Investigation of Novel Radical Scavenging Mechanisms in the Alkaline Environment: Green, Sustainable and Environmentally Friendly Antioxidative Agent(s)
Samo za registrovane korisnike
2024
Autori
Antonijević, MarkoAvdović, Edina
Simijonović, Dušica
Milanović, Žiko
Žižić, Milan
Marković, Zoran
Članak u časopisu (Recenzirana verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Pharmaceutical and industrial utilization of synthetic chemicals has an immerse impact
on the environment. In that sense, novel chemicals with potential for industrial
application should be investigated for their behavior in reactions with hydroxyl radical,
simulating AOPs (Advanced Oxidation Processes). AOPs are known for being highly
effective in wastewater management and natural water remediation. In this paper,
exhaustive research on the radical scavenging activity of a newly synthesized
coumarin derivative (4HCBH), as a representative of the series of coumarin-
benzohydrazides with high antioxidative potential was conducted. This study took into
consideration the pH value range significant for practically all living organisms (pH=7.0-
8.5). According to the experimentally obtained results, the 4HCBH showed an increase
in radical scavenging activity, following the slight increase in pH values, which
suggested that the formation of anionic form of 4HCBH is responsible for... its antiradical
activity. Further investigations led to the postulation of a novel mechanistic approach
called Sequential Proton Loss Electron Transfer – Radical-Radical Coupling (SPLET-
RRC), in which, by a series of steps, a new, stable compound was formed.
Furthermore, it was demonstrated that the product generated through SPLET-RRC
showed lower toxicity than the parent molecule.
Ključne reči:
Electron Paramagnetic Resonance / Alkaline Environment / Coumarin / Advanced Oxidation Processes / Hydroxyl radicalIzvor:
Science of the Total Environment, 2024, 912, 169307-160319Izdavač:
- Elsevier
Finansiranje / projekti:
- Ministarstvo nauke, tehnološkog razvoja i inovacija Republike Srbije, institucionalno finansiranje - 200053 (Univerzitet u Beogradu, Institut za multidisciplinarna istraživanja) (RS-MESTD-inst-2020-200053)
- Ministarstvo nauke, tehnološkog razvoja i inovacija Republike Srbije, institucionalno finansiranje - 200122 (Univerzitet u Kragujevcu, Prirodno-matematički fakultet) (RS-MESTD-inst-2020-200122)
- Ministarstvo nauke, tehnološkog razvoja i inovacija Republike Srbije, institucionalno finansiranje - 200378 (Institut za informacione tehnologije, Kragujevac) (RS-MESTD-inst-2020-200378)
- Ministarstvo nauke, tehnološkog razvoja i inovacija Republike Srbije, institucionalno finansiranje - 200252 (Džavni univerzitet u Novom Pazaru) (RS-MESTD-inst-2020-200252)
Institucija/grupa
Institut za multidisciplinarna istraživanjaTY - JOUR AU - Antonijević, Marko AU - Avdović, Edina AU - Simijonović, Dušica AU - Milanović, Žiko AU - Žižić, Milan AU - Marković, Zoran PY - 2024 UR - http://rimsi.imsi.bg.ac.rs/handle/123456789/3163 AB - Pharmaceutical and industrial utilization of synthetic chemicals has an immerse impact on the environment. In that sense, novel chemicals with potential for industrial application should be investigated for their behavior in reactions with hydroxyl radical, simulating AOPs (Advanced Oxidation Processes). AOPs are known for being highly effective in wastewater management and natural water remediation. In this paper, exhaustive research on the radical scavenging activity of a newly synthesized coumarin derivative (4HCBH), as a representative of the series of coumarin- benzohydrazides with high antioxidative potential was conducted. This study took into consideration the pH value range significant for practically all living organisms (pH=7.0- 8.5). According to the experimentally obtained results, the 4HCBH showed an increase in radical scavenging activity, following the slight increase in pH values, which suggested that the formation of anionic form of 4HCBH is responsible for its antiradical activity. Further investigations led to the postulation of a novel mechanistic approach called Sequential Proton Loss Electron Transfer – Radical-Radical Coupling (SPLET- RRC), in which, by a series of steps, a new, stable compound was formed. Furthermore, it was demonstrated that the product generated through SPLET-RRC showed lower toxicity than the parent molecule. PB - Elsevier T2 - Science of the Total Environment T1 - Investigation of Novel Radical Scavenging Mechanisms in the Alkaline Environment: Green, Sustainable and Environmentally Friendly Antioxidative Agent(s) EP - 160319 SP - 169307 VL - 912 DO - 10.1016/j.scitotenv.2023.169307 ER -
@article{ author = "Antonijević, Marko and Avdović, Edina and Simijonović, Dušica and Milanović, Žiko and Žižić, Milan and Marković, Zoran", year = "2024", abstract = "Pharmaceutical and industrial utilization of synthetic chemicals has an immerse impact on the environment. In that sense, novel chemicals with potential for industrial application should be investigated for their behavior in reactions with hydroxyl radical, simulating AOPs (Advanced Oxidation Processes). AOPs are known for being highly effective in wastewater management and natural water remediation. In this paper, exhaustive research on the radical scavenging activity of a newly synthesized coumarin derivative (4HCBH), as a representative of the series of coumarin- benzohydrazides with high antioxidative potential was conducted. This study took into consideration the pH value range significant for practically all living organisms (pH=7.0- 8.5). According to the experimentally obtained results, the 4HCBH showed an increase in radical scavenging activity, following the slight increase in pH values, which suggested that the formation of anionic form of 4HCBH is responsible for its antiradical activity. Further investigations led to the postulation of a novel mechanistic approach called Sequential Proton Loss Electron Transfer – Radical-Radical Coupling (SPLET- RRC), in which, by a series of steps, a new, stable compound was formed. Furthermore, it was demonstrated that the product generated through SPLET-RRC showed lower toxicity than the parent molecule.", publisher = "Elsevier", journal = "Science of the Total Environment", title = "Investigation of Novel Radical Scavenging Mechanisms in the Alkaline Environment: Green, Sustainable and Environmentally Friendly Antioxidative Agent(s)", pages = "160319-169307", volume = "912", doi = "10.1016/j.scitotenv.2023.169307" }
Antonijević, M., Avdović, E., Simijonović, D., Milanović, Ž., Žižić, M.,& Marković, Z.. (2024). Investigation of Novel Radical Scavenging Mechanisms in the Alkaline Environment: Green, Sustainable and Environmentally Friendly Antioxidative Agent(s). in Science of the Total Environment Elsevier., 912, 169307-160319. https://doi.org/10.1016/j.scitotenv.2023.169307
Antonijević M, Avdović E, Simijonović D, Milanović Ž, Žižić M, Marković Z. Investigation of Novel Radical Scavenging Mechanisms in the Alkaline Environment: Green, Sustainable and Environmentally Friendly Antioxidative Agent(s). in Science of the Total Environment. 2024;912:169307-160319. doi:10.1016/j.scitotenv.2023.169307 .
Antonijević, Marko, Avdović, Edina, Simijonović, Dušica, Milanović, Žiko, Žižić, Milan, Marković, Zoran, "Investigation of Novel Radical Scavenging Mechanisms in the Alkaline Environment: Green, Sustainable and Environmentally Friendly Antioxidative Agent(s)" in Science of the Total Environment, 912 (2024):169307-160319, https://doi.org/10.1016/j.scitotenv.2023.169307 . .