Extracellular vesicles in a maze of glycomic complexity
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Metapodaci
Prikaz svih podataka o dokumentuApstrakt
The carbohydrate portion of proteins and lipids mediates a variety of biological processes. Revealing their
underlying principles is a challenging task that could contribute to a better understanding of many patho/physiological
conditions. On the other hand, the interest in extracellular vesicles (EVs) has increased in recent years due to their
involvement in intercellular communication leading to an array of functional and structural changes in recipient cells.
Their characterization uncovered an exceptional diversity in size, morphology, as well as in membrane and cargo content.
Monitoring/analysis of surface glycosylation of EVs originating from the prostate, termed prostasomes, revealed
their substantial contribution to the complexity of seminal plasma (SP) glycome. Heterogeneity of surface glycans confirm
the existence of several prostasome subpopulations. Presentation of surface glycans on prostasomal membrane is
strongly affected by co-localized membrane-associated glyco...proteins and tetraspanins. They appear to be organized in
established/regular distribution patterns on membrane domains. Surface glycans are a component of EVs membrane
that affects its functionality and potentially a distinction marker of prostasome subpopulations. Further understanding
of the complex composition of glycans on EVs might explain the relation of their structure with functional alterations
in distinct patho/physiological conditions.
Ključne reči:
extracellular vesicle / glycans / prostasomes / seminal plasma / tetraspaninIzvor:
Biologia Serbica, 2022, 44, 1, 25-32Izdavač:
- Faculty of Sciences, Department of Biology, University of Novi Sad, Serbia
Finansiranje / projekti:
- Ministarstvo nauke, tehnološkog razvoja i inovacija Republike Srbije, institucionalno finansiranje - 200019 (Univerzitet u Beogradu, Institut za primenu nuklearne energije - INEP) (RS-MESTD-inst-2020-200019)
Institucija/grupa
Institut za multidisciplinarna istraživanjaTY - JOUR AU - Danilović Luković, Jelena AU - Janković, Tamara AU - Mitić, Ninoslav AU - Goč, Sanja PY - 2022 UR - http://rimsi.imsi.bg.ac.rs/handle/123456789/2476 AB - The carbohydrate portion of proteins and lipids mediates a variety of biological processes. Revealing their underlying principles is a challenging task that could contribute to a better understanding of many patho/physiological conditions. On the other hand, the interest in extracellular vesicles (EVs) has increased in recent years due to their involvement in intercellular communication leading to an array of functional and structural changes in recipient cells. Their characterization uncovered an exceptional diversity in size, morphology, as well as in membrane and cargo content. Monitoring/analysis of surface glycosylation of EVs originating from the prostate, termed prostasomes, revealed their substantial contribution to the complexity of seminal plasma (SP) glycome. Heterogeneity of surface glycans confirm the existence of several prostasome subpopulations. Presentation of surface glycans on prostasomal membrane is strongly affected by co-localized membrane-associated glycoproteins and tetraspanins. They appear to be organized in established/regular distribution patterns on membrane domains. Surface glycans are a component of EVs membrane that affects its functionality and potentially a distinction marker of prostasome subpopulations. Further understanding of the complex composition of glycans on EVs might explain the relation of their structure with functional alterations in distinct patho/physiological conditions. PB - Faculty of Sciences, Department of Biology, University of Novi Sad, Serbia T2 - Biologia Serbica T1 - Extracellular vesicles in a maze of glycomic complexity EP - 32 IS - 1 SP - 25 VL - 44 DO - 10.5281/zenodo.7075050 ER -
@article{ author = "Danilović Luković, Jelena and Janković, Tamara and Mitić, Ninoslav and Goč, Sanja", year = "2022", abstract = "The carbohydrate portion of proteins and lipids mediates a variety of biological processes. Revealing their underlying principles is a challenging task that could contribute to a better understanding of many patho/physiological conditions. On the other hand, the interest in extracellular vesicles (EVs) has increased in recent years due to their involvement in intercellular communication leading to an array of functional and structural changes in recipient cells. Their characterization uncovered an exceptional diversity in size, morphology, as well as in membrane and cargo content. Monitoring/analysis of surface glycosylation of EVs originating from the prostate, termed prostasomes, revealed their substantial contribution to the complexity of seminal plasma (SP) glycome. Heterogeneity of surface glycans confirm the existence of several prostasome subpopulations. Presentation of surface glycans on prostasomal membrane is strongly affected by co-localized membrane-associated glycoproteins and tetraspanins. They appear to be organized in established/regular distribution patterns on membrane domains. Surface glycans are a component of EVs membrane that affects its functionality and potentially a distinction marker of prostasome subpopulations. Further understanding of the complex composition of glycans on EVs might explain the relation of their structure with functional alterations in distinct patho/physiological conditions.", publisher = "Faculty of Sciences, Department of Biology, University of Novi Sad, Serbia", journal = "Biologia Serbica", title = "Extracellular vesicles in a maze of glycomic complexity", pages = "32-25", number = "1", volume = "44", doi = "10.5281/zenodo.7075050" }
Danilović Luković, J., Janković, T., Mitić, N.,& Goč, S.. (2022). Extracellular vesicles in a maze of glycomic complexity. in Biologia Serbica Faculty of Sciences, Department of Biology, University of Novi Sad, Serbia., 44(1), 25-32. https://doi.org/10.5281/zenodo.7075050
Danilović Luković J, Janković T, Mitić N, Goč S. Extracellular vesicles in a maze of glycomic complexity. in Biologia Serbica. 2022;44(1):25-32. doi:10.5281/zenodo.7075050 .
Danilović Luković, Jelena, Janković, Tamara, Mitić, Ninoslav, Goč, Sanja, "Extracellular vesicles in a maze of glycomic complexity" in Biologia Serbica, 44, no. 1 (2022):25-32, https://doi.org/10.5281/zenodo.7075050 . .