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dc.creatorRadotić, Ksenija
dc.creatorSpasojević, Dragica
dc.creatorZmejkoski, Danica Z.
dc.date.accessioned2023-11-24T10:39:23Z
dc.date.available2023-11-24T10:39:23Z
dc.date.issued2023
dc.identifier.isbn978-1-83916-535-1
dc.identifier.urihttp://rimsi.imsi.bg.ac.rs/handle/123456789/2289
dc.description.abstractThe material selected for biomedical application must be biocompatible, stable against physiological media, non-toxic, non-carcinogenic, corrosion-resistant, bio-inert, and stimuli-responsive, and have a low wear rate. Lignin is the most abundant aromatic polymer on Earth with a complex, recalcitrant structure. A lot of knowledge is acquired on its pre-treatments and processing for biomedical uses in the forms of hydrogels, films, composite materials, nanoparticles, and aerogels. To avoid the potential toxicity and to control the cytotoxicity of lignin-based materials, it is necessary to increase the purity of the starting source materials and understand their reactivity. The poor water solubility, broad molecular weight (MW) distribution, and highly complex structure of lignin restrict its wider clinical applications. These limitations may be effectively improved by chemical modifications or by using lignin fractions with a narrow MW range. Antioxidant and antimicrobial properties allow lignin to be used in pharmaceuticals, drug delivery, and wound healing. It is also reported as a good candidate for composite materials intended for bone regeneration scaffolds in tissue engineering. Future challenges for lignin-based materials for biomedical applications include achieving a better understanding of the structure, isolation, and batch properties of lignin, as well as structure–function relationships in its applications.sr
dc.language.isoensr
dc.publisherThe Royal Society of Chemistrysr
dc.relationinfo:eu-repo/grantAgreement/MESTD/inst-2020/200053/RSsr
dc.rightsclosedAccesssr
dc.sourceLignin-based Materials: Health Care and Medical Applicationssr
dc.subjectLigninsr
dc.subjectbiomedical applicationssr
dc.subjectdrug deliverysr
dc.subjectwound healingsr
dc.subjectpharmaceuticalssr
dc.titleLignin-based material for biomedical applications: Basic requirements and propertiessr
dc.typebookPartsr
dc.rights.licenseARRsr
dc.rights.holderThe Royal Society of Chemistrysr
dc.citation.epage105
dc.citation.spage85
dc.identifier.doi10.1039/9781839167843
dc.type.versionpublishedVersionsr


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