Приказ основних података о документу

dc.creatorSpasojević, Ivan
dc.creatorJelic, Svetislav
dc.creatorZakrzewska, Joanna
dc.creatorBačić, Goran
dc.date.accessioned2022-04-05T14:19:05Z
dc.date.available2022-04-05T14:19:05Z
dc.date.issued2009
dc.identifier.issn1420-3049
dc.identifier.urihttp://rimsi.imsi.bg.ac.rs/handle/123456789/309
dc.description.abstractVarious mechanisms have been proposed to account for chemotherapy related ischemia, but none of them can explain the available clinical data. In order to explore the possibility that the decreased ability of erythrocytes to deliver oxygen to the heart could be responsible for cardiotoxicity, we have performed an ex vivo and in vivo study of the effects of cisplatin/5-FU on erythrocytes, using a variety of biophysical techniques. Combining EPR and microscopy it was concluded that both cardiotoxic 5-FU and non-cardiotoxic cisplatin have similar effects on the erythrocyte membrane, thus eliminating those changes as a potential source of cardiotoxicity. On the contrary, P-31-NMR and polarography showed that the effects of these cytostatics on the intracellular milieu differ significantly. 5-FU provoked a pronounced decrease of the O-2 level in blood and affected the metabolism of phosphate compounds, while cisplatin had no such effects. When combined these two drugs showed synergistic effects, which matches the higher frequency of cardiotoxicity of the combination relative to the sole application of 5-FU. Preliminary results acquired on blood of patients receiving cisplatin/5-FU therapy verified observations obtained ex vivo. These results open a possibility of applying NMR in preclinical trials of new drugs in order to predict their ischemic potential.en
dc.publisherMDPI, Basel
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/143016/RS//
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/145055/RS//
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceMolecules
dc.subjectP-31 NMR spectroscopyen
dc.subjectIschemiaen
dc.subjectErythrocytesen
dc.subjectCisplatinen
dc.subject5-Fluorouracilen
dc.titleDecreased Oxygen Transfer Capacity of Erythrocytes as a Cause of 5-Fluorouracil Related Ischemiaen
dc.typearticle
dc.rights.licenseBY
dc.citation.epage67
dc.citation.issue1
dc.citation.other14(1): 53-67
dc.citation.rankM23
dc.citation.spage53
dc.citation.volume14
dc.identifier.doi10.3390/molecules14010053
dc.identifier.fulltexthttp://rimsi.imsi.bg.ac.rs/bitstream/id/562/306.pdf
dc.identifier.pmid19127237
dc.identifier.scopus2-s2.0-58949088362
dc.identifier.wos000262791200006
dc.type.versionpublishedVersion


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Приказ основних података о документу