Fuzzy logic point of view applied to diseases caused by dynamic mutations
Abstract
For the first time, this paper tries to explain the origins of diseases caused by unstable DNA repeats, known as dynamic mutations. It is common to find fairly simplified correlation between the number of DNA repeats and severity of diseases. By examining the case studies, it is possible to see that simplified model does not reflect real condition of the patients, so we have proposed more complex model which involves gender, immunological condition, age of onset and analysis of family tree. Conclusions are related to known molecular biology phenomenon such as DNA methylation, histone binding and RNA secondary structure.
Keywords:
Simplified models / RNA secondary structures / Molecular b / Information science / Family tree / Dynamic mutation / DNA / DNA repeats / DNA Methylation / Complex model / Artificial intelligence / AlkylationSource:
12th IEEE International Symposium on Computational Intelligence and Informatics, CINTI 2011 - Procee, 2011, 319-321Collections
Institution/Community
Institut za multidisciplinarna istraživanjaTY - CONF AU - Savić, A. AU - Jovanović, K. AU - Mihailović, J. AU - Radotić, Ksenija PY - 2011 UR - http://rimsi.imsi.bg.ac.rs/handle/123456789/447 AB - For the first time, this paper tries to explain the origins of diseases caused by unstable DNA repeats, known as dynamic mutations. It is common to find fairly simplified correlation between the number of DNA repeats and severity of diseases. By examining the case studies, it is possible to see that simplified model does not reflect real condition of the patients, so we have proposed more complex model which involves gender, immunological condition, age of onset and analysis of family tree. Conclusions are related to known molecular biology phenomenon such as DNA methylation, histone binding and RNA secondary structure. C3 - 12th IEEE International Symposium on Computational Intelligence and Informatics, CINTI 2011 - Procee T1 - Fuzzy logic point of view applied to diseases caused by dynamic mutations EP - 321 SP - 319 DO - 10.1109/CINTI.2011.6108522 ER -
@conference{ author = "Savić, A. and Jovanović, K. and Mihailović, J. and Radotić, Ksenija", year = "2011", abstract = "For the first time, this paper tries to explain the origins of diseases caused by unstable DNA repeats, known as dynamic mutations. It is common to find fairly simplified correlation between the number of DNA repeats and severity of diseases. By examining the case studies, it is possible to see that simplified model does not reflect real condition of the patients, so we have proposed more complex model which involves gender, immunological condition, age of onset and analysis of family tree. Conclusions are related to known molecular biology phenomenon such as DNA methylation, histone binding and RNA secondary structure.", journal = "12th IEEE International Symposium on Computational Intelligence and Informatics, CINTI 2011 - Procee", title = "Fuzzy logic point of view applied to diseases caused by dynamic mutations", pages = "321-319", doi = "10.1109/CINTI.2011.6108522" }
Savić, A., Jovanović, K., Mihailović, J.,& Radotić, K.. (2011). Fuzzy logic point of view applied to diseases caused by dynamic mutations. in 12th IEEE International Symposium on Computational Intelligence and Informatics, CINTI 2011 - Procee, 319-321. https://doi.org/10.1109/CINTI.2011.6108522
Savić A, Jovanović K, Mihailović J, Radotić K. Fuzzy logic point of view applied to diseases caused by dynamic mutations. in 12th IEEE International Symposium on Computational Intelligence and Informatics, CINTI 2011 - Procee. 2011;:319-321. doi:10.1109/CINTI.2011.6108522 .
Savić, A., Jovanović, K., Mihailović, J., Radotić, Ksenija, "Fuzzy logic point of view applied to diseases caused by dynamic mutations" in 12th IEEE International Symposium on Computational Intelligence and Informatics, CINTI 2011 - Procee (2011):319-321, https://doi.org/10.1109/CINTI.2011.6108522 . .