Pulmonary inflammation is a biological response to cadmium entering the body via the respiratory route. Systemic administration of this metal revealed the lungs as a significant site of its disposition. In this study, the presence of basic indicators of lung inflammation (leukocyte infiltration and activity of cells recovered from lungs by enzyme digestion) was analyzed in the rat model of acute systemic cadmium intoxication. Intraperitoneal administration of both cadmium doses (0.5 mg/kg and 1.0 mg/kg) resulted in increased numbers of neutrophils. Signs of spontaneous activation of lung cells including the capacity of reduction of nitroblue tetrazolium (NBT), increase in myeloperoxidase (MPO) intracellular content and increase in interleukin-6 (IL-6) production were noted at both cadmium doses. Increased lung cell responsiveness to stimulation in vitro was noted at the higher cadmium dose. The presence of pulmonary inflammatory parameters in rats administered intraperitoneally with ca...dmium revealed the lungs as remote inflammatory targets of this metal.
TY - JOUR
AU - Kataranovski, Milena
AU - Mirkov, Ivana
AU - Belij, Sandra
AU - Nikolic, Miroslav
AU - Zolotarevski, Lidija
AU - Ciric, Danica
AU - Kataranovski, Dragan
PY - 2009
UR - http://rimsi.imsi.bg.ac.rs/handle/123456789/342
AB - Pulmonary inflammation is a biological response to cadmium entering the body via the respiratory route. Systemic administration of this metal revealed the lungs as a significant site of its disposition. In this study, the presence of basic indicators of lung inflammation (leukocyte infiltration and activity of cells recovered from lungs by enzyme digestion) was analyzed in the rat model of acute systemic cadmium intoxication. Intraperitoneal administration of both cadmium doses (0.5 mg/kg and 1.0 mg/kg) resulted in increased numbers of neutrophils. Signs of spontaneous activation of lung cells including the capacity of reduction of nitroblue tetrazolium (NBT), increase in myeloperoxidase (MPO) intracellular content and increase in interleukin-6 (IL-6) production were noted at both cadmium doses. Increased lung cell responsiveness to stimulation in vitro was noted at the higher cadmium dose. The presence of pulmonary inflammatory parameters in rats administered intraperitoneally with cadmium revealed the lungs as remote inflammatory targets of this metal.
PB - Elsevier Science Bv, Amsterdam
T2 - Environmental Toxicology and Pharmacology
T1 - Lungs: Remote inflammatory target of systemic cadmium administration in rats
EP - 231
IS - 2
SP - 225
VL - 28
DO - 10.1016/j.etap.2009.04.008
ER -
@article{
author = "Kataranovski, Milena and Mirkov, Ivana and Belij, Sandra and Nikolic, Miroslav and Zolotarevski, Lidija and Ciric, Danica and Kataranovski, Dragan",
year = "2009",
abstract = "Pulmonary inflammation is a biological response to cadmium entering the body via the respiratory route. Systemic administration of this metal revealed the lungs as a significant site of its disposition. In this study, the presence of basic indicators of lung inflammation (leukocyte infiltration and activity of cells recovered from lungs by enzyme digestion) was analyzed in the rat model of acute systemic cadmium intoxication. Intraperitoneal administration of both cadmium doses (0.5 mg/kg and 1.0 mg/kg) resulted in increased numbers of neutrophils. Signs of spontaneous activation of lung cells including the capacity of reduction of nitroblue tetrazolium (NBT), increase in myeloperoxidase (MPO) intracellular content and increase in interleukin-6 (IL-6) production were noted at both cadmium doses. Increased lung cell responsiveness to stimulation in vitro was noted at the higher cadmium dose. The presence of pulmonary inflammatory parameters in rats administered intraperitoneally with cadmium revealed the lungs as remote inflammatory targets of this metal.",
publisher = "Elsevier Science Bv, Amsterdam",
journal = "Environmental Toxicology and Pharmacology",
title = "Lungs: Remote inflammatory target of systemic cadmium administration in rats",
pages = "231-225",
number = "2",
volume = "28",
doi = "10.1016/j.etap.2009.04.008"
}
Kataranovski, M., Mirkov, I., Belij, S., Nikolic, M., Zolotarevski, L., Ciric, D.,& Kataranovski, D.. (2009). Lungs: Remote inflammatory target of systemic cadmium administration in rats. in Environmental Toxicology and Pharmacology
Elsevier Science Bv, Amsterdam., 28(2), 225-231.
https://doi.org/10.1016/j.etap.2009.04.008
Kataranovski M, Mirkov I, Belij S, Nikolic M, Zolotarevski L, Ciric D, Kataranovski D. Lungs: Remote inflammatory target of systemic cadmium administration in rats. in Environmental Toxicology and Pharmacology. 2009;28(2):225-231.
doi:10.1016/j.etap.2009.04.008 .
Kataranovski, Milena, Mirkov, Ivana, Belij, Sandra, Nikolic, Miroslav, Zolotarevski, Lidija, Ciric, Danica, Kataranovski, Dragan, "Lungs: Remote inflammatory target of systemic cadmium administration in rats" in Environmental Toxicology and Pharmacology, 28, no. 2 (2009):225-231,
https://doi.org/10.1016/j.etap.2009.04.008 . .
