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dc.creatorBozic Cvijan, Bojana
dc.creatorKorać Jačić, Jelena
dc.creatorStanković, Dalibor
dc.creatorStanić, Marina
dc.creatorPopovic Bijelic, Ana
dc.creatorBogdanović Pristov, Jelena
dc.creatorSpasojević, Ivan
dc.creatorBajcetic, Milica
dc.date.accessioned2023-12-08T08:29:19Z
dc.date.available2023-12-08T08:29:19Z
dc.date.issued2019
dc.identifier.isbn978-86-80244-01-3
dc.identifier.urihttp://rimsi.imsi.bg.ac.rs/handle/123456789/2847
dc.description.abstractToxic effects of unconjugated bilirubin (BR) in neonatal hyperbilirubinemia have been related to redox and/or coordinate interactions with Cu2+. However, the development and mechanisms of such interactions at physiological pH have not been resolved. This study shows that BR reduces Cu2+ to Cu1+ in 1:1 stoichiometry. Apparently, BR undergoes degradation, i.e. BR and Cu2+ do not form stable complexes. The binding of Cu2+ to inorganic phosphates, liposomal phosphate groups, or to chelating drug penicillamine, impedes redox interactions with BR. Cu1+ undergoes spontaneous oxidation by O2 resulting in hydrogen peroxide accumulation and hydroxyl radical production. In relation to this, copper and BR induced synergistic oxidative/damaging effects on erythrocytes membrane, which were alleviated by penicillamine. The production of reactive oxygen species by BR and copper represents a plausible cause of BR toxic effects and cell damage in hyperbilirubinemia. Further examination of therapeutic potentials of copper chelators in the treatment of severe neonatal hyperbilirubinemia is needed.sr
dc.language.isoensr
dc.publisherSrpsko farmakološko društvo Beograd, Novi Sadsr
dc.rightsopenAccesssr
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.source14th Serbian Congress of Farmacologists and 4th Serbian Congress of Clinical Pharmacology with international participationsr
dc.subjectPenicillamine
dc.subjectbilirubin
dc.subjectcopper
dc.titlePenicillamine prevents damaging redox in vitro interactions of bilirubin and coppersr
dc.typeconferenceObjectsr
dc.rights.licenseBYsr
dc.citation.epage242
dc.citation.spage240
dc.identifier.fulltexthttp://rimsi.imsi.bg.ac.rs/bitstream/id/7271/bitstream_7271.pdf
dc.identifier.rcubhttps://hdl.handle.net/21.15107/rcub_rimsi_2847
dc.type.versionpublishedVersionsr


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