Trovanje kamforom - spektralna analiza aktivnosti mozga pacova
Camphor oil poisoning: Spectral analysis of rat brain activity
Нема приказа
Аутори
Grbić, GordanaĆulić, Milka
Martać, Ljiljana
Kesić, Srđan Ž.
Soković, Marina
Spasić, Slađana
Đoković, Dejan
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
We have decided to detect the seizure brain activity induced by camphor essential oil in rats, as there are still reports of severe intoxication in humans by camphor. The experiments were performed on adult Wistar male rats. The surgery and the acute electrophysiological recordings were done under pentobarbital sodium anesthesia. Local field potentials of cerebral parietal cortex were recorded. The rats were injected by camphor essential oil (150-675 μl/kg b.w., in 1 ml of saline, i.p). We analyzed by Fast Fourier Transform the digitized electrocortical signals before and up 2-3 h after essential oil administration at the sampling rate of 256 Hz. There was a great increase of the mean total power spectra, a relative increase of the power in delta range and decreases of theta and beta ranges when seizural activity with spikes and waves of large amplitude occurred at the level of cerebral cortex 5-30 min after administration of camphor oil at doses >300 μl/kg b.w. It is necessary to inve...stigate further the dose dependent effectiveness of each terpenoid constituent of camphor essential oil on brain activity in order to elucidate the relative safety of the usage of essential oils with these terpenoids.
Кључне речи:
camphor oil / seizure / power spectra / electrocortical activityИзвор:
Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica, 2006, 42, 3, 233-238Издавач:
- Serbian Union of Biological Sciences
Финансирање / пројекти:
- Ефекти трауматских, неуротоксичних и неуропротективних фактора на електричну активност мозга сисара. Анализа и моделирање (RS-MESTD-MPN2006-2010-143021)
Институција/група
Institut za multidisciplinarna istraživanjaTY - JOUR AU - Grbić, Gordana AU - Ćulić, Milka AU - Martać, Ljiljana AU - Kesić, Srđan Ž. AU - Soković, Marina AU - Spasić, Slađana AU - Đoković, Dejan PY - 2006 UR - http://rimsi.imsi.bg.ac.rs/handle/123456789/2945 AB - We have decided to detect the seizure brain activity induced by camphor essential oil in rats, as there are still reports of severe intoxication in humans by camphor. The experiments were performed on adult Wistar male rats. The surgery and the acute electrophysiological recordings were done under pentobarbital sodium anesthesia. Local field potentials of cerebral parietal cortex were recorded. The rats were injected by camphor essential oil (150-675 μl/kg b.w., in 1 ml of saline, i.p). We analyzed by Fast Fourier Transform the digitized electrocortical signals before and up 2-3 h after essential oil administration at the sampling rate of 256 Hz. There was a great increase of the mean total power spectra, a relative increase of the power in delta range and decreases of theta and beta ranges when seizural activity with spikes and waves of large amplitude occurred at the level of cerebral cortex 5-30 min after administration of camphor oil at doses >300 μl/kg b.w. It is necessary to investigate further the dose dependent effectiveness of each terpenoid constituent of camphor essential oil on brain activity in order to elucidate the relative safety of the usage of essential oils with these terpenoids. PB - Serbian Union of Biological Sciences T2 - Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica T1 - Trovanje kamforom - spektralna analiza aktivnosti mozga pacova T1 - Camphor oil poisoning: Spectral analysis of rat brain activity EP - 238 IS - 3 SP - 233 VL - 42 UR - https://hdl.handle.net/21.15107/rcub_rimsi_2945 ER -
@article{ author = "Grbić, Gordana and Ćulić, Milka and Martać, Ljiljana and Kesić, Srđan Ž. and Soković, Marina and Spasić, Slađana and Đoković, Dejan", year = "2006", abstract = "We have decided to detect the seizure brain activity induced by camphor essential oil in rats, as there are still reports of severe intoxication in humans by camphor. The experiments were performed on adult Wistar male rats. The surgery and the acute electrophysiological recordings were done under pentobarbital sodium anesthesia. Local field potentials of cerebral parietal cortex were recorded. The rats were injected by camphor essential oil (150-675 μl/kg b.w., in 1 ml of saline, i.p). We analyzed by Fast Fourier Transform the digitized electrocortical signals before and up 2-3 h after essential oil administration at the sampling rate of 256 Hz. There was a great increase of the mean total power spectra, a relative increase of the power in delta range and decreases of theta and beta ranges when seizural activity with spikes and waves of large amplitude occurred at the level of cerebral cortex 5-30 min after administration of camphor oil at doses >300 μl/kg b.w. It is necessary to investigate further the dose dependent effectiveness of each terpenoid constituent of camphor essential oil on brain activity in order to elucidate the relative safety of the usage of essential oils with these terpenoids.", publisher = "Serbian Union of Biological Sciences", journal = "Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica", title = "Trovanje kamforom - spektralna analiza aktivnosti mozga pacova, Camphor oil poisoning: Spectral analysis of rat brain activity", pages = "238-233", number = "3", volume = "42", url = "https://hdl.handle.net/21.15107/rcub_rimsi_2945" }
Grbić, G., Ćulić, M., Martać, L., Kesić, S. Ž., Soković, M., Spasić, S.,& Đoković, D.. (2006). Trovanje kamforom - spektralna analiza aktivnosti mozga pacova. in Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica Serbian Union of Biological Sciences., 42(3), 233-238. https://hdl.handle.net/21.15107/rcub_rimsi_2945
Grbić G, Ćulić M, Martać L, Kesić SŽ, Soković M, Spasić S, Đoković D. Trovanje kamforom - spektralna analiza aktivnosti mozga pacova. in Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica. 2006;42(3):233-238. https://hdl.handle.net/21.15107/rcub_rimsi_2945 .
Grbić, Gordana, Ćulić, Milka, Martać, Ljiljana, Kesić, Srđan Ž., Soković, Marina, Spasić, Slađana, Đoković, Dejan, "Trovanje kamforom - spektralna analiza aktivnosti mozga pacova" in Acta biologica serbica - serija C: Acta physiologica et pharmacologica serbica, 42, no. 3 (2006):233-238, https://hdl.handle.net/21.15107/rcub_rimsi_2945 .