Antioxidative defense enzymes in placenta protect placenta and fetus in inherited thrombophilia from hydrogen peroxide
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2009
Authors
Bogdanović Pristov, Jelena![](/themes/MirageRIMSI/images/orcid.png)
Spasojević, Ivan
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Miković, Zeljko
Mandic, Vesna
Cerović, Nikola
Spasić, Mihajlo
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Article (Published version)
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Our aim was to investigate the activities of antioxidative defense enzymes in the placenta, fetal blood and amnion fluid in inherited thrombophilia. Thrombophilia was associated with nearly threefold increase of activity (p lt 0.001) of the placental catalase (81.1 +/- 20.6 U/mg of proteins in controls and 270.0 +/- 69.9 U/mg in thrombophilic subjects), glutathione (GSH) peroxidase (C: 20.2 +/- 10.1 U/mg; T. 60.0 +/- 15.5 U/mg), and GSH reductase (C: 28.9 +/- 5.6 U/mg; T. 72.7 +/- 23.0 U/mg). The placental activities of superoxide dismutating enzymes-MnSOD and CuZnSOD, did not differ in controls and thrombophilia. Likewise, the activities of catalase and SOD in the fetal blood, and the level of ascorbyl radical which represents a marker of oxidative status of amniotic fluid, were similar in controls and thrombophilic subjects. From this we concluded that in thrombophilia, placental tissue is exposed to H2O2-mediated oxidative stress, which could be initiated by pro-thrombic condition...s in maternal blood. Increased activity of placental H2O2-removing enzymes protects fetus and mother during pregnancy, but may increase the risk of postpartum thrombosis.
Keywords:
thrombophilia / placenta / oxidative stress / hydrogen peroxide / glutathione / catalase / antioxidative defenseSource:
Oxidative Medicine and Cellular Longevity, 2009, 2, 1, 14-18Publisher:
- Hindawi Ltd, London
Funding / projects:
- Biofizička istraživanja membranskih procesa: interakcija membranskih receptora i kanala sa spoljašnjim faktorima i intracelularna regulacija (RS-MESTD-MPN2006-2010-143016)
- Ispitivanja novih biosenzora za monitoring i dijagnostiku biljaka (RS-MESTD-MPN2006-2010-143043)
- The Role of Redox-Active Substances in the Maintenance of Homeostasis (RS-MESTD-MPN2006-2010-143034)
DOI: 10.4161/oxim.2.1.7705
ISSN: 1942-0900
PubMed: 20046640
WoS: 000271898200004
Scopus: 2-s2.0-77953283808
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Institution/Community
Institut za multidisciplinarna istraživanjaTY - JOUR AU - Bogdanović Pristov, Jelena AU - Spasojević, Ivan AU - Miković, Zeljko AU - Mandic, Vesna AU - Cerović, Nikola AU - Spasić, Mihajlo PY - 2009 UR - http://rimsi.imsi.bg.ac.rs/handle/123456789/330 AB - Our aim was to investigate the activities of antioxidative defense enzymes in the placenta, fetal blood and amnion fluid in inherited thrombophilia. Thrombophilia was associated with nearly threefold increase of activity (p lt 0.001) of the placental catalase (81.1 +/- 20.6 U/mg of proteins in controls and 270.0 +/- 69.9 U/mg in thrombophilic subjects), glutathione (GSH) peroxidase (C: 20.2 +/- 10.1 U/mg; T. 60.0 +/- 15.5 U/mg), and GSH reductase (C: 28.9 +/- 5.6 U/mg; T. 72.7 +/- 23.0 U/mg). The placental activities of superoxide dismutating enzymes-MnSOD and CuZnSOD, did not differ in controls and thrombophilia. Likewise, the activities of catalase and SOD in the fetal blood, and the level of ascorbyl radical which represents a marker of oxidative status of amniotic fluid, were similar in controls and thrombophilic subjects. From this we concluded that in thrombophilia, placental tissue is exposed to H2O2-mediated oxidative stress, which could be initiated by pro-thrombic conditions in maternal blood. Increased activity of placental H2O2-removing enzymes protects fetus and mother during pregnancy, but may increase the risk of postpartum thrombosis. PB - Hindawi Ltd, London T2 - Oxidative Medicine and Cellular Longevity T1 - Antioxidative defense enzymes in placenta protect placenta and fetus in inherited thrombophilia from hydrogen peroxide EP - 18 IS - 1 SP - 14 VL - 2 DO - 10.4161/oxim.2.1.7705 ER -
@article{ author = "Bogdanović Pristov, Jelena and Spasojević, Ivan and Miković, Zeljko and Mandic, Vesna and Cerović, Nikola and Spasić, Mihajlo", year = "2009", abstract = "Our aim was to investigate the activities of antioxidative defense enzymes in the placenta, fetal blood and amnion fluid in inherited thrombophilia. Thrombophilia was associated with nearly threefold increase of activity (p lt 0.001) of the placental catalase (81.1 +/- 20.6 U/mg of proteins in controls and 270.0 +/- 69.9 U/mg in thrombophilic subjects), glutathione (GSH) peroxidase (C: 20.2 +/- 10.1 U/mg; T. 60.0 +/- 15.5 U/mg), and GSH reductase (C: 28.9 +/- 5.6 U/mg; T. 72.7 +/- 23.0 U/mg). The placental activities of superoxide dismutating enzymes-MnSOD and CuZnSOD, did not differ in controls and thrombophilia. Likewise, the activities of catalase and SOD in the fetal blood, and the level of ascorbyl radical which represents a marker of oxidative status of amniotic fluid, were similar in controls and thrombophilic subjects. From this we concluded that in thrombophilia, placental tissue is exposed to H2O2-mediated oxidative stress, which could be initiated by pro-thrombic conditions in maternal blood. Increased activity of placental H2O2-removing enzymes protects fetus and mother during pregnancy, but may increase the risk of postpartum thrombosis.", publisher = "Hindawi Ltd, London", journal = "Oxidative Medicine and Cellular Longevity", title = "Antioxidative defense enzymes in placenta protect placenta and fetus in inherited thrombophilia from hydrogen peroxide", pages = "18-14", number = "1", volume = "2", doi = "10.4161/oxim.2.1.7705" }
Bogdanović Pristov, J., Spasojević, I., Miković, Z., Mandic, V., Cerović, N.,& Spasić, M.. (2009). Antioxidative defense enzymes in placenta protect placenta and fetus in inherited thrombophilia from hydrogen peroxide. in Oxidative Medicine and Cellular Longevity Hindawi Ltd, London., 2(1), 14-18. https://doi.org/10.4161/oxim.2.1.7705
Bogdanović Pristov J, Spasojević I, Miković Z, Mandic V, Cerović N, Spasić M. Antioxidative defense enzymes in placenta protect placenta and fetus in inherited thrombophilia from hydrogen peroxide. in Oxidative Medicine and Cellular Longevity. 2009;2(1):14-18. doi:10.4161/oxim.2.1.7705 .
Bogdanović Pristov, Jelena, Spasojević, Ivan, Miković, Zeljko, Mandic, Vesna, Cerović, Nikola, Spasić, Mihajlo, "Antioxidative defense enzymes in placenta protect placenta and fetus in inherited thrombophilia from hydrogen peroxide" in Oxidative Medicine and Cellular Longevity, 2, no. 1 (2009):14-18, https://doi.org/10.4161/oxim.2.1.7705 . .