Приказ основних података о документу

dc.creatorAndrades, Michael Everton
dc.creatorMorina, Arian
dc.creatorSpasic, Snežana D
dc.creatorSpasojević, Ivan
dc.date.accessioned2022-04-05T14:30:30Z
dc.date.available2022-04-05T14:30:30Z
dc.date.issued2011
dc.identifier.issn1364-8535
dc.identifier.urihttp://rimsi.imsi.bg.ac.rs/handle/123456789/480
dc.description.abstractThe pathogenesis of sepsis and its progression to multiple organ dysfunction syndrome and septic shock have been the subject of investigations for nearly half a century. Controversies still exist with regard to understanding the molecular pathophysiology of sepsis in relation to the complex roles played by reactive oxygen species, nitric oxide, complements and cytokines. In the present review we categorise the key turning points in sepsis development and outline the most probable sequence of events leading to cellular dysfunction and organ failure under septic conditions. We have applied an integrative approach in order to fuse current state-of-the-art knowledge about redox processes involving hydrogen peroxide, nitric oxide, superoxide, peroxynitrite and hydroxyl radical, which lead to mitochondrial respiratory dysfunction. Finally, from this point of view, the potential of redox therapy targeting sepsis is discussed.en
dc.publisherBmc, London
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173014/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/43004/RS//
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceCritical Care
dc.subjectinflammation
dc.subjecthydrogen peroxide
dc.subjectnitric oxide
dc.subjectoxidative stress
dc.subjectperoxynitrite
dc.titleBench-to-bedside review: Sepsis - from the redox point of viewen
dc.typearticle
dc.rights.licenseBY
dc.citation.issue5
dc.citation.other15(5): -
dc.citation.volume15
dc.identifier.doi10.1186/cc10334
dc.identifier.fulltexthttp://rimsi.imsi.bg.ac.rs/bitstream/id/703/477.pdf
dc.identifier.pmid21996422
dc.identifier.scopus2-s2.0-80054678294
dc.identifier.wos000303048200073
dc.type.versionpublishedVersion


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