(Chalcogen)semicarbazones and their cobalt complexes differentiate HL-60 myeloid leukaemia cells and are cytotoxic towards tumor cell lines
Authors
Todorović, TamaraVukašinović, Jelena

Portalone, Gustavo
suleiman, sherif
Gligorijević, Nevenka
Bjelogrlic, Snezana K.
Jovanovic, Katarina
Radulović, Sinisa S
Andjelkovic, Katarina
Cassar, Analisse
Filipović, Nenad
Schembri-WIsmayer, Pierre
Article (Accepted Version)

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Cobaltcomplexeswithsemi-andthiosemicarbazonesof8-quinolinecarboxaldehydehavebeensynthesizedandcharacterizedbyX-raydiffractionanalysis.Thesenovelcomplexesandapreviouslysynthesized cobaltcomplexwithaselenium-basedselenosemicarbazoneligandshowedmyeloiddifferentiationactivity onalltransretinoicacidresistantHL-60acutemyeloidleukaemiacells.Theyalsoshowedvaryinglevelsof cytotoxicityonfivehumantumorcelllines:cervixcarcinomacells(HeLa),lungadenocarcinomacells (A549),colorectaladenocarcinomacells(LS-174),breastcarcinomacells(MDA-MB-361),andchronicmyeloidleukaemia(K562)aswellasonenormalhumancellline:fetallungfibroblastcells(MRC-5).Leukaemia differentiationwasmoststronglyinducedbyametal-freeoxygenligandandtheseleniumligand,whilst thelatterandthecobaltIJII)complexwithanoxygenligandshowedthestrongestdose-dependentcytotoxic activity.Infouroutoffiveinvestigatedtumorcelllines,itwasofthesameorderofmagnitudeascisplatin. Thesebestcompounds,however,hadlowertoxicityonnon-transformedMRC-5cellsthancisplatin.
Keywords:
(Chalcogen)semicarbazones / Cobalt complexes / X-ray diffraction / DNA / Cytotoxic effectSource:
MedChemComm, 2017, 8, 1, 103-111Publisher:
- RSC Publishing
Funding / projects:
- Interactions of natural products, their derivatives and coordination compounds with proteins and nucleic acids (RS-172055)
- Pharmacodynamic and pharmacogenomic research of new drugs in the treatment of solid tumors (RS-41026)
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Institut za multidisciplinarna istraživanjaTY - JOUR AU - Todorović, Tamara AU - Vukašinović, Jelena AU - Portalone, Gustavo AU - suleiman, sherif AU - Gligorijević, Nevenka AU - Bjelogrlic, Snezana K. AU - Jovanovic, Katarina AU - Radulović, Sinisa S AU - Andjelkovic, Katarina AU - Cassar, Analisse AU - Filipović, Nenad AU - Schembri-WIsmayer, Pierre PY - 2017 UR - http://rimsi.imsi.bg.ac.rs/handle/123456789/2027 AB - Cobaltcomplexeswithsemi-andthiosemicarbazonesof8-quinolinecarboxaldehydehavebeensynthesizedandcharacterizedbyX-raydiffractionanalysis.Thesenovelcomplexesandapreviouslysynthesized cobaltcomplexwithaselenium-basedselenosemicarbazoneligandshowedmyeloiddifferentiationactivity onalltransretinoicacidresistantHL-60acutemyeloidleukaemiacells.Theyalsoshowedvaryinglevelsof cytotoxicityonfivehumantumorcelllines:cervixcarcinomacells(HeLa),lungadenocarcinomacells (A549),colorectaladenocarcinomacells(LS-174),breastcarcinomacells(MDA-MB-361),andchronicmyeloidleukaemia(K562)aswellasonenormalhumancellline:fetallungfibroblastcells(MRC-5).Leukaemia differentiationwasmoststronglyinducedbyametal-freeoxygenligandandtheseleniumligand,whilst thelatterandthecobaltIJII)complexwithanoxygenligandshowedthestrongestdose-dependentcytotoxic activity.Infouroutoffiveinvestigatedtumorcelllines,itwasofthesameorderofmagnitudeascisplatin. Thesebestcompounds,however,hadlowertoxicityonnon-transformedMRC-5cellsthancisplatin. PB - RSC Publishing T2 - MedChemComm T1 - (Chalcogen)semicarbazones and their cobalt complexes differentiate HL-60 myeloid leukaemia cells and are cytotoxic towards tumor cell lines EP - 111 IS - 1 SP - 103 VL - 8 DO - https://doi.org/10.1039/c6md00501b ER -
@article{ author = "Todorović, Tamara and Vukašinović, Jelena and Portalone, Gustavo and suleiman, sherif and Gligorijević, Nevenka and Bjelogrlic, Snezana K. and Jovanovic, Katarina and Radulović, Sinisa S and Andjelkovic, Katarina and Cassar, Analisse and Filipović, Nenad and Schembri-WIsmayer, Pierre", year = "2017", abstract = "Cobaltcomplexeswithsemi-andthiosemicarbazonesof8-quinolinecarboxaldehydehavebeensynthesizedandcharacterizedbyX-raydiffractionanalysis.Thesenovelcomplexesandapreviouslysynthesized cobaltcomplexwithaselenium-basedselenosemicarbazoneligandshowedmyeloiddifferentiationactivity onalltransretinoicacidresistantHL-60acutemyeloidleukaemiacells.Theyalsoshowedvaryinglevelsof cytotoxicityonfivehumantumorcelllines:cervixcarcinomacells(HeLa),lungadenocarcinomacells (A549),colorectaladenocarcinomacells(LS-174),breastcarcinomacells(MDA-MB-361),andchronicmyeloidleukaemia(K562)aswellasonenormalhumancellline:fetallungfibroblastcells(MRC-5).Leukaemia differentiationwasmoststronglyinducedbyametal-freeoxygenligandandtheseleniumligand,whilst thelatterandthecobaltIJII)complexwithanoxygenligandshowedthestrongestdose-dependentcytotoxic activity.Infouroutoffiveinvestigatedtumorcelllines,itwasofthesameorderofmagnitudeascisplatin. Thesebestcompounds,however,hadlowertoxicityonnon-transformedMRC-5cellsthancisplatin.", publisher = "RSC Publishing", journal = "MedChemComm", title = "(Chalcogen)semicarbazones and their cobalt complexes differentiate HL-60 myeloid leukaemia cells and are cytotoxic towards tumor cell lines", pages = "111-103", number = "1", volume = "8", doi = "https://doi.org/10.1039/c6md00501b" }
Todorović, T., Vukašinović, J., Portalone, G., suleiman, s., Gligorijević, N., Bjelogrlic, S. K., Jovanovic, K., Radulović, S. S., Andjelkovic, K., Cassar, A., Filipović, N.,& Schembri-WIsmayer, P.. (2017). (Chalcogen)semicarbazones and their cobalt complexes differentiate HL-60 myeloid leukaemia cells and are cytotoxic towards tumor cell lines. in MedChemComm RSC Publishing., 8(1), 103-111. https://doi.org/https://doi.org/10.1039/c6md00501b
Todorović T, Vukašinović J, Portalone G, suleiman S, Gligorijević N, Bjelogrlic SK, Jovanovic K, Radulović SS, Andjelkovic K, Cassar A, Filipović N, Schembri-WIsmayer P. (Chalcogen)semicarbazones and their cobalt complexes differentiate HL-60 myeloid leukaemia cells and are cytotoxic towards tumor cell lines. in MedChemComm. 2017;8(1):103-111. doi:https://doi.org/10.1039/c6md00501b .
Todorović, Tamara, Vukašinović, Jelena, Portalone, Gustavo, suleiman, sherif, Gligorijević, Nevenka, Bjelogrlic, Snezana K., Jovanovic, Katarina, Radulović, Sinisa S, Andjelkovic, Katarina, Cassar, Analisse, Filipović, Nenad, Schembri-WIsmayer, Pierre, "(Chalcogen)semicarbazones and their cobalt complexes differentiate HL-60 myeloid leukaemia cells and are cytotoxic towards tumor cell lines" in MedChemComm, 8, no. 1 (2017):103-111, https://doi.org/https://doi.org/10.1039/c6md00501b . .