Lignin-based material for biomedical applications: Basic requirements and properties
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Поглавље у монографији (Објављена верзија)
,
The Royal Society of Chemistry
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Приказ свих података о документуАпстракт
The material selected for biomedical application must be biocompatible, stable against physiological media, non-toxic, non-carcinogenic, corrosion-resistant, bio-inert, and stimuli-responsive, and have a low wear rate. Lignin is the most abundant aromatic polymer on Earth with a complex, recalcitrant structure. A lot of knowledge is acquired on its pre-treatments and processing for biomedical uses in the forms of hydrogels, films, composite materials, nanoparticles, and aerogels. To avoid the potential toxicity and to control the cytotoxicity of lignin-based materials, it is necessary to increase the purity of the starting source materials and understand their reactivity. The poor water solubility, broad molecular weight (MW) distribution, and highly complex structure of lignin restrict its wider clinical applications. These limitations may be effectively improved by chemical modifications or by using lignin fractions with a narrow MW range. Antioxidant and antimicrobial properties all...ow lignin to be used in pharmaceuticals, drug delivery, and wound healing. It is also reported as a good candidate for composite materials intended for bone regeneration scaffolds in tissue engineering. Future challenges for lignin-based materials for biomedical applications include achieving a better understanding of the structure, isolation, and batch properties of lignin, as well as structure–function relationships in its applications.
Кључне речи:
Lignin / biomedical applications / drug delivery / wound healing / pharmaceuticalsИзвор:
Lignin-based Materials: Health Care and Medical Applications, 2023, 85-105Издавач:
- The Royal Society of Chemistry
Финансирање / пројекти:
Институција/група
Institut za multidisciplinarna istraživanjaTY - CHAP AU - Radotić, Ksenija AU - Spasojević, Dragica AU - Zmejkoski, Danica Z. PY - 2023 UR - http://rimsi.imsi.bg.ac.rs/handle/123456789/2289 AB - The material selected for biomedical application must be biocompatible, stable against physiological media, non-toxic, non-carcinogenic, corrosion-resistant, bio-inert, and stimuli-responsive, and have a low wear rate. Lignin is the most abundant aromatic polymer on Earth with a complex, recalcitrant structure. A lot of knowledge is acquired on its pre-treatments and processing for biomedical uses in the forms of hydrogels, films, composite materials, nanoparticles, and aerogels. To avoid the potential toxicity and to control the cytotoxicity of lignin-based materials, it is necessary to increase the purity of the starting source materials and understand their reactivity. The poor water solubility, broad molecular weight (MW) distribution, and highly complex structure of lignin restrict its wider clinical applications. These limitations may be effectively improved by chemical modifications or by using lignin fractions with a narrow MW range. Antioxidant and antimicrobial properties allow lignin to be used in pharmaceuticals, drug delivery, and wound healing. It is also reported as a good candidate for composite materials intended for bone regeneration scaffolds in tissue engineering. Future challenges for lignin-based materials for biomedical applications include achieving a better understanding of the structure, isolation, and batch properties of lignin, as well as structure–function relationships in its applications. PB - The Royal Society of Chemistry T2 - Lignin-based Materials: Health Care and Medical Applications T1 - Lignin-based material for biomedical applications: Basic requirements and properties EP - 105 SP - 85 DO - 10.1039/9781839167843 ER -
@inbook{ author = "Radotić, Ksenija and Spasojević, Dragica and Zmejkoski, Danica Z.", year = "2023", abstract = "The material selected for biomedical application must be biocompatible, stable against physiological media, non-toxic, non-carcinogenic, corrosion-resistant, bio-inert, and stimuli-responsive, and have a low wear rate. Lignin is the most abundant aromatic polymer on Earth with a complex, recalcitrant structure. A lot of knowledge is acquired on its pre-treatments and processing for biomedical uses in the forms of hydrogels, films, composite materials, nanoparticles, and aerogels. To avoid the potential toxicity and to control the cytotoxicity of lignin-based materials, it is necessary to increase the purity of the starting source materials and understand their reactivity. The poor water solubility, broad molecular weight (MW) distribution, and highly complex structure of lignin restrict its wider clinical applications. These limitations may be effectively improved by chemical modifications or by using lignin fractions with a narrow MW range. Antioxidant and antimicrobial properties allow lignin to be used in pharmaceuticals, drug delivery, and wound healing. It is also reported as a good candidate for composite materials intended for bone regeneration scaffolds in tissue engineering. Future challenges for lignin-based materials for biomedical applications include achieving a better understanding of the structure, isolation, and batch properties of lignin, as well as structure–function relationships in its applications.", publisher = "The Royal Society of Chemistry", journal = "Lignin-based Materials: Health Care and Medical Applications", booktitle = "Lignin-based material for biomedical applications: Basic requirements and properties", pages = "105-85", doi = "10.1039/9781839167843" }
Radotić, K., Spasojević, D.,& Zmejkoski, D. Z.. (2023). Lignin-based material for biomedical applications: Basic requirements and properties. in Lignin-based Materials: Health Care and Medical Applications The Royal Society of Chemistry., 85-105. https://doi.org/10.1039/9781839167843
Radotić K, Spasojević D, Zmejkoski DZ. Lignin-based material for biomedical applications: Basic requirements and properties. in Lignin-based Materials: Health Care and Medical Applications. 2023;:85-105. doi:10.1039/9781839167843 .
Radotić, Ksenija, Spasojević, Dragica, Zmejkoski, Danica Z., "Lignin-based material for biomedical applications: Basic requirements and properties" in Lignin-based Materials: Health Care and Medical Applications (2023):85-105, https://doi.org/10.1039/9781839167843 . .