In anemia of the Belgrade rat ( b b) reticulocytes contain less than half of the normal amount of mRNA for seven adult rat globin chains. cDNA hybridization measurements of the relative sizes of polysomal and nonpolysomal pools of globin mRNAs in these cells show that 45% of all globin mRNA molecules are not used at any given time in protein synthesis. This implies a translational control which ensures a production of globin chains in a correct ratio despite a severe mRNA unbalance.
Keywords:
reticuloendothelial system / reticulocyte / rat / Polyrib / Nucleic Acid Hybridization / nonhuman / Globins / globin messenger rna / DNA / blood and hemopoietic system / Animal / animal cell / Anemia / anemia
Source:
Biochemical and Biophysical Research Communications, 1982, 105, 4, 1524-1531
TY - JOUR
AU - Crkvenjakov, R.
AU - Maksimović, Vesna M
AU - Glišin, V.
PY - 1982
UR - http://rimsi.imsi.bg.ac.rs/handle/123456789/29
AB - In anemia of the Belgrade rat ( b b) reticulocytes contain less than half of the normal amount of mRNA for seven adult rat globin chains. cDNA hybridization measurements of the relative sizes of polysomal and nonpolysomal pools of globin mRNAs in these cells show that 45% of all globin mRNA molecules are not used at any given time in protein synthesis. This implies a translational control which ensures a production of globin chains in a correct ratio despite a severe mRNA unbalance.
T2 - Biochemical and Biophysical Research Communications
T1 - A pool of nonpolysomal globin mRNAs in globin deficient reticulocytes of the anemic Belgrade rat
EP - 1531
IS - 4
SP - 1524
VL - 105
DO - 10.1016/0006-291X(82)90961-5
ER -
@article{
author = "Crkvenjakov, R. and Maksimović, Vesna M and Glišin, V.",
year = "1982",
abstract = "In anemia of the Belgrade rat ( b b) reticulocytes contain less than half of the normal amount of mRNA for seven adult rat globin chains. cDNA hybridization measurements of the relative sizes of polysomal and nonpolysomal pools of globin mRNAs in these cells show that 45% of all globin mRNA molecules are not used at any given time in protein synthesis. This implies a translational control which ensures a production of globin chains in a correct ratio despite a severe mRNA unbalance.",
journal = "Biochemical and Biophysical Research Communications",
title = "A pool of nonpolysomal globin mRNAs in globin deficient reticulocytes of the anemic Belgrade rat",
pages = "1531-1524",
number = "4",
volume = "105",
doi = "10.1016/0006-291X(82)90961-5"
}
Crkvenjakov, R., Maksimović, V. M.,& Glišin, V.. (1982). A pool of nonpolysomal globin mRNAs in globin deficient reticulocytes of the anemic Belgrade rat. in Biochemical and Biophysical Research Communications, 105(4), 1524-1531.
https://doi.org/10.1016/0006-291X(82)90961-5
Crkvenjakov R, Maksimović VM, Glišin V. A pool of nonpolysomal globin mRNAs in globin deficient reticulocytes of the anemic Belgrade rat. in Biochemical and Biophysical Research Communications. 1982;105(4):1524-1531.
doi:10.1016/0006-291X(82)90961-5 .
Crkvenjakov, R., Maksimović, Vesna M, Glišin, V., "A pool of nonpolysomal globin mRNAs in globin deficient reticulocytes of the anemic Belgrade rat" in Biochemical and Biophysical Research Communications, 105, no. 4 (1982):1524-1531,
https://doi.org/10.1016/0006-291X(82)90961-5 . .
