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Effect of aluminium neurotoxicity on the rat brain electrocortical activity

dc.creatorMartać, Ljiljana
dc.creatorKesić, Srđan Ž.
dc.creatorĆulić, Milka
dc.creatorGrbić, Gordana
dc.creatorSpasić, Slađana
dc.creatorSekulić, Slobodan
dc.creatorLalošević, Dušan
dc.date.accessioned2023-12-08T12:46:20Z
dc.date.available2023-12-08T12:46:20Z
dc.date.issued2006
dc.identifier.issn1452-7618
dc.identifier.urihttp://rimsi.imsi.bg.ac.rs/handle/123456789/2877
dc.description.abstractThe aim of our study was to investigate the electrophysiological effects of aluminium neurotoxicity. This animal model of neurodegenerative dementia was induced by chronic treatment of Wistarrats with aluminum chloride for 4 weeks - 2mg Al/kg, i.p, per day. Electrophysiological recordings of left and right somatosensory cortical areas of animals treated by aluminium and the control rats were done under Nembutal anesthesia. Analog to the digital one conversion of the recorded signals was performed at the sampling rate of 256 Hz. Spectral analysis of electrocortical activity during sequences of 120 s (divided in epochs of 8s) was obtained by Fast Fourier Transformation while fractal dimension (FD) of these signals was calculated by Higuchi's algorithm. The relative power spectra of cerebral activity were increased in delta frequency range and decreased in (8.1-32.0 Hz) range in aluminium treated animals compared to the controls. The average fractal dimension of electrocortical activity in aluminium treated animals was lower - 1.290 than the average fractal dimension of electrocortical activity in the control rats - 1.377. Spectral and fractal characteristics of brain activity could bean electrophysiological sign of developing neurodegenerative process similar to the Alzheimer's dementia.sr
dc.language.isoensr
dc.relation"info:eu-repo/grantAgreement/MESTD/MPN2006-2010/143021/RS//"sr
dc.rightsopenAccesssr
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.sourceActa biologica serbica - serija C: Acta physiologica et pharmacologica serbicasr
dc.subjectaluminium neurotoxicitysr
dc.subjectelectrocortical activitysr
dc.subjectpower spectrumsr
dc.subjectfractal dimensionsr
dc.titleEfekat neurotoksičnosti aluminijuma na elektrokortikalnu aktivnost mozga pacovasr
dc.titleEffect of aluminium neurotoxicity on the rat brain electrocortical activitysr
dc.typearticlesr
dc.rights.licenseBYsr
dc.citation.epage225
dc.citation.issue3
dc.citation.spage219
dc.citation.volume42
dc.identifier.rcubhttps://hdl.handle.net/21.15107/rcub_rimsi_2877
dc.type.versionpublishedVersionsr


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