendtneri extracts was also determined using HPLC analysis. Rosmarinic acid was found to be the dominant phenolic compound. The Allium anaphase-telophase genotoxicity assay revealed that the ethanolic extract of H. sendtneri at concentrations of 31.5 mg/l and below does not produce toxic or genotoxic effects. This is the first report of che...mical constituents, genotoxic and antimicrobial activities of the endemic species, H. sendtneri.
Кључне речи:
Phenolic compounds / Halacsya sendtneri / Genotoxicity / Antimicrobial activityИзвор:
Central European Journal of Biology, 2012, 7, 2, 327-333Издавач:
- De Gruyter Poland Sp Z O O, Warsaw
Финансирање / пројекти:
- Ministry of Agriculture, Forestry and Water Management, STAR [401-001972/2010-03]
- Интеракције мембрана са унутарћелијским и апопластичним простором: изучавања биоенергетике и сингализације користећи биофизичке и биохемијске методе (RS-MESTD-Basic Research (BR or ON)-173040)
- Генетичка и фенетичка разноврсност у природним популацијама у различитим срединама - допринос полиморфизма Б хромозома (RS-MESTD-Basic Research (BR or ON)-173003)
DOI: 10.2478/s11535-012-0021-8
ISSN: 1895-104X
WoS: 000302476500017
Scopus: 2-s2.0-84856776841
Институција/група
Institut za multidisciplinarna istraživanjaTY - JOUR AU - Masković, Pavle Z AU - Dragišić Maksimović, Jelena AU - Maksimović, Vuk AU - Blagojević, Jelena AU - Vujosević, Mladen R AU - Manojlović, Nedeljko T AU - Radojković, Marija M AU - Cvijović, Milica S AU - Solujic, Slavica R PY - 2012 UR - http://rimsi.imsi.bg.ac.rs/handle/123456789/556 AB - The objective of this study was to evaluate the efficacy of the ethanolic extract of endemic plant Halacsya sendtneri in inhibiting the growing of the test fungi and bacteria as well as to determine its genotoxic potential and toxicity using the Allium anaphase-telophase assay. Minimum inhibitory concentrations (MIC) were determined for 15 indicator strains of pathogens, representing both bacteria and fungi. The highest susceptibility to the ethanolic extract of H. sendtneri was exhibited by Pseudomonas glycinea (FSB4), (MIC=0.09 mg/ml) among the bacteria, and by Phialophora fastigiata (FSB81), (MIC=1.95 mg/ml) among the fungi. The composition of H. sendtneri extracts was also determined using HPLC analysis. Rosmarinic acid was found to be the dominant phenolic compound. The Allium anaphase-telophase genotoxicity assay revealed that the ethanolic extract of H. sendtneri at concentrations of 31.5 mg/l and below does not produce toxic or genotoxic effects. This is the first report of chemical constituents, genotoxic and antimicrobial activities of the endemic species, H. sendtneri. PB - De Gruyter Poland Sp Z O O, Warsaw T2 - Central European Journal of Biology T1 - Biological activities of phenolic compounds and ethanolic extract of Halacsya sendtneri (Boiss) Dorfler EP - 333 IS - 2 SP - 327 VL - 7 DO - 10.2478/s11535-012-0021-8 ER -
@article{ author = "Masković, Pavle Z and Dragišić Maksimović, Jelena and Maksimović, Vuk and Blagojević, Jelena and Vujosević, Mladen R and Manojlović, Nedeljko T and Radojković, Marija M and Cvijović, Milica S and Solujic, Slavica R", year = "2012", abstract = "The objective of this study was to evaluate the efficacy of the ethanolic extract of endemic plant Halacsya sendtneri in inhibiting the growing of the test fungi and bacteria as well as to determine its genotoxic potential and toxicity using the Allium anaphase-telophase assay. Minimum inhibitory concentrations (MIC) were determined for 15 indicator strains of pathogens, representing both bacteria and fungi. The highest susceptibility to the ethanolic extract of H. sendtneri was exhibited by Pseudomonas glycinea (FSB4), (MIC=0.09 mg/ml) among the bacteria, and by Phialophora fastigiata (FSB81), (MIC=1.95 mg/ml) among the fungi. The composition of H. sendtneri extracts was also determined using HPLC analysis. Rosmarinic acid was found to be the dominant phenolic compound. The Allium anaphase-telophase genotoxicity assay revealed that the ethanolic extract of H. sendtneri at concentrations of 31.5 mg/l and below does not produce toxic or genotoxic effects. This is the first report of chemical constituents, genotoxic and antimicrobial activities of the endemic species, H. sendtneri.", publisher = "De Gruyter Poland Sp Z O O, Warsaw", journal = "Central European Journal of Biology", title = "Biological activities of phenolic compounds and ethanolic extract of Halacsya sendtneri (Boiss) Dorfler", pages = "333-327", number = "2", volume = "7", doi = "10.2478/s11535-012-0021-8" }
Masković, P. Z., Dragišić Maksimović, J., Maksimović, V., Blagojević, J., Vujosević, M. R., Manojlović, N. T., Radojković, M. M., Cvijović, M. S.,& Solujic, S. R.. (2012). Biological activities of phenolic compounds and ethanolic extract of Halacsya sendtneri (Boiss) Dorfler. in Central European Journal of Biology De Gruyter Poland Sp Z O O, Warsaw., 7(2), 327-333. https://doi.org/10.2478/s11535-012-0021-8
Masković PZ, Dragišić Maksimović J, Maksimović V, Blagojević J, Vujosević MR, Manojlović NT, Radojković MM, Cvijović MS, Solujic SR. Biological activities of phenolic compounds and ethanolic extract of Halacsya sendtneri (Boiss) Dorfler. in Central European Journal of Biology. 2012;7(2):327-333. doi:10.2478/s11535-012-0021-8 .
Masković, Pavle Z, Dragišić Maksimović, Jelena, Maksimović, Vuk, Blagojević, Jelena, Vujosević, Mladen R, Manojlović, Nedeljko T, Radojković, Marija M, Cvijović, Milica S, Solujic, Slavica R, "Biological activities of phenolic compounds and ethanolic extract of Halacsya sendtneri (Boiss) Dorfler" in Central European Journal of Biology, 7, no. 2 (2012):327-333, https://doi.org/10.2478/s11535-012-0021-8 . .