The Negative Effect of Soy Extract on Erythrocyte Membrane Fluidity: An Electron Paramagnetic Resonance Study
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2011
Authors
Ajdzanović, Vladimir Z
Spasojević, Ivan

Sosic-Jurjević, Branka T
Filipović, Branko R

Trifunović, Svetlana L
Sekulic, Milka I
Milošević, Verica Lj.
Article (Published version)

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A decrease of erythrocyte membrane fluidity can contribute to the pathophysiology of hypertension. Soy products, which are used as alternative therapeutics in some cardiovascular conditions, contain various isoflavones (genistein, daidzein, and their glucosides, genistin and daidzin), which can incorporate cellular membrane and change its fluidity. The aim of this study was to examine the effects of soy extract (which generally corresponds to the soy products of isoflavone composition) on erythrocyte membrane fluidity at graded depths. We used electron paramagnetic resonance spectroscopy and fatty acid spin probes (5-DS and 12-DS), the spectra of which are dependent on membrane fluidity. After being treated with soy extract, erythrocytes showed a significant (P = 0.016) decrease of membrane fluidity near the hydrophilic surface, while there were no significant changes of fluidity in deeper hydrophobic membrane regions. These results suggest that soy products containing high levels of g...enistein and isoflavone glucosides may not be suitable for use in hypertension because they decrease erythrocyte membrane fluidity.
Keywords:
Spin probes / Soy extract / Membrane fluidity / Isoflavone glucoside / Genistein / Erythrocytes / Electron paramagnetic resonanceSource:
Journal of Membrane Biology, 2011, 239, 3, 131-135Publisher:
- Springer, New York
Funding / projects:
- Uticaj fitoestrogena, steroidnih i peptidnih hormona na ćelije neuroendokrinog sistema (RS-143007)
- Biofizička istraživanja membranskih procesa: interakcija membranskih receptora i kanala sa spoljašnjim faktorima i intracelularna regulacija (RS-143016)
DOI: 10.1007/s00232-010-9332-8
ISSN: 0022-2631
PubMed: 21132426
WoS: 000287142700003
Scopus: 2-s2.0-79957527567
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Institut za multidisciplinarna istraživanjaTY - JOUR AU - Ajdzanović, Vladimir Z AU - Spasojević, Ivan AU - Sosic-Jurjević, Branka T AU - Filipović, Branko R AU - Trifunović, Svetlana L AU - Sekulic, Milka I AU - Milošević, Verica Lj. PY - 2011 UR - http://rimsi.imsi.bg.ac.rs/handle/123456789/482 AB - A decrease of erythrocyte membrane fluidity can contribute to the pathophysiology of hypertension. Soy products, which are used as alternative therapeutics in some cardiovascular conditions, contain various isoflavones (genistein, daidzein, and their glucosides, genistin and daidzin), which can incorporate cellular membrane and change its fluidity. The aim of this study was to examine the effects of soy extract (which generally corresponds to the soy products of isoflavone composition) on erythrocyte membrane fluidity at graded depths. We used electron paramagnetic resonance spectroscopy and fatty acid spin probes (5-DS and 12-DS), the spectra of which are dependent on membrane fluidity. After being treated with soy extract, erythrocytes showed a significant (P = 0.016) decrease of membrane fluidity near the hydrophilic surface, while there were no significant changes of fluidity in deeper hydrophobic membrane regions. These results suggest that soy products containing high levels of genistein and isoflavone glucosides may not be suitable for use in hypertension because they decrease erythrocyte membrane fluidity. PB - Springer, New York T2 - Journal of Membrane Biology T1 - The Negative Effect of Soy Extract on Erythrocyte Membrane Fluidity: An Electron Paramagnetic Resonance Study EP - 135 IS - 3 SP - 131 VL - 239 DO - 10.1007/s00232-010-9332-8 ER -
@article{ author = "Ajdzanović, Vladimir Z and Spasojević, Ivan and Sosic-Jurjević, Branka T and Filipović, Branko R and Trifunović, Svetlana L and Sekulic, Milka I and Milošević, Verica Lj.", year = "2011", abstract = "A decrease of erythrocyte membrane fluidity can contribute to the pathophysiology of hypertension. Soy products, which are used as alternative therapeutics in some cardiovascular conditions, contain various isoflavones (genistein, daidzein, and their glucosides, genistin and daidzin), which can incorporate cellular membrane and change its fluidity. The aim of this study was to examine the effects of soy extract (which generally corresponds to the soy products of isoflavone composition) on erythrocyte membrane fluidity at graded depths. We used electron paramagnetic resonance spectroscopy and fatty acid spin probes (5-DS and 12-DS), the spectra of which are dependent on membrane fluidity. After being treated with soy extract, erythrocytes showed a significant (P = 0.016) decrease of membrane fluidity near the hydrophilic surface, while there were no significant changes of fluidity in deeper hydrophobic membrane regions. These results suggest that soy products containing high levels of genistein and isoflavone glucosides may not be suitable for use in hypertension because they decrease erythrocyte membrane fluidity.", publisher = "Springer, New York", journal = "Journal of Membrane Biology", title = "The Negative Effect of Soy Extract on Erythrocyte Membrane Fluidity: An Electron Paramagnetic Resonance Study", pages = "135-131", number = "3", volume = "239", doi = "10.1007/s00232-010-9332-8" }
Ajdzanović, V. Z., Spasojević, I., Sosic-Jurjević, B. T., Filipović, B. R., Trifunović, S. L., Sekulic, M. I.,& Milošević, V. Lj.. (2011). The Negative Effect of Soy Extract on Erythrocyte Membrane Fluidity: An Electron Paramagnetic Resonance Study. in Journal of Membrane Biology Springer, New York., 239(3), 131-135. https://doi.org/10.1007/s00232-010-9332-8
Ajdzanović VZ, Spasojević I, Sosic-Jurjević BT, Filipović BR, Trifunović SL, Sekulic MI, Milošević VL. The Negative Effect of Soy Extract on Erythrocyte Membrane Fluidity: An Electron Paramagnetic Resonance Study. in Journal of Membrane Biology. 2011;239(3):131-135. doi:10.1007/s00232-010-9332-8 .
Ajdzanović, Vladimir Z, Spasojević, Ivan, Sosic-Jurjević, Branka T, Filipović, Branko R, Trifunović, Svetlana L, Sekulic, Milka I, Milošević, Verica Lj., "The Negative Effect of Soy Extract on Erythrocyte Membrane Fluidity: An Electron Paramagnetic Resonance Study" in Journal of Membrane Biology, 239, no. 3 (2011):131-135, https://doi.org/10.1007/s00232-010-9332-8 . .