The objective of this study was to evaluate the efficacy of the ethanolic extract of endemic plant Halacsya sendtneri in inhibiting the growing of the test fungi and bacteria as well as to determine its genotoxic potential and toxicity using the Allium anaphase-telophase assay. Minimum inhibitory concentrations (MIC) were determined for 15 indicator strains of pathogens, representing both bacteria and fungi. The highest susceptibility to the ethanolic extract of H. sendtneri was exhibited by Pseudomonas glycinea (FSB4), (MIC=0.09 mg/ml) among the bacteria, and by Phialophora fastigiata (FSB81), (MIC=1.95 mg/ml) among the fungi. The composition of H. sendtneri extracts was also determined using HPLC analysis. Rosmarinic acid was found to be the dominant phenolic compound. The Allium anaphase-telophase genotoxicity assay revealed that the ethanolic extract of H. sendtneri at concentrations of 31.5 mg/l and below does not produce toxic or genotoxic effects. This is the first report of che...mical constituents, genotoxic and antimicrobial activities of the endemic species, H. sendtneri.
TY - JOUR
AU - Masković, Pavle Z
AU - Dragišić Maksimović, Jelena
AU - Maksimović, Vuk
AU - Blagojević, Jelena
AU - Vujosević, Mladen R
AU - Manojlović, Nedeljko T
AU - Radojković, Marija M
AU - Cvijović, Milica S
AU - Solujic, Slavica R
PY - 2012
UR - http://rimsi.imsi.bg.ac.rs/handle/123456789/556
AB - The objective of this study was to evaluate the efficacy of the ethanolic extract of endemic plant Halacsya sendtneri in inhibiting the growing of the test fungi and bacteria as well as to determine its genotoxic potential and toxicity using the Allium anaphase-telophase assay. Minimum inhibitory concentrations (MIC) were determined for 15 indicator strains of pathogens, representing both bacteria and fungi. The highest susceptibility to the ethanolic extract of H. sendtneri was exhibited by Pseudomonas glycinea (FSB4), (MIC=0.09 mg/ml) among the bacteria, and by Phialophora fastigiata (FSB81), (MIC=1.95 mg/ml) among the fungi. The composition of H. sendtneri extracts was also determined using HPLC analysis. Rosmarinic acid was found to be the dominant phenolic compound. The Allium anaphase-telophase genotoxicity assay revealed that the ethanolic extract of H. sendtneri at concentrations of 31.5 mg/l and below does not produce toxic or genotoxic effects. This is the first report of chemical constituents, genotoxic and antimicrobial activities of the endemic species, H. sendtneri.
PB - De Gruyter Poland Sp Z O O, Warsaw
T2 - Central European Journal of Biology
T1 - Biological activities of phenolic compounds and ethanolic extract of Halacsya sendtneri (Boiss) Dorfler
EP - 333
IS - 2
SP - 327
VL - 7
DO - 10.2478/s11535-012-0021-8
ER -
@article{
author = "Masković, Pavle Z and Dragišić Maksimović, Jelena and Maksimović, Vuk and Blagojević, Jelena and Vujosević, Mladen R and Manojlović, Nedeljko T and Radojković, Marija M and Cvijović, Milica S and Solujic, Slavica R",
year = "2012",
abstract = "The objective of this study was to evaluate the efficacy of the ethanolic extract of endemic plant Halacsya sendtneri in inhibiting the growing of the test fungi and bacteria as well as to determine its genotoxic potential and toxicity using the Allium anaphase-telophase assay. Minimum inhibitory concentrations (MIC) were determined for 15 indicator strains of pathogens, representing both bacteria and fungi. The highest susceptibility to the ethanolic extract of H. sendtneri was exhibited by Pseudomonas glycinea (FSB4), (MIC=0.09 mg/ml) among the bacteria, and by Phialophora fastigiata (FSB81), (MIC=1.95 mg/ml) among the fungi. The composition of H. sendtneri extracts was also determined using HPLC analysis. Rosmarinic acid was found to be the dominant phenolic compound. The Allium anaphase-telophase genotoxicity assay revealed that the ethanolic extract of H. sendtneri at concentrations of 31.5 mg/l and below does not produce toxic or genotoxic effects. This is the first report of chemical constituents, genotoxic and antimicrobial activities of the endemic species, H. sendtneri.",
publisher = "De Gruyter Poland Sp Z O O, Warsaw",
journal = "Central European Journal of Biology",
title = "Biological activities of phenolic compounds and ethanolic extract of Halacsya sendtneri (Boiss) Dorfler",
pages = "333-327",
number = "2",
volume = "7",
doi = "10.2478/s11535-012-0021-8"
}
Masković, P. Z., Dragišić Maksimović, J., Maksimović, V., Blagojević, J., Vujosević, M. R., Manojlović, N. T., Radojković, M. M., Cvijović, M. S.,& Solujic, S. R.. (2012). Biological activities of phenolic compounds and ethanolic extract of Halacsya sendtneri (Boiss) Dorfler. in Central European Journal of Biology
De Gruyter Poland Sp Z O O, Warsaw., 7(2), 327-333.
https://doi.org/10.2478/s11535-012-0021-8
Masković PZ, Dragišić Maksimović J, Maksimović V, Blagojević J, Vujosević MR, Manojlović NT, Radojković MM, Cvijović MS, Solujic SR. Biological activities of phenolic compounds and ethanolic extract of Halacsya sendtneri (Boiss) Dorfler. in Central European Journal of Biology. 2012;7(2):327-333.
doi:10.2478/s11535-012-0021-8 .
Masković, Pavle Z, Dragišić Maksimović, Jelena, Maksimović, Vuk, Blagojević, Jelena, Vujosević, Mladen R, Manojlović, Nedeljko T, Radojković, Marija M, Cvijović, Milica S, Solujic, Slavica R, "Biological activities of phenolic compounds and ethanolic extract of Halacsya sendtneri (Boiss) Dorfler" in Central European Journal of Biology, 7, no. 2 (2012):327-333,
https://doi.org/10.2478/s11535-012-0021-8 . .
