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Antioxidative defense enzymes in placenta protect placenta and fetus in inherited thrombophilia from hydrogen peroxide

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2009
327.pdf (1.423Mb)
Authors
Bogdanović Pristov, Jelena
Spasojević, Ivan
Miković, Zeljko
Mandic, Vesna
Cerović, Nikola
Spasić, Mihajlo
Article (Published version)
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Abstract
Our aim was to investigate the activities of antioxidative defense enzymes in the placenta, fetal blood and amnion fluid in inherited thrombophilia. Thrombophilia was associated with nearly threefold increase of activity (p lt 0.001) of the placental catalase (81.1 +/- 20.6 U/mg of proteins in controls and 270.0 +/- 69.9 U/mg in thrombophilic subjects), glutathione (GSH) peroxidase (C: 20.2 +/- 10.1 U/mg; T. 60.0 +/- 15.5 U/mg), and GSH reductase (C: 28.9 +/- 5.6 U/mg; T. 72.7 +/- 23.0 U/mg). The placental activities of superoxide dismutating enzymes-MnSOD and CuZnSOD, did not differ in controls and thrombophilia. Likewise, the activities of catalase and SOD in the fetal blood, and the level of ascorbyl radical which represents a marker of oxidative status of amniotic fluid, were similar in controls and thrombophilic subjects. From this we concluded that in thrombophilia, placental tissue is exposed to H2O2-mediated oxidative stress, which could be initiated by pro-thrombic condition...s in maternal blood. Increased activity of placental H2O2-removing enzymes protects fetus and mother during pregnancy, but may increase the risk of postpartum thrombosis.

Keywords:
thrombophilia / placenta / oxidative stress / hydrogen peroxide / glutathione / catalase / antioxidative defense
Source:
Oxidative Medicine and Cellular Longevity, 2009, 2, 1, 14-18
Publisher:
  • Hindawi Ltd, London
Funding / projects:
  • Biofizička istraživanja membranskih procesa: interakcija membranskih receptora i kanala sa spoljašnjim faktorima i intracelularna regulacija (RS-143016)
  • Ispitivanja novih biosenzora za monitoring i dijagnostiku biljaka (RS-143043)
  • The Role of Redox-Active Substances in the Maintenance of Homeostasis (RS-143034)

DOI: 10.4161/oxim.2.1.7705

ISSN: 1942-0900

PubMed: 20046640

WoS: 000271898200004

Scopus: 2-s2.0-77953283808
[ Google Scholar ]
17
9
URI
http://rimsi.imsi.bg.ac.rs/handle/123456789/330
Collections
  • Radovi istraživača / Researchers’ publications
Institution/Community
Institut za multidisciplinarna istraživanja
TY  - JOUR
AU  - Bogdanović Pristov, Jelena
AU  - Spasojević, Ivan
AU  - Miković, Zeljko
AU  - Mandic, Vesna
AU  - Cerović, Nikola
AU  - Spasić, Mihajlo
PY  - 2009
UR  - http://rimsi.imsi.bg.ac.rs/handle/123456789/330
AB  - Our aim was to investigate the activities of antioxidative defense enzymes in the placenta, fetal blood and amnion fluid in inherited thrombophilia. Thrombophilia was associated with nearly threefold increase of activity (p  lt  0.001) of the placental catalase (81.1 +/- 20.6 U/mg of proteins in controls and 270.0 +/- 69.9 U/mg in thrombophilic subjects), glutathione (GSH) peroxidase (C: 20.2 +/- 10.1 U/mg; T. 60.0 +/- 15.5 U/mg), and GSH reductase (C: 28.9 +/- 5.6 U/mg; T. 72.7 +/- 23.0 U/mg). The placental activities of superoxide dismutating enzymes-MnSOD and CuZnSOD, did not differ in controls and thrombophilia. Likewise, the activities of catalase and SOD in the fetal blood, and the level of ascorbyl radical which represents a marker of oxidative status of amniotic fluid, were similar in controls and thrombophilic subjects. From this we concluded that in thrombophilia, placental tissue is exposed to H2O2-mediated oxidative stress, which could be initiated by pro-thrombic conditions in maternal blood. Increased activity of placental H2O2-removing enzymes protects fetus and mother during pregnancy, but may increase the risk of postpartum thrombosis.
PB  - Hindawi Ltd, London
T2  - Oxidative Medicine and Cellular Longevity
T1  - Antioxidative defense enzymes in placenta protect placenta and fetus in inherited thrombophilia from hydrogen peroxide
EP  - 18
IS  - 1
SP  - 14
VL  - 2
DO  - 10.4161/oxim.2.1.7705
ER  - 
@article{
author = "Bogdanović Pristov, Jelena and Spasojević, Ivan and Miković, Zeljko and Mandic, Vesna and Cerović, Nikola and Spasić, Mihajlo",
year = "2009",
abstract = "Our aim was to investigate the activities of antioxidative defense enzymes in the placenta, fetal blood and amnion fluid in inherited thrombophilia. Thrombophilia was associated with nearly threefold increase of activity (p  lt  0.001) of the placental catalase (81.1 +/- 20.6 U/mg of proteins in controls and 270.0 +/- 69.9 U/mg in thrombophilic subjects), glutathione (GSH) peroxidase (C: 20.2 +/- 10.1 U/mg; T. 60.0 +/- 15.5 U/mg), and GSH reductase (C: 28.9 +/- 5.6 U/mg; T. 72.7 +/- 23.0 U/mg). The placental activities of superoxide dismutating enzymes-MnSOD and CuZnSOD, did not differ in controls and thrombophilia. Likewise, the activities of catalase and SOD in the fetal blood, and the level of ascorbyl radical which represents a marker of oxidative status of amniotic fluid, were similar in controls and thrombophilic subjects. From this we concluded that in thrombophilia, placental tissue is exposed to H2O2-mediated oxidative stress, which could be initiated by pro-thrombic conditions in maternal blood. Increased activity of placental H2O2-removing enzymes protects fetus and mother during pregnancy, but may increase the risk of postpartum thrombosis.",
publisher = "Hindawi Ltd, London",
journal = "Oxidative Medicine and Cellular Longevity",
title = "Antioxidative defense enzymes in placenta protect placenta and fetus in inherited thrombophilia from hydrogen peroxide",
pages = "18-14",
number = "1",
volume = "2",
doi = "10.4161/oxim.2.1.7705"
}
Bogdanović Pristov, J., Spasojević, I., Miković, Z., Mandic, V., Cerović, N.,& Spasić, M.. (2009). Antioxidative defense enzymes in placenta protect placenta and fetus in inherited thrombophilia from hydrogen peroxide. in Oxidative Medicine and Cellular Longevity
Hindawi Ltd, London., 2(1), 14-18.
https://doi.org/10.4161/oxim.2.1.7705
Bogdanović Pristov J, Spasojević I, Miković Z, Mandic V, Cerović N, Spasić M. Antioxidative defense enzymes in placenta protect placenta and fetus in inherited thrombophilia from hydrogen peroxide. in Oxidative Medicine and Cellular Longevity. 2009;2(1):14-18.
doi:10.4161/oxim.2.1.7705 .
Bogdanović Pristov, Jelena, Spasojević, Ivan, Miković, Zeljko, Mandic, Vesna, Cerović, Nikola, Spasić, Mihajlo, "Antioxidative defense enzymes in placenta protect placenta and fetus in inherited thrombophilia from hydrogen peroxide" in Oxidative Medicine and Cellular Longevity, 2, no. 1 (2009):14-18,
https://doi.org/10.4161/oxim.2.1.7705 . .

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