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dc.creatorAjdzanović, Vladimir Z
dc.creatorSpasojević, Ivan
dc.creatorFilipović, Branko R
dc.creatorSosic-Jurjević, Branka T
dc.creatorSekulic, Milka I
dc.creatorMilošević, Verica Lj.
dc.date.accessioned2022-04-05T14:26:10Z
dc.date.available2022-04-05T14:26:10Z
dc.date.issued2010
dc.identifier.issn0008-4212
dc.identifier.urihttp://rimsi.imsi.bg.ac.rs/handle/123456789/414
dc.description.abstractThe maintenance of erythrocyte membrane fluidity at the physiological level is an important factor affecting the ability of erythrocytes to pass through blood vessels of small luminal diameter. Genistein and daidzein, which are used as alternative therapeutics in cardiovascular conditions, can be incorporated into the cell membrane and change its fluidity. The aim of this study was to examine the effects of genistein and daidzein on erythrocyte membrane fluidity at graded depths. We used electron paramagnetic resonance (EPR) spectroscopy and fatty acid spin probes (5-DS and 12-DS) where EPR spectra were dependent on fluidity. The results showed that genistein significantly (p lt 0.05) decreased erythrocyte membrane fluidity near the hydrophilic surface, while daidzein significantly (p lt 0.05) increased the same parameter in deeper regions of the membrane. These data suggest that the deep fluidizing effects of daidzein on erythrocyte membranes make it a better therapeutic choice than genistein in some cardiovascular conditions.en
dc.publisherNatl Research Council Canada-N R C Research Press, Ottawa
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/143007/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/143016/RS//
dc.rightsrestrictedAccess
dc.sourceCanadian Journal of Physiology and Pharmacology
dc.subjectspin probesen
dc.subjectorder parameteren
dc.subjectmembrane fluidityen
dc.subjectgenisteinen
dc.subjecterythrocytesen
dc.subjectEPRen
dc.subjectdaidzeinen
dc.titleEffects of genistein and daidzein on erythrocyte membrane fluidity: an electron paramagnetic resonance studyen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage500
dc.citation.issue4
dc.citation.other88(4): 497-500
dc.citation.rankM22
dc.citation.spage497
dc.citation.volume88
dc.identifier.doi10.1139/Y10-020
dc.identifier.pmid20555419
dc.identifier.scopus2-s2.0-77952068968
dc.identifier.wos000279243700012
dc.type.versionpublishedVersion


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