SILVER(I)-BASED METAL-ORGANIC FRAMEWORKS WITH POTENTIAL ANTIMICROBIAL PROPERTIES

Abstract

Jedan od glavnih svetskih problema u javnom zdravlju predstavlja pojava novih otpornih sojeva mikroba. Stoga je potreba za novim antimikrobnim agesima pravi izazov. Metalorganske umrežene strukture (engl. metal-organic frameworks, MOFs) se mogu smatrati obećavajućim antimikrobnim agensima stoga što njihove neorganske i organske komponente mogu da obezbede platformu za visoku antimikrobnu aktivnost. Tokom proteklih godina, nova jedinjenja srebra, uključujući i nove materijale, su se pokazala kao snažni antimikrobni agensi [1]. Uzimajući ovo u obzir, sintetisana su četiri nova MOF-a srebra(I) sa derivatima tiomorfolina i piperazina (Shema 1) koji su okarakterisani rendgenskom strukturnom analizom. Antimikrobna aktivnost je određena na osam bakterijskih sojeva i tri soja gljivica. Kompleks 4 je pokazao dobru antimikrobnu aktivnost na svim testiranim sojevima mikroorganizama.

Resistant microbial strains are continuously emerging which is one of the major worldwide public health concerns. The need for new antimicrobial agents is a real challenge. Metal-organic frameworks (MOFs) can be considered as promising antimicrobial materials because their inorganic and organic components can provide platforms to generate high potent antimicrobial activity. Over recent years, new silver compounds, including new materials, have been proposed as potent antimicrobial agents [1]. Taking this into account, four new silver-based MOFs were synthesized (Scheme 1), using thiomorpholine and piperazine derivatives as ligands, and characterized by X-ray diffraction analysis. The antimicrobial activity was evaluated on eight bacterial and three fungi strains. Complex 4 has good antimicrobial activity on all studied microorganisms.