Приказ основних података о документу

dc.creatorSpasojević, Ivan
dc.creatorMojović, Miloš
dc.creatorStević, Zorica D
dc.creatorSpasic, Snežana D
dc.creatorJones, David R
dc.creatorMorina, Arian
dc.creatorSpasić, Mihajlo
dc.date.accessioned2022-04-05T14:26:22Z
dc.date.available2022-04-05T14:26:22Z
dc.date.issued2010
dc.identifier.issn1351-0002
dc.identifier.urihttp://rimsi.imsi.bg.ac.rs/handle/123456789/417
dc.description.abstractA breakdown in homeostasis of redox-active metals represents an important factor for neurodegeneration. We have used EPR spectroscopy and BMPO spin-trap to investigate the catalytic properties and ligand modulation of redox activity of copper and iron in human cerebrospinal fluid (CSF). In contrast to iron, copper supplementation provoked a statistically significant increase in hydroxyl free radical generation in CSF treated with H(2)O(2). However, in a binary copper/iron containing Fenton system, iron catalytically activated copper. The chelator EDTA, which represents a model of physiological metal ligands, completely prevented copper's redox activity in CSF, while iron chelation led to a significant increase in hydroxyl radical generation, indicating that copper and iron do not only have diverse catalytic properties in the CSF but also that their redox activities are differently modulated by ligands. The application of DDC reduced hydroxyl radical generation in the CSF containing catalytically active metals (free Cu(2+) or Fe(3+)-EDTA complex). We conclude that chelators, such as DDC, are capable of preventing the pro-oxidative activity of both metals and may be suitable for reducing hydroxyl radical formation in certain pathophysiological settings.en
dc.publisherManey Publishing, Leeds
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/143034/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/143016/RS//
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc/4.0/
dc.sourceRedox Report
dc.subjectironen
dc.subjectFenton reactionen
dc.subjectdiethyldithiocarbamateen
dc.subjectcopperen
dc.subjectcerebrospinal fluiden
dc.titleBioavailability and catalytic properties of copper and iron for Fenton chemistry in human cerebrospinal fluiden
dc.typearticle
dc.rights.licenseBY-NC
dc.citation.epage35
dc.citation.issue1
dc.citation.other15(1): 29-35
dc.citation.rankM23
dc.citation.spage29
dc.citation.volume15
dc.identifier.doi10.1179/174329210X12650506623087
dc.identifier.fulltexthttp://rimsi.imsi.bg.ac.rs/bitstream/id/651/414.pdf
dc.identifier.pmid20196926
dc.identifier.scopus2-s2.0-77949463742
dc.identifier.wos000275303600004
dc.type.versionpublishedVersion


Документи

Thumbnail

Овај документ се појављује у следећим колекцијама

Приказ основних података о документу